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Experiences of Mothers on the Utilization of Elimination of Mother to Child Transmission of HIV Services at Mtendere Clinic, Lusaka
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作者 Ireen Kasongo Silavwe Patricia Katowa Mukwato +2 位作者 Sebean Mayimbo Febiano Phiri Laura Lubinda 《Journal of Biosciences and Medicines》 2024年第4期298-318,共21页
Introduction: Acquired immunodeficiency syndrome is one of the leading causes of mortality among women of reproductive age and Mother to Child Transmission of Human immunodeficiency virus is still a challenge affectin... Introduction: Acquired immunodeficiency syndrome is one of the leading causes of mortality among women of reproductive age and Mother to Child Transmission of Human immunodeficiency virus is still a challenge affecting many countries. Globally, an estimation of 180,000 children under 15 years acquire the Human immunodeficiency virus every day, and more than 90% of those infections are due to Mother to Child Transmission. The study sought to explore the experiences of mothers on the Elimination of Mother to Child Transmission-HIV services at Mtendere Clinic, Lusaka. Materials and Methods: Qualitative interpretive phenomenology study design was employed using in-depth interviews to collect data from a sample that was selected using purposive sampling technique. Thirteen participants were recruited, and these were HIV-positive mothers at least between the ages of 15 and 49 years and enrolled in the Elimination of Mother To Child Transmission-HIV program. The in-depth interviews were audiotape recorded and transcribed verbatim. Data was analyzed using thematic method. Findings: Three main themes that emerged are;living with HIV, support system and barriers to utilization of Elimination of Mother To Child Transmission-HIV services. Most of the participants expressed having acquired knowledge from the program, and received counselling and support from spouses, family as well as health personnel at Mtendere health facility which culminated into a positive experience and enhanced their uptake of the Elimination of Mother to Child Transmission-HIV services. However, barriers to service utilization were identified and these included fear of stigma, negative attitudes from health workers, long waiting times, lack of support and lack of transport to the health facility. Conclusion: Interventions such as community awareness campaigns on Elimination of Mother To Child Transmission-HIV, male involvement and implementing mother-to-mother peer support strategies in Elimination of Mother To Child Transmission-HIV service utilization should be prioritized so as to alleviate stigma and enhancing a positive experience for these mothers thus reducing on the Mother to Child HIV Transmission burden and mortality rates. 展开更多
关键词 Elimination of Mother-to-Child Transmission experiences Barriers UTILIZATION HIV/AIDS
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Qualitative exploration of home life experiences and care needs among elderly patients with temporary intestinal stomas
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作者 Si-Meng Wang Jian-Ling Jiang +5 位作者 Rui Li Juan-Juan Wang Chun-Hong Gu Jia Zeng Xiao-Hui Wei Mei Chen 《World Journal of Gastroenterology》 SCIE CAS 2024年第22期2893-2901,共9页
BACKGROUND This study employed a phenomenological research approach within qualitative research to explore the challenges encountered by elderly individuals with temporary colostomies in managing their daily lives and... BACKGROUND This study employed a phenomenological research approach within qualitative research to explore the challenges encountered by elderly individuals with temporary colostomies in managing their daily lives and care needs.Protecting the anus surgery combined with temporary colostomy has emerged as a prevalent treatment modality for low rectal cancer.However,the ileostomy is susceptible to peri-stoma skin complications,as well as fluid,electrolyte,and nutritional imbalances,posing challenges to effective management.The successful selfmanagement of patients is intricately linked to their adjustment to temporary colostomy;nonetheless,there remains a dearth of research examining the factors influencing self-care among temporary colostomy patients and the obstacles they confront.AIM To investigate the lived experiences,perceptions,and care requirements of temporary colostomy patients within their home environment,with the ultimate goal of formulating a standardized management protocol.METHODS Over the period of June to August 2023,a purposive sampling technique was utilized to select 12 patients with temporary intestinal stomas from a tertiary hospital in Shanghai,China.Employing a phenomenological research approach,a semi-structured interview guide was developed,and qualitative interviews were conducted using in-depth interview techniques.The acquired data underwent coding,analysis,organization,and summarization following Colaizzi’s seven-step method.RESULTS The findings of this study revealed that the experiences and needs of patients with temporary intestinal stomas can be delineated into four principal themes:Firstly,Temporary colostomy patients bear various burdens and concerns about the uncertainty of disease progression;secondly,patients exhibit limited self-care capabilities and face information deficits,resulting in heightened reliance on healthcare professionals;thirdly,patients demonstrate the potential for internal motivation through proactive self-adjustment;and finally,patients express a significant need for emotional and social support.CONCLUSION Home-living patients with temporary intestinal stomas confront multifaceted challenges encompassing burdens,inadequate self-care abilities,informational deficits,and emotional needs.Identifying factors influencing patients’self-care at home and proposing strategies to mitigate barriers can serve as a foundational framework for developing and implementing nursing interventions tailored to the needs of patients with temporary intestinal stomas. 展开更多
关键词 ELDERLY Temporary intestinal stomas Life experiences Intestinal ostomy complications Qualitative study
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Community Caregivers’ Experiences and Programmatic Strategies to Improve Active Case Finding in Community Tuberculosis Care in Botswana 2016-2021
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作者 Unami Modongo-Mathebula Mary Moleki Tefera Agizew 《Journal of Tuberculosis Research》 2024年第2期105-118,共14页
Background: The community tuberculosis care program was started to reduce the impact of TB and increase successful treatment outcomes, thus contributing to meeting WHO targets on TB. According to the Botswana Ministry... Background: The community tuberculosis care program was started to reduce the impact of TB and increase successful treatment outcomes, thus contributing to meeting WHO targets on TB. According to the Botswana Ministry of Health, community tuberculosis care was introduced with the main goal of reducing tuberculosis-related morbidity and mortality among communities through the expansion of direct observed therapy and community involvement to community settings. The community caregivers were to support tuberculosis patients throughout their treatment period until they were cured or had completed their treatment. Settings: Two major cities of Botswana, Francistown and Gaborone, with more than twenty-two health clinics offering tuberculosis care. Objective: To investigate community caregivers’ experiences and identify programmatic strategies to improve active TB case findings under the community TB care (CTBC) program in Botswana during 2016-2021. Methods: We adopted a descriptive qualitative research design, followed by convenience purposive sampling. We obtained consent and interviewed 40 participants who met the inclusion criteria, 16 out of 73 in Gaborone and 24 out of 38 from Francistown. Results: We interviewed 40 caregivers with a mean age of 43.4 years. Accepting the caregiving role was identified as the main experience by more than two thirds of the caregivers. While at least more than two-fifth felt obligated to care for the patient at home due to personal relations. More than half of the respondents found caregiving difficult or frustrating due to some challenges encountered during the caregiving role. Behavioral modifications were suggested under different subthemes as strategies to improve active case finding. [-rId13-]Conclusion: Acceptance was the major experience in CTBC. Intensification of known programmatic strategies was suggested by caregivers to improve tuberculosis active case finding in CTBC. 展开更多
关键词 Community experiences CAREGIVERS Active Case Finding TUBERCULOSIS Community Tuberculosis Care
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The Tenth Anniversary of Free Trade Pilot Zones in China:Fundamental Experiences and Enhancement Strategies
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作者 Pei Changhong 《China Economist》 2024年第3期2-20,共19页
Since the 18th National Congress of the Communist Party of China,the country has established 21 Free Trade Pilot Zones(FTZs),achieving significant pioneering results in reform and opening up and creating a strong demo... Since the 18th National Congress of the Communist Party of China,the country has established 21 Free Trade Pilot Zones(FTZs),achieving significant pioneering results in reform and opening up and creating a strong demonstrative effect nationwide.The basic experience from a decade of FTZs includes:adhering to the centralized and unified leadership of the CPC Central Committee;combining top-level design with encouragement of grassroots innovation;leveraging the distinct characteristics and strengths of FTZs to form a differentiated development pattern;maintaining the integration of opening up with domestic reforms;using openness to drive reforms;and organically combining openness with national security assurance.Under the current and future new circumstances,China’s FTZs face new challenges and tasks.In accordance with the directives of the 20th National Congress of the Communist Party of China,an enhancement strategy for the FTZs needs to be implemented.This involves the following:First,accurately understanding and responding to the changing situation to create strategic opportunities.Second,shifting paradigms to implement innovation-driven strategies,using the new development pattern concept to guide the reform experiments and construction of the FTZs.Third,granting more autonomy to FTZs for reforms,pursuing progress while maintaining stability,and solidly advancing the reform experiments in the FTZs.Fourth,orderly expanding the opening up of the service sector and cautiously advancing the internationalization of the renminbi.Fifth,promoting innovative development in trade to build a strong trade nation.Sixth,establishing synergy with bilateral FTZs,Belt and Road cooperation,and national diplomatic strategies to enhance the linkage effect. 展开更多
关键词 Tenth anniversary of Free Trade Pilot Zones experience summary enhancement strategy conception
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Transforming Digital Experiences: The Evolution of Digital Experience Platforms (DXPs) from Monoliths to Microservices: A Practical Guide
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作者 Sourabh Sethi Sarah Panda 《Journal of Computer and Communications》 2024年第2期142-155,共14页
The research aims to explore the transition from monolithic Digital Experience Platforms (DXPs) to Microservices-based DXPs, addressing scalability challenges. The study systematically decomposes monolithic structures... The research aims to explore the transition from monolithic Digital Experience Platforms (DXPs) to Microservices-based DXPs, addressing scalability challenges. The study systematically decomposes monolithic structures into Microservices, emphasizing business capability and subdomain decomposition. Concrete insights, challenges, and solutions encountered during this transformation process are presented. The research contributes valuable insights into the challenges and benefits of adopting Microservices in DXPs. Results highlight the importance of architectural patterns and strategic scaling dimensions for improved performance and scalability. The case study on Backbase’s Engagement Banking Platform showcases successful implementation, providing flexibility, integration, and efficient development in the evolving DXP landscape. 展开更多
关键词 Digital Experience Platforms (DXPs) Microservices Software Evolution Distributed Systems Architectural Patterns
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Mothers’challenges and experiences of children with cerebral palsy:a qualitative meta-synthesis
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作者 Meng-Yun Peng Yi-Fu Lu 《Frontiers of Nursing》 2024年第2期169-179,共11页
Objective:To examine what challenges and experiences a mother faces in caring for children with cerebral palsy(CP).As the main caregiver of children with CP,mothers are under multiple pressures.Even though mothers’ch... Objective:To examine what challenges and experiences a mother faces in caring for children with cerebral palsy(CP).As the main caregiver of children with CP,mothers are under multiple pressures.Even though mothers’challenges and experiences of children with CP will affect their quality of life and the rehabilitation of the children,little is known about their challenges and experiences during the whole care.Methods:A qualitative meta-synthesis was conducted to extract and analyze qualitative research from the PubMed,CINAHL,PsycINFO,Web of Science,Ovid and MEDLINE databases.Thirteen articles were selected and analyzed using thematic syntheses.Results:From 2522 screened abstracts,84 texts were reviewed,and 13 studies met the inclusion criteria.Mothers’challenges and experiences of children with CP include 4 themes,both positive and negative.Conclusions:The mothers of children with CP suffer from physical burden,as well as psychological pressure,in the care experience;social and healthcare support are their main challenges.Interventions to help them face the difficulties and adapt to the role of caregivers as soon as possible should target multiple aspects in order to maximize effectiveness,to promote the healthy growth of children with CP. 展开更多
关键词 CHALLENGES children with cerebral palsy EXPERIENCE META-SYNTHESIS mothers
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Exploring the meaning of care among lived experiences of patients with blindness:an interpretive phenomenological study
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作者 Mohammad Ali Mohammadi Mehdi Heidarzadeh +1 位作者 Saeed Mehri Mahmood Shamshiri 《Frontiers of Nursing》 2024年第3期319-326,共8页
Objective:To explore the meaning of care experienced by people with blindness in hospitals.Methods:Interpretive phenomenology along with the 6-step method of van Manen was used to conduct the study.Using purposeful sa... Objective:To explore the meaning of care experienced by people with blindness in hospitals.Methods:Interpretive phenomenology along with the 6-step method of van Manen was used to conduct the study.Using purposeful sampling,15 people with legal blindness were interviewed.Thematic analysis was used to isolate the meaning of care.Results:Five themes emerged:(a)nurses in the eyes of patients with blindness;(b)negligence in the caring moments;(c)being cared for in ambiguity;(d)Uncoordinated care;and(e)Psychological discomfor t.These sub-themes were condensed into an overarching theme titled as“marginalized patients inside the stereotypical healthcare system.”Conclusions:Lived experiences of patients with blindness revealed that hospitals provide stereotypic or inappropriate care for this minority group in society.Health professionals par ticularly nurses should be skilled to provide person-centered and coordinated care for patients with blindness. 展开更多
关键词 HOSPITALIZATION lived experience meaning of care people with blindness PHENOMENOLOGY
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Nurses’experiences in providing antenatal care during COVID-19 lockdown in Ghana
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作者 Matilda Acquah Mensah Richard Nana Abankwah Owusu Mensah 《Nursing Communications》 2024年第18期1-5,共5页
Background:The coronavirus disease 2019(COVID-19)pandemic posed a major global health threat,leading to the disruption and strain of numerous health systems globally.The situation deprived essential routine healthcare... Background:The coronavirus disease 2019(COVID-19)pandemic posed a major global health threat,leading to the disruption and strain of numerous health systems globally.The situation deprived essential routine healthcare services,including antenatal care,of the needed attention,significantly affecting facility workers.This study therefore aimed to explore the lived experiences and challenges faced by nurses providing antenatal care during the COVID-19 pandemic.Methods:Data were collected through in-depth interviews with seven antenatal care nurses.The interviews were transcribed and analyzed using thematic analysis to identify recurring themes.Four main themes emerged:(1)Knowledge capital,which refers to the essential knowledge and skills required;(2)Interventions,highlighting the measures taken to adapt care;(3)Antenatal care challenges,detailing the specific obstacles faced;and(4)Coping strategies,outlining the methods used by nurses to manage stress and maintain care quality.Results:The results highlight the emotional and economic toll of the pandemic on antenatal care nurses and the importance of effective collaboration and coping strategies.The findings also underscore the crucial role of teamwork,dedication,quick adjustment,and the role of information communication technology in maneuvering through pandemics to provide continuous essential care.Conclusion:These insights are crucial for health agencies and organizations to develop supportive strategies that ensure the continuity of healthcare delivery and safeguard the well-being of healthcare workers during crises. 展开更多
关键词 antenatal care COVID-19 pandemic mobility and health nurses’experiences routine healthcare services TELEHEALTH
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电动叶菜收获机速度协同控制系统设计与试验
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作者 左志宇 李东旭 +5 位作者 毛罕平 韩绿化 胡建平 张晓东 牟晋东 顾灵杰 《农机化研究》 北大核心 2025年第1期33-38,共6页
针对电动叶菜收获机切割、输送和行走三者速度不协调导致的叶菜损伤率高、功耗大和收获效率低等问题,开发了一种电动叶菜收获机速度协同控制系统。系统以可编程逻辑控制器为核心,利用信息传感模块对割刀电机的电流、电压和转速进行数据... 针对电动叶菜收获机切割、输送和行走三者速度不协调导致的叶菜损伤率高、功耗大和收获效率低等问题,开发了一种电动叶菜收获机速度协同控制系统。系统以可编程逻辑控制器为核心,利用信息传感模块对割刀电机的电流、电压和转速进行数据采集;主控模块根据速度协同控制算法对采集信号进行处理,得到负载信息并协同切割、输送和行走三者速度。田间试验结果表明:系统稳定可靠,能够根据收获情况动态协同各部件速度参数,叶菜损伤率为8.88%;与传统定速控制方法相比,收获机功耗降低了13.1%,收获效率提升了33.4%。 展开更多
关键词 叶菜收获机 速度协同 损伤率 田间试验
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地震宽角反射/折射方法发展述评
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作者 王夫运 田晓峰 刘汉奇 《地球与行星物理论评(中英文)》 2025年第2期118-130,共13页
本文从地震宽角反射/折射方法的仪器装备、观测系统、观测实验、震相识别、数据分析等主要技术环节的出现、改进、发展、完善,回顾了该方法的百年发展历史.按照我们的见解,将其发展过程分为萌芽期、诞生期、成长期和发展期.对于早期的追... 本文从地震宽角反射/折射方法的仪器装备、观测系统、观测实验、震相识别、数据分析等主要技术环节的出现、改进、发展、完善,回顾了该方法的百年发展历史.按照我们的见解,将其发展过程分为萌芽期、诞生期、成长期和发展期.对于早期的追溯,重点放在方法的孕育和诞生起到关键作用的人物和事件上,并且尽可能详细;对后期的回顾,聚焦在方法的技术内容的萌发、出现、改进、应用和重点文献等方面,如,何时出现了剖面方法、相遇和追逐观测、地震宽角反射/折射剖面数据的完备性等,成果表述不作为重点,而且叙述简略.述及了天然地震学、地震折射勘探、地震反射勘探、电子技术、通讯技术、测量技术、计算机技术、计算数学等相关学科的进步,对地震宽角反射/折射方法发展的促进作用.展望未来,宽角反射/折射方法在我国深部探测与矿产资源勘查领域大有可为.以此文致敬追寻科学真理的地学前辈. 展开更多
关键词 地震宽角反射/折射方法 轻便地震仪 观测系统 观测实验 资料分析
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内皮细胞特异性骨形态发生蛋白2对血管新生的影响:生物信息学分析和实验验证
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作者 燕茹 王凯茹 +2 位作者 张飞燕 贾绍斌 丛广志 《中国组织工程研究》 CAS 北大核心 2025年第1期103-110,共8页
背景:血管新生是心血管疾病的主要干预靶点,骨形态发生蛋白2具有调控血管新生作用,但内皮细胞特异性骨形态发生蛋白2对血管新生的调控作用不清楚。目的:探讨内皮细胞特异性骨形态发生蛋白2对血管新生的影响。方法:(1)生物信息学分析:通... 背景:血管新生是心血管疾病的主要干预靶点,骨形态发生蛋白2具有调控血管新生作用,但内皮细胞特异性骨形态发生蛋白2对血管新生的调控作用不清楚。目的:探讨内皮细胞特异性骨形态发生蛋白2对血管新生的影响。方法:(1)生物信息学分析:通过Panglao DB公共基因表达数据库单细胞转录组荟萃分析观察骨形态发生蛋白2细胞群表达丰度和定位。血管新生小鼠和内皮(心内膜)过表达骨形态发生蛋白2小鼠转录组测序数据集探索内皮细胞骨形态发生蛋白2对血管新生信号通路的调控作用。(2)体内实验验证:建立小鼠后肢缺血模型,对比模型小鼠患侧与健侧缺血后肢7,14和21 d血流灌注情况,免疫荧光和免疫组织化学染色评估小鼠骨形态发生蛋白2和CD31的表达定位情况。(3)体外实验验证:体外培养人脐静脉内皮细胞,分为对照组、缺氧组和骨形态发生蛋白2抑制剂(Noggin蛋白)干预组,培养24 h,观察各组内皮细胞血管新生情况。结果与结论:(1)内皮细胞是表达骨形态发生蛋白2的重要细胞亚群,在血管新生内皮细胞和骨形态发生蛋白2过表达内皮细胞转录组再分析均发现骨形态发生蛋白2表达明显升高,血管新生通路明显激活。(2)缺血7 d小鼠新生血管周围骨形态发生蛋白2阳性血管明显增加(P<0.05),缺血2周骨形态发生蛋白2阳性血管明显减少(P<0.001)。(3)体外培养人脐静脉内皮细胞,缺氧干预后,内皮细胞迁移能力和血管出芽明显增加,血管新生因子血管内皮生长因子和血小板衍生生长因子的表达明显升高,Noggin明显减少了缺氧诱导的内皮细胞血管新生(P<0.001),并下调血管内皮生长因子和血小板衍生生长因子的表达(P<0.01)。(4)结果证实,内皮细胞特异性骨形态发生蛋白2具有调控血管新生作用,靶向性内皮细胞骨形态发生蛋白2可望改善血管新生。 展开更多
关键词 内皮细胞 骨形态发生蛋白2 血管新生 单细胞RNA测序 批量RNA测序 信号通路 后肢缺血模型 成管实验
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长期施肥下土壤氮素指标与小麦/玉米产量关系研究
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作者 丁世杰 黄绍敏 +5 位作者 张水清 郭斗斗 宋晓 张珂珂 岳克 郭腾飞 《核农学报》 CAS 北大核心 2025年第1期157-169,共13页
为明确施肥对典型潮土区土壤氮素指标的影响以及氮素指标与作物产量的量化关系,本研究利用长期定位施肥试验系统评估施肥对土壤全氮、碱解氮、酸解有机氮组分、微生物量氮含量的影响,并进一步定量分析氮素指标与小麦、玉米产量间的关系... 为明确施肥对典型潮土区土壤氮素指标的影响以及氮素指标与作物产量的量化关系,本研究利用长期定位施肥试验系统评估施肥对土壤全氮、碱解氮、酸解有机氮组分、微生物量氮含量的影响,并进一步定量分析氮素指标与小麦、玉米产量间的关系。结果表明,与单施化肥或不施肥相比,长期化肥与秸秆或有机肥配施在显著提高土壤全氮含量的同时,对碱解氮、酸解总氮、酸解铵态氮、氨基酸态氮与微生物量氮含量的提高也有明显的促进作用。除土壤全氮外的其他氮素指标含量在高量化肥-有机肥配施、化肥-秸秆还田和常量化肥-有机肥配施处理间无显著差异。土壤全氮、微生物量氮和碱解氮含量是对作物产量影响程度相对较大的氮素指标。土壤全氮含量每增加0.1 g·kg^(−1),小麦和玉米分别增产822.7和968.2 kg·hm^(-2)。土微生物量氮与碱解氮含量每增加1 mg·kg^(−1),小麦增产195.2与58.1 kg·hm^(-2);玉米增产189.9与79.1 kg·hm^(-2)。酸解总氮与氨基酸态氮含量对小麦产量也有显著影响,酸解总氮与氨基酸态氮含量每增加1 mg·kg^(−1),小麦分别增产15.8与30.0 kg·hm^(-2)。综上所述,化肥与秸秆或有机肥配施可提高潮土氮素库容与供氮能力。小麦、玉米产量随土壤全氮、微生物量氮与碱解氮含量的提高呈线性增长,小麦产量与酸解总氮和氨基酸态氮含量呈显著正相关。本研究为典型潮土区地力培育与粮食丰产提供了理论依据和技术支撑。 展开更多
关键词 长期定位试验 施肥 土壤氮素指标 作物产量
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滨水空间视觉特征的注意力和情绪效应——基于高校在校学生眼动追踪实验的证据
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作者 罗玮菁 袁媛 +1 位作者 王琳婷 吴丽娟 《中山大学学报(自然科学版)(中英文)》 CAS 北大核心 2025年第1期207-217,共11页
随着社会竞争压力倍增以及城市生活高速运转,高校在校学生心理健康问题日益凸显。大量研究证实蓝绿空间具有多重健康效益。作为一种日常疗愈景观,蓝绿空间是促进心理健康的重要“自然处方”和环境资产。本研究基于视觉景观感知理论,采... 随着社会竞争压力倍增以及城市生活高速运转,高校在校学生心理健康问题日益凸显。大量研究证实蓝绿空间具有多重健康效益。作为一种日常疗愈景观,蓝绿空间是促进心理健康的重要“自然处方”和环境资产。本研究基于视觉景观感知理论,采用虚拟现实眼动追踪实验,收集51名高校在校学生的眼动行为和情绪数据,探究滨水空间视觉特征对高校在校学生注意力分配和情绪反应的作用。结果显示:公共活动型水岸引起的注视行为和愉悦情绪显著更多,不同观赏视角之间滨水空间感知的瞳孔反应和愉悦情绪存在差异。不同水平植被密度、植被结构层次和水面可视度对注意力和情绪的影响存在显著差异,且在不同空间类型和观赏视角下显示出异质性特征,即滨水空间属性之间具有交互作用。研究有助于丰富蓝绿空间人地感知理论的实验性循证探索和差异化研究,结论可为人本尺度下滨水空间精细化场所营造提供参考,以期为我国青年友好滨水空间建设提供实证支撑。 展开更多
关键词 滨水空间 注意力 情绪 眼动实验 青年友好
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局部麻醉下机器人辅助经皮椎体后凸成形伤椎注入骨水泥的患者体验分析
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作者 李佳鸿 林书 +3 位作者 唐六一 胡豇 俞阳 张伟 《中国组织工程研究》 CAS 北大核心 2025年第22期4647-4652,共6页
背景:局部麻醉下传统C臂辅助经皮椎体后凸成形手术需多次透视以调整穿刺方向,工作通道建立时间较长,患者术中疼痛刺激较大;而机器人辅助经皮椎体后凸成形手术可一次性精准穿刺成功,明显改善患者术中体验,同时减少骨水泥渗漏风险。目的:... 背景:局部麻醉下传统C臂辅助经皮椎体后凸成形手术需多次透视以调整穿刺方向,工作通道建立时间较长,患者术中疼痛刺激较大;而机器人辅助经皮椎体后凸成形手术可一次性精准穿刺成功,明显改善患者术中体验,同时减少骨水泥渗漏风险。目的:比较局部麻醉下机器人辅助和传统C臂辅助经皮椎体后凸成形手术的患者体验和其他疗效。方法:选择四川省医学科学院·四川省人民医院(电子科技大学附属医院)收治的单节段骨质疏松性椎体压缩骨折患者241例,其中132例在局部麻醉下进行机器人辅助经皮椎体后凸成形手术治疗(机器人辅助组),109例在局部麻醉下进行传统C臂辅助经皮椎体后凸成形手术治疗(传统透视组),记录患者术中体验评价、骨水泥注射量、手术时间、工作通道建立时间、住院费用及并发症,术后1 d通过影像学评估穿刺偏差与骨水泥渗漏。结果与结论:(1)机器人组59例患者术中体验评价为“非常好”,43例为“好”,16例为“一般”,10例为“差”,4例为“非常差”;传统透视组30例患者术中体验评价为“非常好”,44例为“好”,21例为“一般”,9例为“差”,5例为“非常差”,两组间术中体验评价比较差异有显著性意义(Z=-2.546,P=0.011);机器人组患者术中目测类比评分低于传统透视组(t=-9.513,P=0.000);机器人组、传统透视组愿意在必要时再次接受经皮椎体后凸成形手术的患者分别为84例和47例,组间比较差异有显著性意义(Z=-2.730,P=0.006);(2)机器人组患者手术时间、住院费用均多于传统透视组(t=2.860,P=0.003;t=36.522,P=0.000),工作通道建立时间短于传统透视组(t=-27.066,P=0.000),穿刺精度优于传统透视组(Z=-3.656,P=0.000),骨水泥渗漏率低于传统透视组(χ^(2)=7.284,P=0.007);(3)结果表明,局部麻醉后在机器人辅助行经皮椎体后凸成形手术患者的手术体验较好,具有穿刺精确、工作通道建立时间短、骨水泥渗漏率低的优势。 展开更多
关键词 机器人 骨质疏松性椎体压缩骨折 经皮椎体后凸成形 患者体验 局部麻醉
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体外实验中压应力对细胞的作用和影响
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作者 闫鹏安 蔡逸帆 +3 位作者 闫振兴 魏雨乔 耿彬 夏亚一 《中国组织工程研究》 CAS 北大核心 2025年第23期4993-5001,共9页
背景:沃尔夫定律指出,机体缺乏机械应力会导致骨组织的微结构退化、质量损失和代谢紊乱,并最终导致骨质疏松症,这提示机械应力在骨组织生长、重建及成形中具有重要作用。目前机械应力对成骨细胞的相关研究主要集中在流体剪切力上,但其... 背景:沃尔夫定律指出,机体缺乏机械应力会导致骨组织的微结构退化、质量损失和代谢紊乱,并最终导致骨质疏松症,这提示机械应力在骨组织生长、重建及成形中具有重要作用。目前机械应力对成骨细胞的相关研究主要集中在流体剪切力上,但其在体内干预较为困难,同时有研究发现压应力在一定程度上也可以起到与流体剪切力类似的作用,探究压应力在体外对细胞的作用方式和影响,可以丰富机械应力与细胞的相互作用关系,有助于为包括骨质疏松在内的代谢性骨病和其他疾病的研究提供理论依据。目的:综述体外实验中压应力对细胞的施加方式、引起细胞产生不同的生物学行为、可能的作用信号途径以及未来可能应用的领域。方法:检索PubMed、Web of Science、中国知网及万方数据库2000年1月至2024年3月发表的相关文献,中文检索词为“压应力,机械应力,静水压力,细胞”,英文检索词为“compressive stress,mechanical stress,hydrostatic pressure,cell”。纳入压应力作用于细胞的基础研究及微观机制研究,最终对纳入的63文献进行综述。结果与结论:(1)压应力的施加方式多样,不同实验设备对细胞加载压应力的方式不尽相同,需要进一步规范实验设备和标准化力学单位,减少混杂因素,使不同实验组之间具有参考性和可比性;(2)压应力可引起细胞增殖、分化、自噬、凋亡、迁移等变化,且在多数情况下压应力的作用效果具有时间或剂量依赖性;(3)目前大部分体外实验研究表明,压应力可能主要是通过MAPK信号途径、Wnt/β-catenin信号通路作用于成骨细胞,引起成骨细胞产生不同的应答;(4)压应力可对不同细胞产生不同的作用效果,还需要进一步研究其对不同组织的生物学作用;(5)对压应力的更深入研究有助于为骨科、口腔、肿瘤等疾病的治疗提供理论依据,利用静水压力进行温和消毒是一种前景巨大的消毒手段。 展开更多
关键词 成骨细胞 压应力 机械应力 生物力学 细胞实验 信号通路
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童年逆境与成年期高血压患病的研究进展
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作者 姜申 吴静 +6 位作者 周佳丽 蒋德楠 孙炜迪 程思清 朱思雨 侯乐莹 宋培歌 《中国全科医学》 CAS 北大核心 2025年第3期358-364,共7页
童年逆境(ACEs)是指发生在儿童时期(18岁以前)的各种创伤事件或情况。长期并持续的ACEs可能对儿童身心健康造成终身影响。目前,欧美地区的多项研究证实了ACEs可增加个体成年期高血压的患病风险,然而不同分型的ACEs与成年期高血压的关联... 童年逆境(ACEs)是指发生在儿童时期(18岁以前)的各种创伤事件或情况。长期并持续的ACEs可能对儿童身心健康造成终身影响。目前,欧美地区的多项研究证实了ACEs可增加个体成年期高血压的患病风险,然而不同分型的ACEs与成年期高血压的关联仍存在争议。本文对不同分型的ACEs与成年期高血压相关研究进行综述,探讨童年期不同分型逆境对成年期高血压患病的影响及其发生、发展机制,归纳总结两者间的研究现状并提出展望,为改善儿童早期发展环境、预防其成年期高血压研究提供依据。 展开更多
关键词 童年不良经历 童年逆境 成年期高血压 高血压 疾病负担 综述
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基于生物信息学对骨关节炎铁超载关键基因的筛选与验证
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作者 邓柯淇 李光第 +2 位作者 GOSWAMI ASHUTOSH 刘星余 何孝勇 《中国组织工程研究》 CAS 北大核心 2025年第9期1972-1980,共9页
背景:铁超载是指体内铁积累过多的情况,可引起各种组织的病理改变。目前,对于骨关节炎中铁超载相关的分子机制和潜在基因靶点,仍有待进一步的研究和探索。目的:通过生物信息学手段分析骨关节炎铁超载关键基因,并利用动物实验加以验证,... 背景:铁超载是指体内铁积累过多的情况,可引起各种组织的病理改变。目前,对于骨关节炎中铁超载相关的分子机制和潜在基因靶点,仍有待进一步的研究和探索。目的:通过生物信息学手段分析骨关节炎铁超载关键基因,并利用动物实验加以验证,以期为铁超载角度防治骨关节炎提供新的思路。方法:使用GEO数据库和GeneCards数据库筛选出与骨关节炎相关的基因和铁超载相关的基因。然后,取两者的交集,得到骨关节炎和铁超载共同相关的基因集合。采用GO和KEGG富集分析筛选这些基因的功能和通路。为了进一步研究这些基因之间的相互作用,构建PPI网络,并利用Cytoscape软件的5种计算方法来识别骨关节炎铁超载的关键基因(Hub基因)。将12只雄性SD大鼠分为骨关节炎组与对照组(正常大鼠),每组6只,骨关节炎组大鼠采用改良Hulth方法建立膝骨关节炎模型,并使用PCR检测Hub基因在两组大鼠膝关节组织中的表达情况。结果与结论:①共获得51个骨关节炎铁超载基因,GO富集分析表明其主要参与细胞因子受体结合、趋化因子受体结合、细胞因子活性、生长因子受体结合及寡糖结合等过程;②KEGG富集分析表明骨关节炎铁超载基因主要参与肿瘤坏死因子信号通路、脂质和动脉粥样硬化等信号通路;③构建蛋白质-蛋白质相互作用网络,进一步分析获得细胞间黏附分子1(intercellular cell adhesion molecule-1,ICAM-1)、肿瘤坏死因子配体超家族成员11(tumor necrosis factor superfamily member 11,TNFSF11)、骨髓瘤细胞癌基因(myelocytomatosis oncogene,MYC)、Janus激酶2(janus kinase 2,JAK2)及白细胞介素6,5个骨关节炎铁超载Hub基因,动物实验证实其在对照组与骨关节炎组大鼠膝关节组织中的表达有显著差异(P<0.05);④结果显示,ICAM-1,TNFSF11,MYC,JAK2及白细胞介素6可作为骨关节炎铁超载的关键基因,有望成为防治骨关节炎的新靶点。 展开更多
关键词 骨关节炎 铁超载 关键基因 差异基因 生物信息学 动物实验 实验验证 生物标志物
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旅游地魅力对旅游者忠诚影响的中介与调节作用
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作者 郭安禧 郭英之 《海南大学学报(人文社会科学版)》 2025年第1期236-246,共11页
旅游地魅力是近些年被提出和关注的新话题,目前考察旅游地魅力如何影响旅游者忠诚的研究尚少。本研究基于理智人模型、心理连续体模型和期望不一致理论,以享乐幸福感、实现幸福感、地方依赖、地方认同为中介和旅游体验质量为调节,探讨... 旅游地魅力是近些年被提出和关注的新话题,目前考察旅游地魅力如何影响旅游者忠诚的研究尚少。本研究基于理智人模型、心理连续体模型和期望不一致理论,以享乐幸福感、实现幸福感、地方依赖、地方认同为中介和旅游体验质量为调节,探讨旅游地魅力对旅游者忠诚影响的中介路径和边界条件。通过对旅游者问卷调查获得的444份有效问卷进行实证分析,结果显示:旅游地魅力对旅游者忠诚没有显著直接影响,享乐幸福感、地方依赖、地方认同在二者间起完全中介作用;旅游地魅力能提升享乐幸福感和实现幸福感,享乐幸福感会提升旅游者忠诚度,但实现幸福感不会提升旅游者忠诚度;旅游地魅力能增强地方依赖和地方认同,地方依赖和地方认同又能增强旅游者忠诚;旅游体验质量在旅游地魅力与实现幸福感、地方依赖、地方认同的作用关系中起正向调节作用。 展开更多
关键词 旅游地魅力 旅游者幸福感 地方依恋 旅游者忠诚 旅游体验质量
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Worldwide experiences of endoscopic submucosal dissection:Not just Eastern acrobatics 被引量:49
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作者 Kwang Bum Cho Won Joong Jeon Jae J Kim 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第21期2611-2617,共7页
The high incidence of gastric cancer has led to the initiation of cancer screening programs.As a result,the number of early gastric cancer cases has increased and consequentially,the cancer mortality rate has decrease... The high incidence of gastric cancer has led to the initiation of cancer screening programs.As a result,the number of early gastric cancer cases has increased and consequentially,the cancer mortality rate has decreased.Moreover,the development of minimally invasive endoscopic treatment has been introduced for these early lesions.Endoscopic submucosal dissection(ESD) is now recognized as one of the preferred treatment modalities for premalignant gastrointestinal epithelial lesions and early gastric cancer without lymph node metastasis.We review the results of ESD including experiences in Japan and Korea,as well as western countries. 展开更多
关键词 experiences Endoscopic submucosal dissection
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Registered Nurses’ Experiences with Clinical Teaching Environment in Malawi 被引量:7
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作者 Thokozani Bvumbwe Atupele Malema Mep Chipeta 《Open Journal of Nursing》 2015年第10期927-934,共8页
Clinical practice remains an integral part of nursing curriculum because clinical practice provides students with an opportunity to achieve professional competence. Creating a conducive learning environment for studen... Clinical practice remains an integral part of nursing curriculum because clinical practice provides students with an opportunity to achieve professional competence. Creating a conducive learning environment for students is responsibility of academic staff, clinical nurses and students alike. However, studies in Malawi have reported poor clinical learning environment for students. This study therefore aimed at exploring nurses’ experiences of clinical teaching environment in Malawi. The study used a qualitative research design utilizing a descriptive phenomenological approach. Participants were randomly identified from teaching hospitals across Malawi by nursing managers to attend a six week clinical preceptorship training at one University nursing college. Immediately before commencement of the training, participants were invited to voluntarily participate in a focus group discussion pertaining to their experiences with clinical environment. We conducted focus group discussions with 9 trainees in 2013 and 12 trainees in 2014 training cohorts. Findings reveal that nurses meet a number of challenges in teaching students in the clinical area. Four themes emerged from the study, namely, inadequate faculty support, poor clinical teaching environment, poor competence among nurses and unsupportive working conditions. Nurses require support from academic staff and their managers to ensure a conducive clinical teaching environment. 展开更多
关键词 Preceptors’ experiences CLINICAL LEARNING ENVIRONMENT CLINICAL TEACHING
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