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Test and analysis of influencing factors on the permeability coefficient of steel slag permeable concrete 被引量:3
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作者 YANG Gang WANG Youqin WANG Hailong JIN Qiang 《Baosteel Technical Research》 CAS 2011年第2期24-26,共3页
The steel slag (SS) permeable concrete was prepared by SS. The influences of the aggregate-cement rate, the aggregate particle size, the water-cement rate, the admixture dosage and other factors on the permeability ... The steel slag (SS) permeable concrete was prepared by SS. The influences of the aggregate-cement rate, the aggregate particle size, the water-cement rate, the admixture dosage and other factors on the permeability coefficient of SS permeable concrete were analyzed. The law of influence was also investigated. The study serves as a technological reference for the construction and design of SS permeable concrete. 展开更多
关键词 steel slag permeable concrete permeability coefficient influencing factors
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The coefficient of variation representing the non-uniformity of the strain field and its implication to detect earthquake precursor
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作者 Yonghong Zhao Yue Zhao +3 位作者 Xiaofan Li Zhongcheng Cao Zhen Li Muhammad Irfan Ehsan 《Earthquake Science》 2020年第5期246-255,共10页
Before the major earthquake or rock damage occurs,it is often accompanied by a sudden change in the degree of non-uniformity of the strain field.In order to find a stronger non-uniformity signal before the rock failur... Before the major earthquake or rock damage occurs,it is often accompanied by a sudden change in the degree of non-uniformity of the strain field.In order to find a stronger non-uniformity signal before the rock failure,the coefficient of variation(Cv)is examined and reformed in this study.We test the Cv calculation way of the"normal-abnormal"model proposed in the previous studies.Based on the analysis of the physical process of rock failure and its relationship to the shear strain field,we construct a new way to calculate the Cv value.The variation of shear strain field on rock sample with the increase of stress is obtained by the digital speckle correlation method(DSCM).The new Cv value calculation way is used to study the non-uniformity of the spatial distribution for the shear strain field.The results show that this Cv calculation way can get more obvious abnormal signals.When the number of observation points are limited,the specific distribution of points can increase the signal strength,which may provide reference for the research on precursor detection of earthquakes. 展开更多
关键词 rock failure shear strain field non-uniformity coefficient of variation
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Design formulas of transmission coefficients for permeable breakwaters 被引量:2
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作者 Su-xiang ZHANG Xi LI 《Water Science and Engineering》 EI CAS CSCD 2014年第4期457-467,共11页
New empirical formulas of the transmission coefficient for permeable breakwaters were suggested based on available experimental data regarding the low-crest structure (LCS), including the permeable rubble mound brea... New empirical formulas of the transmission coefficient for permeable breakwaters were suggested based on available experimental data regarding the low-crest structure (LCS), including the permeable rubble mound breakwater and pile-type breakwater. The rationality of the present formulas was verified by their comparison with existing empirical and analytical formulas. Numerical flume results were obtained by solving the modified Boussinessq-type wave equations (MBEs), and a new expression relating the friction coefficient of to the relative submerged depth Rt/H8 was also derived. Comparative analysis shows that the results of the present formulas agree with the numerical flume results as well as available experimental data, and the present formulas are superior to the existing empirical and analytical expressions in estimating the transmission coefficient. The present formulas can provide references for estimation of the transmission coefficient in engineering practice. 展开更多
关键词 permeable breakwater transmission coefficient wave reflection nonlinear wave Boussinesq wave model low-crest structure
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Anisotropic Rock Poroelasticity Evolution in Ultra-low Permeability Sandstones under Pore Pressure,Confining Pressure,and Temperature:Experiments with Biot's Coefficient 被引量:3
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作者 DU Shuheng 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2021年第3期937-945,共9页
This study aimed to show anisotropic poroelasticity evolution in ultra-low permeability reservoirs under pore pressure,confining pressure,and temperature.Several groups of experiments examining Biot's coefficient ... This study aimed to show anisotropic poroelasticity evolution in ultra-low permeability reservoirs under pore pressure,confining pressure,and temperature.Several groups of experiments examining Biot's coefficient under different conditions were carried out.Results showed that Biot's coefficient decreased with increased pore pressure,and the variation trend is linear,but the decreasing rate is variable between materials.Biot's coefficient increased with increased confining pressure;the variation trend is linear,but the increasing rate varies by material as well.Generally,Biot's coefficient remains stable with increased temperature.Lithology,clay mineral content,particle arrangement,and pore arrangement showed impacts on Biot's coefficient.For strong hydrophilic clay minerals,expansion in water could result in a strong surface adsorption reaction,which could result in an increased fluid bulk modulus and higher Biot's coefficient.For skeleton minerals with strong lipophilicity,such as quartz and feldspar,increased oil saturation will also result in an adsorption reaction,leading to increased fluid bulk modulus and a higher Biot's coefficient.The study's conclusions provide evidence of poroelasticity evolution of ultra-low permeability and help the enhancing oil recovery(EOR)process. 展开更多
关键词 Biot's coefficient ultra-low permeability pore pressure confining pressure temperature
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Rules for confidence intervals of permeability coefficients for water flow in over-broken rock mass 被引量:7
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作者 Liu Weiqun Fei Xiaodong Fang Jingnian 《International Journal of Mining Science and Technology》 2012年第1期29-33,共5页
Based on the steady-state seepage method, we used the Mechanical Testing and Simulation 815.02 System and a self-designed seepage instrument for over-broken stone to measure seepage properties of water flows in three ... Based on the steady-state seepage method, we used the Mechanical Testing and Simulation 815.02 System and a self-designed seepage instrument for over-broken stone to measure seepage properties of water flows in three types of crushed rock samples. Three methods of confidence interval in describing permeability coefficients are presented: the secure interval, the calculated interval and the systemic interval. The lower bound of the secure interval can be applied to water-inrush and the upper bound can solve the problem of connectivity. For the calculated interval, as the axial pressure increases, the length of confidence interval is shortened and the upper and lower bounds are reduced. For the systemic interval, the length of its confidence interval, as well as the upper and lower bounds, clearly vary under low axial pressure but are fairly similar under high axial pressure. These three methods provide useful information and references for analyzing the permeability coefficient of over-broken rock. 展开更多
关键词 Over-broken rock mass permeability coefficient Secure interval Calculated interval Systemic interval
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Water inflow forecasting for tunnel considering nonlinear variation of permeability coefficient 被引量:1
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作者 CHENG Pan ZHAO Lian-heng +4 位作者 ZHANG Shao-wei LI Liang SHEN Zhi-qiang NING Peng-fei ZHANG Ze-hai 《Journal of Central South University》 SCIE EI CAS CSCD 2017年第7期1612-1618,共7页
To assess the water inflow which is more suitable to the actual conditions of tunnel,an empirical correlation about the permeability coefficient changing with depth is introduced.Supposing that the surrounding rock is... To assess the water inflow which is more suitable to the actual conditions of tunnel,an empirical correlation about the permeability coefficient changing with depth is introduced.Supposing that the surrounding rock is heterogeneous isotropy,the formula for calculating water inflow of tunnel with the nonlinear variation of permeability coefficient is deduced.By the contrast analysis with the existing formulas,the presented method has the similar value to them;moreover,the presented method has more simple form and easy to use.Due to parameter analysis,the water inflow decreases after considering the nonlinear variation of permeability coefficient.When the attenuation coefficient a>0,the water inflow increases first till reaches the maximum at a certain depth,then decreases and is close to 0 finally if deep enough.Thus,it is better to keep away from the certain depth where it is with the maximum water inflow for safe operation and economical construction,and reduce the water damage.Based on the analysis,the radius of tunnel has less impact on the amount of water inflow,and the water inflow just increases by 6.7% when the radius of tunnel increases by 1 m. 展开更多
关键词 water INFLOW forecasting heterogeneous ISOTROPY of SURROUNDING rock permeability coefficient TUNNEL
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One-dimensional horizontal infiltration experiment for determining permeability coefficient of loamy sand 被引量:3
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作者 HU Shunjun ZHU Hai CHEN Yongbao 《Journal of Arid Land》 SCIE CSCD 2017年第1期27-37,共11页
A knowledge of soil permeability is essential to evaluate hydrologic characteristics of soil, such as water storage and water movement, and soil permeability coefficient is an important parameter that reflects soil pe... A knowledge of soil permeability is essential to evaluate hydrologic characteristics of soil, such as water storage and water movement, and soil permeability coefficient is an important parameter that reflects soil permeability. In order to confirm the acceptability of the one-dimensional horizontal infiltration method(one-D method) for simultaneously determining both the saturated and unsaturated permeability coefficients of loamy sand, we first measured the cumulative infiltration and the wetting front distance under various infiltration heads through a series of one-dimensional horizontal infiltration experiments, and then analyzed the relationships of the cumulative horizontal infiltration with the wetting front distance and the square root of infiltration time. We finally compared the permeability results from Gardner model based on the one-D method with the results from other two commonly-used methods(i.e., constant head method and van Genuchten model) to evaluate the acceptability and applicability of the one-D method. The results showed that there was a robust linear relationship between the cumulative horizontal infiltration and the wetting front distance, suggesting that it is more appropriate to take the soil moisture content after infiltration in the entire wetted zone as the average soil moisture content than as the saturated soil moisture content. The results also showed that there was a robust linear relationship between the cumulative horizontal infiltration and the square root of infiltration time, suggesting that the Philip infiltration formula can better reflect the characteristics of cumulative horizontal infiltration under different infiltration heads. The following two facts indicate that it is feasible to use the one-D method for simultaneously determining the saturated and unsaturated permeability coefficients of loamy sand. First, the saturated permeability coefficient(prescribed in the Gardner model) of loamy sand obtained from the one-D method well agreed with the value obtained from the constant head method. Second, the relationship of unsaturated permeability coefficient with soil water suction for loamy sand calculated using Gardner model based on the one-D method was nearly identical with the same relationship calculated using van Genuchten model. 展开更多
关键词 permeability coefficient one-dimensional horizontal infiltration cumulative horizontal infiltration wetting front distance Philip infiltration formula Gardner model
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A method of determining the permeability coefficient of coal seam based on the permeability of loaded coal 被引量:6
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作者 Li Bo Wei Jianping +2 位作者 Wang Kai Li Peng Wang Ke 《International Journal of Mining Science and Technology》 SCIE EI 2014年第5期637-641,共5页
This study developed the equipment for thermo-fluid–solid coupling of methane-containing coal, and investigated the seepage character of loaded coal under different working conditions. Regarding the effective pressur... This study developed the equipment for thermo-fluid–solid coupling of methane-containing coal, and investigated the seepage character of loaded coal under different working conditions. Regarding the effective pressure as a variable, the variation characteristics of the gas permeability of loaded methane-containing coal has been studied under the conditions of different confining pressures and pore pressures. The qualitative and quantitative relationship between effective stress and permeability of loaded methane-containing coal has been established, considering the adsorption of deformation, amount of pore gas compression and temperature variation. The results show that the permeability of coal samples decreases along with the increasing effective stress. Based on the Darcy law, the correlation equation between the effective stress and permeability coefficient of coal seam has been established by combining the permeability coefficient of loaded coal and effective stress. On the basis of experimental data, this equation is used for calculation, and the results are in accordance with the measured gas permeability coefficient of coal seam. In conclusion, this method can be accurate and convenient to determine the gas permeability coefficient of coal seam, and provide evidence for forecasting that of the deep coal seam. 展开更多
关键词 permeability coefficient Coal seam Effective pressure Loaded coal Pore pressure
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A Review of Test Methods for the Determination of the Permeability Coefficient of Gravelly Soils Used for Embankment Dams 被引量:1
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作者 Zhenggang Zhan Han Chen +2 位作者 Yanyi Zhang Ruilin Cheng Gang Deng 《Fluid Dynamics & Materials Processing》 EI 2022年第1期131-144,共14页
The factors influencing the permeability coefficient of gravelly soils used for the development of embankment dams(core wall)are analyzed.Such factors include(but are not limited to)soil size,anisotropy,density and bo... The factors influencing the permeability coefficient of gravelly soils used for the development of embankment dams(core wall)are analyzed.Such factors include(but are not limited to)soil size,anisotropy,density and boundary effects.A review of the literature is conducted and new directions of research are proposed.In such a framework,it is shown that gravelly soil with controlled density and vertical stress should be used to optimize the measurement of the vertical and horizontal permeability coefficients,respectively. 展开更多
关键词 Wide-grading gravelly soil core wall materials permeability coefficient test method
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Investigating the Relationship between Porosity and Permeability Coefficient for Pervious Concrete Pavement by Statistical Modelling 被引量:4
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作者 Hassan Tajik Ghashghaei Abolfazl Hassani 《Materials Sciences and Applications》 2016年第2期101-107,共7页
A study evaluating the relationship between porosity and permeability coefficient for pervious concrete (PC) is presented. In addition, the effect of mixture design parameters particularly, water-to-cement ratio (W/C)... A study evaluating the relationship between porosity and permeability coefficient for pervious concrete (PC) is presented. In addition, the effect of mixture design parameters particularly, water-to-cement ratio (W/C) and size of aggregate on the permeability coefficient of PC was investigated. The PC mixtures were made with 4 range of W/C and 2 range size of aggregate. PC mixes were made from each aggregate and were tested. The results showed that the W/C and aggregate size are key parameters which significantly affect the characteristic performance of PC. Permeability coefficient of coarse pervious concrete (CPC) is bigger than fine pervious concrete (FPC) and the porosity of CPC are bigger than porosity of FPC. A regression model (RM) along with analysis of variance (ANOVA) was conducted to study the significance of porosity distribution on permeability coefficient of PC. The statistical model developed in this study can facilitate prediction permeability coefficient of CPC and FPC as the sustainable pavements. 展开更多
关键词 Pervious Concrete W/C POROSITY permeability coefficient
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Effect of non-uniform swelling on coal multiphysics during gas injection: The triangle approach
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作者 Yifan Huang Jishan Liu +2 位作者 Yaoyao Zhao Derek Elsworth Yee-Kwong Leong 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第4期1362-1372,共11页
In current dual porosity/permeability models,there exists a fundamental assumption that the adsorption-induced swelling is distributed uniformly within the representative elementary volume (REV),irrespective of its in... In current dual porosity/permeability models,there exists a fundamental assumption that the adsorption-induced swelling is distributed uniformly within the representative elementary volume (REV),irrespective of its internal structures and transient processes.However,both internal structures and transient processes can lead to the non-uniform swelling.In this study,we hypothesize that the non-uniform swelling is responsible for why coal permeability in experimental measurements is not only controlled by the effective stress but also is affected by the adsorption-induced swelling.We propose a concept of the swelling triangle composed of swelling paths to characterize the evolution of the non-uniform swelling and serve as a core link in coupled multiphysics.A swelling path is determined by a dimensionless volumetric ratio and a dimensionless swelling ratio.Different swelling paths have the same start and end point,and each swelling path represents a unique swelling case.The swelling path as the diagonal of the triangle represents the case of the uniform swelling while that as the two perpendicular boundaries represents the case of the localized swelling.The paths of all intermediate cases populate inside the triangle.The corresponding relations between the swelling path and the response of coal multiphysics are established by a non-uniform swelling coefficient.We define this method as the triangle approach and corresponding models as swelling path-based ones.The proposed concept and models are verified against a long-term experimental measurement of permeability and strains under constant effective stress.Our results demonstrate that during gas injection,coal multiphysics responses have a close dependence on the swelling path,and that in both future experiments and field predictions,this dependence must be considered. 展开更多
关键词 Transient process HETEROGENEITY Swelling triangle Swelling path non-uniform swelling coefficient
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A Novel ISSA–DELM Model for Predicting Rock Mass Permeability
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作者 Chen Xing Leihua Yao Yingdong Wang 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第9期2825-2848,共24页
In pumped storage projects,the permeability of rock masses is a crucial parameter in engineering design and construction.The rock mass permeability coefficient(K)is influenced by various geological parameters,and prev... In pumped storage projects,the permeability of rock masses is a crucial parameter in engineering design and construction.The rock mass permeability coefficient(K)is influenced by various geological parameters,and previous studies aimed to establish an accurate relationship between K and geological parameters.This study uses the improved sparrow search algorithm(ISSA)to optimize the parameter settings of the deep extreme learning machine(DELM),constructing a prediction model with flexible parameter selection and high accuracy.First,the Spearman method is applied to analyze the correlation between geological parameters.A sample database is built by comprehensively selecting four geological indexes:burial depth,rock quality designation(RQD),fracture density characteristic index(FD),and rock mass integrity designation(RID).Hence,the defects of the sparrow search algorithm(SSA)are enhanced using the improved strategy,and the initial input weights of the DELM are optimized.Finally,the proposed ISSA–DELM model is employed to predict the permeability coefficient of rock mass in the entire study area.The results showed that the predictive performance of the model is superior to that of the DELM and SSA–DELM.Therefore,this model successfully provides insights into the distribution characteristics of rock mass permeability at engineering sites. 展开更多
关键词 ISSA DELM rock mass permeability coefficient geological parameter correlation analysis
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Relation of Damage Variable and Gas Permeability Coefficient of Concrete under Stress
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作者 TANG Guanbao YAO Yan 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2018年第6期1481-1485,共5页
Compressive stress and tensile stress were applied to concrete specimens using test rigs designed by RILEM TC 246-TDC. Ultrasonic wave velocity and autoclam permeability system were used to characterize the damage var... Compressive stress and tensile stress were applied to concrete specimens using test rigs designed by RILEM TC 246-TDC. Ultrasonic wave velocity and autoclam permeability system were used to characterize the damage variable and gas permeability coefficient of concrete, respectively. The experimental results show that the strain value of concrete increases with the increasing of stress level and loading time. The damage variable and gas permeability coefficient of concrete under compressive stress decrease at first and increase after a threshold value between 0 and 0.6. When the concrete is under tensile load, the damage variable and gas permeability coefficient increase with tensile stress, with a significant increase from 0.3 to 0.6 tensile stress. There is a strong linear relationship between the damage variable and the gas permeability coefficient, suggesting both as good indicators to characterize the damage of concrete under stress. 展开更多
关键词 compression tension STRAIN damage variable gas permeability coefficient
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SENSITIVITY COEFFICIENTS OF SINGLE-PHASE FLOW IN LOW-PERMEABILITY HETEROGENEOUS RESERVOIRS
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作者 程时清 张盛宗 +1 位作者 黄延章 朱维耀 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2002年第6期712-720,共9页
Theoretical equations for computing sensitivity coefficients of wellbore pressures to estimate the reservoir parameters in low-permeability reservoirs conditioning to non-Darcy flow data at low velocity were obtained.... Theoretical equations for computing sensitivity coefficients of wellbore pressures to estimate the reservoir parameters in low-permeability reservoirs conditioning to non-Darcy flow data at low velocity were obtained. It is shown by a lot of numerical calculations that the wellbore pressures are much more sensitive to permeability very near the well than to permeability a few gridblocks away from the well. When an initial pressure gradient existent sensitivity coefficients in the region are closer to the active well than to the observation well. Sensitivity coefficients of observation well at the line between the active well and the observation well are influenced greatly by the initial pressure gradient. 展开更多
关键词 non-Darcy flow through porous media permeability POROSITY sensitivity coefficient inverse problem low-permeability reservoir
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Stochastic back analysis of permeability coefficient using generalized Bayesian method
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作者 Zheng Guilan Wang Yuan +1 位作者 Wang Fei Yang Jian 《Water Science and Engineering》 EI CAS 2008年第3期83-92,共10页
Owing to the fact that the conventional deterministic back analysis of the permeability coefficient cannot reflect the uncertainties of parameters, including the hydraulic head at the boundary, the permeability coeffi... Owing to the fact that the conventional deterministic back analysis of the permeability coefficient cannot reflect the uncertainties of parameters, including the hydraulic head at the boundary, the permeability coefficient and measured hydraulic head, a stochastic back analysis taking consideration of uncertainties of parameters was performed using the generalized Bayesian method. Based on the stochastic finite element method (SFEM) for a seepage field, the variable metric algorithm and the generalized Bayesian method, formulas for stochastic back analysis of the permeability coefficient were derived. A case study of seepage analysis of a sluice foundation was performed to illustrate the proposed method. The results indicate that, with the generalized Bayesian method that considers the uncertainties of measured hydraulic head, the permeability coefficient and the hydraulic head at the boundary, both the mean and standard deviation of the permeability coefficient can be obtained and the standard deviation is less than that obtained by the conventional Bayesian method. Therefore, the present method is valid and applicable. 展开更多
关键词 permeability coefficient stochastic back analysis generalized Bayesian method variable metric algorithm
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Hydrodynamic Coefficient Investigation on a Partial Permeable Stepped Breakwater Under Regular Waves
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作者 YIN Zegao ZHENG Zihan +1 位作者 YU Ning WANG Haojian 《Journal of Ocean University of China》 SCIE CAS CSCD 2021年第6期1341-1352,共12页
Traditional breakwater takes the advantage of high protection performance and has been widely used.However,it contributes to high wave reflection in the seaside direction and poor water exchange capacity between open ... Traditional breakwater takes the advantage of high protection performance and has been widely used.However,it contributes to high wave reflection in the seaside direction and poor water exchange capacity between open seawater and an inside harbor.Consequently,a partially permeable stepped breakwater(PPSB)is proposed to ensure safety and good water exchange capacity for an inside harbor,and a 3-D computational fluid dynamics(CFD)mathematical model was used to investigate the hydrodynamic coefficients using Reynolds-Averaged Navier-Stokes equations,Re-Normalization Group(RNG)k-εequations,and the VOF technique.A series of experiments are conducted to measure the wave heights for validating the mathematical model,and a series of dimensionless parameters considering wave and PPSB effects were presented to assess their relationships with hydrodynamic coefficients,respectively.With the increase in the reciprocal value of PPSB slope,incident wave steepness and permeable ratio below still water level(SWL),the wave reflection coefficient decreases.The wave transmission coefficient decreases with an increase in the reciprocal value of the PPSB slope and incident wave steepness;however,it increases with the increase in the permeable ratio below SWL.With increases in the reciprocal value of the PPSB slope,permeable ratio below SWL and incident wave steepness for relatively high wave period scenarios,the wave energy dissipation coefficient increases;however,it decreases slightly with increases in the incident wave steepness for the smallest wave period scenarios.Furthermore,simple prediction formulas are conducted for predicting the hydrodynamic coefficients and they are well validated with the related data. 展开更多
关键词 regular waves partially permeable stepped breakwater wave reflection coefficient wave transmission coefficient wave energy dissipation coefficient mathematical model
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Method for Tentative Evaluation of Membrane Permeability Coefficients for Sodium and Potassium Ions in Unicellular Organisms
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作者 Atanas Todorov Atanasov 《Open Journal of Biophysics》 2013年第1期91-98,共8页
The membrane permeability coefficient for sodium and potassium ions in unicellular organisms can be calculated using the data for cell volume, surface and mean generation time during growth and dividing of cells by bi... The membrane permeability coefficient for sodium and potassium ions in unicellular organisms can be calculated using the data for cell volume, surface and mean generation time during growth and dividing of cells by binary. Accordingly theory of proposed method, the membrane permeability coefficients for passed trough outer cell membrane sodium and potassium ions, is equal to the volume of unicellular organism divided to product between cell surface and mean generation time of cells. The calculated by this way diapason of values overlaps with experimentally measured diapason of values of permeability coefficient for sodium and potassium ions. The deviation between the theoretically calculated and experimentally measured values of permeability coefficient does not exceed one order of magnitude. 展开更多
关键词 PROKARYOTES EUKARYOTES permeability coefficient SODIUM POTASSIUM Ion
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Prediction of Dermal Permeability Coefficient of Nevirapine—Effect of Cosolvents, Anionic, Nonionic and Cationic Surfactants
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作者 Chika J. Mbah Theophilus C. Onyekaba Agatha O. Uwakwe 《Pharmacology & Pharmacy》 2016年第7期283-289,共7页
Transdermal drug delivery not only has contributed immensely to medical practice, but has enjoyed enormous interest in the field of cosmetic and pharmaceutical industries. Nevirapine, a non‐nucleoside reverse transcr... Transdermal drug delivery not only has contributed immensely to medical practice, but has enjoyed enormous interest in the field of cosmetic and pharmaceutical industries. Nevirapine, a non‐nucleoside reverse transcriptase inhibitor (NNRTI) is used clinically for the treatment of HIV‐ 1 infection. The aim of the present study is to investigate the influence of cosolvents (glycerol, propylene glycol, ethanol, polyethylene glycol 400) and surfactants (polysorbate 20, polysorbate 80, sodium lauryl sulfate, sodium cholate and cetrimide) on the dermal permeability coefficient of nevirapine by utilizing established and recognized mathematical model that employs partition coefficient as one of its molecular descriptors. The partition coefficient of nevirapine is determined in chloroform-water system at room temperature using the shake flask method. The results show that all the cosolvents used in this study decrease the partition coefficient of nevirapine. The same decrease in the partition coefficient of nevirapine is observed with all the surfactants investigated. The order of dermal enhancement potential of the vehicles studied based on the predicted permeability coefficient is glycerol > propylene glycol > ethanol > polyethylene glycol 400 for the cosolvents while tween 20 > tween 80 > sodium lauryl sulfate > sodium cholate > cetrimide for the surfactants. The maximum predicted flux through skin was obtained by multiplying the predicted permeability coefficient and the drug aqueous solubility. As the rate of penetration into the skin is quantitatively assessed by the use of permeability coefficient, the findings suggest that for dermal formulation of nevirapine, glycerol and tween 20 are the most preferred vehicles out of the vehicles investigated. Furthermore, the results of the correlation coefficients obtained by plotting permeability coefficient or maximum predicted flux, versus logarithm partition coefficient indicate that permeability coefficient can be a more reliable parameter to predict transdermal absorption of nevirapine than flux. 展开更多
关键词 COSOLVENTS SURFACTANTS Partition coefficient Dermal permeability coefficient NEVIRAPINE
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Evaluation of Coefficient of Permeability on Contaminated Granitic Residual Soil
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作者 L.J. Andrade Pais L.M. Ferreira Gomes 《Journal of Environmental Science and Engineering》 2011年第2期206-213,共8页
This paper reports laboratory research carried out on natural and contaminated granitic residual soil from Covilha region (Portugal) to evaluate the coefficient of permeability in accordance with Darcy's law. The s... This paper reports laboratory research carried out on natural and contaminated granitic residual soil from Covilha region (Portugal) to evaluate the coefficient of permeability in accordance with Darcy's law. The soils are contaminated with hydrocarbon (Benzene Toluene Etilbenzene and Xilenes elements) and leached of urban solid waste. The specimens remained saturated and the consolidation and swelling are substantially completed at different effective confining pressures (25 to 400 kPa) before the measurements are performed at different hydraulic gradient to determine the effect of the void ratio, fabric and contamination of soil. 展开更多
关键词 Granitic residual soil contaminated soil coefficient of permeability.
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Effect of Membrane Thickness on Permeability Coefficient of Microcapsule
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作者 邹黎明 伺瑾馨 《Journal of China Textile University(English Edition)》 EI CAS 1998年第3期43-45,共3页
The effect of membrane thickness of mieroeapsule, measured by optical microseope duplex focusing, on its permeability coefflcient is discussed. The results reveal that the membrane thickness is of great imiportance on... The effect of membrane thickness of mieroeapsule, measured by optical microseope duplex focusing, on its permeability coefflcient is discussed. The results reveal that the membrane thickness is of great imiportance on the permeabillty coefficient with changes of formaldehyde dosage, complex coacervation times, core dosage, agitation rate and emulsification time. 展开更多
关键词 MICROCAPSULE MEMBRANE thickness permeability coefficient.
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