Preoperative albumin-bilirubin score and liver resection percentage determine postoperative liver regeneration after partial hepatectomy

BACKGROUND The success of liver resection relies on the ability of the remnant liver to regenerate.Most of the knowledge regarding the pathophysiological basis of liver regeneration comes from rodent studies,and data on humans are scarce.Additionally,there is limited knowledge about the preoperative factors that influence postoperative regeneration.AIM To quantify postoperative remnant liver volume by the latest volumetric software and investigate perioperative factors that affect posthepatectomy liver regenera-tion.METHODS A total of 268 patients who received partial hepatectomy were enrolled.Patients were grouped into right hepatectomy/trisegmentectomy(RH/Tri),left hepa-tectomy(LH),segmentectomy(Seg),and subsegmentectomy/nonanatomical hepatectomy(Sub/Non)groups.The regeneration index(RI)and late rege-neration rate were defined as(postoperative liver volume)/[total functional liver volume(TFLV)]×100 and(RI at 6-months-RI at 3-months)/RI at 6-months,respectively.The lower 25th percentile of RI and the higher 25th percentile of late regeneration rate in each group were defined as“low regeneration”and“delayed regeneration”.“Restoration to the original size”was defined as regeneration of the liver volume by more than 90%of the TFLV at 12 months postsurgery.RESULTS The numbers of patients in the RH/Tri,LH,Seg,and Sub/Non groups were 41,53,99 and 75,respectively.The RI plateaued at 3 months in the LH,Seg,and Sub/Non groups,whereas the RI increased until 12 months in the RH/Tri group.According to our multivariate analysis,the preoperative albumin-bilirubin(ALBI)score was an independent factor for low regeneration at 3 months[odds ratio(OR)95%CI=2.80(1.17-6.69),P=0.02;per 1.0 up]and 12 months[OR=2.27(1.01-5.09),P=0.04;per 1.0 up].Multivariate analysis revealed that only liver resection percentage[OR=1.03(1.00-1.05),P=0.04]was associated with delayed regeneration.Furthermore,multivariate analysis demonstrated that the preoperative ALBI score[OR=2.63(1.00-1.05),P=0.02;per 1.0 up]and liver resection percentage[OR=1.02(1.00-1.05),P=0.04;per 1.0 up]were found to be independent risk factors associated with volume restoration failure.CONCLUSION Liver regeneration posthepatectomy was determined by the resection percentage and preoperative ALBI score.This knowledge helps surgeons decide the timing and type of rehepatectomy for recurrent cases.

Combined preoperative albumin bilirubin score and hepatectomy percentage for evaluate the liver regeneration after partial hepatectomy

Surgical resection is a pivotal therapeutic approach for addressing hepatic space-occupying lesions,with liver volume restoration and hepatic functional recovery being crucial for assessing surgical prognosis.The preoperative albumin-bilirubin(ALBI)score,encompassing serum albumin and bilirubin levels,can be determined via blood analysis,effectively mitigating human error and providing an accurate depiction of liver function.The hepatectomy ratio,which is the proportion of the liver volume removed to the total liver volume,is critical in preserving an adequate liver tissue volume to ensure postoperative hepatic functional compensation,minimize surgical complications,and reduce mortality rates.Incorporating the preoperative ALBI score and hepatectomy ratio aids surgeons in assessing the optimal timing and extent of partial hepatectomy.The introduction of preoperative albumin bilirubin score and hepatectomy percentage is beneficial for the surgeons to evaluate the timing and magnitude of partial liver resection.

A novel nondestructive detection approach for seed cotton lint percentage using deep learning

Background The lint percentage of seed cotton is one of the most important parameters for evaluating seed cotton quality and affects its price.The traditional measuring method of lint percentage is labor-intensive and time-consuming;thus,an efficient and accurate measurement method is needed.In recent years,classification-based deep learning and computer vision have shown promise in solving various classification tasks.Results In this study,we propose a new approach for detecting the lint percentage using MobileNetV2 and transfer learning.The model is deployed on a lint percentage detection instrument,which can rapidly and accurately determine the lint percentage of seed cotton.We evaluated the performance of the proposed approach using a dataset comprising 66924 seed cotton images from different regions of China.The results of the experiments showed that the model with transfer learning achieved an average classification accuracy of 98.43%,with an average precision of 94.97%,an average recall of 95.26%,and an average F1-score of 95.20%.Furthermore,the proposed classification model achieved an average accuracy of 97.22%in calculating the lint percentage,showing no significant difference from the performance of experts(independent-sample t-test,t=0.019,P=0.860).Conclusion This study demonstrated the effectiveness of the MobileNetV2 model and transfer learning in calculating the lint percentage of seed cotton.The proposed approach is a promising alternative to traditional methods,providing a rapid and accurate solution for the industry.

Experimental Study on the Performance of ORC System Based on Ultra-Low Temperature Heat Sources

This paper discussed the experimental results of the performance of an organic Rankine cycle(ORC)system with an ultra-low temperature heat source.The low boiling point working medium R134a was adopted in the system.The simulated heat source temperature(SHST)in this work was set from 39.51°C to 48.60°C by the simulated heat source module.The influence of load percentage of simulated heat source(LPSHS)between 50%and 70%,the rotary valve opening(RVO)between 20%and 100%,the resistive load between 36Ωand 180Ωor the no-load of the generator,as well as the autumn and winter ambient temperature on the system performance were studied.The results showed that the stability of the system was promoted when the generator had a resistive load.The power generation(PG)and generator speed(GS)of the system in autumn were better than in winter,but the expander pressure ratio(EPR)was lower than in winter.Keep RVO unchanged,the SHST,the mass flow rate(MFR)of the working medium,GS,and the PG of the system increased with the increasing of LPSHS for different generator resistance load values.When the RVO was 60%,LPSHS was 70%,the SHST was 44.15°C and the resistive load was 72Ω,the highest PG reached 15.11 W.Finally,a simulation formula was obtained for LPSHS,resistance load,and PG,and its correlation coefficient was between 0.9818 and 0.9901.The formula can accurately predict the PG.The experimental results showed that the standard deviation between the experimental and simulated values was below 0.0792,and the relative error was within±5%.

Breeding of a New Peanut Variety Shanghua No.6 with High Shelling Percentage and Big Fruit

Shanghua No.6, a new peanut variety with high shelling percentage and bigfruit, was bred through sexual hybridization（female parent Pukehua No.2 × male parent Yuanza 9102） by Shangqiu Academy of Agriculture and Forestry Sciences. In the big peanut regional tests in north China in 2011-2012, Shanghua No.6 had the average yield of pod and seed respectively of 4 695.30 kg/hm^2 and 3 514.73 kg/hm^2;in the production test in 2013, its average yield of pod and seed were 4 531.0 5kg/hm^2 and 3 312.15 kg/hm^2. Its crude fat content was 50.46-53.46%, oleic acid content was 50.9-51.7%, and oil oleic acid/linoleic acid value was 1.69-1.76. The variety was high-resistant to brown spot and focal spot, susceptible to black spot,resistant to net blotch and stem rot. Its 100-pod weight was 256.2 g, 100-seed weight 111.2 g, and shelling percentage was 74.75%. The variety was certificated by National Crop Variety Approval Committee in 2014（identification number：2014010）, which was suitable for planting in Shandong, Henan, Hebei, Liaoning,Beijing, north of Huaihe River in Jiangsu and Anhui provinces.

Vibration reduction evaluation of a linear system with a nonlinear energy sink under a harmonic and random excitation

The nonlinear behaviors and vibration reduction of a linear system with a nonlinear energy sink(NES)are investigated.The linear system is excited by a harmonic and random base excitation,consisting of a mass block,a linear spring,and a linear viscous damper.The NES is composed of a mass block,a linear viscous damper,and a spring with ideal cubic nonlinear stiffness.Based on the generalized harmonic function method,the steady-state Fokker-Planck-Kolmogorov equation is presented to reveal the response of the system.The path integral method based on the Gauss-Legendre polynomial is used to achieve the numerical solutions.The performance of vibration reduction is evaluated by the displacement and velocity transition probability densities,the transmissibility transition probability density,and the percentage of the energy absorption transition probability density of the linear oscillator.The sensitivity of the parameters is analyzed for varying the nonlinear stiffness coefficient and the damper ratio.The investigation illustrates that a linear system with NES can also realize great vibration reduction under harmonic and random base excitations and random bifurcation may appear under different parameters,which will affect the stability of the system.

Body Mass Index and Body Fat Percentage in Assessment of Obesity Prevalence in Saudi Adults

Objective To assess the obesity prevalence in body mass index （BMI） and body fat percentage Saudi adults according to the international standards of （BF%）. Methods Five hundred and thirty healthy Saudi adults aged 18-72 years （mean 36.91＋15.22 years） were enrolled in this study. Their body composition was assessed by bioelectrical impendence analysis with a commercially available body composition analyzer. Standard BMI and BF% values were used to define obesity. Results The prevalence of underweight, normal underweight, overweight and obesity in Saudi adults according to the BMI criteria （〈18.5 kg/mz, 18.5-24.4 kg/m2, 25-29.9 kg/m2, 30 k＆/m2 and above, respectively） was 2.5%, 30.2%, 33.6%, and 33.8%, respectively, whereas the obesity prevalence was 60% （n=31g） in Saudi adults according to the BF% criteria （25% for males and 30% for females）, which was significantly higher than that according to BMI criteria. However, it was 50.6% （n=268） when the BMI cutoff point was 27.5 kg/m2, proposed by WHO for the Asian population. Kappa analysis showed that the obesity prevalence defined by BMI and BF% was higher in females than in males （k=0.530 vs k=0.418, P〈O.O001）. The sensitivity and specificity of BMI （30 kg/m2 and 27.5 kg/m2） were 54.1% and 96.7% and 76.4% and 88.2%, respectively, for obesity. A lower BMI cutoff point （26.60 kg/m2） was proposed in this study, which gave the maximum sensitivity （84.3%） and specificity （85.4%）, with a moderate kappa agreement （k=0.686）. Moreover, the obesity prevalence at this cutoff point （56.4%） was significantly higher than that recommended by WHO. Conclusion The specificity of BMI for obesity is high and its sensitivity is low in both sexes. Its sensitivity can be increased by changing BMI cutoff to a lower value. The choice of BF% reference is of great influence for the assessment of obesity prevalence according to the BMI.

Optimal Percentage of Reclaimed Asphalt Pavement in Central Plant Hot Recycling Mixture

For determining the optimal percentage of RAP material in central plant hot recycling, binder was recovered from RAP by means of Abson recovery method, and properties tests of mixed binders consisting of recovered asphalt and fresh asphalt at different ratios were performed. In addition, the performances of mixture with different percentages of RAP such as rutting resistance, anti-cracking, moisture susceptibility and fatigue resistance were tested. The binder test results showed that the high temperature performance was improved with the increase of the percentage of the RAP, while the low temperature performance was declined. When the percentage of the recovered binder was less than 30%, the mixed binder could match the technical standards for fresh asphalt. Tests on the mixtures showed that rutting resistance increased gradually as RAP percentage increased, while thermal anti-cracking at low temperature and fatigue properties declined. The effect of the percentage of RAP on moisture susceptibility was limited. It is indicated that low temperature performance and fatigue properties are important for selecting the optimal percentage of RAP. Based on data obtained from binders and mixtures, it is concluded that the maximum percentage of RAP is approximately 30% without the addition of rejuvenating agent.

Tb(III) Transport in Dispersion Supported Liquid Membrane System with D2EHPA as Carrier in Kerosene

The transport of Tb（III） in dispersion supported liquid membrane（DSLM） with polyvinylidene fluoride membrane（PVDF） as the support and dispersion solution including HCl solution as the stripping solution and di（2-ethylhexyl） phosphoric acid（D2EHPA） dissolved in kerosene as the membrane solution, has been studied. The effects of pH value, initial concentration of Tb（III） and different ionic strength in the feed phase, volume ratio of membrane solution to stripping solution, concentration of HCl solution, concentration of carrier, different stripping agents in the dispersion phase on the transport of Tb（III） have also been investigated, respectively. As a result, the optimum transport conditions of Tb（III） were obtained, i.e., the concentration of HCl solution was 4.0 mol/L, the concentration of D2EHPA was 0.16 mol/L, the volume ratio of membrane solution to stripping solution was 30：30 in the dispersion phase and pH value was 4.5 in the feed phase. Ionic strength had no obvious effect on the transport of Tb（III）. Under the optimum conditions, the transport percentage of Tb（III） was up to 96.1% in a transport time of 35 min when the initial concentration of Tb（IIl） was 1.0× 10 -4 mol/L. The diffusion coefficient of Tb（III） in the membrane and the thickness of diffusion layer between feed phase and membrane phase were obtained and the values were 1.82×10 -8 m2/s and 5.61 um, respectively. The calculated results were in good agreement with the literature data.

S Phase Cell Percentage Normalized BrdU Incorporation Rate, a New Parameter for Determining S Arrest

In this study, a new parameter, S phase cell percentage （S fraction） normalized BrdU （SFN-BrdU） incorporation rate, was introduced to detect $ arrest. The results showed a positive linear correlation between the BrdU incorporation rate and the S fraction in unperturbed 16HBE cells. Theoretical analysis indicated that only S arrest could result in a decrease in the SFN-BrdU incorporation rate. Additionally, the decrease in SFN-BrdU incorporation rate and the activation of DNA damage checkpoints further demonstrated that S arrest was induced by diethyl sulfate treatment of 16HBE cells. In conclusion, $FN-BrdU incorporation rate can be used to detecting S arrest.

Comparison and Evaluation of Two Analytical Methods for Cation Exchange Capacity and Exchangeable Sodium Percentage of Five Soil Types in Central Sudan

Twenty-six soil samples were collected from five soil profiles at different climatological and ecological regions in central Sudan. Soil profile was dug in each studied area and morphological profile description was carried out for different horizons. All samples were analyzed using two different methods to determine Cation Exchange Capacity (CEC) and exchangeable sodium percentage (ESP). Statistical analysis (T-test) was used in order to investigate the differences between soil samples for the studied locations. Significant differences appeared when compared the two methods for CEC determination at Gedaref area, Wad Medani and Nile flood plain and that appeared in evaluation of ESP at Nile flood plain and Shambat area. The results also revealed that, the developed method used in this study was more practical, simple and reliable for determination of CEC and ESP as the currently used in most soil laboratories. In addition, it will be safer than the other methods in some problematic soils. The adoption of this developed method is advisable because it is less time consuming as it omits the washing step. In contrast, the old method cannot be a good substitute in laboratories which have no possibility to determine sodium by using flame photometer. We conclude that when the developed method is used to determine CEC and ESP time will be saved, that fewer amounts of chemicals will be used and that accurate results will be achieved.

Effect of Window Opening Percentage on the Air Flow Rate of Wind-Driven Natural Ventilation Rooms

According to the investigations of window opening percentage (WOP) of Shanghai in 2011, the WOP varies significantly from season to season and thus affects the air flow rate of natural ventilation rooms. A three-dimensional computional fluid dynamic(CFD) model was applied to simulating the flow fields in a street canyon under different wind speed and WOP. The numerical simulations show that WOP has a significant influence on the static pressure distribution of the downwind building. Therefore, a correction factor k can be used for calculating the flow rate of wind-driven natural ventilation. The results show that k ranges from 0.43 to 0.49 when WOP is 4.44%; when WOP increases to 9.78%, the correction factor k lies in 0.32 and 0.36.

Stable major QTL on chromosomes A07 and A08 increase shelling percentage in peanut(Arachis hypogaea L.)

Peanut is a major oilseed and food legume.Shelling percentage(SP),closely associated with seed yield,is a trait whose improvement is a major goal of peanut breeding.In this study,a mapping population(Xuhua 13×Zhonghua 6)was used to map quantitative trait loci(QTL)controlling SP in four environments.Two stable major QTL for SP were mapped on both SSR-and SNP-based genetic maps.q SPA07.1 on chromosome A07 explained up to 31.7%of phenotypic variation,and q SPA08.2 on chromosome A08 explained up to 10.8%.Favorable alleles of q SPA07.1 and q SPA08.2 were derived from the female and male parents,respectively.Eight recombinant inbred lines(RILs)carrying both favorable alleles showed superiority in SP over the two parents in all environmental trials.A combination of the two favorable alleles using the linked markers was verified to increase SP by~5%in the RIL population and by~3%SP in diverse peanut cultivars.q SPA07.1 and q SPA08.2 were delimited to respectively a 0.73-Mb interval harboring 96 genes and a 3.93-Mb interval harboring 238 genes.Respectively five and eight genes with high expression in pods,including enzymes and transcription factors,were assigned as candidate genes for q SPA07.1 and q SPA08.2.These consistent major QTL provide an opportunity for fine mapping of genes controlling SP,and the linked markers may be useful for genetic improvement of SP in peanut.

Global burden of inflammatory bowel disease 1990-2019:A systematic examination of the disease burden and twenty-year forecast

BACKGROUND Inflammatory bowel disease(IBD)is an idiopathic intestinal disease with various levels and trends in different countries and regions.Understanding the current burden and trends of IBD in various geographical locations is essential to establish effective strategies for prevention and treatment.We report the average annual percentage change(AAPC)and estimated annual percentage change(EAPC)in age-standardized rates(ASR)of IBD in different regions based on the Global Burden of Disease(GBD)study from 1990-2019,and the relationships between IBD and the human development index(HDI)and socio-demographic index(SDI).The prevalence trends of IBD were predicted by gender from 2019-2039.AIM To comprehensively investigate IBD data,providing further insights into the management of this chronic disease.METHODS We collected the information on the incidence of IBD from the GBD study from 1990-2019 to calculate the AAPC and EAPC in ASR of IBD in different regions.The relationships between IBD,HDI,and SDI were analyzed.The Nordpred and Bayesian age-period-cohort models were used to predict the prevalence trends of IBD by gender from 2019-2039,and the reliability of the results was validated.RESULTS North America consistently had the highest IBD ASR,while Oceania consistently had the lowest.East Asia had the fastest average annual growth in ASR(2.54%),whereas Central Europe had the fastest decline(1.38%).Countries with a low age-standardized incidence rates in 1990 showed faster growth in IBD while there was no significant correlation in 2019.Additionally,IBD increased faster in countries with a low age-standardized death rates in 1990,whereas the opposite was true in 2019.Analysis of SDI and IBD ASR showed that countries with a high SDI generally had a higher IBD ASR.Finally,the projections showed a declining trend in the incidence of IBD from 2019-2039,but a gradual increase in the number of cases.CONCLUSION As the global population increases and ages,early monitoring and prevention of IBD is important to reduce the disease burden,especially in countries with a high incidence of IBD.

Study on PEG6000 Treatment on Budding Percentage And Germination Rate of Allium Tuberosum Roxb.Seeds

Allium tuberosum Roxb is very popular for its function of stomach-strengthening,spirit-freshening,yang-warming and kidney essencereplenishing,however,its seeds appear to low bud,irregular sapling and other side effects,which result in low yield and poor quality.This paper analyzed effects of PEG6000 concentration on budding percentage in detail.It comes to conclusions that budding percentage of No.1 seed increases from 71% to 92% on the basis of 36 h treatment by 20% PEG6000 and 24 h water-drying,that of No.3 seed ranges from 30.4% to 53.4% on the basis of the same treatment by 10% PEG6000.

Predicting Base Saturation Percentage by pH—A Case Study of Red Soil Series in South China

pH and base saturation percentage (BSP) are two basic indexes in identifying soil types in Chinese Soil Taxonomy. Some studies proved that there is significant correlation between BSP and pH, thus it could save the cost of laboratory work if we can infer BSP directly from pH. In this study, the measured values of BSP and pH of 162 and 232 horizon samples from 48 and 55 red soil series surveyed from 2009 to 2011 in Fujian and Guangdong respectively were adopted from Soil Series Database to set up the optimal correlation model between BSP and pH. The results showed that: 1) BSP ranged from 2.30% to 94.02% with a mean of 25.07%, while pH from 3.42 to 6.91 with a mean of 4.98 for the total soil samples. 2) There were significant differences in pH between different soil types (R2 were 0.624 for Ferralosols, 0.507 for Ferrosols, 0.515 for Argosols, and 0.456 for Cambosols, p 2 were 0.580 for Quaternary red clay, 0.434 for granite, 0.642 for sandstone, and 0.712 for basalt, p 2 were 0.623 for dryland, and 0.404 for forest land, p 0), their probability density curves were mainly in flat or normal curves (y = 6.84x2 &#8722;45.86x + 81.52, R2 = 0.494, p < 0.01).

The Regulatory B Cell in Active Systemic Lupus Erythematosus Patients:A Systemic Review and Meta-analysis

Background:The study of regulatory B cells(Bregs)in systemic lupus erythematosus(SLE)has been in full swing in recent years,but the number and function of Bregs in SLE patients have also present quite contradictory results.Therefore,we conducted a meta-analysis to verify the changes in Bregs in active SLE.Methods:We identified studies reporting the proportions of Bregs in SLE patients by searching Pubmed,Embase,Web of Science,Cochrane and CNKI.Due to the degree of heterogeneity is very high,we used a random effects model to assess the mean differences in percentages of Bregs between active SLE and controls.Then,sensitivity analysis and subgroup analysis were performed to verify potential sources of heterogeneity.Results:Seven eligible articles involving 301 active SLE patients and 218 controls were included in the meta-analysis.The pooled percentages of Bregs were found no significant difference between active SLE patients and healthy controls[0.259,(−1.150,1.668),p=0.719],with great heterogeneity(I2=97.5%).The result of sensitivity analysis showed that exclusion of any single study or single article did not materially resolve the heterogeneity,but after excluding the article conducted by Cai X and his colleagues,the percentages of Bregs were significantly higher in active SLE than those in controls[1.394,(0.114,2.675),p=0.033].The results of subgroup analysis revealed that when the disease activity was judged by SLEDAI score≥5,the percentages of Bregs were significantly lower in the SLE groups than in the control groups[-1.99,(-3.241,-0.739),p=0.002],but when the threshold of SLEDAI score≥6 chosen for active SLE,the percentages of Bregs were significantly increased in the SLE groups[2.546,(1.333,3.759),p<0.001].Meanwhile,other subgroup analysis based on the different phenotypes of Bregs,diagnostic criteria,enrolled research countries,treatment status,and organ involvement did not differ in proportion of Bregs between SLE patients and controls.Conclusions:The study implies that Bregs may play a role in the pathogenesis of active SLE,and the thresholds of SLEDAI score to distinguish between active and inactive SLE patients are important factors affecting the percentages of Bregs.

Preparation of High Percentage α-Calcium Sulfate Hemihydrate via a Hydrothermal Method

α-calcium sulfate hemihydrate (α-HH) is known to be suitable for application as bone void filler. High percentage of α-HH is obviously needed for medical applications, especially for implantation. Three commercially available calcium sulfate dihydrates (DH, CaSO4·2H2O) with different sizes and surface morphologies were used as starting materials to synthesize high percentage α-HH via a hydrothermal method. The median particle sizes of the three types of DH were 946.7 μm, 162.4 μm and 62.4 μm, respectively. They were named as DH-L, DH-M and DH-S in this paper. The particle size distribution, morphology and phase composition of the raw materials were evaluated before synthesis. SEM results revealed that DH-L consisted of irregular large particles, while DH-M and DH-S were composed of plate-like particles with some small ones. High percentage HH can be obtained with proper synthesis parameters by hydrothermal method, specifically, 105 &deg;C/90 min for DH-L (achieving 98.8% HH), 105&deg;C/30 min for DH-M (achieving 96.7% HH) and 100&deg;C/45 min for DH-S (achieving 98.4% HH). All the synthesized HH were hexagonal columns, demonstrating that they were α-phase HH. The particle size and morphology of starting material (DH) have significant influences on not only the rate of phase transition but also the morphology of the synthesized α-HH. Calcium sulfate dihydrate cements were prepared by the synthesized α-HH. The highest compressive strength of calcium sulfate dihydrate cement was 17.2 MPa. The results show that the preparation of high percentage α-HH is feasible via a hydrothermal method and the process can be further scaled up to industrial scale production.

Effects of Ce and Impurities on Percentage Elongation and Recrystallization in Al-Li Alloys

The effects of the contents of Ce and deleterious impurities on the ductility and recrystallized microstructure have been investigated for Al Li based alloys 2090 and 8090 sheets. The relationships between the parameters of recrystallized microstructure and percentage elongation( δ ) in the transverse orientation of the sheets have been obtained. The beneficial behavior of Ce microalloying can be markedly shown in the alloy 2090 containing a certain amount of impurities Fe and Si or in the alloy 8090 containing a certain amount of impurities Na and K. Ce microalloying can still improve δ to a certain degree, even though impurities Fe, Si, Na and K coexist and their concentration is rather high in the alloy 8090. When the recrystallized volume, coarse grained volume and grain average width increase because of the variation in the contents of Ce element and impurities, δ decreases for the alloys 2090 and 8090. When the grain aspect ratio increases, δ increases for the alloy 2090 and decreases for the alloy 8090.

The prognostic significance of percentage of tumour involvement according to disease risk group in men treated with radical prostatectomy

We investigated the prognostic significance of percentage of tumour involvement （PTI） according to the clinicopathological features of prostate cancer among patients who underwent radical prostatectomy （RP）. A retrospective study of 534 patients who underwent RP between September 2003 and March 2008 without any neoadjuvant or adjuvant therapy was performed. The associations of PTI with various clinicopathological features and biochemical recurrence-free survival were examined via uni- and multivariate analyses. The predictive accuracy of the multivariate model was assessed with a receiver operating characteristics-derived area under the curve. PTI was demonstrated to be significantly associated with preoperative prostate-specific antigen （PSA） level （P=0.001）, pathological Gleason score （P〈0.001）, extraprostatic tumour extension （P〈0.001）, seminal vesicle invasion （P〈0.001） and positive surgical margin （P〈0.001） in univariate analyses. When patients were stratified into disease risk groups, PTI was an independent predictor of biochemical recurrence-free survival in multivariate analysis only among the low-risk group （P=0.033） but not the intermediate- （P=0.287） or the high-risk groups （P=0.828）. The addition of the PTI did not significantly increase the accuracy of the multivariate model devised for the prediction of biochemical recurrence-free survival among both total patients （P=-0.459） and the low-risk group （P=0.268）, respectively. In conclusion, although PTI appeared to be a more significant prognostic factor among patients with low-risk disease than among those with higher risk diseases, overall, the PTI may not provide additional prognostic information beyond what can already be obtained via established prognostic factors.