Effect of hospital discharge plan for children with type 1 diabetes on discharge readiness,discharge education quality,and blood glucose control

BACKGROUND Type 1 diabetes is one of the most common chronic diseases in childhood.The number of type 1 diabetes patients in China still ranks fourth in the world.Therefore,children with type 1 diabetes in China are a group that needs attention.The management of type 1 diabetes mellitus(T1DM)involves many aspects of daily life.It is extremely challenging for children and their families.T1DM children have complex medical care needs.Despite the continuous development of therapeutic medicine and treatment technologies,blood glucose control in children with T1DM is still not ideal.They and their parents need to acquire more knowledge and skills before being discharged.AIM To explore the influence of hospital discharge plan based on parental care needs of children with T1DM on discharge readiness,quality of discharge education and blood glucose control level.METHODS In total,102 parents of children with type 1 diabetes were divided into control group and intervention group according to admission time.Fifty cases from February to June 2019 were selected as the control group,and 52 cases from July to October 2019 were selected as the intervention group to implement the discharge plan.The Readiness for Hospital Discharge Scale,Hospital Discharged Education Quality Scale and children's blood glucose metabolism indicators were used to compare the differences in discharge preparation,discharge education quality and blood glucose control between the two groups of children and their parents.RESULTS On the day of discharge,the two groups of children had the following scores of readiness for discharge:The intervention group score was 225.34±32.47,and the control group score was 208.68±29.31.The P value was 0.007,and the difference was statistically significant.The discharge education quality scores were as follows:The intervention group score was 135.11±19.86,the control group score was 124.13±15.56,the P value was 0.002 and the difference was statistically significant.Three months after discharge,the blood glucose metabolism indicator showed that the glycosylated hemoglobin value of the two groups was(7.45%±1.04%),and that of the control group was(8.04%±1.27%),P=0.012.Therefore,the improvement of parents'readiness for discharge,quality of discharge education and blood glucose metabolism indicators(glycosylated hemoglobin,fasting blood glucose and postprandial blood glucose)in the intervention group were better than those in the control group(P<0.05),and the difference was statistically significant.CONCLUSION The discharge plan for children with T1DM can help the children and their families realize the transition from hospital care to home self-management and improve the parents'readiness for discharge,thereby improving children’s blood glucose control levels.

Effects of DPP-4 inhibitor combined with metformin on blood glucose control, oxidative stress and inflammatory response in patients with type 2 diabetes mellitus

Objective: To investigate the effects of DPP-4 inhibitor combined with metformin on blood glucose control, oxidative stress and inflammatory response in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 138 patients with newly diagnosed T2DM who were treated in the hospital between March 2016 and April 2017 were divided into routine group (n=69) and combined treatment group (n=69) by random number table method. Routine group were treated with metformin alone and combined treatment group received DPP-4 inhibitor combined with metformin therapy. The differences in blood glucose control as well as oxidative stress-related indicator and inflammatory factor contents were compared between the two groups before and after treatment. Results: Before treatment, the differences in blood glucose index levels in peripheral blood as well as the oxidative stress index and inflammatory mediator contents in serum were not statistically significant between the two groups. After 4 weeks of treatment, blood glucose indexes FBG and HOMA-IR levels in peripheral blood of combined treatment group were lower than those of routine group;oxidative stress indexes MDA and LHP contents in serum were lower than those of routine group whereas GSH-Px and T-AOC contents were higher than those of routine group;inflammatory mediators hs-CRP, IL-1 and IL-6 contents in serum were lower than those of routine group. Conclusion: DPP-4 inhibitor combined with metformin therapy can effectively control the blood glucose and suppress the systemic oxidative stress and inflammatory response in T2DM paients.

Blood glucose control in the intensive care unit: Where is the data?

Blood glucose control, including hyperglycemia correction, maintaining glucose at optimal level and avoiding hypoglycemia, is a challenge clinicians face every day in intensive care units (ICUs). If managed inadequately, its related mortality can increase. Prior to 2001, no relevant data from randomized, controlled studies assessing glucose control in the ICU were available. In the past 18 years, however, many clinical trials have defined criteria for managing abnormal blood glucose levels, as well as provided suggestions for glycemic monitoring. Point-ofcare blood glucose monitors have become the preferred bedside technology to aid in glycemic management. In addition, in some institutions, continuous glucose monitoring is now available. Cost-effectiveness of adequate glycemic control in the ICU must be taken into consideration when addressing this complex issue. Newer types of glycemic monitoring may reduce nursing staff fatigue and shorten times for the treatment of hyperglycemia or hypoglycemia. There are a variety of glycemic care protocols available. However, not all ICU clinicians are aware of them. The following minireview describes some of these concepts.

Is nonlinear model predictive control with fuzzy predictive model proper for managing the blood glucose level in typeI diabetes?

In recent decades, due to the increasing risk of diabetes, the measurement and control of the blood sugar is of great importance. In typeI diabetes, because of the lack of insulin secretion, the cells cannot absorb glucose, and thus have a low level of glucose. To control blood glucose, the insulin must be injected to the body. In fact, the injection must be in a completely controlled environment. If the level of the insulin exceeds the physiological limits, it may cause death. This paper presents an online approach to control the blood glucose level using a nonlinear model predictive control. This method, maintains the level of blood glucose concentration within a normal range. Thus, the blood glucose level is measured in each minute and predicted for the next time interval. If that is not in the normal range, amount of the insulin which must be injected will be determined. The proposed control approach includes important features such as model uncertainties and prevents acute decrease in the blood glucose level, and instability. In order to assess performance of the proposed controller, computer simulations have been carried out in Matlab/Simulink. Simulation results will reveal the effectiveness of the proposed nonlinear model predictive controller in adjusting the blood glucose level by injecting required insulin. So if the nutrition of the person decreases instantly, the hypoglycemia does not happen.

Self monitoring of blood glucose and its association with glycaemic control and lipid levels in type 2 diabetic patients aged 40 - 75 in Trinidad and Tobago

This study was done to assess whether self monitoring of blood glucose is associated with better glycaemic control in type 2 diabetic Trinidadians. Data was collected from 146 type 2 diabetics via interviews and medical files. Variables extracted included fasting blood glucose, HbA1c and lipid profile. Recent users of the glucometer had better glycemic control compared with longstanding users (HbA1c: 8.4% ± 0.28% vs 9.4% ± 0.62%). Diabetics using a glucometer for >11 years had the highest cholesterol (234 ± 27mg/dL) while those using it 6 months to 5 yrs had the lowest values (206 ± 8 mg/dL). Using the glucometer occasionally or once a week had little impact on these indices. Usage of insulin preparation was positively correlated with HbA1c (r = 0.295;p = 0.001) while those relying on oral hypoglycaemic agents showed a negative correlation (r = -0.265). Further, those who took their medication as prescribed had a lower HbA1c than those who took their medication occasionally. Ironically, HbA1c fell with increasing duration between clinic visits with those visiting annually having the lowest HbA1c (9.0% ± 0.2% vs 7.1% ± 0.7%). Compliance with lifestyle and exercise resulted in lower HbA1c and blood lipids. Poor client education on glucometer usage, administration of insulin and non-compliance with diet and exercise were associated with higher HbA1c.

Establishment of blood glucose control model in diabetic mice

AIM:To explore the established method of the diabetic mouse blood glucose control model and preliminar y observation of its influence on the retinas of diabetic mice.METHODS:The db/db BKS-DB(Lepr^(ko/ko))mice were randomly divided into two groups:the poor blood glucose control group(PG group,n=18)and the stable blood glucose control group(SG group,n=12),with BKS-DB(Lepr^(wt/wt))as the normal blood glucose control group(NG group,n=18).According to the blood glucose values for 5 intervals which were monitored during the period of adaption,the PG group was injected with insulin aspart twice daily,fasted for 2h and then returned to normal.The SG group was injected with insulin aspart twice and insulin glargine once daily and fed with a quantitative ration.Fundus images were collected after eight weeks.The glycosylated hemoglobin(Hb A1c),mean blood glucose level(MBG),standard deviation of blood glucose(SDBG),coefficient of variation of blood glucose(CVBG),and mean amplitude of glycemic excursion(MAGE)in each group were examined and calculated.RESULTS:The Hb A1c,MBG,SDBG,CVBG,and MAGE levels in the PG group were significantly higher than those in the NG and SG groups(all P<0.05).MBG,SDBG,CVBG,and MAGE levels in the SG group were higher than those in the NG group(all P<0.05).There was no significant difference in Hb A1c levels between the NG and SG groups(P>0.05).Preliminary observation of fundus images in the PG group and SG groups showed scattered retinal bleeding spots,while bleeding was more obvious in the PG group.CONCLUSION:The blood glucose control model of type 2 diabetes mellitus mice can be successfully established by subcutaneous injection of insulin aspart insulin glargine and rationed food,which is valuable for studying the mechanism of blood glucose fluctuations in diabetic complications in vivo.

A Fuzzy Controller for Blood Glucose-Insulin System

Diabetes therapy is normally based on discrete insulin infusion that uses long-time interval measurements. Nevertheless, in this paper, a continuous drug infusion closed-loop control system was proposed to avoid the traditional discrete approaches by automating diabetes therapy. Based on a continuous insulin injection model, two controllers were designed to deal with this plant. The controllers designed in this paper are: proportional integral derivative (PID), and fuzzy logic controllers (FLC). Simulation results have illustrated that the fuzzy logic controller outperformed the PID controller. These results were based on serious disturbances to glucose, such as exercise, delay or noise in glucose sensor and nutrition mixed meal absorption at meal time.

Investigation on Blood Glucose Control Nursing of ICU Severe Patients

Objective:To analyze the effect of blood glucose control mursing in intensive care umit (ICU)patients.Methods:The clinical data of 70 severe patients in ICU of ou hospital fom January 2019 to May 2020 were retrospectively analyzed.The climical data of 34 patients with routine intervention were divided into the control group,and the clinical data of 36 patients with routine intervention and blood glucose control mursing were divided into the observation group,all were intervened for 14 days.The blood glucose levels and prognosis of the two groups were compared before intervention and at the end of 14 days of intervention,the time required o achieve the standard blood glucose level of the two groups was recorded Results:After 14 days of intervention,the fasting blood glucose level of the observation group was lower than the control group,the difference was satisically significant(P<0.05);the time of blood glucose reaching the standard in the observation group was shorter than that in the control group,the difference was statistically significant(P<0.05);on the 14th day of intervention,the sequential organ failure asessment score(SOFA)score of the two groups was lower than before intervention,the SOFA score of the observation group was lower than control group,the difference was statistically significant(P<0.05).Conclusion:The effect of blood glucose control mursing in ICU is better,which effectively controlled the blood glucose level of patients and improved the prognosis of patients.

Correlation of anxiety state with blood glucose control, microinflammation and oxidative stress in patients with type 2 diabetes mellitus

Objective:To study the correlation of anxiety state with blood glucose control, microinflammation and oxidative stress in patients with type 2 diabetes mellitus.Methods:A total of 138 patients with type 2 diabetes mellitus were divided into the non-anxiety group (n=43) (SAS score < 50 points), mild-to-moderate anxiety group (n=71) (SAS score 50-69 points) and severe anxiety group (n=24) (SAS score 70 points) according to the self-rating anxiety scale (SAS) score. The differences in levels of glucose metabolism indexes, microinflammation indexes and oxidative stress indexes were compared among the three groups.Results: Peripheral blood FPG, P2hPG, HOMA-IR, CRP, ASAA, IL-6, MDA and ROS levels of mild-to-moderate anxiety group and severe anxiety group were higher than those of non-anxiety group while CAT and GSH-Px contents were lower than those of non-anxiety group;peripheral blood FPG, P2hPG, HOMA-IR, CRP, ASAA, IL-6, MDA and ROS levels of severe anxiety group were higher than those of mid-to-moderate anxiety group while CAT and GSH-Px contents were lower than those of mid-to-moderate anxiety group.Conclusion:The increase of anxiety in patients with type 2 diabetes mellitus is a direct factor leading to the abnormal glucose metabolism as well as the aggravation of microinflammatory state and oxidative stress state.

Analysis on the Correlation between Fasting Blood-glucose and Gestational Diabetes Mellitus

Objective： The correlation between the fasting blood-glucose （FBG） in early pregnancy and the gestational diabetes mellitus （GDM） was studied. Methods： The clinical data of 300 pregnant women receiving a treatment from Yongqing Hospital of Traditional Chinese Medicine and Langfang Health Vocational College from September 2012 to September 2013 was chosen; these cases were divided into group 6.9-6.0 mmol/L （35 cases）, group 5.9~5.0 mmol/L （58 cases）, group 4.9~4.5 mmol/L （120 cases）, and group 4.4~4.0mmol/L （108 cases） according to the range of the normal FBG. The proportional differences among the pregnant women diagnosed with GDM in different groups during the late pregnancy as well as the maternal and fetal prognosis were compared. Results： The proportion of the pregnant women diagnosed with GDM in group 6.9-6.0 mmol/L and group 5.9-5.0 mmol/L during the middle-late pregnancy was significantly higher than that of group 4.9-4.5 mmol/L and group 4.4-4.0mmol/L; there was no significant proportional difference among the pregnant women diagnosed with GDM in group 6.9~6.0 mmol/L and group 5.9-5.0 mmol/L during the middle-late pregnancy; there was no significant proportional difference among the pregnant women diagnosed with GDM in group 4.9-4.5 mmol/L and group 4.4-4.0mmol/L during the middle-late pregnancy. Conclusion： The risk of the pregnant women with FBG is higher than that of the normal pregnant women in suffering GDM during the early pregnancy, so attention should be paid to early blood glucose test and the blood glucose level should be positively controlled once they are defmitely diagnosed with GDM, and then the perinatal and maternal survival quality can be improved.

互联网自我管理模式对2型糖尿病患者血糖控制和自我管理水平的影响

目的探讨基于互联网的自我管理模式对2型糖尿病(T2DM)患者血糖控制和自我管理水平的影响。方法选取我院2021年6月至2022年12月收治的138例T2DM患者,经随机数字表法分为试验组(n=69)及对照组(n=69),对照组予以常规健康管理,试验组予以基于互联网的自我管理模式。比较两组血糖、血压及体重控制情况、干预前后代谢指标、自我管理水平[采用中文版糖尿病自我管理活动问卷(SDSCA)]及生活质量[采用糖尿病生存质量量表(DSQL)]。结果干预后,两组糖化血红蛋白、空腹血糖(FPG)、餐后2 h血糖、舒张压、收缩压、体质量指数均低于干预前,且试验组低于对照组(P<0.05);两组低密度脂蛋白胆固醇、总胆固醇及甘油三酯均低于干预前,且试验组低于对照组(P<0.05);两组足部护理、血糖监测、运动及饮食等维度评分均高于干预前,且试验组高于对照组(P<0.05);两组治疗、社会关系、心理、生理功能等维度评分均低于干预前,且试验组低于对照组(P<0.05)。结论基于互联网的自我管理模式有利于T2DM患者控制血糖、血压及体重控制,能改善患者代谢指标,提高管理水平及生活质量。

胰岛素不同注射方式对糖尿病血糖控制效果的影响研究

目的分析胰岛素不同注射方式对2型糖尿病患者血糖控制情况的影响。方法选取2021年9月—2023年9月安溪县医院收治的186例2型糖尿病患者为研究对象,利用最新统计学软件生成随机序列后将其分为对照组、观察组,各93例。两组研究对象均选用门冬胰岛素治疗,其中对照组注射方式为多次胰岛素皮下注射,观察组注射方式为胰岛素泵持续泵注。对比两组血糖控制情况、胰岛素使用剂量、血糖达标情况以及胰岛β细胞功能。结果观察组空腹血糖、餐后2 h血糖及糖化血红蛋白水平均低于对照组,差异有统计学意义(P均<0.05)。观察组平均每天胰岛素使用量低于对照组,血糖达标时间短于对照组,且在达标即刻使用的胰岛素总量少于对照组,差异有统计学意义(P均<0.05)。观察组胰岛β细胞功能优于对照组,差异有统计学意义(P<0.05)。结论对于2型糖尿病患者,采用胰岛素泵持续泵注这一注射方式,有利于改善血糖、血压及血脂水平,同时改善胰岛β细胞功能,且使用胰岛素剂量更低,能够更快速地达到控糖标准。

度拉糖肽对2型糖尿病血糖控制的影响因素分析

目的分析度拉糖肽对2型糖尿病血糖控制的影响因素。方法回顾性分析2018年1月至2022年12月采用度拉糖肽治疗的2型糖尿病患者290例,收集患者治疗前后的临床资料,分析度拉糖肽血糖控制效果的影响因素。结果度拉糖肽治疗8周后,血糖控制良好223例,血糖控制不佳67例。血糖控制良好组治疗前单核细胞计数、HOMA-β以及血清钠水平比血糖控制不佳组高,糖尿病周围神经病变率、C-反应蛋白、甘油三酯以及ALT水平明显比血糖控制不佳组低,差异有统计学意义(P<0.05);二元Logistic回归分析显示,度拉糖肽治疗前HOMA-β、血清钠、C-反应蛋白、甘油三酯以及ALT水平可影响2型糖尿病的血糖控制效果(P<0.05)。结论度拉糖肽治疗后大部分2型糖尿病患者均能获得良好的血糖控制效果,同时HOMA-β、血清钠、C-反应蛋白、甘油三酯以及ALT水平为影响度拉糖肽治疗后血糖控制效果的因素,在为患者制定治疗方案时需注意。

基于IMB模型的运动干预对妊娠期糖尿病孕妇血糖控制、自我管理能力及妊娠结局的影响

目的:探讨基于信息-动机-行为技巧模型(IMB模型)的运动干预对妊娠期糖尿病(GDM)孕妇血糖控制、自我管理能力及妊娠结局的影响。方法:将100例GDM患者根据干预方式的不同分为两组,予以常规运动干预的为对照组(n=50);予以基于IMB模型运动干预的为观察组(n=50)。两组均干预4周。比较两组干预前后GDM运动知、信、行水平[GDM运动知识-态度-行为问卷]、自我管理能力[孕妇自我保健管理评定问卷]、血糖水平[空腹血糖(FPG)、糖化血红蛋白(HbAlc)水平,餐后2 h血糖(2 hPG)],随访至患者分娩,比较两组患者血糖控制不佳入院率、孕期体重增长超标、分娩后口服葡萄糖耐量试验(OGTT)不达标率及妊娠结局。结果:相较于对照组,干预后,观察组GDM运动知识、态度及行为评分均更高(P<0.05);孕妇自我保健管理评定问卷总分及各维度评分均更高(P<0.05);观察组FBG、2 hPG及HbA1c均更低(P<0.05),血糖控制不佳入院、孕期体重增长超标及分娩后OGTT不达标总发生率均更低(P<0.05)。观察组患者妊娠不良结局总发生率均低于对照组(P<0.05)。结论:基于IMB模型的运动干预可提高GDM患者运动知、信、行水平及自我管理能力,有效控制患者血糖,改善母婴结局。

2型糖尿病血糖控制中二甲双胍联合门冬胰岛素治疗的作用价值

目的探究二甲双胍与门冬胰岛素联合治疗2型糖尿病(Diabetes Mellitus Type 2,T2DM)对血糖的控制效果。方法选取2021年6月—2023年6月吉林省人民医院收治的100例T2DM患者为研究对象,以投掷硬币法分为参照组(n=50,二甲双胍治疗)、观察组(n=50,二甲双胍与门冬胰岛素联合治疗)。比较两组临床治疗效果、不良反应总发生率、血糖控制情况及血清炎性因子水平。结果观察组治疗总有效率(96.00%)高于参照组(84.00%),差异有统计学意义(χ^(2)=4.000,P<0.05)。两组不良反应总发生率对比,差异无统计学意义(P>0.05)。与治疗前相比,两组治疗半年后血糖水平、白细胞介素-6、白细胞介素-12水平均降低、白细胞介素-10水平升高,且观察组上述指标优于参照组,差异有统计学意义(P均<0.05)。结论二甲双胍与门冬胰岛素联合治疗T2DM患者时可提高疗效,患者血糖控制情况更佳,血清炎性因子水平也得到明显改善,安全性较高。

西安市药店慢病管理的2型糖尿病患者用药和血糖控制情况分析

目的 了解西安市连锁药店慢病管理的2型糖尿病患者用药及血糖控制情况,为完善基层糖尿病的管理政策提供参考。方法 利用随机抽样法抽取西安市6个主城区的若干连锁药店,并以问卷调查的方式对其慢病管理的2型糖尿病患者进行实地访问,收集患者基本信息、用药情况(用药方案、药物依从性等)、糖尿病相关情况(血糖情况、家族史、病程和并发症等)的数据,采用多因素logistic回归模型分析患者血糖控制的影响因素。结果 共调查403例2型糖尿病患者。仅用口服降糖药的人数最多(53.4%),其次是胰岛素用药(包括单用胰岛素和胰岛素与口服降糖药联用)(35.7%),不同用药方案患者在病程与血糖控制方面的差异均有统计学意义(P <0.05),仅43.7%的患者用药依从性较好;另外,患者空腹血糖达标率仅为39.2%;多因素logistic回归分析结果显示,用药依从性较好[OR=1.744,95%CI(1.104,2.754),P=0.017]是空腹血糖达标的独立影响因素。结论 西安市连锁药店慢病管理的2型糖尿病患者用药依从性有待加强,血糖控制不佳,药店应重视并充分发挥药师的专业优势、服务优势,实现药店的职能作用,加强糖尿病管理。

Glucagon-like peptide-1 receptor agonists as a possible intervention to delay the onset of type 1 diabetes:A new horizon

Type 1 diabetes(T1D)is a chronic autoimmune condition that destroys insulinproducing beta cells in the pancreas,leading to insulin deficiency and hyperglycemia.The management of T1D primarily focuses on exogenous insulin replacement to control blood glucose levels.However,this approach does not address the underlying autoimmune process or prevent the progressive loss of beta cells.Recent research has explored the potential of glucagon-like peptide-1 receptor agonists(GLP-1RAs)as a novel intervention to modify the disease course and delay the onset of T1D.GLP-1RAs are medications initially developed for treating type 2 diabetes.They exert their effects by enhancing glucose-dependent insulin secretion,suppressing glucagon secretion,and slowing gastric emptying.Emerging evidence suggests that GLP-1RAs may also benefit the treatment of newly diagnosed patients with T1D.This article aims to highlight the potential of GLP-1RAs as an intervention to delay the onset of T1D,possibly through their potential immunomodulatory and anti-inflammatory effects and preservation of beta-cells.This article aims to explore the potential of shifting the paradigm of T1D management from reactive insulin replacement to proactive disease modification,which should open new avenues for preventing and treating T1D,improving the quality of life and long-term outcomes for individuals at risk of T1D.

基于专科护士主导的MMC管理模式在2型糖尿病患者自我管理中的应用探讨

目的 探究2型糖尿病患者应用基于专科护士主导的标准化代谢性疾病管理中心(Metabolic Managament Center, MMC)管理模式对改善自我管理水平的作用。方法 将2023年1—10月泰州市第二人民医院收治的60例2型糖尿病患者纳入研究。采用奇偶分组法分为专科组(n=30)、常规组(n=30)。常规组行一般护理,专科组加用基于专科护士主导的MMC管理模式。比较两组的自我管理水平、血糖控制情况。结果 专科组的自我管理水平中饮食、运动、血糖监测、监测频率、足部护理、用药评分均高于常规组,差异有统计学意义(P均<0.05);专科组的血糖控制情况优于常规组,差异有统计学意义(P<0.05)。结论 基于专科护士主导的MMC管理模式能够提高2型糖尿病患者的自我管理水平,降低血糖水平。

群组化孕期保健模式对妊娠期糖尿病孕妇血糖控制与妊娠结局影响的Meta分析

目的系统评价群组化孕期保健模式(GPC)对妊娠期糖尿病(GDM)孕妇血糖控制与妊娠结局的影响。方法计算机检索PubMed、Web of Science、Springer Link、中国知网(CNKI)、维普(VIP)与万方数据库等数据库中关于GPC对GDM孕妇血糖控制及妊娠结局影响的随机对照试验(RCT),采用Rev Man 5.4.1软件对数据进行meta分析。检索时间为2013年1月1日-2023年1月1日。结果共纳入6篇文献。meta分析结果表明:干预组(GPC)孕妇空腹血糖[WMD=-0.41,95%CI(-0.49,-0.33),P<0.00001]、餐后2 h血糖[WMD=-0.58,95%CI(-0.77,-0.38),P<0.001]及妊娠不良结局{妊娠高血压综合征[OR=0.37,95%CI(0.14,0.96),P=0.04]、剖宫产[OR=0.46,95%CI(0.27,0.78),P=0.04]、巨大儿[OR=0.19,95%CI(0.09,0.41),P<0.001]、产后出血[OR=0.19,95%CI(0.06,0.57),P=0.003]发生情况均低于对照组(传统孕期保健模式),差异均有统计学意义(P<0.05)。结论GPC能有效控制GDM孕妇血糖,减少妊娠不良结局的发生。