Changes in the permeability of blood brain barrier and endothelial cell damage after cerebral ischemia

OBJECTIVE： To investigate the effect of endothelial cells on the permeability of blood brain barrier （BBB） after brain injury and its effect mechanism. DATA SOURCES： We searched for the articles of permeability of BBB and endothelial cell injury after brain is- chemia, which were published between January 1982 and December 2005, with the key words of ＂cerebral ischemia damage,blood brain barrier （ BBB）,permeability,effect of endothelial cell （EC） and its variation mechanism＂in English. STUDY SELECTION： The materials were primarily selected. The articles related to the changes in the permeability of BBB and the effect of endothelial cells as well as the change mechanism after cerebral ischemia damage were chosen. Repetitive studies or review articles were excluded. DATA EXTRACTION： Totally 55 related articles were collected, and 35 were excluded due to repetitive or review articles, finally 20 articles were involved. DATA SYNTHESIS： The content or viewpoints of involved literatures were analyzed. Cerebral ischemia had damage for endothelial cells, such as the inflow of a lot of Ca2^＋, the production of nitrogen monoxide and oxygen free radical, and aggravated destruction of BBB. After acceptors of inflammatory mediators on cerebrovascular endothelial cell membrane, such as histamine, bradykinin , 5-hydroxytryptamine and so on are activated, endothelial cells shrink and the permeability of BBB increases. Its mechanism involves in the inflow of extracellular Ca^＋2and the release of intracellular Ca^2＋ in the cells. Glycocalyx molecule on the surface of endothelial cell, having structural polytropy, is the determinative factor of the permeability of BBB. VEGF, intensively increasing the vasopermeability and mainly effecting on postcapillary vein and veinlet, is the strongest known blood vessel permeation reagent. Its chronic overexpression in the brain can lead the destruction of BBB. CONCLUSION： The injury of endothelial cell participants in the pathological mechanism of BBB destruction after cerebral ischemla.

Anisotropic dynamic permeability model for porous media

Based on the tortuous capillary network model,the relationship between anisotropic permeability and rock normal strain,namely the anisotropic dynamic permeability model(ADPM),was derived and established.The model was verified using pore-scale flow simulation.The uniaxial strain process was calculated and the main factors affecting permeability changes in different directions in the deformation process were analyzed.In the process of uniaxial strain during the exploitation of layered oil and gas reservoirs,the effect of effective surface porosity on the permeability in all directions is consistent.With the decrease of effective surface porosity,the sensitivity of permeability to strain increases.The sensitivity of the permeability perpendicular to the direction of compression to the strain decreases with the increase of the tortuosity,while the sensitivity of the permeability in the direction of compression to the strain increases with the increase of the tortuosity.For layered reservoirs with the same initial tortuosity in all directions,the tortuosity plays a decisive role in the relative relationship between the variations of permeability in all directions during pressure drop.When the tortuosity is less than 1.6,the decrease rate of horizontal permeability is higher than that of vertical permeability,while the opposite is true when the tortuosity is greater than 1.6.This phenomenon cannot be represented by traditional dynamic permeability model.After the verification by experimental data of pore-scale simulation,the new model has high fitting accuracy and can effectively characterize the effects of deformation in different directions on the permeability in all directions.

Nonlinear model characterizing stress-strain relationship and permeability change of contact compression fracture at closing stage

Understanding the stress-strain relationship and permeability change for contact compression fracture at closing stage has been a hot issue for a long time.Previous investigations of this topic were mainly focused on experimental tests;however,theoretical approaches were rarely reported.Based on this,this paper focuses on the contact fracture at closing stage when rock is uniaxially loaded,and then a theoretical model is proposed.Based on the change of fracture elasticity modulus,it shows that as crack apertures are gradually reduced in the loading process,the permeability of rock sample will decrease progressively.This scenario shows that theoretical computation matches well with the experimental results.Finally,the effects of ratio of sample size to fracture aperture(n).pore pressure(P),and initial aperture(b) on stress-strain relationship and permeability change for contact compression fracture at closing stage are analyzed.

Unconventional resource's production under desorption-induced effects

Thousands of horizontal wells are drilled into the shale formations across the U.S.and hydrocarbon production is substantially increased during past years.This fact is accredited to advances obtained in hydraulic fracturing and pad drilling technologies.The contribution of shale rock surface desorption to production is widely accepted and confirmed by laboratory and field evidences.Nevertheless,the subsequent changes in porosity and permeability due to desorption combined with hydraulic fracture closures caused by increased net effective rock stress state,have not been captured in current shale modeling and simulation.Hence,it is essential to investigate the effects of induced permeability,porosity,and stress by desorption on ultimate hydrocarbon recovery.We have developed a numerical model to study the effect of changes in porosity,permeability and compaction on four major U.S.shale formations considering their Langmuir isotherm desorption behavior.These resources include;Marcellus,New Albany,Barnett and Haynesville Shales.First,we introduced a model that is a physical transport of single-phase gas flow in shale porous rock.Later,the governing equations are implemented into a one-dimensional numerical model and solved using a fully implicit solution method.It is found that the natural gas production is substantially affected by desorption-induced porosity/permeability changes and geomechancis.This paper provides valuable insights into accurate modeling of unconventional reservoirs that is more significant when an even small correction to the future production prediction can enormously contribute to the U.S.economy.