Percutaneous microballoon compression of the trigeminal ganglion is a brand new operative technique for the treatment of trigeminal neuralgia. However, it is unclear how the procedure mediates pain relief, and there a...Percutaneous microballoon compression of the trigeminal ganglion is a brand new operative technique for the treatment of trigeminal neuralgia. However, it is unclear how the procedure mediates pain relief, and there are no standardized criteria, such as compression pressure, com- pression time or balloon shape, for the procedure. In this study, percutaneous microballoon compression was performed on the rabbit trigeminal ganglion at a mean inflation pressure of 1,005 ＋ 150 mmHg for 2 or 5 minutes. At 1, 7 and 14 days after percutaneous microballoon compression, the large-diameter myelinated nerves displayed axonal swelling, rupture and demy- elination under the electron microscope. Fragmentation of myelin and formation of digestion chambers were more evident after 5 minutes of compression. Image analyzer results showed that the diameter of trigeminal ganglion cells remained unaltered after compression. These experi- mental findings indicate that a 2-minute period of compression can suppress pain transduction. Immunohistochemical staining revealed that vascular endothelial growth factor expression in the ganglion cells and axons was significantly increased 7 days after trigeminal ganglion compression, however, the changes were similar after 2-minute compression and 5-minute compression. The upregulated expression of vascular endothelial growth factor in the ganglion cells after percu- taneous microballoon compression can promote the repair of the injured nerve. These findings suggest that long-term compression is ideal for patients with recurrent trigeminal neuralgia.展开更多
Background: Trigeminal neuralgia is a chronic pain syndrome characterized by paroxysmal, shock-like, stabbing, recurrent episodes of pain localized in the distribution area of one or more branches of the trigeminal ne...Background: Trigeminal neuralgia is a chronic pain syndrome characterized by paroxysmal, shock-like, stabbing, recurrent episodes of pain localized in the distribution area of one or more branches of the trigeminal nerve. The Initial approach for treating trigeminal neuralgia consists of pharmacological therapy. Many patients experience initial pain relief with pharmacological therapy;however, most of those patients eventually undergo surgery. Patients and Methods: In this descriptive prospective study, we evaluate the efficiency and safety of percutaneous balloon compression (PBC) and percutaneous radiofrequency ablation (RFA) in treating patients with typical idiopathic trigeminal neuralgia. This study includes 21 patients (divided into two groups, PBC = 15 patients and RFA = six patients) who met our inclusion and exclusion criteria, from May 2018 to April 2019, with a follow-up period of six months. Results: At one month postoperative follow-up, all patients in both groups were pain-free. At six months postoperative follow-up, in group 1 (PBC), 14 (95.24%) patients were pain-free, while in group 2 (RFA) all patients remained pain-free. The most common encountered postoperative complications are masticatory muscles weakness (Four patients in PBC group, and one patient in RFA group) and facial hypothesia (12 patients in PBC group and four patients in RFA group). Conclusions: In our study, patients with trigeminal neuralgia were not controlled by drug treatment, but percutaneous balloon compression and percutaneous radiofrequency ablation proved to be very effective treatment options, with no major complications.展开更多
基金supported by a grant from Shengjing Hospital,China Medical University,China,No.201010252
文摘Percutaneous microballoon compression of the trigeminal ganglion is a brand new operative technique for the treatment of trigeminal neuralgia. However, it is unclear how the procedure mediates pain relief, and there are no standardized criteria, such as compression pressure, com- pression time or balloon shape, for the procedure. In this study, percutaneous microballoon compression was performed on the rabbit trigeminal ganglion at a mean inflation pressure of 1,005 ＋ 150 mmHg for 2 or 5 minutes. At 1, 7 and 14 days after percutaneous microballoon compression, the large-diameter myelinated nerves displayed axonal swelling, rupture and demy- elination under the electron microscope. Fragmentation of myelin and formation of digestion chambers were more evident after 5 minutes of compression. Image analyzer results showed that the diameter of trigeminal ganglion cells remained unaltered after compression. These experi- mental findings indicate that a 2-minute period of compression can suppress pain transduction. Immunohistochemical staining revealed that vascular endothelial growth factor expression in the ganglion cells and axons was significantly increased 7 days after trigeminal ganglion compression, however, the changes were similar after 2-minute compression and 5-minute compression. The upregulated expression of vascular endothelial growth factor in the ganglion cells after percu- taneous microballoon compression can promote the repair of the injured nerve. These findings suggest that long-term compression is ideal for patients with recurrent trigeminal neuralgia.
文摘Background: Trigeminal neuralgia is a chronic pain syndrome characterized by paroxysmal, shock-like, stabbing, recurrent episodes of pain localized in the distribution area of one or more branches of the trigeminal nerve. The Initial approach for treating trigeminal neuralgia consists of pharmacological therapy. Many patients experience initial pain relief with pharmacological therapy;however, most of those patients eventually undergo surgery. Patients and Methods: In this descriptive prospective study, we evaluate the efficiency and safety of percutaneous balloon compression (PBC) and percutaneous radiofrequency ablation (RFA) in treating patients with typical idiopathic trigeminal neuralgia. This study includes 21 patients (divided into two groups, PBC = 15 patients and RFA = six patients) who met our inclusion and exclusion criteria, from May 2018 to April 2019, with a follow-up period of six months. Results: At one month postoperative follow-up, all patients in both groups were pain-free. At six months postoperative follow-up, in group 1 (PBC), 14 (95.24%) patients were pain-free, while in group 2 (RFA) all patients remained pain-free. The most common encountered postoperative complications are masticatory muscles weakness (Four patients in PBC group, and one patient in RFA group) and facial hypothesia (12 patients in PBC group and four patients in RFA group). Conclusions: In our study, patients with trigeminal neuralgia were not controlled by drug treatment, but percutaneous balloon compression and percutaneous radiofrequency ablation proved to be very effective treatment options, with no major complications.
