Pharmacological intervention for chronic phase of spinal cord injury

Spinal cord injury is an intractable traumatic injury. The most common hurdles faced during spinal cord injury are failure of axonal regrowth and reconnection to target sites. These also tend to be the most challenging issues in spinal cord injury. As spinal cord injury progresses to the chronic phase, lost motor and sensory functions are not recovered. Several reasons may be attributed to the failure of recovery from chronic spinal cord injury. These include factors that inhibit axonal growth such as activated astrocytes, chondroitin sulfate proteoglycan, myelin-associated proteins, inflammatory microglia, and fibroblasts that accumulate at lesion sites. Skeletal muscle atrophy due to denervation is another chronic and detrimental spinal cord injury–specific condition. Although several intervention strategies based on multiple outlooks have been attempted for treating spinal cord injury, few approaches have been successful. To treat chronic spinal cord injury, neural cells or tissue substitutes may need to be supplied in the cavity area to enable possible axonal growth. Additionally, stimulating axonal growth activity by extrinsic factors is extremely important and essential for maintaining the remaining host neurons and transplanted neurons. This review focuses on pharmacotherapeutic approaches using small compounds and proteins to enable axonal growth in chronic spinal cord injury. This review presents some of these candidates that have shown promising outcomes in basic research(in vivo animal studies) and clinical trials: AA-NgR(310)ecto-Fc(AXER-204), fasudil, phosphatase and tensin homolog protein antagonist peptide 4, chondroitinase ABC, intracellular sigma peptide,(-)-epigallocatechin gallate, matrine, acteoside, pyrvate kinase M2, diosgenin, granulocyte-colony stimulating factor, and fampridine-sustained release. Although the current situation suggests that drug-based therapies to recover function in chronic spinal cord injury are limited, potential candidates have been identified through basic research, and these candidates may be subjects of clinical studies in the future. Moreover, cocktail therapy comprising drugs with varied underlying mechanisms may be effective in treating the refractory status of chronic spinal cord injury.

Low‑Temperature Oxidation Induced Phase Evolution with Gradient Magnetic Heterointerfaces for Superior Electromagnetic Wave Absorption

Gradient magnetic heterointerfaces have injected infinite vitality in optimizing impedance matching,adjusting dielectric/magnetic resonance and promoting electromagnetic(EM)wave absorption,but still exist a significant challenging in regulating local phase evolution.Herein,accordion-shaped Co/Co_(3)O_(4)@N-doped carbon nanosheets(Co/Co_(3)O_(4)@NC)with gradient magnetic heterointerfaces have been fabricated via the cooperative high-temperature carbonization and lowtemperature oxidation process.The results indicate that the surface epitaxial growth of crystal Co_(3)O_(4) domains on local Co nanoparticles realizes the adjustment of magnetic-heteroatomic components,which are beneficial for optimizing impedance matching and interfacial polarization.Moreover,gradient magnetic heterointerfaces simultaneously realize magnetic coupling,and long-range magnetic diffraction.Specifically,the synthesized Co/Co_(3)O_(4)@NC absorbents display the strong electromagnetic wave attenuation capability of−53.5 dB at a thickness of 3.0 mm with an effective absorption bandwidth of 5.36 GHz,both are superior to those of single magnetic domains embedded in carbon matrix.This design concept provides us an inspiration in optimizing interfacial polarization,regulating magnetic coupling and promoting electromagnetic wave absorption.

基于CTA颅内动脉瘤形态联合PHASES评分对破裂出血预测研究

目的:分析头颈部计算机断层扫描血管成像(CTA)联合PHASES评分对颅内动脉瘤(IA)破裂出血的预测价值。方法:回顾性分析2021年10月—2023年9月东莞市长安医院诊治的IA患者临床资料,根据IA破裂出血与否分为IA破裂组(n=46)和IA未破裂组(n=44),收集两组临床资料,对比两组患者CTA影像瘤体特征参数和PHASES评分结果。采用受试者工作特征(ROC)曲线分析两者联合预测动脉瘤破裂的效能。结果:IA破裂组高血压、糖尿病发生率及PHASES评分均高于IA未破裂组,差异有统计学意义(P <0.05)。两组病灶位置以颈内动脉(ICA)和大脑中动脉(MCA)为主,但IA破裂组病灶位置在MCA的占比为41.30%,高于IA未破裂组的20.45%,瘤体>7 mm的最多(瘤体7~9.9 mm占65.22%),瘤体形态不规则占58.7%,未破裂组病灶位置在ICA最多(68.18%),瘤体<7 mm的居多(75.00%),瘤体形态规则囊状动脉瘤占93.18%,差异有统计学意义(P <0.05)。CTA瘤体特征参数比较,IA破裂组患者瘤颈宽度、瘤体高度、瘤体长度、动脉瘤最大直径、入射夹角、动脉瘤体颈比等参数均高于IA未破裂组,差异有统计学意义(P <0.05)。CTA瘤体特征参数+PHASES评分联合预测曲线下面积为0.916,高于CTA瘤体特征参数(0.901)和PHASES评分(0.731)。结论:CTA瘤体特征参数+PHASES评分联合预测IA患者破裂出血效能最佳。

Neural adaptive PSD decoupling controller and its application in three-phase electrode adjusting system of submerged arc furnace

Taking three-phase electrode adjusting system of submerged arc furnace as study object which has nonlinear, time-variant, multivariable and strong coupling features, a neural adaptive PSD(proportion, sum and differential) dispersive decoupling controller was developed by combining neural adaptive PSD algorithm with dispersive decoupling network. In this work, the production technology process and control difficulties of submerged arc furnace were simply introduced, the necessity of establishing a neural adaptive PSD dispersive decoupling controller was discussed, the design method and the implementation steps of the controller are expounded in detail, and the block diagram of the controlled system is presented. By comparison with experimental results of the conventional PID controller and the adaptive PSD controller, the decoupling ability, adaptive ability, self-learning ability and robustness of the neural adaptive PSD dispersive decoupling controller have been testified effectively. The controller is applicable to the three-phase electrode adjusting system of submerged arc furnace, and it will play an important role for achieving the power balance of three-phrase electrodes, saving energy and reducing consumption in the process of smelting.

Phase-stabilized RF transmission system based on LLRF controller and optical delay line

Radio frequency(RF)transmission systems with high-precision phase stability are required by the next generation of particle colliders and light sources.An RF transmission system was designed to meet this requirement.In this system,RF signal generated at the sending end is modulated onto a continuous wave(CW)optical carrier,transmitted through an optical fiber,and demodulated at the receiving end.The phase drift is detected by a digital phase monitor with femtosecond-level accuracy and compensated by a motorized optical fiber delay line(ODL).The measurement results show that the long-term phase drifts can be stabilized to within 100 fs(pk-pk),500 fs(pk-pk),and 1.8 ps(pk-pk)in a 400-meter-long optical fiber over 1 h,24 h,and 10 days,respectively.

Fuzzy Controller Based 3Phase 4Wire Shunt Active Filter for Mitigation of Current Harmonics with Combined p-q and Id-Iq Control Strategies

As more and more variable frequency drives (VFDs), electronic ballasts, battery chargers, and static Var compensators are installed in facilities, the problems related to harmonics are expected to get worse. As a result Active power filter (APF) gains much more attention due to excellent harmonic compensation. But still the performance of the active filter seems to be in contradictions with different control strategies. This paper presents detailed analysis to compare and elevate the performance of two control strategies for ex-tracting reference currents of shunt active filters under balanced, un-balanced and non-sinusoidal conditions by using Fuzzy controller. The well known methods, instantaneous real active and reactive power method (p-q) and active and reactive current method (id-iq) are two control methods which are extensively used in active filters. Extensive Simulations are carried out with fuzzy controller for both p-q and Id-Iq methods for different voltage conditions and adequate results were presented. Simulation results validate the superior per-formance of active and reactive current control strategy (id-iq) with fuzzy controller over active and reactive power control strategy (p-q) with fuzzy controller.

Negative Imaginary Approached High Performance Robust Resonant Controller Design for Single-Phase Islanded Microgrid and Its Voltage Observation on Different Load Condition

This paper presents the design of a high performance robust resonant controller for the islanded single-phase microgrid operation on different loads conditions. The design of the controller is done using the results of Negative Imaginary approach. The performance of the proposed controller has been found much effective to track the instantaneous reference grid voltage. The simulation work has been done with the help of MATLAB/SimPower System toolbox. This shows that the proposed controller provides effective control of voltage against the uncertain load conditions.

Modified Single Phase SRF d-q Theory Based Controller for DVR Mitigating Voltage Sag in Case of Nonlinear Load

This paper mainly concentrates on design of improved controller and its implementation based on single phase synchronous reference frame theory (SRFT) for Dynamic Voltage Restorer (DVR) compensating voltage sag particularly for nonlinear load. In case of single phase distribution line with nonlinear load, the complexity of controller’s design becomes more serious issue. The present single phase and/or three phase theories applicable to DVR shows poor response to restore voltage sag in case of nonlinear load due to presence of harmonics. Hence restoration of voltage sag in single phase nonlinear load connected system has been a serious concern. Therefore, new controller for DVR has been proposed incorporating effective design concept for fundamental component extraction in case of nonlinear load. The single phase SRFT based main controller for DVR works on two separate closed path viz. feed forward path for quick transient response and feedback path for reducing the steady state error. Moreover, pre-sag mitigation strategy of DVR has been adapted through these two aforementioned paths. Complete design of proposed controller is based on phasor analysis. It also consist of proportional integral (PI) controller to reduce the error in the DC-link voltage during compensation time. The controller performance has been verified in MATLAB Simulink for both types (linear and nonlinear) of load. The results obtained indicates that the proposed controller is effective in its performance.

Internal phase control of fiber laser array based on photodetector array

Coherent beam combining(CBC) of fiber laser array is a promising technique to realize high output power while maintaining near diffraction-limited beam quality. To implement CBC, an appropriate phase control feedback structure should be established to realize phase-locking. In this paper, an innovative internal active phase control CBC fiber laser array based on photodetector array is proposed. The dynamic phase noises of the laser amplifiers are compensated before being emitted into free space. And the static phase difference compensation of emitting laser array is realized by interference measurement based on photodetector array. The principle of the technique is illustrated and corresponding simulations are carried out, and a CBC system with four laser channels is built to verify the technique. When the phase controllers are turned on, the phase deviation of the laser array is less than λ/20, and ~ 95% fringe contrast of the irradiation distribution is obtained. The technique proposed in this paper could provide a reference for the system design of a massive high-power CBC system.

Position Control of Synchronous Motor Drive by Modified Adaptive Two-phase Sliding Mode Controller

A modified adaptive two-phase sliding mode controller for the synchronous motor drive that is highly robust to uncertain- ties and external disturbances is proposed in this paper.The proposed controller uses two-phase sliding mode control (SMC) where the 1st phase mainly controls the system in steady states and disturbed states-it is a smoothing phase.The 2nd phase is used mainly in the case of disturbed states.Also,it is an autotuning phase and uses a simple adaptive algorithm to tune the gain of conventional variable structure control (VSC).The modified controller is useful in position control of a permanent magnet synchronous drive.

The Implementation and Lateral Control Optimization of a UAV Based on Phase Lead Compensator and Signal Constraint Controller

Unmanned Aero Vehicles (UAV) has become a useful entity for quite a good number of industries and facilities. It is an agile, cost effective and reliable solution for communication, defense, security, delivery, surveillance and surveying etc. However, their reliability is dependent on the resilient and stabilizes performance based on control systems embedded behind the body. Therefore, the UAV is majorly dependent upon controller design and the requirement of particular performance parameters. Nevertheless, in modern technologies there is always a room for improvement. In the similar manner a UAV lateral control system was implemented and researched in this study, which has been optimized using Proportional, Integral and Derivative (PID) controller, phase lead compensator and signal constraint controller. The significance of this study is the optimization of the existing UAV controller plant for improving lateral performance and stability. With this UAV community will benefit from designing robust controls using the optimized method utilized in this paper and moreover this will provide sophisticated control to operate in unpredictable environments. It is observed that results obtained for optimized lateral control dynamics using phase lead compensator (PLC) are efficacious than the simple PID feedback gains. However, for optimizing unwanted signals of lateral velocity, yaw rate, and yaw angle modes, PLC were integrated with PID to achieve dynamical stability.

Phase-engineering modulation of Mn-based oxide cathode for constructing super-stable sodium storage

The Mn-based oxide cathode with enriched crystal phase structure and component diversity can provide the excellent chemistry structure for Na-ion batteries.Nevertheless,the broad application prospect is obstructed by the sluggish Na^(+)kinetics and the phase transitions upon cycling.Herein,we establish the thermodynamically stable phase diagram of various Mn-based oxide composites precisely controlled by sodium content tailoring strategy coupling with co-doping and solid-state reaction.The chemical environment of the P2/P'3 and P2/P3 biphasic composites indicate that the charge compensation mechanism stems from the cooperative contribution of anions and cations.Benefiting from the no phase transition to scavenge the structure strain,P2/P'3 electrode can deliver long cycling stability(capacity retention of 73.8%after 1000 cycles at 10 C)and outstanding rate properties(the discharge capacity of 84.08 mA h g^(-1)at 20 C)than P2/P3 electrode.Furthermore,the DFT calculation demonstrates that the introducing novel P'3 phase can significantly regulate the Na^(+)reaction dynamics and modify the local electron configuration of Mn.The effective phase engineering can provide a reference for designing other high-performance electrode materials for Na-ion batteries.

Recent advances in graphene-based phase change composites for thermal energy storage and management

Energy storage and conservation are receiving increased attention due to rising global energy demands.Therefore,the development of energy storage materials is crucial.Thermal energy storage(TES)systems based on phase change materials(PCMs)have increased in prominence over the past two decades,not only because of their outstanding heat storage capacities but also their superior thermal energy regulation capability.However,issues such as leakage and low thermal conductivity limit their applicability in a variety of settings.Carbon-based materials such as graphene and its derivatives can be utilized to surmount these obstacles.This study examines the recent advancements in graphene-based phase change composites(PCCs),where graphene-based nanostructures such as graphene,graphene oxide(GO),functionalized graphene/GO,and graphene aerogel(GA)are incorporated into PCMs to substantially enhance their shape stability and thermal conductivity that could be translated to better storage capacity,durability,and temperature response,thus boosting their attractiveness for TES systems.In addition,the applications of these graphene-based PCCs in various TES disciplines,such as energy conservation in buildings,solar utilization,and battery thermal management,are discussed and summarized.

MODIFIED AUTOMATIC TUNING OF PI/D CONTROLLERS BASED ON PHASE AND AMPLITUDE MARGIN SPECIFICATIONS

A new auto tuning procedure for PI/D controller based on phase and amplitude margin specifications was proposed.The procedure applied a modified relay feedback experiment to identifying the process frequency response of the point where the Nyquist curve intersects the negative imaginary axis,and the PI/D controller settings can be obtained based on this single point.The auto tuning method has all the merits of the tuning method that Astrom and Hagglund had proposed,and overcomes its problems.The simulation results show that the proposed tuning method has better performance than Astrom Hagglund’s tuning method.

A novel current vector decomposition controller design for six-phase permanent magnet synchronous motor

The vector control algorithm based on vector space decomposition （VSD） transformation method has a more flexible control freedom, which can control the fundamental and harmonic subspace separately. To this end, a current vector decoupling control algorithm for six-phase permanent magnet synchronous motor （PMSM） is designed. Using the proposed synchronous rotating coordinate transformation matrix, the fundamental and harmonic components in d-q subspace are changed into direct current （DC） component, only using the traditional proportional integral （PI） controller can meet the non-static difference adjustment, and the controller parameter design method is given by employing intemal model principle. In addition, in order to remove the 5th and 7th harmonic components of stator current, the current PI controller parallel with resonant controller is employed in x-y subspace to realize the specific harmonic component compensation. Simulation results verify the effectiveness of current decoupling vector controller.

Phase separation and transcriptional regulation in cancer development

Liquid-liquid phase separation,a novel biochemical phenomenon,has been increasingly studied for its medical applications.It underlies the formation of membrane-less organelles and is involved in many cellular and biological processes.During transcriptional regulation,dynamic condensates are formed through interactions between transcriptional elements,such as transcription factors,coactivators,and mediators.Cancer is a disease characterized by uncontrolled cell proliferation,but the precise mechanisms underlying tumorigenesis often remain to be elucidated.Emerging evidence has linked abnormal transcriptional condensates to several diseases,especially cancer,implying that phase separation plays an important role in tumorigenesis.Condensates formed by phase separation may have an effect on gene transcription in tumors.In the present review,we focus on the correlation between phase separation and transcriptional regulation,as well as how this phenomenon contributes to cancer development.

A repetitive-PI Current Controller for Boost Single Phase PFC Converters

In this paper, the Author presents the theory and application of repetitive proportional integral current con-troller for boost single phase ac-dc converter with power factor correction (PFC). A repetitive controller which is inserted in series with the proportional integral ( PI) controller shows very low crossover distortion of input current, low total harmonic distortion and very low tracking error when is compared with the con-ventional proportional integral controller. Full analysis of proposed controller is given and Matlab/Simulink is used for simulation. The simulation results show the validity of the proposed control method.

Shikimic acid accelerates phase change and flowering in Chinese jujube

The juvenile-to-adult phase change with first flowering as the indicator plays a crucial role in the lifecycle of fruit trees. However, the molecular mechanisms underlying phase change in fruit trees remain largely unknown. Shikimic acid (ShA) pathway is a main metabolic pathway closely related to the synthesis of hormones and many important secondary metabolites participating in plant phase change. So,whether ShA regulates phase change in plants is worth clarifying. Here, the distinct morphological characteristics and the underlying mechanisms of phase change in jujube (Ziziphus jujuba Mill.), an important fruit tree native to China with nutritious fruit and outstanding tolerance abiotic stresses, were clarified. A combined transcriptome and metabolome analysis found that ShA is positively involved in jujube(Yuhong’×Xing 16’) phase change. The genes in the upstream of ShA synthesis pathway (ZjDAHPS, ZjDHQS and ZjSDH), the contents of ShA and the downstream secondary metabolites like phenols were significantly upregulated in the phase change period. Further, the treatment of spraying exogenous ShA verified that ShA at a very low concentration (60 mg·L^(-1)) can substantially speed up the phase change and flowering of jujube and other tested plants including Arabidopsis, tomato and wheat. The exogenous ShA (60 mg·L^(-1)) treatment in jujube seedlings could increase the accumulation of endogenous ShA, enhance leaf photosynthesis and the synthesis of phenols especially flavonoids and phenolic acids, and promote the expression of genes (ZjCOs, ZjNFYs and ZjPHYs) involved in flowering pathway. Basing on above results, we put forward a propose for the underlying mechanism of ShA regulating phase change, and a hypothesis that ShA could be considered a phytohormone-like substance because it is endogenous, ubiquitous, movable and highly efficient at very low concentrations. This study highlights the critical role of ShA in plant phase change and its phytohormone-like properties.

Self‑Assembly of Binderless MXene Aerogel for Multiple‑Scenario and Responsive Phase Change Composites with Ultrahigh Thermal Energy Storage Density and Exceptional Electromagnetic Interference Shielding

The severe dependence of traditional phase change materials(PCMs)on the temperature-response and lattice deficiencies in versatility cannot satisfy demand for using such materials in complex application scenarios.Here,we introduced metal ions to induce the self-assembly of MXene nanosheets and achieve their ordered arrangement by combining suction filtration and rapid freezing.Subsequently,a series of MXene/K^(+)/paraffin wax(PW)phase change composites(PCCs)were obtained via vacuum impregnation in molten PW.The prepared MXene-based PCCs showed versatile applications from macroscale technologies,successfully transforming solar,electric,and magnetic energy into thermal energy stored as latent heat in the PCCs.Moreover,due to the absence of binder in the MXene-based aerogel,MK3@PW exhibits a prime solar-thermal conversion efficiency(98.4%).Notably,MK3@PW can further convert the collected heat energy into electric energy through thermoelectric equipment and realize favorable solar-thermal-electric conversion(producing 206 mV of voltage with light radiation intensity of 200 mw cm^(−2)).An excellent Joule heat performance(reaching 105℃with an input voltage of 2.5 V)and responsive magnetic-thermal conversion behavior(a charging time of 11.8 s can achieve a thermal insulation effect of 285 s)for contactless thermotherapy were also demonstrated by the MK3@PW.Specifically,as a result of the ordered arrangement of MXene nanosheet self-assembly induced by potassium ions,MK3@PW PCC exhibits a higher electromagnetic shielding efficiency value(57.7 dB)than pure MXene aerogel/PW PCC(29.8 dB)with the same MXene mass.This work presents an opportunity for the multi-scene response and practical application of PCMs that satisfy demand of next-generation multifunctional PCCs.

Microstructure and damping properties of LPSO phase dominant Mg-Ni-Y and Mg-Zn-Ni-Y alloys

This work studied the microstructure,mechanical properties and damping properties of Mg_(95.34)Ni_(2)Y_(2.66) and Mg_(95.34)Zn_(1)Ni_(1)Y_(2.66)alloys systematically.The difference in the evolution of the long-period stacked ordered(LPSO)phase in the two alloys during heat treatment was the focus.The morphology of the as-cast Mg_(95.34)Ni_(2)Y_(2.66)presented a disordered network.After heat treatment at 773 K for 2 hours,the eutectic phase was integrated into the matrix,and the LPSO phase maintained the 18R structure.As Zn partially replaced Ni,the crystal grains became rounded in the cast alloy,and lamellar LPSO phases and more solid solution atoms were contained in the matrix after heat treatment of the Mg_(95.34)Zn_(1)Ni_(1)Y_(2.66)alloy.Both Zn and the heat treatment had a significant effect on damping.Obvious dislocation internal friction peaks and grain boundary internal friction peaks were found after temperature-dependent damping of the Mg_(95.34)Ni_(2)Y_(2.66)and Mg_(95.34)Zn_(1)Ni_(1)Y_(2.66)alloys.After heat treatment,the dislocation peak was significantly increased,especially in the alloy Mg_(95.34)Ni_(2)Y_(2).66.The annealed Mg_(95.34)Ni_(2)Y_(2.66)alloy with a rod-shaped LPSO phase exhibited a good damping performance of 0.14 atε=10^(−3),which was due to the difference between the second phase and solid solution atom content.These factors also affected the dynamic modulus of the alloy.The results of this study will help in further development of high-damping magnesium alloys.