BACKGROUND Persistent vegetative state(PVS)is a devastating and long-lasting clinical condition with high morbidity and mortality;currently,there are no available effective interventions.CASE SUMMARY We report the cas...BACKGROUND Persistent vegetative state(PVS)is a devastating and long-lasting clinical condition with high morbidity and mortality;currently,there are no available effective interventions.CASE SUMMARY We report the case of an 11-year-old boy with PVS caused by severe intracerebral bleeding in the left hemisphere following anticoagulation treatment.The patient’s PVS severity showed no notable improvement after 2-mo neuroprotective treatment and rehabilitation,including nerve growth factor and baclofen,hyperbaric oxygen,and comprehensive bedside rehabilitation therapies.Daily inhalation treatment(4-6 h)of high-concentration hydrogen(H2)gas(66.6%H2+33.3%O2)was provided.Surprisingly,the patient’s orientation,consciousness,ability to speak,facial expressions,and locomotor function were significantly restored,along with improvements in essential general health status,after H2 gas inhalation treatment,which was consistent with stabilized neuropathology in the left hemisphere and increased Hounsfield unit values of computed tomography in the right hemisphere.The patient finally recovered to a near normal conscious state with a Coma Recovery Scale-Revised Score of 22 from his previous score of 3.CONCLUSION Phase 1 clinical trials are needed to explore the safety and efficacy of H2 gas inhalation in patients with PVS.展开更多
AIM:To investigate the changes and significance of dopamine(DA) in cerebrospinal fluid and serum in the cats with persistent vegetative state(PVS). METHODS:To measure the level of DA in cerebrospinal fluid and serum w...AIM:To investigate the changes and significance of dopamine(DA) in cerebrospinal fluid and serum in the cats with persistent vegetative state(PVS). METHODS:To measure the level of DA in cerebrospinal fluid and serum with high performance liquid chromatography and electrical chemical detect (HPLC ECD) in the cats with PVS and compared with control group.RESULTS:The level of DA in cerebrospinal fluid and serum in the cats with PVS was obviously lower than that of control group.CONCLUSION:Decrease of DA might be one of important factors of PVS formation.展开更多
文摘BACKGROUND Persistent vegetative state(PVS)is a devastating and long-lasting clinical condition with high morbidity and mortality;currently,there are no available effective interventions.CASE SUMMARY We report the case of an 11-year-old boy with PVS caused by severe intracerebral bleeding in the left hemisphere following anticoagulation treatment.The patient’s PVS severity showed no notable improvement after 2-mo neuroprotective treatment and rehabilitation,including nerve growth factor and baclofen,hyperbaric oxygen,and comprehensive bedside rehabilitation therapies.Daily inhalation treatment(4-6 h)of high-concentration hydrogen(H2)gas(66.6%H2+33.3%O2)was provided.Surprisingly,the patient’s orientation,consciousness,ability to speak,facial expressions,and locomotor function were significantly restored,along with improvements in essential general health status,after H2 gas inhalation treatment,which was consistent with stabilized neuropathology in the left hemisphere and increased Hounsfield unit values of computed tomography in the right hemisphere.The patient finally recovered to a near normal conscious state with a Coma Recovery Scale-Revised Score of 22 from his previous score of 3.CONCLUSION Phase 1 clinical trials are needed to explore the safety and efficacy of H2 gas inhalation in patients with PVS.
基金(1) Great Item of Military Medical Research Ten Five"Project (01Z054) (2) Item of 2001 He'nan University Outstanding Research Person Innovation Project (2001KYCX003)
文摘AIM:To investigate the changes and significance of dopamine(DA) in cerebrospinal fluid and serum in the cats with persistent vegetative state(PVS). METHODS:To measure the level of DA in cerebrospinal fluid and serum with high performance liquid chromatography and electrical chemical detect (HPLC ECD) in the cats with PVS and compared with control group.RESULTS:The level of DA in cerebrospinal fluid and serum in the cats with PVS was obviously lower than that of control group.CONCLUSION:Decrease of DA might be one of important factors of PVS formation.
文摘目的 观察经颈动脉注射促醒药物治疗持续植物状态的疗效。方法 33 例持续植物状态患者分为治疗组(n=15)和对照组(n=18),在常规康复治疗的基础上,治疗组加用颈动脉注射促醒药物,评定两组患者的疗效。结果 治疗后,两组患者均有疗效( P <0.05),但治疗组疗效优于对照组( P <0.05)。结论 颈动脉注射促醒药物对持续植物状态患者有明显疗效。
