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Influence of Omega 3 Fatty Acid Supplementation on Phase Angle Values of People Living with HIV/AIDS with Lipodystrophy Secondary to Antiretroviral Therapy: A Randomized Clinical Trial
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作者 Thalita Bandeira Dantas Alline Peralta Castro +1 位作者 Fernando de Souza Flexa Ribeiro Filho Rosana Maria Feio Libonati 《Food and Nutrition Sciences》 CAS 2024年第1期58-70,共13页
Objective: The measurement of phase angles is an important monitoring parameter and supplementation with omega-3 could promote benefits by modulating the electrical potential of membranes and increasing body cell mass... Objective: The measurement of phase angles is an important monitoring parameter and supplementation with omega-3 could promote benefits by modulating the electrical potential of membranes and increasing body cell mass. This study aimed to evaluate the effectiveness of omega-3 fatty acid supplementation on the phase angle of people living with HIV/AIDS. Methods: In this study, 63 individuals of all genders who were undergoing outpatient follow-up and showed lipodystrophy due to highly active antiretroviral therapy were analyzed. Our sample consisted of two groups, one that received supplementation containing 2550 mg of omega-3/day (1080 mg of eicosapentaenoic acid and 720 mg of docosahexaenoic acid) for three months (n = 32) and another that underwent nutrition guidance (n = 31). Phase angle and body cell mass were assessed for both groups and compared at the beginning of research (T0) and after our intervention (T1) for each group separately. Results: Phase angle averaged 6.45° ± 1.06 SD. The comparison between T0 and T1 showed a significant increase in phase angle and body cell mass, whereas the guidance group showed a decrease in body cell mass at T1 in relation to T0, with a significant p-value. Variance in phase angle between moments showed significant values between T0 and T1 in the supplementation group for all genders. Conclusion: Omega-3 positively modulated patients phase angle and body cell mass, but we emphasize the need for other studies that can solidify knowledge about supplementation dosage and intervention time. 展开更多
关键词 HIV LIPODYSTROPHY Omega-3 phase angle
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Diagnosing ratio of electron density to collision frequency of plasma surrounding scaled model in a shock tube using low-frequency alternating magnetic field phase shift
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作者 吴明兴 谢楷 +3 位作者 刘艳 徐晗 张宝 田得阳 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第5期519-530,共12页
A non-contact low-frequency(LF)method of diagnosing the plasma surrounding a scaled model in a shock tube is proposed.This method utilizes the phase shift occurring after the transmission of an LF alternating magnetic... A non-contact low-frequency(LF)method of diagnosing the plasma surrounding a scaled model in a shock tube is proposed.This method utilizes the phase shift occurring after the transmission of an LF alternating magnetic field through the plasma to directly measure the ratio of the plasma loop average electron density to collision frequency.An equivalent circuit model is used to analyze the relationship of the phase shift of the magnetic field component of LF electromagnetic waves with the plasma electron density and collision frequency.The applicable range of the LF method on a given plasma scale is analyzed.The upper diagnostic limit for the ratio of the electron density(unit:m^(-3))to collision frequency(unit:Hz)exceeds 1×10^(11),enabling an electron density to exceed 1×10^(20)m^(-3)and a collision frequency to be less than 1 GHz.In this work,the feasibility of using the LF phase shift to implement the plasma diagnosis is also assessed.Diagnosis experiments on shock tube equipment are conducted by using both the electrostatic probe method and LF method.By comparing the diagnostic results of the two methods,the inversion results are relatively consistent with each other,thereby preliminarily verifying the feasibility of the LF method.The ratio of the electron density to the collision frequency has a relatively uniform distribution during the plasma stabilization.The LF diagnostic path is a loop around the model,which is suitable for diagnosing the plasma that surrounds the model.Finally,the causes of diagnostic discrepancy between the two methods are analyzed.The proposed method provides a new avenue for diagnosing high-density enveloping plasma. 展开更多
关键词 low-frequency alternating magnetic field phase shift shock-tube plasma diagnosis electron density collision frequency
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Role of the phase angle in the prognosis of the cirrhotic patient:15 years of follow-up
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作者 Letícia Pereira Pinto Claudio Augusto Marroni +3 位作者 Juliana Czermainski Maria Luiza Fernandes Dahlem Randhall B Carteri Sabrina Alves Fernandes 《World Journal of Methodology》 2023年第4期238-247,共10页
BACKGROUND In 2019,cirrhosis accounted for 2.4%of global deaths.The projection for 2030 is an increase in this index.In recent years,hospitalization costs have escalated by 36%for compensated cirrhosis and 24%for deco... BACKGROUND In 2019,cirrhosis accounted for 2.4%of global deaths.The projection for 2030 is an increase in this index.In recent years,hospitalization costs have escalated by 36%for compensated cirrhosis and 24%for decompensated cirrhosis.Therefore,it is necessary to identify a tool capable of predicting the mortality of these patients according to their clinical condition and consequently extending their survival time.Different studies have shown that the phase angle(PA)can be a feasible method in clinical practice,with the potential to guide assertive patient management in the therapeutic of chronic liver disease.AIM To evaluate the prognostic role of PA in cirrhotic patients over a 15-year followup period.METHODS Retrospective cohort study with 129 cirrhotic patients of both sexes over 18 years old.Diagnosis of cirrhosis by liver biopsy.The first year of data collection was 2007,and data regarding outcomes was collected in 2023.Data were gathered from medical records,such as esophageal varices(EV),EV bleeding,ascites,spontaneous bacterial peritonitis(SBP),encephalopathy,laboratory findings and PA.The cut-off value for the PA was 5.4°,a value described in 2012 by Fernandes et al for 129 patients evaluated in this study and the cut-off points for the Brazilian population presented in percentiles(P),as described by Mattiello et al.The mortality was assessed using the PA percentile through Kaplan-Meier curves and multivariate binary logistic regression models.RESULTS Patients were divided into two groups according to the PA 5.4th(PA>5.4°,n=40;PA≤5.4°,n=89)PA percentile(<P50,n=56;≥P50 n=73).The percentile classification was more accurate in identifying long-term deaths than the 5.4ºPA.Patients with<P50 had a higher number of relevant complications such as ascites,SBP,liver encephalopathy and HCC.PA is strongly correlated with serum albumin(P<0.001),International Normalized Ratio(P=0.01),total bilirubin(P=0.02)and direct bilirubin(P=0.003).PA is correlated with survival time(P<0.001)and length of stay(P=0.02).Logistic regression analysis shows that an increase of 1°in PA enlarges the cirrhotic patient's chance of survival by 17.7%.CONCLUSION PA is a good predictor of morbidity and mortality for cirrhotic patients.The PA by percentile showed greater sensitivity in predicting mortality compared to the cut-off point of 5.4º. 展开更多
关键词 Liver cirrhosis phase angle PROGNOSIS Liver transplantation Electrical bioimpedance
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Discrete Phase Shifts Control and Beam Selection in RIS-Aided MISO System via Deep Reinforcement Learning 被引量:1
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作者 Dongting Lin Yuan Liu 《China Communications》 SCIE CSCD 2023年第8期198-208,共11页
Reconfigurable intelligent surface(RIS)for wireless networks have drawn lots of attention in both academic and industry communities.RIS can dynamically control the phases of the reflection elements to send the signal ... Reconfigurable intelligent surface(RIS)for wireless networks have drawn lots of attention in both academic and industry communities.RIS can dynamically control the phases of the reflection elements to send the signal in the desired direction,thus it provides supplementary links for wireless networks.Most of prior works on RIS-aided wireless communication systems consider continuous phase shifts,but phase shifts of RIS are discrete in practical hardware.Thus we focus on the actual discrete phase shifts on RIS in this paper.Using the advanced deep reinforcement learning(DRL),we jointly optimize the transmit beamforming matrix from the discrete Fourier transform(DFT)codebook at the base station(BS)and the discrete phase shifts at the RIS to maximize the received signal-to-interference plus noise ratio(SINR).Unlike the traditional schemes usually using alternate optimization methods to solve the transmit beamforming and phase shifts,the DRL algorithm proposed in the paper can jointly design the transmit beamforming and phase shifts as the output of the DRL neural network.Numerical results indicate that the DRL proposed can dispose the complicated optimization problem with low computational complexity. 展开更多
关键词 reconfigurable intelligent surface discrete phase shifts transmit beamforming deep reinforcement learning
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Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis 被引量:6
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作者 Astrid Ruiz-Margáin Ricardo Ulises Macías-Rodríguez +7 位作者 Javier Ampuero Francisco Javier Cubero Luis Chi-Cervera Silvia L Ríos-Torres Andrés Duarte-Rojo Ángeles Espinosa-Cuevas Manuel Romero-Gómez Aldo Torre 《World Journal of Gastroenterology》 SCIE CAS 2016年第45期10064-10070,共7页
AIM Evaluate the association between phase angle and the development of hepatic encephalopathy in the longterm follow-up of cirrhotic patients.METHODS This was a prospective cohort study. Clinical, nutritional and bio... AIM Evaluate the association between phase angle and the development of hepatic encephalopathy in the longterm follow-up of cirrhotic patients.METHODS This was a prospective cohort study. Clinical, nutritional and biochemical evaluations were performed. MannWhitney's U and χ2 tests were used as appropriate. Kaplan-Meier curves and Cox proportional Hazards analysis were used to evaluate the prediction and incidence of hepatic encephalopathy.RESULTS Two hundred and twenty were included; the most frequent etiology of cirrhosis was hepatitis C infection, 52% of the patients developed hepatic encephalopathy(18.6% covert and 33.3% overt); the main precipitating factors were infections and variceal bleeding. KaplanMeier curves showed a higher proportion of HE in the group with low phase angle(39%) compared to the normal phase angle group(13%)(P = 0.012). Furthermore, creatinine and phase angle remained independently associated to hepatic encephalopathy in the Cox regression multivariate analysis [hazard ratio = 1.80(1.07-3.03)]. CONCLUSION In our cohort of patients low phase angle was associated with an increased incidence of hepatic encephalopathy. Phase angle is a useful nutritional marker that evaluates cachexia and could be used as a part of the integral assessment in patients with cirrhosis. 展开更多
关键词 MALNUTRITION Hepatic encephalopathy phase angle CACHEXIA PROGNOSIS
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Nutritional evaluation in cirrhosis: Emphasis on the phase angle 被引量:7
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作者 Sabrina Alves Fernandes Angelo Alves de Mattos +1 位作者 Cristiane Valle Tovo Claudio Augusto Marroni 《World Journal of Hepatology》 CAS 2016年第29期1205-1211,共7页
Protein-calorie malnutrition (PCM) is a common condition in cirrhotic patients, leading to a worse prognosis, complications, poor quality of life and lower survival rates. Among ways of assessing nutritional status, t... Protein-calorie malnutrition (PCM) is a common condition in cirrhotic patients, leading to a worse prognosis, complications, poor quality of life and lower survival rates. Among ways of assessing nutritional status, there are anthropometric methods such as the evaluation of the triceps skinfold, the arm circumference, the arm muscle circumference and the body mass index, and non-anthropometric methods such as the subjective global assessment, the handgrip strength of non-dominant hand, and the bioelectrical impedance analysis (BIA). PCM is frequently under-diagnosed in clinical settings in patients with cirrhosis due to the limitations of nutritional evaluation methods in this population. BIA is a useful method, but cannot be indicated in patients with abnormal body composition. In these situations, the phase angle (PA) has been used, and can become an important tool in assessing nutritional status in any situation. The PA is superior to anthropometric methods and might be considered as a nutritional indicator in cirrhosis. The early characterization of the nutritional status in patients with cirrhosis means an early nutritional intervention, with a positive impact on patients&rsquo; overall prognosis. Among the usually accepted methods for nutritional diagnosis, the PA provides information in a quick and objective manner. 展开更多
关键词 MALNUTRITION Bioelectrical impedance phase angle SARCOPENIA NUTRITION
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Phase angle obtained by bioelectrical impedance analysis independently predicts mortality in patients with cirrhosis 被引量:11
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作者 Giliane Belarmino Maria Cristina Gonzalez +9 位作者 Raquel S Torrinhas Priscila Sala Wellington Andraus Luiz Augusto Carneiro D'Albuquerque Rosa Maria R Pereira Valéria F Caparbo Graziela R Ravacci Lucas Damiani Steven B Heymsfield Dan L Waitzberg 《World Journal of Hepatology》 CAS 2017年第7期401-408,共8页
AIM To evaluate the prognostic value of the phase angle(PA)obtained from bioelectrical impedance analysis(BIA) for mortality prediction in patients with cirrhosis. METHODS In total, 134 male cirrhotic patients prospec... AIM To evaluate the prognostic value of the phase angle(PA)obtained from bioelectrical impedance analysis(BIA) for mortality prediction in patients with cirrhosis. METHODS In total, 134 male cirrhotic patients prospectively completed clinical evaluations and nutritional assessment by BIA to obtain PAs during a 36-mo follow-up period. Mortality risk was analyzed by applying the PA cutoff point recently proposed as a malnutrition marker(PA ≤ 4.9°) in Kaplan-Meier curves and multivariate Cox regression models. RESULTS The patients were divided into two groups according to the PA cutoff value(PA > 4.9°, n = 73; PA ≤ 4.9°, n = 61). Weight, height, and body mass index were similar in both groups, but patients with PAs > 4.9° were younger and had higher mid-arm muscle circumference, albumin, and handgrip-strength values and lower severe ascites and encephalopathy incidences, interleukin(IL)-6/IL-10 ratios and C-reactive protein levels than did patients with PAs ≤ 4.9°(P ≤ 0.05). Forty-eight(35.80%) patients died due to cirrhosis, with a median of 18 mo(interquartile range, 3.3-25.6 mo) follow-up until death. Thirty-one(64.60%) of these patients were from the PA ≤ 4.9° group. PA ≤ 4.9° significantly and independently affected the mortality model adjusted for Model for End-Stage Liver Disease score and age(hazard ratio = 2.05, 95%CI: 1.11-3.77, P = 0.021). In addition, Kaplan-Meier curves showed that patients with PAs ≤ 4.9° were significantly more likely to die. CONCLUSION In male patients with cirrhosis, the PA ≤ 4.9° cutoff was associated independently with mortality and identified patients with worse metabolic, nutritional, and disease progression profiles. The PA may be a useful and reliable bedside tool to evaluate prognosis in cirrhosis. 展开更多
关键词 Bioelectrical impedance analysis Body composition phase angle Nutritional assessment Liver disease CIRRHOSIS MORTALITY
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Variations in electrical impedance and phase angle among seedlings of Pinus densata and parental species in Pinus tabuliformis habitat environment 被引量:1
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作者 Xinyu Chen Huwei Yuan +4 位作者 Xiange Hu Jingxiang Meng Xianqing Zhou Xiao-Ru Wang Yue Li 《Journal of Forestry Research》 SCIE CAS CSCD 2015年第3期777-783,共7页
Electrical impedance (El) and phase angle (PHI) parameters in AC impedance spectroscopy are important electrical parameters in the study of medical pathology. However, little is known about their application in va... Electrical impedance (El) and phase angle (PHI) parameters in AC impedance spectroscopy are important electrical parameters in the study of medical pathology. However, little is known about their application in variation and genetic relationship studies of forest trees. In order to test whether impedance parameters could be used in genetic relationship analysis among conifer species, E1 and PHI were measured in a seedling experiment test composed of Pinus tabuliformis, Pinus yunnanensis, and Pinus densata in a habitat of Pinus tabuliformis. The results showed that variations in both EI and PHI among species were sig- nificant in different electric frequencies, and the EI and PHI values measured in the two populations of P. densata were between the two parental species, P. yunnanensis and P. tabuliformis. These results show that these two impedance parameters could reflect the genetic relationship among pine species. This was the first time using the two AC impedance spectroscopy parameters to test the genetic relationship analysis between tree species, and would be a hopeful novelreference methodology for future studies in evolution and genetic variation of tree species. 展开更多
关键词 Electrical impedance phase angle Pinustabuliformis Pinus yunnanensis . Pinus densata . Seedlingneedle Genetic variation
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Shaped Offset Quadrature Phase Shift Keying Based Waveform for Fifth Generation Communication
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作者 R.Ann Caroline Jenifer M.A.Bhagyaveni +1 位作者 V.Saroj Malini M.Shanmugapriya 《Intelligent Automation & Soft Computing》 SCIE 2023年第5期2165-2176,共12页
Fifth generation(5G)wireless networks must meet the needs of emerging technologies like the Internet of Things(IoT),Vehicle-to-everything(V2X),Video on Demand(VoD)services,Device to Device communication(D2D)and many o... Fifth generation(5G)wireless networks must meet the needs of emerging technologies like the Internet of Things(IoT),Vehicle-to-everything(V2X),Video on Demand(VoD)services,Device to Device communication(D2D)and many other bandwidth-hungry multimedia applications that connect a huge number of devices.5G wireless networks demand better bandwidth efficiency,high data rates,low latency,and reduced spectral leakage.To meet these requirements,a suitable 5G waveform must be designed.In this work,a waveform namely Shaped Offset Quadrature Phase Shift Keying based Orthogonal Frequency Division Multiplexing(SOQPSK-OFDM)is proposed for 5G to provide bandwidth efficiency,reduced spectral leakage,and Bit Error Rate(BER).The proposed work is evaluated using a real-time Software Defined Radio(SDR)testbed-Wireless open Access Research Platform(WARP).Experimental and simulation results show that the proposed 5G waveform exhibits better BER performance and reduced Out of Band(OOB)radia-tion when compared with other waveforms like Offset Quadrature Phase Shift Key-ing(OQPSK)and Quadrature Phase Shift Keying(QPSK)based OFDM and a 5G waveform candidate Generalized Frequency Division Multiplexing(GFDM).BER analysis shows that the proposed SOQPSK-OFDM waveform attains a Signal to Noise Ratio(SNR)gain of 7.2 dB at a BER of 10�3,when compared with GFDM in a real-time indoor environment.An SNR gain of 8 and 6 dB is achieved by the proposed work for a BER of 10�4 when compared with QPSK-OFDM and OQPSK-OFDM signals,respectively.A significant reduction in OOB of nearly 15 dB is achieved by the proposed work SOQPSK-OFDM when compared to 16 Quadrature Amplitude Modulation(QAM)mapped OFDM. 展开更多
关键词 5G waveform orthogonal frequency division multiplexing shaped offset quadrature phase shift keying wireless open access research platform
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Effect of the Wick Deflection Angles on Heat Transfer Characteristics for the Flat LHP
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作者 Zhuohuan Hu Sixian Sun +2 位作者 Chengwei Yuan Yan Cao Jiayin Xu 《Frontiers in Heat and Mass Transfer》 EI 2023年第1期107-123,共17页
Loop Heat Pipe(LHP)is an efficient two-phase heat transfer device,which can be used in waste heat recovery,electronics cooling,aerospace and other fields.The wick,the core component of LHP,plays an important role in i... Loop Heat Pipe(LHP)is an efficient two-phase heat transfer device,which can be used in waste heat recovery,electronics cooling,aerospace and other fields.The wick,the core component of LHP,plays an important role in its start-up and operation.In this paper,the wick fabricated by 3D printing technology had uniform and interconnected pores.In the experiment,the position of the parallel vapor removal grooves was always fixed towards the vapor outlet.When the cylindrical wick was placed in the evaporator,the rotation angle relative to its central axis could be changed,thus changing the number and shape of the pores facing the vapor removal grooves.The wick deflection angle represented its change in spatial position relative to the fixed vapor removal grooves.The effect of the wick deflection angles on the heat transfer characteristics of the flat LHP was experimentally investigated.It was found that with the change of deflection angle,the number of pores in the evaporation-oriented zone would also change,which had a significant impact on the start-up process and heat transfer performance of LHP.When the deflection angle was 30°,LHP could start fastest at a low heat load of 20 W and operate stable at a high heat load of 180 W. 展开更多
关键词 Loop heat pipe heat transfer phase change 3D-printed wick deflection angle
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Bioelectrical Impedance Phase Angle as a Predictors of Mortality in Patients with Lung Cancer:a Prospective Study 被引量:2
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作者 Jing Guo Fei Fei Chong +7 位作者 Liang Yu Yin Xin Lin Meng Yuan Zhang Mu Li Shi Hong Mei Zhang Jie Liu Hong Xia Xu Jun Kang 《Journal of Nutritional Oncology》 2022年第1期38-48,共11页
Objective Bioelectrical impedance analysis(BIA)is used to measure a patient's body composition.The phase angle(PA),the major parameter in BIA,is one of the most sensitive indicators of malnutrition.The aim of the ... Objective Bioelectrical impedance analysis(BIA)is used to measure a patient's body composition.The phase angle(PA),the major parameter in BIA,is one of the most sensitive indicators of malnutrition.The aim of the current study was to investigate whether the PA can be used to predict survival in lung cancer patients.Methods One hundred sixty-six lung cancer patients were prospectively included from January 2014 to August 2016 in Daping Hospital.Anthropometric measurements,hematological values,the nutritional risk screening(NRS 2002)score,patient generated-subjective global assessment(PG-SGA)score,Karnofsky performance status(KPS)scale,European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire(EORTC QLQ C-30)score,and BIA were investigated within 48 hours after admission to the hospital.A Spearman correlation analysis was applied to test the correlations between the study characteristics and PA.A Kaplan-Meier analysis and log-rank test were conducted to analyze the association between the overall survival(OS)and PA.Results The mean age for all patients was 63 years old(42 females and 124 males).The median PA was 5.5°(4.70°,6.23°).The PA was positively associated with the body mass index,hand grip strength,mid-arm circumference,mid-arm muscle circumference,albumin,prealbumin,C-reactive protein,red blood cells,hemoglobin and KPS score.The PG-SGA scores,QLQ-C30 score,and NRS2002 score showed a significant negative association with the PA.According to a multivariate analysis,the PA(HR=0.47;95%CI:0.27-0.81)was independent predictor of the lung cancer patients'long-term OS.Patients with a higher PA(≥5°)had better overall survival(median=426 days)compared to those with a lower PA(<5°)(median=96 days)based on the one-year follow-up data(P<0.0001).Conclusions These studies indicate that the PA is a sensitive and early indicator to predict survival in lung cancer patients. 展开更多
关键词 Bioelectric impedance analysis phase angle MALNUTRITION Nutritional assessment Lung cancer MORTALITY
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Low Phase Angle Predicts Poor Survival in Patients with Hepatocellular Carcinoma:A Retrospective Study 被引量:2
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作者 Jin Yu Shi Guang Yang +6 位作者 Bo Liu Xiao Shang Guo Zhen Cui Jia Xin Huang Wan Ting Wang Ke Yu Chen Nan Ya Wang 《Journal of Nutritional Oncology》 2022年第2期75-84,共10页
Background The phase angle(PA)is an indicator of nutritional status derived from bioelectrical impedance analysis(BIA).Studies have shown that the PA is one of several factors related to the survival of cancer patient... Background The phase angle(PA)is an indicator of nutritional status derived from bioelectrical impedance analysis(BIA).Studies have shown that the PA is one of several factors related to the survival of cancer patients.However,the correlation between the PA and prognosis in patients with hepatocellular carcinoma(HCC)has not been reported.This study aimed to explore the relationship between the PA,nutrition-related indicators,and patient prognosis.Methods The data from 248 HCC patients who underwent BIA between January 2015 and December 2019 at the First Hospital of Jilin University were retrospectively analyzed.Patients were divided into two groups according to the median PA value,then the nutrition-related indicators and overall survival(OS)were compared between the two groups.The correlations between the PA and laboratory test nutrition-related indicators and the results of a body composition analysis were determined using Pearson correlation analysis.Independent predictors of the patient prognosis were identified using univariate and multivariate analyses.Results The median OS in the high and low PA groups were 70 and 54.6 months,respectively(P=0.004).The Pearson correlation analysis revealed that the PA was associated with both laboratory test nutrition-related indicators and the results of a body composition analysis.The multivariable Cox regression analysis identified the PA as an independent risk factor affecting the prognosis of patients with Barcelona Clinic Liver Cancer stage A or B.Conclusion The PA is a good biomarker for the nutritional status.We found that the PA was associated with the prognosis in patients with HCC,with a low PA indicating a poor nutritional status and worse prognosis. 展开更多
关键词 phase angle Hepatocellular carcinoma NUTRITION Bioelectrical impedance analysis Body composition analysis
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Solid-state NMR studies of proteins in condensed phases
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作者 Jiani Xiang Xialian Wu +1 位作者 Angelo L.Chu Junxia Lu 《Magnetic Resonance Letters》 2024年第3期1-10,共10页
Some proteins perform their biological functions by changing their material states through liquid-liquid phase separation.Upon phase separation,the protein condenses into a concentrated liquid phase and sometimes into... Some proteins perform their biological functions by changing their material states through liquid-liquid phase separation.Upon phase separation,the protein condenses into a concentrated liquid phase and sometimes into a gel phase,changing its dynamic properties and intermolecular interactions,thereby regulating cellular functions.Although the biological significance of this phenomenon has been widely recognized by researchers,there is still a lack of a comprehensive understanding of the structural and dynamic properties of the protein in the condensed phase.In this phase,molecules usually contain domains with varied dynamic properties and undergo intermediate exchanges.Magic angle spinning(MAS)solid-state NMR(SSNMR)experiments are very powerful in studying rigid protein polymers such as amyloid.The incorporation of solution-like experiments into SSNMR and the development of J-coupling based MAS SSNMR techniques extend its ability to study partially mobile segments of proteins in a condensed liquid or gel phase which are not visible by solution NMR or dipolar-coupling based SSNMR.Therefore,it has been applied in studying protein condensation and has provided very important information that is hard to obtain by other techniques. 展开更多
关键词 Magic angle spinning(MAS)solid-state NMR(SSNMR) Protein condenses J-coupling based MAS SSNMR Liquid-liquid phase separation
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Phase Properties of Two-Mode Squeezing-Rotating Entangled Representation
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作者 YUAN Hong-Chun LI Heng-Mei QI Kai-Guo 《Communications in Theoretical Physics》 SCIE CAS CSCD 2006年第5X期838-842,共5页
By virtue of the squeezing-rotating entangled representation, we mainly establish the new two-mode phase operator and phase angle operat, or, which is a general form including the foregoing formalist in two-mode Fock ... By virtue of the squeezing-rotating entangled representation, we mainly establish the new two-mode phase operator and phase angle operat, or, which is a general form including the foregoing formalist in two-mode Fock space. In addition, the corresponding phase distribution function is given in the entangled representation. In terms of this definition, we also analyze the phase behavior of some simple two-mode states such as squeezing-rotatlng coherent state, squeezing-rotating vacuum state, and so on. It is found that the results exactly agree with the foregoing phase theory. 展开更多
关键词 phase operator phase angle operator phase distribution function squeezing-rotating entangled representation
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Relationship between phase angle,steatosis,and liver fibrosis in patients coinfected with human immunodeficiency virus/hepatitis C virus
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作者 Sabrina Alves Fernandes Cristiane Valle Tovo +3 位作者 AndréLuiz Machado da Silva Letícia Pereira Pinto Randhall B Carteri Angelo A Mattos 《World Journal of Hepatology》 2022年第6期1173-1181,共9页
BACKGROUND Malnutrition,lipodystrophy,and dyslipidemia are prevalent characteristics in patients with human immunodeficiency virus(HIV)infection with or without previous treatment.Such a clinical condition can lead to... BACKGROUND Malnutrition,lipodystrophy,and dyslipidemia are prevalent characteristics in patients with human immunodeficiency virus(HIV)infection with or without previous treatment.Such a clinical condition can lead to the hypothesis of the presence of hepatic steatosis with possible progression to fibrosis and the risk of hepatocellular carcinoma.Notably,a low phase angle(PA),evaluated by bioelectrical impedance analysis(BIA),is an independent prognostic marker of clinical progression and survival in HIV-infected patients.AIM To evaluate the relationship between PA and body composition with steatosis and hepatic fibrosis in HIV/hepatitis C virus(HCV)-coinfected patients.METHODS A retrospective observational study by convenience sampling of coinfected HIV/HCV patients,in which all patients underwent transient elastography(Fibroscan)and BIA evaluation.Student’s t test was used for group comparisons,and Spearman’s or Pearson’s correlation test was used when appropriate.The significance level was set at 5%,and analyses were performed using SPSS version 21.0.RESULTS Forty-three patients who received antiretroviral therapy met the inclusion criteria,and 23(53.5%)were under treatment with protease inhibitors(PIs).There was no difference in PA between those who used PIs and those who did not(P=0.635).There was no correlation between fibrosis grade and PA(P=0.355)or lean mass(P=0.378).There was a significant inverse correlation between the controlled attenuation parameter(CAP)and lean mass(P=0.378),positive correlation between PA and lean mass(P=0.378),and negative correlation between PA and fatty mass(P=0.378),although the CAP and PA were not correlated.When evaluated by sex,no significant correlations were found.CONCLUSION PA determines the muscle function of HIV/HCV-coinfected patients,and the CAP values reinforce the association with lean mass,suggesting that patients require early nutritional interventions. 展开更多
关键词 phase angle Bioelectrical impedance COINFECTION Human immunodeficiency virus Hepatitis C virus NUTRITION
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Phase angle and non-alcoholic fatty liver disease before and after bariatric surgery
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作者 Joise Teixeira Claudio Augusto Marroni +5 位作者 Paula Rosales Zubiaurre Ana Henz Lais Faina Lilian KethelynPinheiro Claudio Cora Mottin Sabrina Alves Fernandes 《World Journal of Hepatology》 2020年第11期1004-1019,共16页
BACKGROUND Obesity is a global health problem that is continuing to increase in the young population.In Brazil,the frequency of obesity in 2018 was 19.8%.Several comorbidities are directly associated with obesity,such... BACKGROUND Obesity is a global health problem that is continuing to increase in the young population.In Brazil,the frequency of obesity in 2018 was 19.8%.Several comorbidities are directly associated with obesity,such as non-alcoholic fatty liver disease(NAFLD),which is considered the most common liver disorder in Western countries and affects up to 46%of adults.Bariatric surgery is effective in treating obesity and can improve NAFLD;however,the effect of bariatric surgery on body composition,phase angle(PA),and improving NAFLD needs to be further studied.AIM To analyze the PA in the postoperative period of bariatric surgery and to correlate it with changes in body composition and liver disease.METHODS This study is a retrospective cohort study of the analysis of the medical records of patients undergoing bariatric surgery in a reference center of a teaching hospital in Porto Alegre over a 2-year period.Patients older than 18 years whose record contained all information relevant to the study were included.The data analyzed were body composition and PA through electrical bioimpedance and NAFLD through liver biopsy in the pre-and postoperative period.The level of significance adopted for the statistical analyses was 5%.RESULTS We evaluated 379 patients with preoperative data.Regarding PA,169 patients were analyzed,and 33 patients had liver biopsy pre-and postoperatively with NAFLD information.In total,79.4%were female,with a mean age of 39.1±10.6 years.The average body mass index(BMI)was 45.9±7.5 kg/m².The PA showed a mean of 5.8±0.62°in the preoperative period and a significant reduction in the postoperative period.A postoperative reduction in body composition data(skeletal muscle mass,fat percentage,fat mass,body cell mass,BMI and visceral fat area)was shown as well.Regarding liver disease,all patients presented a reduction in the degrees and stages of liver disease in the postoperative period,and some had no degree of liver disease at all.CONCLUSION PA decreased after bariatric surgery,with a direct correlation with weight loss and changes in body composition.The decrease in PA was not correlated with the improvement in NAFLD. 展开更多
关键词 OBESITY Body composition Bariatric surgery phase angle Non-alcoholic fatty liver disease Liver disease
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Phase angle through electrical bioimpedance as a predictor of cellularity in inflammatory bowel disease
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作者 Sabrina A Fernandes Carina Rossoni +4 位作者 Vivian W Koch Marcello Imbrizi Rosana Evangelista-Poderoso Leticia Pereira Pinto Letiia Pereira Pinto 《Artificial Intelligence in Gastroenterology》 2021年第4期111-123,共13页
It is estimated in Western industrialized countries that inflammatory bowel disease(IBD)has a prevalence of 1 for every 200 inhabitants.In the past,the fat mass disproportionate increase in relation to the fat-free ma... It is estimated in Western industrialized countries that inflammatory bowel disease(IBD)has a prevalence of 1 for every 200 inhabitants.In the past,the fat mass disproportionate increase in relation to the fat-free mass was considered uncommon in patients with IBD,due to the observation of the disease being more common with weight loss and malnutrition.However,more in-depth investigations demonstrate that the fat/lean mass disproportion stands out both in prevalence in patients with new diagnoses of ulcerative colitis or Crohn's disease as well as a factor of poor prognosis to the natural evolution of the disease or to the therapeutic response.Another important aspect associated with obesity in IBD is the increased risk of drug clearance[including anti-tumor necrosis factor(TNF)and anti-integrin agents],resulting in short half-life and low trough drug concentrations,since the levels of TNF secreted by adipocytes sequester anti-TNF agents,which could result in suboptimal response to biologics.In view of these characteristic aspects of the inflammatory process of IBD,the identification of cellular functioning is necessary,which can be associated with the staging of the underlying disease,biochemical parameters,and body composition,helping as an indicator for a more accurate clinical and nutritional conduct. 展开更多
关键词 Inflammatory bowel disease Crohn's disease Ulcerative colitis phase angle CELLULARITY Bioelectrical impedance
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Application of the Phase Angle in Patients with Malignant Tumors
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作者 Xue Lian Ma Jian Hua Deng +1 位作者 Xian Xu Su Hui Wang 《Journal of Nutritional Oncology》 2022年第4期161-174,共14页
Bioelectrical impedance analysis(BIA)is a noninvasive and reproducible technique for assessing changes in body composition and nutritional status.The phase angle(PA),a major parameter of BIA,is one of the most sensiti... Bioelectrical impedance analysis(BIA)is a noninvasive and reproducible technique for assessing changes in body composition and nutritional status.The phase angle(PA),a major parameter of BIA,is one of the most sensitive indicators used to detect malnutrition in patients,and is also a prognostic marker in various clinical diseases.The incidence of malnutrition in cancer patients is high,and malnutrition seriously affects the treatment process and prognosis of patients.Reasonable and effective nutritional interventions are therefore of great significance for cancer patients.Compared with traditional nutritional assessment tools,the PA has unique advantages in the nutritional assessment,efficacy monitoring and prognostic prediction of patients with malignant tumors,and it has broad application prospects in clinical practice.This article reviews the research progress on the application of the PA in patients with malignant tumors to provide clinicians with a tool to predict malnutrition,and provide a more favorable basis for the nutritional assessment,treatment and prognostic prediction of cancer patients. 展开更多
关键词 Bioelectrical impedance analysis phase angle Malignant tumor Nutritional assessment PROGNOSIS Sarcopenia syndrome
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Error-CompensatingFive-SamplePhase-Shifting Algorithm Based on Phase-Shift Error Estimation
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作者 黄文宇 龚建伟 陆际联 《Journal of Beijing Institute of Technology》 EI CAS 2001年第4期337-341,共5页
A new error compensating five sample phase shifting algorithm which is insensitive to phase shift error is proposed to retrieve the phase distribution of a fringe pattern. It includes two steps. First, the linear ... A new error compensating five sample phase shifting algorithm which is insensitive to phase shift error is proposed to retrieve the phase distribution of a fringe pattern. It includes two steps. First, the linear phase shift error is estimated using four sample images. Then, the phase distribution is calculated with error corrected by using the phase shift error estimated in the first step. As the equations of error estimation and phase calculation are simple, this new algorithm is practical as well as effective. Computer simulations were carried out to verify the effectiveness of the algorithm. Results of two other well known error compensating algorithms are also presented, which show the new algorithm is the least sensitive to phase shift error. 展开更多
关键词 phase shifting algorithm phase measuring profilometry optical measurement
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Applications of Wavelet Analysis in Differential Propagation Phase Shift Data De-noising 被引量:18
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作者 HU Zhiqun LIU Liping 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2014年第4期825-835,共11页
Using numerical simulation data of the forward differential propagation shift (ΦDP) of polarimetric radar,the principle and performing steps of noise reduction by wavelet analysis are introduced in detail.Profiting... Using numerical simulation data of the forward differential propagation shift (ΦDP) of polarimetric radar,the principle and performing steps of noise reduction by wavelet analysis are introduced in detail.Profiting from the multiscale analysis,various types of noises can be identified according to their characteristics in different scales,and suppressed in different resolutions by a penalty threshold strategy through which a fixed threshold value is applied,a default threshold strategy through which the threshold value is determined by the noise intensity,or a ΦDP penalty threshold strategy through which a special value is designed for ΦDP de-noising.Then,a hard-or soft-threshold function,depending on the de-noising purpose,is selected to reconstruct the signal.Combining the three noise suppression strategies and the two signal reconstruction functions,and without loss of generality,two schemes are presented to verify the de-noising effect by dbN wavelets:(1) the penalty threshold strategy with the soft threshold function scheme (PSS); (2) the ΦDP penalty threshold strategy with the soft threshold function scheme (PPSS).Furthermore,the wavelet de-noising is compared with the mean,median,Kalman,and finite impulse response (FIR) methods with simulation data and two actual cases.The results suggest that both of the two schemes perform well,especially when ΦDP data are simultaneously polluted by various scales and types of noises.A slight difference is that the PSS method can retain more detail,and the PPSS can smooth the signal more successfully. 展开更多
关键词 polarimetric radar wavelet analysis differential propagation phase shift DE-NOISING
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