Studies have shown that per-and polyfluoroalkyl substances(PFASs)may be hepatotoxic in animals or humans.However,data on clinical epidemiology are very limited.In this study,21PFASs were determined in patients with li...Studies have shown that per-and polyfluoroalkyl substances(PFASs)may be hepatotoxic in animals or humans.However,data on clinical epidemiology are very limited.In this study,21PFASs were determined in patients with liver diseases,with the highest median concentrations detected in the serum sample(26.7 ng/mL),followed by blood(10.7 ng/mL)and urine(5.02 ng/mL).Higher total PFAS concentrations were found in hepatocellular carcinoma(HCC)patients compared to non-HCC patients,with significant discrepancies in serum and blood samples.Besides,significant correlations were also found among PFAS concentrations and age,gender,body mass index(BMI),and liver function biomarkers levels.For example,PFAS concentrations are significantly higher in males than in females;Several serum PFASs concentrations increase with age and BMI,while the serum perfluorohexane sulfonic acid(PFHxS)concentrations are negatively correlated with age.In addition,multiple regression models adjusted for age,gender and BMI found that increased serum perfluorobutane sulfonic acid(PFBS),perfluoroheptane sulfonic acid(PFHpS)and perfluorohexylphosphonic acid(PFHxPA)conentrations are correlated with elevated alkaline phosphatase(ALP),aspartate aminotransferase(AST),and alpha-fetoprotein(AFP)(p<0.05).Our results provide epidemiological support for the future study on the potential clinical hepatotoxicity of PFAS.展开更多
Perfluorooctanoic acid(PFOA), its salts, and related compounds were listed as new persistent organic pollutants by the Stockholm Convention in 2019.In this study, the occurrence of residues of PFOA and other per-and p...Perfluorooctanoic acid(PFOA), its salts, and related compounds were listed as new persistent organic pollutants by the Stockholm Convention in 2019.In this study, the occurrence of residues of PFOA and other per-and polyfluoroalkyl substances(PFASs) in raw materials and fluoropolymer products from the Chinese fluoropolymer industries are reported for the first time.The PFOA concentrations in raw materials and fluoropolymer products were in the range of 6.7 to 1.1 × 10^(6) ng/g, and <MDL(method detection limit) to 5.3 × 10^(3) ng/g,respectively.Generally, the levels of PFOA in raw materials were higher than in products,implying that PFOA in the emulsion/dispersion resin could be partly removed during the polymerization or post-processing steps.By tracking a company’s polytetrafluoroethylene(PTFE) production line, it was found that over a 5 year period, the residual levels of PFOA in emulsion samples declined from 1.1 × 10^(6) to 28.4 ng/g, indicating that the contamination of PFOA in fluoropolymer products from production source gradually decreased after its use had been discontinued.High concentrations of HFPO-TrA(2.7 × 10^(5) to 8.2 × 10^(5) ng/g) were detected in some emulsion samples indicating this alternative has been widely applied in fluoropolymer manufacturing in China.展开更多
Atmospheric particulate matter(PM)is a dominant source of air pollution,in particular,molecules less than 2.5μm in diameter,endangering human health.An estimated 2.1 million deaths from exposure to PM2.5 and 700,000 ...Atmospheric particulate matter(PM)is a dominant source of air pollution,in particular,molecules less than 2.5μm in diameter,endangering human health.An estimated 2.1 million deaths from exposure to PM2.5 and 700,000 cases of respiratory disease caused by atmospheric pollution were reported on an annual basis.The main components of PM2.5 include heavy metal elements,water-soluble ions,carbon aerosols,ozone,and organic compounds.Per-and polyfluoroalkyl substances(PFASs)are a large group of representative pollutants among the organic compounds absorbed in PM2.5.PFASs are widely used in industrial production and hardly degraded in the environment,resulting in their accumulation in water,food,and air,and abosorbed by humans via ingestion and inhalation.On the other hand,accumulation of PFAS in the human body is proving to be associated with some unfavorable health outcomes,whereas the mechanisms underlying the effects of PFAS exposure on human lung diseases remain unclear at present.The toxicological effects of organic components are a significant focus of research.This review will fix our attention on the changes in the distribution,composition,and content of PFAS in PM2.5 by location and year,and provide an overview on the influence of PM2.5 and PFAS on lung health,with indications of possible synergistic adverse effects of PM2.5 and PFAS on pulmonary homeostasis.展开更多
基金supported by the National Natural Science Foundation of China(No.42177408)Guangdong(China)Innovative and Entrepreneurial Research Team Program(No.2016ZT06N258)。
文摘Studies have shown that per-and polyfluoroalkyl substances(PFASs)may be hepatotoxic in animals or humans.However,data on clinical epidemiology are very limited.In this study,21PFASs were determined in patients with liver diseases,with the highest median concentrations detected in the serum sample(26.7 ng/mL),followed by blood(10.7 ng/mL)and urine(5.02 ng/mL).Higher total PFAS concentrations were found in hepatocellular carcinoma(HCC)patients compared to non-HCC patients,with significant discrepancies in serum and blood samples.Besides,significant correlations were also found among PFAS concentrations and age,gender,body mass index(BMI),and liver function biomarkers levels.For example,PFAS concentrations are significantly higher in males than in females;Several serum PFASs concentrations increase with age and BMI,while the serum perfluorohexane sulfonic acid(PFHxS)concentrations are negatively correlated with age.In addition,multiple regression models adjusted for age,gender and BMI found that increased serum perfluorobutane sulfonic acid(PFBS),perfluoroheptane sulfonic acid(PFHpS)and perfluorohexylphosphonic acid(PFHxPA)conentrations are correlated with elevated alkaline phosphatase(ALP),aspartate aminotransferase(AST),and alpha-fetoprotein(AFP)(p<0.05).Our results provide epidemiological support for the future study on the potential clinical hepatotoxicity of PFAS.
基金supported by the National Natural Science Foundation of China (No.21625702)。
文摘Perfluorooctanoic acid(PFOA), its salts, and related compounds were listed as new persistent organic pollutants by the Stockholm Convention in 2019.In this study, the occurrence of residues of PFOA and other per-and polyfluoroalkyl substances(PFASs) in raw materials and fluoropolymer products from the Chinese fluoropolymer industries are reported for the first time.The PFOA concentrations in raw materials and fluoropolymer products were in the range of 6.7 to 1.1 × 10^(6) ng/g, and <MDL(method detection limit) to 5.3 × 10^(3) ng/g,respectively.Generally, the levels of PFOA in raw materials were higher than in products,implying that PFOA in the emulsion/dispersion resin could be partly removed during the polymerization or post-processing steps.By tracking a company’s polytetrafluoroethylene(PTFE) production line, it was found that over a 5 year period, the residual levels of PFOA in emulsion samples declined from 1.1 × 10^(6) to 28.4 ng/g, indicating that the contamination of PFOA in fluoropolymer products from production source gradually decreased after its use had been discontinued.High concentrations of HFPO-TrA(2.7 × 10^(5) to 8.2 × 10^(5) ng/g) were detected in some emulsion samples indicating this alternative has been widely applied in fluoropolymer manufacturing in China.
基金supported by the Major Research Plan-Integrated Program of National Natural Science Foundation of China(No.92143301)the National Natural Science Foundation of China(No.31971318)Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Science(No.CIFMS 2019-I2M-5-018).
文摘Atmospheric particulate matter(PM)is a dominant source of air pollution,in particular,molecules less than 2.5μm in diameter,endangering human health.An estimated 2.1 million deaths from exposure to PM2.5 and 700,000 cases of respiratory disease caused by atmospheric pollution were reported on an annual basis.The main components of PM2.5 include heavy metal elements,water-soluble ions,carbon aerosols,ozone,and organic compounds.Per-and polyfluoroalkyl substances(PFASs)are a large group of representative pollutants among the organic compounds absorbed in PM2.5.PFASs are widely used in industrial production and hardly degraded in the environment,resulting in their accumulation in water,food,and air,and abosorbed by humans via ingestion and inhalation.On the other hand,accumulation of PFAS in the human body is proving to be associated with some unfavorable health outcomes,whereas the mechanisms underlying the effects of PFAS exposure on human lung diseases remain unclear at present.The toxicological effects of organic components are a significant focus of research.This review will fix our attention on the changes in the distribution,composition,and content of PFAS in PM2.5 by location and year,and provide an overview on the influence of PM2.5 and PFAS on lung health,with indications of possible synergistic adverse effects of PM2.5 and PFAS on pulmonary homeostasis.
