Progress in defining heterogeneity and modeling periglomerular cells in the olfactory bulb

In recent years the evolution of olfactory bulb periglomerular cells,as well as the function of periglomerular cells in olfactory encoding,has attracted increasing attention.Studies of neural information encoding based on the analysis of simulation and modeling have given rise to electrophysiological models of periglomerular cells,which have an important role in the understanding of the biology of these cells.In this review we provide a brief introduction to the anatomy of the olfactory system and the cell types in the olfactory bulb.We elaborate on the latest progress in the study of the heterogeneity of periglomerular cells based on different classification criteria,such as molecular markers,structure,ion channels and action potentials.Then,we discuss the several existing electrophysiological models of periglomerular cells,and we highlight the problems and defects of these models.Finally,considering our present work,we propose a future direction for electrophysiological investigations of periglomerular cells and for the modeling of periglomerular cells and olfactory information encoding.

嗅球神经系统的发放模式与同步运动

在嗅觉神经系统的信号传导过程中,僧帽细胞同步振荡活动模式的变化对于嗅球的编码与解码是十分重要的。为了研究颗粒细胞和球旁细胞如何影响僧帽细胞的同步发放,构造了僧帽细胞、颗粒细胞和球旁细胞这三种细胞的动力学模型,通过数值模拟得到了这三种细胞的发放模式。并通过构建网络模型,比较了各种不同细胞和在网络条件下它们之间的发放的差别。最后分析僧帽细胞群的同步运动,发现颗粒细胞和球旁细胞的抑制性作用促进了僧帽细胞的同步性。

多巴胺对嗅球神经回路调节作用的研究进展

多巴胺是中枢神经系统内很重要的神经递质,发挥很多生理功能,如认知活动和运动功能的调控。对帕金森病患者早期临床研究表明,脑内多巴胺水平也与嗅觉功能有关。嗅球是嗅觉系统中很重要的组成部分。近年来对多巴胺在嗅球嗅觉信息处理的作用多有研究。文中就多巴胺在嗅球中的分布及其作用进行综述。