Microbial resistance has now become a global public health concern,and the spread of multidrug-resistant bacteria also threatens human health.Antimicrobial peptides(AMPs)are a class of small peptides with antibacteria...Microbial resistance has now become a global public health concern,and the spread of multidrug-resistant bacteria also threatens human health.Antimicrobial peptides(AMPs)are a class of small peptides with antibacterial,anti-inflammatory,anti-infective,antioxidation,anti-tumor,antiviral functions and immune regulation activities.Due to the small sizes,their structures are easily studied by nuclear magnetic resonance(NMR)techniques.Compared to traditional antibiotics,AMPs have specific antibacterial mechanisms,and do not easily result in the production of drug-resistant strains.Thus,the development of new antimicrobial peptides and their wide use instead of chemical antibiotics are of great significance to human health.In this review,we first summarized the relationship between the structures and functions of antimicrobial peptides.Then,we focused on examples,cathelicidins,a group of cationic antimicrobial peptides with multiple biological activities.Especially,cathelicidin BF30 or BF34,composed of 30 or 34 amino acids,were from the venom glands of the Bungarus fasciatus snake and were considered to be the most active antibacterial peptides among different cathelicidin members.Their solution structures determined by NMR are a-helixes,which are useful in designing new and stable peptides with similar framework,including stapple peptides by inducing chemical modifications in the sidechains of some residues,as well as cyclic peptides by inducing disulfide bond between cysteines in the sequences.展开更多
Heart function and plasma atrial natriuretic peptide (ANP).plasma renin actiity(PRA) andangiotensionⅡ(Ang Ⅱ) were examined with echocardiography and radioimmunoassay in patients with dilated cardiomyopathy(DCM),
Study is undertaken of spherical function spectral structures of long-term mean and anomaly patterns of the Northern Hemisphere 500 hPa monthly mean geopotential height together with the seasonal and interannual varia...Study is undertaken of spherical function spectral structures of long-term mean and anomaly patterns of the Northern Hemisphere 500 hPa monthly mean geopotential height together with the seasonal and interannual variations investigated.Results show that they are marked by low dimensions and low orders,and the mean and anomaly fields can be described in terms of 20 and 50 spherical function components,respectively.展开更多
基金National Science Foundation of China(NSFC)under No.22174155,22177127 and 21977110.
文摘Microbial resistance has now become a global public health concern,and the spread of multidrug-resistant bacteria also threatens human health.Antimicrobial peptides(AMPs)are a class of small peptides with antibacterial,anti-inflammatory,anti-infective,antioxidation,anti-tumor,antiviral functions and immune regulation activities.Due to the small sizes,their structures are easily studied by nuclear magnetic resonance(NMR)techniques.Compared to traditional antibiotics,AMPs have specific antibacterial mechanisms,and do not easily result in the production of drug-resistant strains.Thus,the development of new antimicrobial peptides and their wide use instead of chemical antibiotics are of great significance to human health.In this review,we first summarized the relationship between the structures and functions of antimicrobial peptides.Then,we focused on examples,cathelicidins,a group of cationic antimicrobial peptides with multiple biological activities.Especially,cathelicidin BF30 or BF34,composed of 30 or 34 amino acids,were from the venom glands of the Bungarus fasciatus snake and were considered to be the most active antibacterial peptides among different cathelicidin members.Their solution structures determined by NMR are a-helixes,which are useful in designing new and stable peptides with similar framework,including stapple peptides by inducing chemical modifications in the sidechains of some residues,as well as cyclic peptides by inducing disulfide bond between cysteines in the sequences.
文摘Heart function and plasma atrial natriuretic peptide (ANP).plasma renin actiity(PRA) andangiotensionⅡ(Ang Ⅱ) were examined with echocardiography and radioimmunoassay in patients with dilated cardiomyopathy(DCM),
基金This work is sponsored by the Program on Long-Range Weather Forecasting Theory and Methodology of China.
文摘Study is undertaken of spherical function spectral structures of long-term mean and anomaly patterns of the Northern Hemisphere 500 hPa monthly mean geopotential height together with the seasonal and interannual variations investigated.Results show that they are marked by low dimensions and low orders,and the mean and anomaly fields can be described in terms of 20 and 50 spherical function components,respectively.
