The property theory of Chinese materia medica is one of the foundations of traditional Chinese medicine.The property of Chinese materia medica(PCMM)is a multi-dimensional expression of the effect of Chinese materia me...The property theory of Chinese materia medica is one of the foundations of traditional Chinese medicine.The property of Chinese materia medica(PCMM)is a multi-dimensional expression of the effect of Chinese materia medica(CMM),and it is related to the clinical prescription that fully reflects the clinical effect evaluation of CMM in a holistic,systematic,and scientific way.This paper discusses the source,development,and application of the PCMM by considering not only the five dimensions that constitute the PCMM but also the recognition of the human body and disease as given in traditional Chinese medicine.This paper aims to provide theoretical guidance for the rational use and development of CMM.展开更多
The research on the dose-effect relationship in Chinese materia medica is delayed due to the complexity of its composition, multi-efficacy, multi-targeting and other factors. Many experts put forward re...The research on the dose-effect relationship in Chinese materia medica is delayed due to the complexity of its composition, multi-efficacy, multi-targeting and other factors. Many experts put forward relevant research ideas and methods and worked out more and more research results in literature, experimental and clinical categories because of the progress of statistical methods and scientific and technological means in recent years. In this paper, these results were preliminarily combed to show the basic situation of dose-effect relationship research in Chinese materia medica.展开更多
Taking the Ben Cao Gang Mu(《本草纲目》Compendium of Materia Medica)(Jinling edition金陵本)as the research object and“Jing”as the search term,this article summarizes the quantity of medicinals containing“Jing”in B...Taking the Ben Cao Gang Mu(《本草纲目》Compendium of Materia Medica)(Jinling edition金陵本)as the research object and“Jing”as the search term,this article summarizes the quantity of medicinals containing“Jing”in Ben Cao Gang Mu,analyzes the connotation and application of“Jing”in traditional Chinese medicine,and finds that the application of“Jing”in medicine does not deviate from the original meaning of“Jing,”but endows it with the concepts of medicine and pharmacy,and expands the application scope of“Jing.”This study is helpful to understand and use spermicide more reasonably.展开更多
Objective: To analyze the research status, development context and trend of traditional Chinese medicine (TCM) network pharmacology from birth to the present. Methods: In this study, bibliographic data and references ...Objective: To analyze the research status, development context and trend of traditional Chinese medicine (TCM) network pharmacology from birth to the present. Methods: In this study, bibliographic data and references of articles on TCM network pharmacology were collected from Web of Science Core Collection (WoSCC), and software including CiteSpace, VOSviewer and Microsoft Excel were applied for the bibliometric analysis of periodicals and the quantity of literature, and for the construction and analysis of the co-occurrence network of countries, journals, research institutes and authors, clusters of co-cited references, and time distribution network of keywords. Results: 249 articles were included in this study. The time span was from 2011 to 2018, and the annual volume of publications showed an increasing trend year by year. The 77 journals contain relevant literature, and the average impact factor of the journal is 3.215. Chinese Journal of Natural Medicines, Scientific Reports, PLoS One have high influence in the field of TCM network pharmacology. Universities and research institutes including China Academy of Chinese Medical Science and Northwest Agriculture & Forestry University are the major forces in this field. Wang Yonghua and Li Shao are authors with high influence in this field, with a considerable number of relevant documents and citations. According to the clustering results of co-cited references, research topics can be classified into 13 development contexts such as “compound danshen formula”,“computational tool”, and “new multi-compound drug discovery”. Hotspots of TCM network pharmacology include “drug discovery”,“mechanism” and “cardiovascular disease”, and relevant research methods and research contents including drugs and diseases tend to be constantly enriched. Conclusion: This study comprehensively demonstrates the research status, development context and trends of TCM network pharmacology, and provides a scientific reference for TCM network pharmacology researchers.展开更多
Medicinal plants or Chinese materia medica(CMM)are now attracting worldwide attention as they have increasingly prominent advantages over chemical drugs in disease treatment and healthcare.Since the 1990s,World Health...Medicinal plants or Chinese materia medica(CMM)are now attracting worldwide attention as they have increasingly prominent advantages over chemical drugs in disease treatment and healthcare.Since the 1990s,World Health Organization(WHO)and International Organization for Standardization established the Technical Committee of Traditional Chinese Medicine(ISO/TC 249)have carried out the development of quality standards on medicinal plants or CMMs respectively,and a considerable number of monographs and international standards have been published.Since the two international organizations adhere to different principles,the standards they develop naturally have different emphasis.Driven by market demand and international trade,ISO mainly takes quality,efficacy and safety into consideration when developing standards,while WHO pays more attention to clinical practice,quality control and medication guidance.Up to now,there is a lack of comparative analysis on the records,background,principles,basic content,and main requirements of quality standards on medicinal plants or CMMs respectively published by WHO and ISO.Therefore,based on international standards of CMM developed by ISO/TC 249 platform and WHO Monographs on Selected Medicinal Plants,this paper systematically compares the purposes,selected principles,standard-developing process,basic content,and main quality requirements to summarize their similarities and differences,and find their merits,aiming to serve as a reference to the development of international standards for CMMs that helps them go global.展开更多
目的:通过文献研究阐述中药干预肥胖型多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者代谢异常的有效性及安全性。方法:计算机检索国内外主流医药数据库中关于中医、中西医结合对比单纯西药治疗PCOS的随机对照试验(randomized con...目的:通过文献研究阐述中药干预肥胖型多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者代谢异常的有效性及安全性。方法:计算机检索国内外主流医药数据库中关于中医、中西医结合对比单纯西药治疗PCOS的随机对照试验(randomized controlled trial,RCT)。参照Cochrane系统评价手册对全文的设计方案进行质量评价,采用RevMan 5.4软件进行Meta分析。结果:纳入22项RCT进行Meta分析,中药或中西药联合治疗不仅在提升排卵率这一主要研究指标上优于单纯西药治疗(P<0.05),还在改善胰岛素抵抗指数(homeostasis model assessment of insulin resistance,HOMA-IR)、空腹胰岛素(fasting insulin,FINS)、体质量指数(body mass index,BMI)、三酰甘油(triglyceride,TG)、总胆固醇(total cholesterol,TC)、低密度脂蛋白(low density lipoprotein,LDL)、高密度脂蛋白(high density lipoprotein,HDL)等方面优于单纯西药治疗(均P<0.05),但在调节空腹血糖(fasting blood glucose,FBG)和腰臀比(waist-to-hip ratio,WHR)方面与西药治疗差异无统计学意义(均P>0.05)。结论:中药或中西药联合干预肥胖型PCOS糖脂代谢异常,具有多途径、多靶点调控作用,无严重不良反应,优于单纯西药治疗。展开更多
目的运用网络药理学和分子对接探讨清热药作用机制。方法检索TCMSP、TCMID、NPASS数据库获取5类清热中药活性成分,检索DrugBank、NPASS数据库收集对应靶点,使用UniProt数据库规范靶点名称。使用STRING数据库构建交集靶点蛋白相互作用网...目的运用网络药理学和分子对接探讨清热药作用机制。方法检索TCMSP、TCMID、NPASS数据库获取5类清热中药活性成分,检索DrugBank、NPASS数据库收集对应靶点,使用UniProt数据库规范靶点名称。使用STRING数据库构建交集靶点蛋白相互作用网络,采用Cytoscape3.9.1软件筛选核心靶点。使用在线软件DAVID进行GO功能、KEGG通路及疾病富集分析,使用Metascape数据库分析特有靶点。使用Discovery Studio 4.5.0软件对清热药共有成分与核心靶点进行分子对接。结果获得清热泻火药活性成分297个、清热燥湿药活性成分609个、清热解毒药活性成分1196个、清热凉血药活性成分224个、清虚热药活性成分为389个,对应靶点分别为117、241、402、87和260个;获得共有活性成分7个,对应靶点196个。GO功能、KEGG通路及疾病富集分析显示,清热药可能通过调节外源代谢过程、单碳代谢过程中的代谢途径对乳腺癌和肿瘤发挥治疗作用。分子对接结果表明,清热药发挥抗肿瘤、抗乳腺癌的核心化学成分可能为棕榈酸、槲皮素、亚油酸。结论清热类中药可通过多途径发挥治疗作用,其中,清热泻火药、清热燥湿药、清热解毒药的生物过程及信号通路较为相似,均可通过调节外源代谢过程、单碳代谢过程、葡萄糖醛酸基转移酶活性的负调控、细胞葡萄糖醛酸化的负调控、雌激素代谢过程、细胞葡萄糖醛酸化中的新陈代谢类信号通路发挥治疗乳腺癌的作用。展开更多
The rapid development of science and technology calls for an urgent need to systemize the studies in a certain field on the basis of a common target. A case in point was the research and development of atomic bombs th...The rapid development of science and technology calls for an urgent need to systemize the studies in a certain field on the basis of a common target. A case in point was the research and development of atomic bombs that was based on the latest development in many fields.展开更多
基金This study was supported by the National Natural Science Foundation of China(81430094)。
文摘The property theory of Chinese materia medica is one of the foundations of traditional Chinese medicine.The property of Chinese materia medica(PCMM)is a multi-dimensional expression of the effect of Chinese materia medica(CMM),and it is related to the clinical prescription that fully reflects the clinical effect evaluation of CMM in a holistic,systematic,and scientific way.This paper discusses the source,development,and application of the PCMM by considering not only the five dimensions that constitute the PCMM but also the recognition of the human body and disease as given in traditional Chinese medicine.This paper aims to provide theoretical guidance for the rational use and development of CMM.
文摘The research on the dose-effect relationship in Chinese materia medica is delayed due to the complexity of its composition, multi-efficacy, multi-targeting and other factors. Many experts put forward relevant research ideas and methods and worked out more and more research results in literature, experimental and clinical categories because of the progress of statistical methods and scientific and technological means in recent years. In this paper, these results were preliminarily combed to show the basic situation of dose-effect relationship research in Chinese materia medica.
文摘Taking the Ben Cao Gang Mu(《本草纲目》Compendium of Materia Medica)(Jinling edition金陵本)as the research object and“Jing”as the search term,this article summarizes the quantity of medicinals containing“Jing”in Ben Cao Gang Mu,analyzes the connotation and application of“Jing”in traditional Chinese medicine,and finds that the application of“Jing”in medicine does not deviate from the original meaning of“Jing,”but endows it with the concepts of medicine and pharmacy,and expands the application scope of“Jing.”This study is helpful to understand and use spermicide more reasonably.
基金the Major Project for Research on Modernization of Traditional Chinese Medicine under National Key R&D Program of China (no. 2017YFC1704004)National Natural Science Foundation of China (no. 81674097)+3 种基金Guangxi Scholarship Fund of Guangxi Education Department (No. Gui Jiao Ren 〔2018〕18)Guangxi First-class Discipline Construction Project (No. Gui Jiao Ke Yan 〔2018〕12)Development Program of High-level Talent Team under Qihuang Project of Guangxi University of Chinese Medicine (No.2018005)Innovative Research Project for Postgraduates of Guangxi University of Chinese Medicine (no.YCSY20190010).
文摘Objective: To analyze the research status, development context and trend of traditional Chinese medicine (TCM) network pharmacology from birth to the present. Methods: In this study, bibliographic data and references of articles on TCM network pharmacology were collected from Web of Science Core Collection (WoSCC), and software including CiteSpace, VOSviewer and Microsoft Excel were applied for the bibliometric analysis of periodicals and the quantity of literature, and for the construction and analysis of the co-occurrence network of countries, journals, research institutes and authors, clusters of co-cited references, and time distribution network of keywords. Results: 249 articles were included in this study. The time span was from 2011 to 2018, and the annual volume of publications showed an increasing trend year by year. The 77 journals contain relevant literature, and the average impact factor of the journal is 3.215. Chinese Journal of Natural Medicines, Scientific Reports, PLoS One have high influence in the field of TCM network pharmacology. Universities and research institutes including China Academy of Chinese Medical Science and Northwest Agriculture & Forestry University are the major forces in this field. Wang Yonghua and Li Shao are authors with high influence in this field, with a considerable number of relevant documents and citations. According to the clustering results of co-cited references, research topics can be classified into 13 development contexts such as “compound danshen formula”,“computational tool”, and “new multi-compound drug discovery”. Hotspots of TCM network pharmacology include “drug discovery”,“mechanism” and “cardiovascular disease”, and relevant research methods and research contents including drugs and diseases tend to be constantly enriched. Conclusion: This study comprehensively demonstrates the research status, development context and trends of TCM network pharmacology, and provides a scientific reference for TCM network pharmacology researchers.
基金Supported by the National Social Science Fund of China(No.19CGJ037)Three-Year Action Plan for Development of Traditional Chinese Medicine in Shanghai[No.ZY(2021-2023)-0212)Shanghai Association for Science and Technology(No.20DZ2200800)。
文摘Medicinal plants or Chinese materia medica(CMM)are now attracting worldwide attention as they have increasingly prominent advantages over chemical drugs in disease treatment and healthcare.Since the 1990s,World Health Organization(WHO)and International Organization for Standardization established the Technical Committee of Traditional Chinese Medicine(ISO/TC 249)have carried out the development of quality standards on medicinal plants or CMMs respectively,and a considerable number of monographs and international standards have been published.Since the two international organizations adhere to different principles,the standards they develop naturally have different emphasis.Driven by market demand and international trade,ISO mainly takes quality,efficacy and safety into consideration when developing standards,while WHO pays more attention to clinical practice,quality control and medication guidance.Up to now,there is a lack of comparative analysis on the records,background,principles,basic content,and main requirements of quality standards on medicinal plants or CMMs respectively published by WHO and ISO.Therefore,based on international standards of CMM developed by ISO/TC 249 platform and WHO Monographs on Selected Medicinal Plants,this paper systematically compares the purposes,selected principles,standard-developing process,basic content,and main quality requirements to summarize their similarities and differences,and find their merits,aiming to serve as a reference to the development of international standards for CMMs that helps them go global.
文摘目的:通过文献研究阐述中药干预肥胖型多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者代谢异常的有效性及安全性。方法:计算机检索国内外主流医药数据库中关于中医、中西医结合对比单纯西药治疗PCOS的随机对照试验(randomized controlled trial,RCT)。参照Cochrane系统评价手册对全文的设计方案进行质量评价,采用RevMan 5.4软件进行Meta分析。结果:纳入22项RCT进行Meta分析,中药或中西药联合治疗不仅在提升排卵率这一主要研究指标上优于单纯西药治疗(P<0.05),还在改善胰岛素抵抗指数(homeostasis model assessment of insulin resistance,HOMA-IR)、空腹胰岛素(fasting insulin,FINS)、体质量指数(body mass index,BMI)、三酰甘油(triglyceride,TG)、总胆固醇(total cholesterol,TC)、低密度脂蛋白(low density lipoprotein,LDL)、高密度脂蛋白(high density lipoprotein,HDL)等方面优于单纯西药治疗(均P<0.05),但在调节空腹血糖(fasting blood glucose,FBG)和腰臀比(waist-to-hip ratio,WHR)方面与西药治疗差异无统计学意义(均P>0.05)。结论:中药或中西药联合干预肥胖型PCOS糖脂代谢异常,具有多途径、多靶点调控作用,无严重不良反应,优于单纯西药治疗。
文摘目的运用网络药理学和分子对接探讨清热药作用机制。方法检索TCMSP、TCMID、NPASS数据库获取5类清热中药活性成分,检索DrugBank、NPASS数据库收集对应靶点,使用UniProt数据库规范靶点名称。使用STRING数据库构建交集靶点蛋白相互作用网络,采用Cytoscape3.9.1软件筛选核心靶点。使用在线软件DAVID进行GO功能、KEGG通路及疾病富集分析,使用Metascape数据库分析特有靶点。使用Discovery Studio 4.5.0软件对清热药共有成分与核心靶点进行分子对接。结果获得清热泻火药活性成分297个、清热燥湿药活性成分609个、清热解毒药活性成分1196个、清热凉血药活性成分224个、清虚热药活性成分为389个,对应靶点分别为117、241、402、87和260个;获得共有活性成分7个,对应靶点196个。GO功能、KEGG通路及疾病富集分析显示,清热药可能通过调节外源代谢过程、单碳代谢过程中的代谢途径对乳腺癌和肿瘤发挥治疗作用。分子对接结果表明,清热药发挥抗肿瘤、抗乳腺癌的核心化学成分可能为棕榈酸、槲皮素、亚油酸。结论清热类中药可通过多途径发挥治疗作用,其中,清热泻火药、清热燥湿药、清热解毒药的生物过程及信号通路较为相似,均可通过调节外源代谢过程、单碳代谢过程、葡萄糖醛酸基转移酶活性的负调控、细胞葡萄糖醛酸化的负调控、雌激素代谢过程、细胞葡萄糖醛酸化中的新陈代谢类信号通路发挥治疗乳腺癌的作用。
文摘The rapid development of science and technology calls for an urgent need to systemize the studies in a certain field on the basis of a common target. A case in point was the research and development of atomic bombs that was based on the latest development in many fields.
