Trivalent organoarsenic compounds have attracted a great deal of interest because of their potential antineoplastic activities. In this work, we synthesized a series of arsenic-containing amino acid analogues by intro...Trivalent organoarsenic compounds have attracted a great deal of interest because of their potential antineoplastic activities. In this work, we synthesized a series of arsenic-containing amino acid analogues by introducing the structure of 1-arsino-2,6,7- trithiobicyclo[2.2.2]octane to the side chain of modified amino acid derivatives. The protected amino acid （6a） as a typical objective compound was applied in peptide synthesis via the classic procedures for the formation of peptide bond or removal of protecting groups. Our results showed that the application of compound 6a （or 5a） in the peptide chemistry was satisfactory.展开更多
Inorganic polyhedral oligomeric silsesquioxane （POSS） was used as the core for the synthesis of poly（t- lysine） peptide dendrimer via copper-catalyzed azide-alkyne click chemistry. The inorganic/organic composite ...Inorganic polyhedral oligomeric silsesquioxane （POSS） was used as the core for the synthesis of poly（t- lysine） peptide dendrimer via copper-catalyzed azide-alkyne click chemistry. The inorganic/organic composite dendrimer was characterized by MS, 1H NMR, FTIR, GPC and DLS.展开更多
文摘Trivalent organoarsenic compounds have attracted a great deal of interest because of their potential antineoplastic activities. In this work, we synthesized a series of arsenic-containing amino acid analogues by introducing the structure of 1-arsino-2,6,7- trithiobicyclo[2.2.2]octane to the side chain of modified amino acid derivatives. The protected amino acid （6a） as a typical objective compound was applied in peptide synthesis via the classic procedures for the formation of peptide bond or removal of protecting groups. Our results showed that the application of compound 6a （or 5a） in the peptide chemistry was satisfactory.
基金supported by the National Basic Research Program of China(National 973 program,No.2011CB606206)National Science Foundation of China(NSFC,Nos.31170921,51133004)+1 种基金the National Science Foundation for Excellent Young Scholars(No.51222304)Program for Changjiang Scholars and Innovative Research Team in University(No.IRT1163)
文摘Inorganic polyhedral oligomeric silsesquioxane （POSS） was used as the core for the synthesis of poly（t- lysine） peptide dendrimer via copper-catalyzed azide-alkyne click chemistry. The inorganic/organic composite dendrimer was characterized by MS, 1H NMR, FTIR, GPC and DLS.
