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Comparative Cytological and Histopathological Study of Peri-Implantitis and Periodontitis
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作者 Masaaki Suemitsu Yoshikazu Nakayama +3 位作者 Mao Yamamoto Mitsuko Nakayama Tadahiko Utsunomiya Kayo Kuyama 《Open Journal of Stomatology》 2023年第11期385-395,共11页
Peri-implant diseases, such as peri-implant mucositis and peri-implantitis, pose significant challenges to the long-term prognosis of dental implants. This study aimed to comprehensively compare peri-implantitis with ... Peri-implant diseases, such as peri-implant mucositis and peri-implantitis, pose significant challenges to the long-term prognosis of dental implants. This study aimed to comprehensively compare peri-implantitis with periodontitis from cytological and histopathological perspectives, shedding light on the morphological characteristics associated with peri-implantitis. Thirteen patients, including six with peri-implantitis and seven with periodontitis, were included in the study. Cytological examination of affected gingival mucosa revealed distinct differences between the two conditions. Peri-implantitis exhibited an inflammatory background predominantly composed of neutrophils with lobulated nuclei, accompanied by stratified squamous epithelial cells showing signs of keratinization. In contrast, periodontitis showed a similar neutrophilic inflammatory background but with non-keratinized epithelial cells. Histopathological examination further confirmed these differences, with peri-implantitis showing keratinized epithelium in the inner epithelial layer. This histological finding aligns with the notion that peri-implantitis has a distinct mucosal profile compared to periodontitis. Additionally, cytological analysis revealed that peri-implantitis had a lower occurrence rate of Light green-positive cells, indicating a tendency toward keratinization. This finding suggests that the presence of keratinized mucosa might be associated with peri-implant health, although further research is needed to clarify this relationship. Overall, this study demonstrates the potential of cytological examination and Papanicolaou staining for assessing mucosal inflammatory conditions and distinguishing between keratinized and non-keratinized cells. These findings underscore the utility of oral mucosal smears as a valuable tool for diagnosing peri-implantitis and enhancing our understanding of its pathogenesis. 展开更多
关键词 peri-implant Disease peri-implantitis Oral Cytology
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Investigation of Bacteria Species Most Involved in Peri-Implantitis
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作者 Hiroshi Murakami Osamu Tsuzukibashi +12 位作者 Akira Fukatsu Yuji Takahashi Keisuke Idei Keisuke Usuda Mana Fuchigami Chiaki Komine Satoshi Uchibori Koji Umezawa Sachiyo Hayashi Takashi Asano Masanobu Wakami Taira Kobayashi Masahiko Fukumoto 《Open Journal of Stomatology》 2023年第10期353-366,共14页
Purpose: Currently, bacteriological examinations of implant treatments target periodontopathic bacteria such as red complex bacteria, including Porphyromonas gingivalis, and detect them qualitatively or quantitatively... Purpose: Currently, bacteriological examinations of implant treatments target periodontopathic bacteria such as red complex bacteria, including Porphyromonas gingivalis, and detect them qualitatively or quantitatively. However, it seems that those examinations do not reflect the peri-implant tissue conditions precisely, because periodontopathic bacteria are also frequently detected from healthy peri-implant sites. The purpose of the present study was to investigate bacteria species most involved in peri-implantitis using a PCR method. Methods: Polymerase chain reaction (PCR) primers in this study were designed based on partial sequences of 16S rDNA of bacteria species involved in peri-implantitis that were described in numerous previous studies. Peri-implant sulcus fluid (PISF) samples were collected from thirty periodontally healthy patients with implants (HI) and thirty patients with peri-implantitis (PI). Each detection frequency of bacteria species in PISFs of both groups was investigated using a PCR method, and was compared using Fisher’s exact test. Results: In PI group, detection frequencies of Corynebacterium durum, Fretibacterium fastidiosum and Slackia exigua were significantly higher than those of HI group (p P. gingivalis and Tannerella forsythia belonging to red complex were frequently detected in the PISF samples of HI group (p > 0.05). Conclusion: It was suggested that monitoring C. durum and F. fastidiosum levels in PISF samples was useful as a clinical indicator for the evaluation of peri-implant tissue conditions. 展开更多
关键词 peri-implantitis PCR Method Bacteria Flora in peri-implant Sulcus Red Complex
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Activation of hypoxia-inducible factor 1 attenuates periapical inflammation and bone loss 被引量:20
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作者 Kimito Hirai Hisako Furusho +1 位作者 Kiichi Hirota Hajime Sasaki 《International Journal of Oral Science》 SCIE CAS CSCD 2018年第2期92-101,共10页
Hypoxia(low oxygen level) is an important feature during infections and affects the host defence mechanisms. The host has evolved specific responses to address hypoxia, which are strongly dependent on the activation... Hypoxia(low oxygen level) is an important feature during infections and affects the host defence mechanisms. The host has evolved specific responses to address hypoxia, which are strongly dependent on the activation of hypoxia-inducible factor 1(HIF-1).Hypoxia interferes degradation of HIF-1 alpha subunit(HIF-1α), leading to stabilisation of HIF-1α, heterodimerization with HIF-1 beta subunit(HIF-1β) and subsequent activation of HIF-1 pathway. Apical periodontitis(periapical lesion) is a consequence of endodontic infection and ultimately results in destruction of tooth-supporting tissue, including alveolar bone. Thus far, the role of HIF-1 in periapical lesions has not been systematically examined. In the present study, we determined the role of HIF-1 in a wellcharacterised mouse periapical lesion model using two HIF-1α-activating strategies, dimethyloxalylglycine(DMOG) and adenovirusinduced constitutively active HIF-1α(CA-HIF1 A). Both DMOG and CA-HIF1 A attenuated periapical inflammation and tissue destruction. The attenuation in vivo was associated with downregulation of nuclear factor-κappa B(NF-κB) and osteoclastic gene expressions. These two agents also suppressed NF-κB activation and subsequent production of proinflammatory cytokines by macrophages. Furthermore, activation of HIF-1α by DMOG specifically suppressed lipopolysaccharide-stimulated macrophage differentiation into M1 cells, increasing the ratio of M2 macrophages against M1 cells. Taken together, our data indicated that activation of HIF-1 plays a protective role in the development of apical periodontitis via downregulation of NF-κB, proinflammatory cytokines, M1 macrophages and osteoclastogenesis. 展开更多
关键词 CA Activation hypoxia-inducible factor attenuates periapical inflammation bone loss HIF
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Long-term observation of the mineral trioxide aggregate extrusion into the periapical lesion:a case series 被引量:5
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作者 Seok-Woo Chang Tae-Seok Oh +2 位作者 WooCheol Lee Gary Shun-Pan Cheung Hyeon-Cheol Kim 《International Journal of Oral Science》 SCIE CAS CSCD 2013年第1期54-57,共4页
One-step apexification using mineral trioxide aggregate(MTA) has been reported as an alternative treatment modality with more benefits than the use of long-term calcium hydroxide for teeth with open apex.However,ortho... One-step apexification using mineral trioxide aggregate(MTA) has been reported as an alternative treatment modality with more benefits than the use of long-term calcium hydroxide for teeth with open apex.However,orthograde placement of MTA is a challenging procedure in terms of length control.This case series describes the sequence of events following apical extrusion of MTA into the periapical area during a one-step apexification procedure for maxillary central incisor with an infected immature apex.Detailed long-term observation revealed complete resolution of the periapical radiolucent lesion around the extruded MTA.These cases revealed that direct contact with MTA had no negative effects on healing of the periapical tissues.However,intentional MTA overfilling into the periapical lesion is not to be recommended. 展开更多
关键词 EXTRUSION immature apex mineral trioxide aggregate one-step apexification open apex periapical healing
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Six cases report of differential diagnosis of periapical diseases 被引量:1
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作者 Wen-wei Xia Ya-qin Zhu Xiao-yi Wang 《International Journal of Oral Science》 SCIE CAS CSCD 2011年第3期153-159,共7页
The distinction of some particular forms of periapical area, involving diseases from regular periapical disease, is a matter of considerable importance when choosing a correct treatment. The aim of this study is to de... The distinction of some particular forms of periapical area, involving diseases from regular periapical disease, is a matter of considerable importance when choosing a correct treatment. The aim of this study is to describe the differential diagnosis of F,eriapical diseases from six rare cases in clinical practice. The six rare cases are examples of situations where it is difficult to make a differential diagnosis in clinical practice. By retrospective surveys on the clinical examination, radiographs and pathological results, six patients referred to endodontic treatment in our department were analyzed for the accuracy of diagnosis and therapy. The pathoses of the six cases included two atypical radical cysts, periapical cemental dysplasia, cemento-ossifying fibroma, thymus cancer metastasis in the periapical site and tuberculosis. This report indicates that endodontists should be cognizant of a few particular circumstances when clinically treating periapical diseases. 展开更多
关键词 periapical diseases differential diagnosis ENDODONTIC
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Immediate implant placement in combination with platelet rich-fibrin into extraction sites with periapical infection in the esthetic zone:A case report and review of literature 被引量:7
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作者 Jiao Fang Xi-Rui Xin +3 位作者 Wen Li Han-Chi Wang Hui-Xin Lv Yan-Min Zhou 《World Journal of Clinical Cases》 SCIE 2021年第4期960-969,共10页
BACKGROUND In this case,platelet-rich fibrin(PRF)was added to guided tissue regeneration as a biomaterial in proper order for immediate planting in aesthetic area with periapical infection.CASE SUMMARY With the histor... BACKGROUND In this case,platelet-rich fibrin(PRF)was added to guided tissue regeneration as a biomaterial in proper order for immediate planting in aesthetic area with periapical infection.CASE SUMMARY With the history of endodontic failure in maxillary central incisor,a 34-year-old female patient required the extraction of maxillary anterior residual root and immediate implantation.Cone beam computed tomography and clinical observation were used to assess the regeneration of soft and bone tissue.Before operation,cone beam computed tomography showed the anterior residual root had serious periapical periodontitis with insufficient labial bone in the aesthetic zone.The patient underwent immediate implant placement and reconstruction of the bone substitution by modified guided bone regeneration.The barrier was a three-layer structure of PRF-collagen membrane-PRF that covered the mixture of PRF and Bio-Oss to promote both osteogenesis and soft tissue healing.At 6 mo postoperatively,the definitive crown was placed after accomplished finial impression.One-year follow-up showed a satisfactory aesthetic effect with no obvious absorption of the labial bone and soft tissue.CONCLUSION The use of PRF in combination with guided bone regeneration can serve as a reliable and simple adjuvant for immediate implanting in infected socket and result in a stable osteogenic effect with good aesthetic outcome. 展开更多
关键词 Immediate implant Platelet rich-fibrin periapical infection Esthetic zone Guided bone regeneration Case report
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In vitro antimicrobial effects of grape seed extract on peri-implantitis microflora in craniofacial implants 被引量:1
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作者 Binit Shrestha M.L.Srithavaj Theerathavaj +1 位作者 Sroisiri Thaweboon Boonyanit Thaweboon 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2012年第10期822-825,共4页
Objective:To determine the antimicrobial effects of grape seed on peri-implantitis microflora.Methods:The grape seed extract was tested against peri-implantitis microflora most commonly found in craniofacial implants ... Objective:To determine the antimicrobial effects of grape seed on peri-implantitis microflora.Methods:The grape seed extract was tested against peri-implantitis microflora most commonly found in craniofacial implants including reference strains of Staphylococcus aureus(S.aureus),Escherichia coli(E.coli),Candida albicans(C.albicans)and clinical strains of S.aureus,Klebsiella pneumonia(K.pneumonia)and Candida parapsilosis(C.parapsilosis)by disk diffusion test.Minimum inhibitory concentrations(MIC)and minimum cidal concentrations(MCC)were determined using modified agar dilution millpore method.The extract was further combined with polyethylene glycol and propylene glycol,and was tested for antimicrobial effects.Results:Grape seed extract showed positive inhibitory effects with S.aureus at MIC of 0.625 mg/mL and MCC of1.25 mg/mL respectively.However the extracts showed minimal or no reactivity against strains of E.coli,K.pneumonia,C.parapsilosis and C.albicans.The use of grape seed extract in combination with polyethylene glycol and propylene glycol also showed dose dependent inhibitory effect on S.aureus.Conclusions:The results of the study showed that grape seed has potential antimicrobial effects which can be further studied and developed to be used in the treatment of infected skinabutment interface of craniofacial implants. 展开更多
关键词 peri-implantitis Grape seed extract CRANIOFACIAL IMPLANTS STAPHYLOCOCCUS AUREUS
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Expression of cellular fibronectin mRNA in adult periodontitis and peri-implantitis: a real-time polymerase chain reaction study 被引量:1
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作者 Yan-Yun Wu Huan-Huan Cao +2 位作者 Ning Kang Ping Gong Guo-Min Ou 《International Journal of Oral Science》 SCIE CAS CSCD 2013年第4期212-216,共5页
Cellular fibronectin (cFn) is a type of bioactive non-collagen glycoprotein regarded as the main substance used to maintain periodontal attachment. The content of cFn in some specific sites can reflect the progress ... Cellular fibronectin (cFn) is a type of bioactive non-collagen glycoprotein regarded as the main substance used to maintain periodontal attachment. The content of cFn in some specific sites can reflect the progress of periodontitis or peri-implantitis. This study aims to evaluate the expression of cFn messenger RNA (mRNA) in tissues of adult periodontitis and peri-implantitis by real-time fluorescent quantitative polymerase chain reaction (PCR) and to determine its clinical significance. A total of 30 patients were divided into three groups of 10: healthy, adult periodontitis and peri-implantitis. Periodontal tissue biopsies (1 mmx I mmx I mm) from each patient were frozen in liquid nitrogen. Total RNA was extracted from these tissues, and the content, purity and integrity were detected. Specific primers were designed according to the sequence, and the mRNA expression levels of cellular fibronectin were detected by real-time PCR. The purity and integrity of the extracted total RNA were both high, and the specificity of amplified genes was very high with no other pollution. The mRNA expression of cFn in the adult periodontitis group (1.526+0.441) was lower than that in the healthy group (3.253+0.736). However, the mRNA expression of cFn in the peri-implantitis group (3.965+0.537) was significantly higher than that in the healthy group. The difference revealed that although both processes were destructive inflammatory reactions in the periodontium, the pathomechanisms were different and the variation started from the transcription level of the cFn gene. 展开更多
关键词 adult periodontitis cellular fibronectin peri-implantitis real-time polymerase chain reaction
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Peri-implantitis and periodontitis: Use of bacteriological test in dental practice 被引量:1
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作者 Francesco Carinci Rosa Maria Gaudio 《Forensic Medicine and Anatomy Research》 2013年第3期50-56,共7页
Peri-implantitis has been defined as an inflamematory condition involving dental implants, surrounding mucosa and bone, which lose supporting bone. Although high success rates for endosseous implants have been reporte... Peri-implantitis has been defined as an inflamematory condition involving dental implants, surrounding mucosa and bone, which lose supporting bone. Although high success rates for endosseous implants have been reported, failures occur, and some implants are lost or removed. At least 10% of the failures have been suggested to be the result of peri-implantitis. One of the major causes of the peri-implantitis is the bacterial colonization of implant surfaces but additional risk factors such as periodontitis, poor oral hygiene, tobacco consumption, prepost operative therapies and genetic susceptibility should be considered. In the present study a real-time PCR bases assay was designed to detect and quantify red complex species, then used to investigate 307 periodontal pocket samples from 127 periodontitis patients and 180 controls. Results demonstrated a significant higher prevalence of red complex species and increased amount of Porphyromonas gingivalis and Treponema denticolain periodontal pocket of periodontitis. Since a higher risk of peri-implantitis occurs in periodontally affected patients, detection and treatment of bacteria is a fundamental objective to ensure dental implant survival. 展开更多
关键词 peri-implantitis PERIODONTITIS Microbia BACTERIAL TEST GENETIC TEST
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Double Roots of Mandibular Premolar in Full-mouth Periapical Films
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作者 Ling-jia Kong Kuo Wan Deng-gao Liu 《Chinese Medical Sciences Journal》 CAS CSCD 2015年第3期174-178,共5页
Objective To evaluate the incidence of two-rooted mandibular premolar morphology using full-mouth periapical film series in a Chinese population,with particular emphasis on bilateral incidence,so as to provide a clini... Objective To evaluate the incidence of two-rooted mandibular premolar morphology using full-mouth periapical film series in a Chinese population,with particular emphasis on bilateral incidence,so as to provide a clinical anatomical basis for root canal treatment in mandibular premolars.Methods A total of 2015 patients who underwent dental treatment and had full mouth periapical radiographs at the Peking University School of Stomatology from April 2011 to April 2012 were enrolled in this study.Three experienced dentists reviewed the patients' periapical films and classified the root morphology of mandibular premolars bilaterally.The incidence of unilateral and bilateral double roots were recorded and calculated,including confirmed and suspected bucco-lingual root types.Results In terms of the morphology of two-rooted mandibular first premolars,of the 2015 cases with complete root formation,two-rooted first premolars were detected in 120 cases,with a total number of 159 teeth.According to the number of teeth,the overall incidence of double roots was 4.03%(159/3972).In terms of the morphology of two-rooted mandibular second premolars,of the 2015 cases with complete root formation,two-rooted second premolars were detected in 24 cases,with a total number of 33 teeth.According to the number of teeth,the overall incidence of double roots was 0.85%(33/3880).Conclusions The roots of mandibular premolars display specific morphological patterns.Based on a large sample,we observed and calculated not only the occurrence rate of bucco-lingual and mesio-distal double roots in first and second mandibular premolars,but also the incidence of unilateral or bilateral double roots within the same mandible.These findings could provide useful information on the anatomical structure of mandibular premolars for endodontic,prosthodontic and surgical procedures,and could improve the quality of treatment and reduce complications. 展开更多
关键词 first MANDIBULAR PREMOLAR SECOND MANDIBULAR PREMOLAR DOUBLE ROOTS full-mouth periapical film
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Differentiation of periapical granulomas and cysts by using dental MRI: a pilot study
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作者 Alexander Juerchott Thorsten Pfefferle +4 位作者 Christa Flechtenmacher Johannes Mente Martin Bendszus Sabine Heiland Tim Hilgenfeld 《International Journal of Oral Science》 SCIE CAS CSCD 2018年第3期152-159,共8页
The purpose of this pilot study was to evaluate whether periapical granulomas can be differentiated from periapical cysts in vivo by using dental magnetic resonance imaging(MRI). Prior to apicoectomy, 11 patients with... The purpose of this pilot study was to evaluate whether periapical granulomas can be differentiated from periapical cysts in vivo by using dental magnetic resonance imaging(MRI). Prior to apicoectomy, 11 patients with radiographically confirmed periapical lesions underwent dental MRI, including fat-saturated T2-weighted(T2 wFS) images, non-contrast-enhanced T1-weighted images with and without fat saturation(T1 w/T1 wFS), and contrast-enhanced fat-saturated T1-weighted(T1 wFS+C) images. Two independent observers performed structured image analysis of MRI datasets twice. A total of 15 diagnostic MRI criteria were evaluated, and histopathological results(6 granulomas and 5 cysts) were compared with MRI characteristics. Statistical analysis was performed using intraclass correlation coefficient(ICC), Cohen’s kappa(κ), Mann–Whitney U-test and Fisher’s exact test. Lesion identification and consecutive structured image analysis was possible on T2 wFS and T1 wFS+C MRI images. A high reproducibility was shown for MRI measurements of the maximum lesion diameter(intraobserver ICC = 0.996/0.998; interobserver ICC = 0.997), for the "peripheral rim" thickness(intraobserver ICC = 0.988/0.984; interobserver ICC = 0.970), and for all non-quantitative MRI criteria(intraobserver-κ = 0.990/0.995; interobserver-κ = 0.988). In accordance with histopathological results, six MRI criteria allowed for a clear differentiation between cysts and granulomas:(1) outer margin of lesion,(2) texture of "peripheral rim" in T1 wFS+C,(3)texture of "lesion center" in T2 wFS,(4) surrounding tissue involvement in T2 wFS,(5) surrounding tissue involvement in T1 wFS+C and(6) maximum "peripheral rim" thickness(all: P < 0.05). In conclusion, this pilot study indicates that radiation-free dental MRI enables a reliable differentiation between periapical cysts and granulomas in vivo. Thus, MRI may substantially improve treatment strategies and help to avoid unnecessary surgery in apical periodontitis. 展开更多
关键词 Differentiation of periapical granulomas and cysts by using dental MRI a pilot study
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Effect of tea polyphenols combined with photodynamic therapy on the efficacy and RANKL and Shh levels in patients with early peri-implantitis
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作者 Feng Hui Chen Yi Lyu Zong-kai 《Journal of Hainan Medical University》 2019年第17期76-79,共4页
Objective: To analyze the effect of tea polyphenols combined with photodynamic therapy on the efficacy and RANKL and Shh levels in patients with early peri-implantitis. Methods:Eighty patients with early peri-implanti... Objective: To analyze the effect of tea polyphenols combined with photodynamic therapy on the efficacy and RANKL and Shh levels in patients with early peri-implantitis. Methods:Eighty patients with early peri-implantitis admitted to our hospital from January 2017 to December 2018 were randomly divided into the observation group and the control group;the control group was treated with photodynamic therapy, and the observation group was treated with tea polyphenols combined with photodynamic therapy. The levels of mPLI, PPD, mSBI and BOP were measured before treatment and 3 months after the treatment, and the levels of CRP, TNF-α, IL-6, RANKL and Shh in the gingival crevicular fluid were measured. Results:The levels of mPLI, PPD, mSBI and BOP in the observation group were significantly lower than those in the control group, and the difference was statistically significant (P<0.05). The levels of CRP, TNF-α, IL-6, RANKL and Shh in the gingival crevicular fluid were observed in the observation group. The differences were significantly lower than the control group, and the difference was statistically significant (P<0.05). Conclusions: The combination of tea polyphenols and photodynamic therapy for patients with early peri-implantitis can significantly improve clinical efficacy and reduce the inflammatory response, and can effectively improve the levels of RANKL and Shh in gingival crevicular fluid. 展开更多
关键词 TEA POLYPHENOLS Photodynamic therapy EARLY peri-implantitis RANKL SHH
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Health Indicator Bacteria That Is Useful for Risk Assessment of Peri-Implantitis
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作者 Hidenori Suzuki Osamu Tsuzukibashi Akira Fukatsu 《Open Journal of Stomatology》 2021年第9期360-372,共13页
We established a novel identification method for oral Rothia species using one-step multiplex PCR analysis to investigate whether the monitoring of oral <em>Rothia</em> species levels is useful for peri-im... We established a novel identification method for oral Rothia species using one-step multiplex PCR analysis to investigate whether the monitoring of oral <em>Rothia</em> species levels is useful for peri-implantitis risk assessment, and to examine the oxygen concentration that these organisms need for growth <em>in vitro</em>. The mean number and proportion of <em>Rothia </em><em>aeria </em>in peri-implant sulcus fluid (PISF) samples was significantly higher in the healthy implant group than in the peri-implantitis group (P < 0.05). Moreover, <em>R. aeria</em> under aerobic conditions vigorously grew compared with those under anaerobic conditions, and this organism grew only at the upper layer where high oxygen concentrations existed in a semi-liquid nutrient medium. Therefore, the monitoring of <em>R. aeria</em> levels may be suitable as an indicator of healthy peri-implant tissue conditions for the prevention of peri-implantitis. 展开更多
关键词 peri-implantitis Multiplex PCR Rothia aeria Oral Cavity
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Histopathological and Immunohistochemical Study of Peri-Implant Epithelium
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作者 Yoshikazu Nakayama Chieko Taguchi +2 位作者 Mitsuko Nakayama Masaaki Suemitsu Kayo Kuyama 《Open Journal of Stomatology》 2023年第9期309-321,共13页
Background: Human beta-defensins (HBDs), epithelial-derived antimicrobial peptides, contribute to gingival health and periodontal disease. Particularly, the upregulation of HBD-3 expression in periodontal tissues is d... Background: Human beta-defensins (HBDs), epithelial-derived antimicrobial peptides, contribute to gingival health and periodontal disease. Particularly, the upregulation of HBD-3 expression in periodontal tissues is described to contribute to periodontal tissue regeneration. Specifically, the upregulation of HBD-3 expression in periodontal tissues is described to contribute to periodontal tissue regeneration. But there has been insufficient investigation of the inner epithelium in peri-implantitis, especially the HBD expression patterns as protection against oral infection. Objectives: The purpose of this study was to investigate the histopathological characteristics of the inner implant epithelium in peri-implantitis using histopathological and immunohistochemical methods and to compare it with the inner marginal epithelium in periodontitis. Materials and Methods: The biopsied cases consisted of 10 peri-implantitis, 11 periodontitis, and 10 controls. HE observation, measurement of the thickness of the inner epithelium, and immunohistochemical analysis for Ki-67 and HBD-3 were conducted. Results: Concerning the thickness of the inner epithelium, it was significantly higher in periodontitis (156.2 [138.0, 186.4] μm) than in peri-implantitis and control, 70.7 [67.5, 97.5] μm and 80.7 [76.6, 89.4] μm, respectively (p Conclusion: Decreased production of HBD-3 in keratinocytes composing the inner implant epithelium may be one of the factors affecting tissue repair in peri-implantitis. 展开更多
关键词 peri-implantitis PERIODONTITIS Ki-67 HBD-3 Inner Epithelium
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Dental Implant Patients Grouped by the Brinkman Index: Their Attitude toward Smoking, Nicotine Dependence, and Knowledge of Peri-Implantitis
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作者 Ken Yukawa Noriko Tachikawa Shohei Kasugai 《Open Journal of Regenerative Medicine》 2016年第2期55-60,共6页
Purpose: This study investigated the attitude of patients, grouped by the Brinkman index, towards smoking by using the Kano Test for Social Nicotine Dependence (KTSND) and their knowledge of peri-implantitis. Methods:... Purpose: This study investigated the attitude of patients, grouped by the Brinkman index, towards smoking by using the Kano Test for Social Nicotine Dependence (KTSND) and their knowledge of peri-implantitis. Methods: The participants were 3093 new patients who visited the Tokyo Medical and Dental University Hospital from January 2012 to December 2013 for an oral implant. The methodology included a questionnaire about sex, age, smoking status, daily average number of cigarettes, years of smoking, knowledge of peri-implantitis, and the KTSND. The patients were grouped according to their smoking status by calculating their Brinkman index (over 200 or not): current smokers with the possibility of nicotine dependence (BI(+)CS), current smokers with no possibility of nicotine dependence (BI(-)CS), ex-smokers (ES), and non-smokers (NS). The Brinkman index is obtained by multiplying one’s daily average number of cigarettes by the number of years they have been smoking. Results: Data were collected from 2182 respondents (response rate = 71%). The KTSND scores of BI(+)CS (16.89 ± 4.26) were significantly higher than the scores of ES (11.99 ± 4.52) and NS (11.53 ± 5.01). In current smokers, there were no significant differences between BI(+)CS and BI(-)CS. The patients replied “I don’t know” about peri-implantitis most often in all groups;however, there were no significant differences between the groups. Discussion: BI(+)CS were more dependent on nicotine in social situations than the other groups were. In Japan, a Brinkman index over 200 is required for a nicotine-dependence management fee to be instituted for health insurance treatment. This is a major concern for young smokers, who may be excluded from treatment because their years of smoking are substantially less. Results revealed that there were no significant differences between BI(+)CS and BI(-)CS. Therefore, it was suggested that the Brinkman index did not sufficiently group the participants. 展开更多
关键词 Dental Implant peri-implantitis SMOKING Smoking Cessation Kano Test for Social Nicotine Dependence (KTSND)
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锥形束计算机断层扫描评估上颌后牙区施耐德膜增厚与根尖周病变的相关性分析
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作者 冯博 李凤翔 杜启涛 《华西口腔医学杂志》 CAS CSCD 北大核心 2024年第5期644-651,共8页
目的 评估患者上颌窦内衬黏膜上皮,即施耐德膜(SM)增厚的情况及其与上颌后牙区根尖周病变(PAL)的关系,以期为牙源性上颌窦炎的预防和治疗提供参考。方法 回顾性分析符合纳入标准的301例患者554个上颌窦的锥形束计算机断层扫描(CBCT)影... 目的 评估患者上颌窦内衬黏膜上皮,即施耐德膜(SM)增厚的情况及其与上颌后牙区根尖周病变(PAL)的关系,以期为牙源性上颌窦炎的预防和治疗提供参考。方法 回顾性分析符合纳入标准的301例患者554个上颌窦的锥形束计算机断层扫描(CBCT)影像学资料,以确定上颌后牙PAL与SM增厚的相关性。记录病理性黏膜增厚的病例数,并根据SM增厚的程度与类型进行分类。评估SM增厚与PAL的直径,PAL上缘与上颌窦底的波及关系及有PAL的患牙是否进行根管治疗之间的相关性。结果 在上颌后牙区,当患者出现PAL时,SM增厚的检出率高于无PAL,并且PAL与SM增厚之间具有相关性。PAL各项检测指标与SM增厚程度相关性分析结果显示,CBCT根尖周指数(CBCT-PAI) PAL直径与SM增厚程度呈现正相关性,而PAL上缘与上颌窦底的3种不同波及关系、有PAL的患牙是否进行根管治疗与SM增厚程度不具有相关性。PAL各项检测指标与SM增厚类型相关性分析结果显示,有PAL的患牙是否进行根管治疗与SM增厚类型之间具有相关性,而PAL直径和PAL上缘与上颌窦底的3种不同波及关系与SM增厚类型不具有相关性。结论 上颌后牙PAL与SM增厚密切相关,PAL直径与SM增厚程度呈正相关;有PAL且进行过根管治疗的患牙常见出现SM息肉型增厚,PAL上缘与上颌窦底的波及关系不影响SM的发展。 展开更多
关键词 施耐德膜增厚 根尖周病变 锥形束计算机断层扫描
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重点环节护理模式在慢性根尖周炎患者根管治疗中的临床效果
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作者 覃沅华 宋朝晖 +2 位作者 曲晓东 邹鲜芳 周燕平 《临床医学工程》 2024年第6期731-732,共2页
目的探讨重点环节护理模式应用于慢性根尖周炎患者根管治疗中的临床效果。方法94例慢性根尖周炎行根管治疗的患者随机分为两组,对照组予以常规护理,观察组予以重点环节护理模式,比较两组的焦虑症状、疼痛程度以及并发症。结果干预后,观... 目的探讨重点环节护理模式应用于慢性根尖周炎患者根管治疗中的临床效果。方法94例慢性根尖周炎行根管治疗的患者随机分为两组,对照组予以常规护理,观察组予以重点环节护理模式,比较两组的焦虑症状、疼痛程度以及并发症。结果干预后,观察组的SAS评分、NRS评分均低于对照组(P<0.05)。观察组的并发症发生率为6.38%,低于对照组的21.28%(P<0.05)。结论重点环节护理模式有利于减轻慢性根尖周炎根管治疗患者的焦虑症状及疼痛程度,降低并发症发生风险。 展开更多
关键词 慢性根尖周炎 根管治疗 重点环节护理 焦虑症状 疼痛 并发症
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微螺钉支抗治疗对口腔正畸患者牙龈指标及牙根周组织的影响分析
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作者 张春波 《中国现代药物应用》 2024年第15期55-57,共3页
目的分析微螺钉支抗治疗对口腔正畸患者牙龈指标及牙根周组织的影响。方法选取100例口腔正畸患者,随机分为对照组(50例)与研究组(50例)。对照组选择非种植体支抗治疗,研究组则选择微螺钉支抗治疗。比较两组的临床疗效、牙龈指标[牙菌斑... 目的分析微螺钉支抗治疗对口腔正畸患者牙龈指标及牙根周组织的影响。方法选取100例口腔正畸患者,随机分为对照组(50例)与研究组(50例)。对照组选择非种植体支抗治疗,研究组则选择微螺钉支抗治疗。比较两组的临床疗效、牙龈指标[牙菌斑指数(PLI)、牙龈指数(GI)以及龈沟出血指数(SBI)]、牙根周组织损伤情况。结果研究组的总有效率96.0%显著高于对照组的82.0%(P<0.05)。相比于治疗前,两组治疗后的PLI、GI及SBI均明显下降(P<0.05);且研究组治疗后的PLI(1.28±0.25)分、GI(1.06±0.11)分、SBI(1.15±0.14)分均明显低于对照组的(1.87±0.34)、(1.43±0.14)、(1.68±0.15)分(P<0.05)。研究组的牙根周组织受损率24.0%显著高于对照组的8.0%(P<0.05)。结论选择微螺钉支抗治疗口腔正畸患者能取得显著疗效,能对牙龈情况进行显著改善,但是却会在一定程度上影响、损伤牙根周组织,所以在实际的临床治疗中应严格遵循相关的规范开展各项操作,以减少操作失误。 展开更多
关键词 微螺钉支抗 口腔正畸 牙菌斑指数 牙根周组织
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探讨IL-34在小鼠慢性根尖周炎模型中的动态表达
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作者 王敏 徐丽 +3 位作者 朱永娜 张伟健 武庆华 刘茜 《淮海医药》 CAS 2024年第2期120-124,共5页
目的:探讨白介素-34(IL-34)在小鼠慢性根尖周炎模型中的表达及变化情况。方法:选择35只SD小鼠,对其下颌第一磨牙开髓制造根尖周炎的模型,并在0、7、14、21、28 d随机脱颈处死,解剖分离含有第一磨牙的下颌骨,进行影像学检查,了解模型中... 目的:探讨白介素-34(IL-34)在小鼠慢性根尖周炎模型中的表达及变化情况。方法:选择35只SD小鼠,对其下颌第一磨牙开髓制造根尖周炎的模型,并在0、7、14、21、28 d随机脱颈处死,解剖分离含有第一磨牙的下颌骨,进行影像学检查,了解模型中根尖周的破坏情况。将下颌骨标本制备切片,进行HE染色观察根尖周组织病理学改变以及抗酒石酸酸性磷酸酶(TRAP)染色检测破骨细胞,实时荧光定量PCR(RT-qPCR)检测IL-34与肿瘤坏死因子-α(TNF-α)在根尖周炎模型中的动态表达。结果:影像学检查显示,0~7 d根尖无明显异常,14~21 d开始出现轻度根尖破坏,28 d根尖阴影变大,范围增宽。HE染色显示,0 d根尖周组织正常未见明显改变,7 d炎性因子浸润开始增多,14 d出现明显的骨质破坏以及坏死中心,21 d炎性渗出减少,小范围的骨质破坏区域增多,28 d炎性细胞浸润趋于稳定,小范围的骨质破坏连接成片,大范围的骨质破坏形成。TRAP染色显示,0 d几乎看不到破骨细胞,7~14 d破骨细胞数目明显增加,在21 d时到达高峰,28 d时轻微下降,但7、14、21、28 d时均高于0 d(P<0.05)。RT-qPCR检测显示,7~28 d的IL-34及TNF-α的mRNA表达量均逐渐增高,且在14 d到达顶峰,在21 d呈现下降的趋势,28 d又呈现上升趋势,在7~28 d的表达量均高于0 d(P<0.05),并且呈现正相关关系。结论:IL-34的mRNA表达量随着根尖周炎病变程度发展而改变,尤其是与骨质破坏的程度相关,并与TNF-α有着密切的联系,出现短暂的表达量下降说明其表达受到了抑制,有助于为临床治疗提供方向。 展开更多
关键词 根尖周炎 白介素-34(IL-34) 肿瘤坏死因子-α(TNF-α)
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根管治疗中Vitapex糊剂与奥硝唑碘仿糊剂对窦道型根尖周炎的疗效比较 被引量:2
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作者 侯佳丽 蔡佳 江煜 《中国现代医学杂志》 CAS 2024年第1期89-93,共5页
目的分析根管治疗中Vitapex糊剂与奥硝唑碘仿糊剂对窦道型根尖周炎疗效的影响。方法选取2019年1月—2022年2月青岛大学附属青岛市海慈医院收治的118例窦道型根尖周炎患者,以随机数字表法分为研究组和对照组,各59例。两组均进行根管治疗... 目的分析根管治疗中Vitapex糊剂与奥硝唑碘仿糊剂对窦道型根尖周炎疗效的影响。方法选取2019年1月—2022年2月青岛大学附属青岛市海慈医院收治的118例窦道型根尖周炎患者,以随机数字表法分为研究组和对照组,各59例。两组均进行根管治疗,对照组充填奥硝唑碘仿糊剂,研究组充填Vitapex糊剂,治疗后随访6个月。比较两组充填治疗后的疼痛反应、窦道愈合情况、根尖愈合情况、综合疗效及牙周炎症因子(高敏C反应蛋白、白细胞介素-6、白细胞介素-8)水平。结果两组充填治疗后疼痛反应发生率比较,差异无统计学意义(P>0.05)。研究组窦道愈合率高于对照组(P<0.05)。两组治疗前、治疗3个月、治疗6个月的根尖透射区面积比较,采用重复测量设计的方差分析,结果:(1)不同时间点的根尖透射区面积有差异(P<0.05);(2)两组的根尖透射区面积有差别(P<0.05),研究组治疗3个月、治疗6个月的根尖透射区面积均低于对照组;(3)两组根尖透射区面积的变化趋势有差异(P<0.05)。研究组的成功率高于对照组(P<0.05)。研究组治疗前后的高敏C反应蛋白、白细胞介素-6、白细胞介素-8差值均高于对照组(P<0.05)。结论与奥硝唑碘仿糊剂比较,Vitapex糊剂对窦道型根尖周炎患者根管治疗的窦道愈合、根尖愈合及减轻牙周炎症反应方面更具优势,综合治疗效果更佳。 展开更多
关键词 窦道型根尖周炎 根管治疗 VITAPEX糊剂 奥硝唑碘仿糊剂 效果
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