Volcanically Driven Terrestrial Environmental Perturbations during the Carnian Pluvial Episode in the Eastern Tethys

The Carnian Pluvial Episode(CPE)fingerprints global environmental perturbations and biological extinction on land and oceans and is potentially linked to the Wrangellia Large Igneous Province(LIP).However,the correlation between terrestrial environmental changes and Wrangellia volcanism in the Ordos Basin during the CPE remains poorly understood.Records of negative carbon isotopic excursions(NCIEs),mercury(Hg),Hg/TOC,and Hg enrichment factor(HgEF)from oil shales in a large-scale terrestrial Ordos Basin in the Eastern Tethys were correlated with marine and other terrestrial successions.The three significant NCIEs in the study section were consistently correlated with those in the CPE successions of Europe,the UK,and South and North China.The U-Pb geochronology indicates a Ladinian-Carnian age for the Chang 7 Member.A comprehensive overview of the geochronology,NCIE correlation,and previous bio-and chronostratigraphic frameworks shows that the Ladinian-Carnian boundary is located in the lower part of Chang 7 in the Yishicun section.HgEF may be a more reliable proxy for tracing volcanic eruptions than the Hg/TOC ratio because the accumulation rates of TOC content largely vary in terrestrial and marine successions.The records of Hg,Hg/TOC,HgEF,and NCIEs in the Ordos Basin aligned with Carnian successions worldwide and were marked by similar anomalies,indicating a global response to the Wrangellia LIP during the CPE.Anoxia,a warm-humid climate,enhancement of detrital input,and NCIEs are synchronous with the CPE interval in the Ordos Basin,which suggests that the CPE combined with the regional Qinling Orogeny should dominate the enhanced rate of terrigenous input and paleoenvironmental evolution in the Ordos Basin.

A proteomic landscape of pharmacologic perturbations for functional relevance

Pharmacological perturbation studies based on protein-level signatures are fundamental for drug discovery. In the present study, we used a mass spectrometry (MS)-based proteomic platform to profile the whole proteome of the breast cancer MCF7 cell line under stress induced by 78 bioactive compounds. The integrated analysis of perturbed signal abundance revealed the connectivity between phenotypic behaviors and molecular features in cancer cells. Our data showed functional relevance in exploring the novel pharmacological activity of phenolic xanthohumol, as well as the noncanonical targets of clinically approved tamoxifen, lovastatin, and their derivatives. Furthermore, the rational design of synergistic inhibition using a combination of histone methyltransferase and topoisomerase was identified based on their complementary drug fingerprints. This study provides rich resources for the proteomic landscape of drug responses for precision therapeutic medicine.

A generalization of Banach's lemma and its applications to perturbations of bounded linear operators

Let X be a Banach space and let P:X→X be a bounded linear operator.Using an algebraic inequality on the spectrum of P,we give a new sufficient condition that guarantees the existence of(I-P)^(-1) as a bounded linear operator on X,and a bound on its spectral radius is also obtained.This generalizes the classic Banach lemma.We apply the result to the perturbation analysis of general bounded linear operators on X with commutative perturbations.

Investigation on the roles of equilibrium toroidal rotation during edge-localized mode mitigated by resonant magnetic perturbations

The effects of equilibrium toroidal rotation during edge-localized mode(ELM)mitigated by resonant magnetic perturbation(RMP)are studied with the experimental equilibria of the EAST tokamak based on the four-field model in the BOUT++code.As the two main parameters to determine the toroidal rotation profiles,the rotation shear and magnitudes were separately scanned to investigate their roles in the impact of RMPs on peeling-ballooning(P-B)modes.On one hand,the results show that strong toroidal rotation shear is favorable for the enhancement of the self-generated E×B shearing rate<ω_(E×B)>with RMPs,leading to significant ELM mitigation with RMP in the stronger toroidal rotation shear region.On the other hand,toroidal rotation magnitudes may affect ELM mitigation by changing the penetration of the RMPs,more precisely the resonant components.RMPs can lead to a reduction in the pedestal energy loss by enhancing the multimode coupling in the turbulence transport phase.The shielding effects on RMPs increase with the toroidal rotation magnitude,leading to the enhancement of the multimode coupling with RMPs to be significantly weakened.Hence,the reduction in pedestal energy loss by RMPs decreased with the rotation magnitude.In brief,the results show that toroidal rotation plays a dual role in ELM mitigation with RMP by changing the shielding effects of plasma by rotation magnitude and affecting<ω_(E×B)>by rotation shear.In the high toroidal rotation region,toroidal rotation shear is usually strong and hence plays a dominant role in the influence of RMP on P-B modes,whereas in the low rotation region,toroidal rotation shear is weak and has negligible impact on P-B modes,and the rotation magnitude plays a dominant role in the influence of RMPs on the P-B modes by changing the field penetration.Therefore,the dual role of toroidal rotation leads to stronger ELM mitigation with RMP,which may be achieved both in the low toroidal rotation region and the relatively high rotation region that has strong rotational shear.

Growth and Interactions of Multi-Source Perturbations in Convection-Allowing Ensemble Forecasts

This study investigated the growth of forecast errors stemming from initial conditions(ICs),lateral boundary conditions(LBCs),and model(MO)perturbations,as well as their interactions,by conducting seven 36 h convectionallowing ensemble forecast(CAEF)experiments.Two cases,one with strong-forcing(SF)and the other with weak-forcing(WF),occurred over the Yangtze-Huai River basin(YHRB)in East China,were selected to examine the sources of uncertainties associated with perturbation growth under varying forcing backgrounds and the influence of these backgrounds on growth.The perturbations exhibited distinct characteristics in terms of temporal evolution,spatial propagation,and vertical distribution under different forcing backgrounds,indicating a dependence between perturbation growth and forcing background.A comparison of the perturbation growth in different precipitation areas revealed that IC and LBC perturbations were significantly influenced by the location of precipitation in the SF case,while MO perturbations were more responsive to convection triggering and dominated in the WF case.The vertical distribution of perturbations showed that the sources of uncertainties and the performance of perturbations varied between SF and WF cases,with LBC perturbations displaying notable case dependence.Furthermore,the interactions between perturbations were considered by exploring the added values of different source perturbations.For the SF case,the added values of IC,LBC,and MO perturbations were reflected in different forecast periods and different source uncertainties,suggesting that the combination of multi-source perturbations can yield positive interactions.In the WF case,MO perturbations provided a more accurate estimation of uncertainties downstream of the Dabie Mountain and need to be prioritized in the research on perturbation development.

Suppression of Plasma Bubbles over South America under Weak Geomagnetic Perturbations

During a long-term Equatorial Plasma Bubbles(EPBs)occurrence between October 2020 and March 2021,a significant EPB suppression event was identified on November 22 and the observations from multi-instrument have been utilized to investigate this event.Global-scale Observations of the Limb and Disk(GOLD)satellite observed prominent EPBs between 23:40 UT and 23:55 UT during the long-term occurrence days.However,no dark stripes representing EPBs were observed on November 22,and the Equatorial Ionization Anomaly(EIA)structure remained intact.The Total Electron Content(TEC)maps show that these EPBs appeared in the region between 35°W and 65°W longitudes and the magnitudes of the TEC loss in EPBs regions were about 20 TECU.Except for 22 November,the S4 index was consistently greater than 0.6 throughout November,indicating significant ionospheric scintillation.The Rate Of TEC Index(ROTI)maps revealed that the spatial extent and intensity of EPBs increased after their suppression,and the EPBs were locally generated.The swarm electron density measurements indicated that the variation amplitudes of EPBs at 510 km altitude were approximately 3 to 5 times larger than that at 460 km altitude.The impact region of EPBs at 510 km was between 15°S and 20°N latitudes,while at 460 km,it was between 0°and 17°N latitudes.During the period of EPB suppression,the average h’f at three ionosonde stations decreased by about 50 km,and the vertical drift velocity(V z)approached~0 m/s while it was more than 20 m/s during the long-term occurrence.

Cover Enhancement Method for Audio Steganography Based on Universal Adversarial Perturbations with Sample Diversification

Steganography techniques,such as audio steganography,have been widely used in covert communication.However,the deep neural network,especially the convolutional neural network(CNN),has greatly threatened the security of audio steganography.Besides,existing adversarial attacks-based countermeasures cannot provide general perturbation,and the trans-ferability against unknown steganography detection methods is weak.This paper proposes a cover enhancement method for audio steganography based on universal adversarial perturbations with sample diversification to address these issues.Universal adversarial perturbation is constructed by iteratively optimizing adversarial perturbation,which applies adversarial attack tech-niques,such as Deepfool.Moreover,the sample diversification strategy is designed to improve the transferability of adversarial perturbations in black-box attack scenarios,where two types of common audio-processing operations are considered,including noise addition and moving picture experts group audio layer III(MP3)compression.Furthermore,the perturbation ensemble method is applied to further improve the attacks’transferability by integrating perturbations of different detection networks with heterogeneous architec-tures.Consequently,the single universal adversarial perturbation can enhance different cover audios against a CNN-based detection network.Extensive experiments have been conducted,and the results demonstrate that the average missed-detection probabilities of the proposed method are higher than those of the state-of-the-art methods by 7.3%and 16.6%for known and unknown detection networks,respectively.It verifies the efficiency and transferability of the proposed methods for the cover enhancement of audio steganography.

The Influence of Arctic Sea Ice Concentration Perturbations on Subseasonal Predictions of North Atlantic Oscillation Events

The influence of Arctic sea ice concentration (SIC) on the subseasonal prediction of the North Atlantic Oscillation (NAO) event is investigated by utilizing the Community Atmospheric Model version 4. The optimal Arctic SIC perturbations which exert the greatest influence on the onset of an NAO event from a lead of three pentads (15 days) are obtained with a conditional nonlinear optimal perturbation approach. Numerical results show that there are two types of optimal Arctic SIC perturbations for each NAO event, with one weakening event (marked as type-1) and another strengthening event (marked as type-2). For positive NAO events, type-1 optimal SIC perturbations mainly show positive SIC anomalies in the Greenland, Barents, and Okhotsk Seas, while type-2 perturbations mainly feature negative SIC anomalies in these regions. For negative NAO events, the optimal SIC perturbations have almost opposite patterns to those in positive events, although there are some differences among these SIC perturbations due to different atmospheric initial conditions. Further diagnosis reveals that the optimal Arctic SIC perturbations first modify the surface turbulent heat flux and the temperature in the lower troposphere via diabatic processes. Afterward, the temperature in the low troposphere is mainly affected by dynamic advection. Finally, potential vorticity advection plays a crucial role in the 500-hPa geopotential height prediction in the northern North Atlantic sector during pentad 4, which influences NAO event prediction. These results highlight the importance of Arctic SIC on NAO event prediction and the spatial characteristics of the SIC perturbations may provide scientific support for target observations of SIC in improving NAO subseasonal predictions.

Advances in experiments and numerical simulations on the effects of stress perturbations on fault slip

Laboratory experiments and numerical simulations on rock friction perturbations,an important means for understanding the mechanism and influencing factors of stress-triggered earthquakes,are of great significance for studying earthquake mechanisms and earthquake hazard analysis.We reviews the experiments and numerical simulations on the effects of stress perturbations on fault slip,and the results show that stress perturbations can change fault stress and trigger earthquakes.The Coulomb failure criterion can shed light on some questions about stress-triggering earthquakes but cannot explain the time dependence of earthquake triggering nor be used to investigate the effect of heterogeneous stress perturbations.The amplitude and period are important factors affecting the correlation between stress perturbation and fault instability.The effect of the perturbation period on fault instability is still controversial,and the effect of the high-frequency perturbation on earthquakes may be underestimated.Normal and shear stress perturbation can trigger fault instability,but their effects on fault slip differ.It is necessary to distinguish whether the stress perturbation is dominated by shear or normal stress change when it triggers fault instability.Fault tectonic stress plays a decisive effect on the mode of fault instability and earthquake magnitude.Acoustic emission activity can reflect the changes in fault stress and the progression of fault nucleation,and identify the meta-instability stage and precursor of fault instability,providing a reference for earthquake prediction.

Boundedness Types of Perturbations on the Growth of Semigroups

We study types of boundedness of a semigroup on a Banach space in terms of the Cesáro-average and the behavior of the resolvent at the origin and also exhibit a characterization of type Hille-Yosida for the generators of ϕj-bounded strongly continuous semigroups. Furthermore, these results are used to investigate the effect of the Perturbation on the type of the growth of sequences.

Impacts of New Implementing Strategies for Surface and Model Physics Perturbations in TREPS on Forecasts of Landfalling Tropical Cyclones

To improve the ensemble prediction system of the tropical regional atmosphere model for the South China Sea(TREPS) in predicting landfalling tropical cyclones(TCs), the impacts of three new implementing strategies for surface and model physics perturbations in TREPS were evaluated for 19 TCs making landfall in China during 2014–16. For sea surface temperature(SST) perturbations, spatially uncorrelated random perturbations were replaced with spatially correlated ones. The multiplier f, which is used to form perturbed tendency in the Stochastically Perturbed Parameterization Tendency(SPPT) scheme, was inflated in regions with evident convective activity(f-inflated SPPT). Lastly, the Stochastically Perturbed Parameterization(SPP) scheme with 14 perturbed parameters selected from the planetary boundary layer, surface layer, microphysics, and cumulus convection parameterizations was added. Overall, all these methods improved forecasts more significantly for non-intensifying than intensifying TCs. Compared with f-inflated SPPT,the spatially correlated SST perturbations generally showed comparable performance but were more(less) skillful for intensifying(non-intensifying) TCs. The advantages of the spatially correlated SST perturbations and f-inflated SPPT were mainly present in the deterministic guidance for both TC track and wind and in the probabilistic guidance for reliability of wind. For intensifying TCs, adding SPP led to mixed impacts with significant improvements in probability-matched mean of modest winds and in probabilistic forecasts of rainfall;while for non-intensifying TCs, adding SPP frequently led to positive impacts on the deterministic guidance for track, intensity, strong winds, and moderate rainfall and on the probabilistic guidance for wind and discrimination of rainfall.

Study on Multi-Scale Blending Initial Condition Perturbations for a Regional Ensemble Prediction System

An initial conditions （ICs） perturbation method was developed with the aim to improve an operational regional ensemble prediction system （REPS）. Three issues were identified and investigated： （1） the impacts of perturbation scale on the ensemble spread and forecast skill of the REPS; （2） the scale characteristic of the IC perturbations of the REPS; and （3） whether the REPS＇s skill could be improved by adding large-scale information to the IC perturbations. Numerical experiments were conducted to reveal the impact of perturbation scale on the ensemble spread and forecast skill. The scales of IC perturbations from the REPS and an operational global ensemble prediction system （GEPS） were analyzed. A ＂multi-scale blending＂ （MSB） IC perturbation scheme was developed, and the main findings can be summarized as follows： The growth rates of the ensemble spread of the REPS are sensitive to the scale of the IC perturbations; the ensemble forecast skills can benefit from large-scale perturbations; the global ensemble IC perturbations exhibit more power at larger scales, while the regional ensemble IC perturbations contain more power at smaller scales; the MSB method can generate IC perturbations by combining the small-scale component from the REPS and the large-scale component from the GEPS; the energy norm growth of the MSB-generated perturbations can be appropriate at all forecast lead times; and the MSB-based REPS shows higher skill than the original system, as determined by ensemble forecast verification.

Delay-range-dependent Stability Criterion for Interval Time-delay Systems with Nonlinear Perturbations

In this paper, we consider the problem of robust stability for a class of linear systems with interval time-varying delay under nonlinear perturbations using Lyapunov-Krasovskii （LK） functional approach. By partitioning the delay-interval into two segments of equal length, and evaluating the time-derivative of a candidate LK functional in each segment of the delay-interval, a less conservative delay-dependent stability criterion is developed to compute the maximum allowable bound for the delay-range within which the system under consideration remains asymptotically stable. In addition to the delay-bi-segmentation analysis procedure, the reduction in conservatism of the proposed delay-dependent stability criterion over recently reported results is also attributed to the fact that the time-derivative of the LK functional is bounded tightly using a newly proposed bounding condition without neglecting any useful terms in the delay-dependent stability analysis. The analysis, subsequently, yields a stable condition in convex linear matrix inequality （LMI） framework that can be solved non-conservatively at boundary conditions using standard numerical packages. Furthermore, as the number of decision variables involved in the proposed stability criterion is less, the criterion is computationally more effective. The effectiveness of the proposed stability criterion is validated through some standard numerical examples.

Large Scale Perturbations in Extratropical Atmosphere-Part Ⅰ: On Rossby Waves

This study reexamines the propagation mechanism and geostrophic property of the classical two-dimensional Rossby waves in a non-divergent barotropic atmosphere. It will be found that propagation of large scale atmospheric waves depends crucially on horizontal divergence. A small Rossby number in Rossby waves is not sufficient for the waves to have a small ageostrophic component, because the two-dimensional classical Rossby waves do not manifest the geostrophic balance as good as observed in the atmosphere.

GC/MS-based differential metabolic profiling of human peptic ulcer disease to study Helicobacter pylori-induced metabolic perturbations

Helicobacter pylori infection has been significantly linked to Peptic Ulcer Disease and Gastric Cancer.Metabolomic fingerprinting may offer a principal way of early diagnosis and to understand the molecular mechanism of H.pylori-induced pathogenicity.The rationale of the study is to explore the underlying distinct metabolic mechanisms of H.pylori-induced PUD and to identify potential biomarkers for disease diagnosis and associated risks using Gas chromatography/mass spectrometry.GC/MS-based analytical method was used to compare metabolic profiles of healthy controls(N=20)and peptic ulcer patients(N=45).Acquired metabolomic data were analyzed by constructing a diagnostic model using principal component analysis and a non-parametric two-tailed paired Wilcoxon analysis to identify disease-specific metabolic biomarkers.A total of 75 low-molecular-weight endogenous metabolites were detected during comparative metabolomic analysis of PUD vs.healthy gut tissues,among which 16 metabolites are being proposed to be diagnostic markers of Human PUD.Perturbations related to amino acids,carbohydrates,fatty acids,organic acids,and sterol metabolism were significantly revealed during this differential metabolomic profiling.Results convincingly suggest that metabolic profiles can contribute immensely in early diagnosis of the disease and understanding molecular mechanisms of disease progression for predicting novel drug targets for prophylactic and anaphylactic measures.

An Improved Robust Model Predictive Control Approach to Systems with Linear Fractional Transformation Perturbations

In this paper, a robust model predictive control approach is proposed for a class of uncertain systems with time-varying, linear fractional transformation perturbations. By adopting a sequence of feedback control laws instead of a single one, the control performance can be improved and the region of attraction can be enlarged compared with the existing model predictive control （MPC） approaches. Moreover, a synthesis approach of MPC is developed to achieve high performance with lower on-line computational burden. The effectiveness of the proposed approach is verified by simulation examples.

Large Scale Perturbations in Extratropical Atmosphere-Part Ⅱ: On Geostrophic Waves

We have examined, in Part Ⅰ, the propagation mechanism and geostrophic property of classical Rossby waves in a non-divergent barotropic atmosphere. As we found that the non-divergent Rossby waves do not propagate in a hydrostatically equilibrium atmosphere, and do not manifest a good geostrophic property, an alternative large scale circulation pattern of geostrophic waves has been proposed (McHall, 1991a). The propagation mechanism and geostrophic property of these waves are examined in the present study.

EXISTENCE OF SOLUTIONS OF NONLOCAL PERTURBATIONS OF DIRICHLET DISCRETE NONLINEAR PROBLEMS

This paper is devoted to the study of second order nonlinear difference equations. A Nonlocal Perturbation of a Dirichlet Boundary Value Problem is considered. An exhaustive study of the related Green＇s function to the linear part is done. The exact expression of the function is given, moreover the range of parameter for which it has constant sign is obtained. Using this, some existence results for the nonlinear problem are deduced from monotone iterative techniques, the classical Krasnoselski fixed point theorem or by application of recent fixed point theorems that combine both theories.

Delay-dependent robust stabilization for a class ofneutral systems with nonlinear perturbations

This note deals with the problem of stabilization/stability for neutral systems with nonlinear perturbations. A new stabilization/stability scheme is presented. Using improved Lyapunov functionals, less conservative stabilization/stability conditions are derived for such systems based on linear matrix inequalities （LMI）. Numerical examples are provided to show that the proposed results significantly improve the allowed upper bounds of the delay size over some existing ones in the literature.

Periodic Solution of n-Species Gilpin-Ayala Competition System with Impulsive Perturbations

The principle aim of this paper is to explore the existence of periodic solution of n-Species Gilpin-Ayala competition system with impulsive perturbations. Sufficient and realistic conditions are obtained by using Mawhin's continuation theorem of the coincidence degree. Further, some numerical simulations show that our model can occur in many forms of complexities including periodic oscillation and chaotic strange attractor.