Overview of SSRF phase-Ⅱ beamlines

The SSRF phase-Ⅱ beamline project was launched in 2016. Its major goal was to establish a systematic state-of-the-art experimental facility for third-generation synchrotron radiation to solve problems in cutting-edge science and technology.Currently, the construction is fully completed. All 16 newly built beamlines with nearly 60 experimental methods passed acceptance testing by the Chinese Academy of Sciences and are in operation.

Phase-Based Optical Flow Method with Optimized Parameter Settings for Enhancing Displacement Measurement Adaptability

To enhance the applicability and measurement accuracy of phase-based optical flow method using complex steerable pyramids in structural displacement measurement engineering applications, an improved method of optimizing parameter settings is proposed. The optimized parameters include the best measurement points of the Region of Interest (ROI) and the levels of pyramid filters. Additionally, to address the issue of updating reference frames in practical applications due to the difficulty in estimating the maximum effective measurement value, a mechanism for dynamically updating reference frames is introduced. Experimental results demonstrate that compared to representative image gradient-based displacement measurement methods, the proposed method exhibits higher measurement accuracy in engineering applications. This provides reliable data support for structural damage identification research based on vibration signals and is expected to broaden the engineering application prospects for structural health monitoring.

Unexpected Twinning and Phase-Transition of the Indentation Standards, Their Transition Energies, and Scientific Dichotomy

The general use of aluminium as an indentation standard for the iteration of contact heights for the determination of ISO-14577 hardness and elastic modulus is challenged because of as yet not appreciated phase-changes in the physical force-depth standard curve that seemed to be secured by claims from 1992. The physical and mathematical analyses with closed formulas avoid the still world-wide standardized energy-law violation by not reserving 33.33% (h2 belief) (or 20% h3/2 physical law) of the loading force and thus energy for all not depth producing events but using 100% for the depth formation is a severe violation of the energy law. The not depth producing part of the indentation work cannot be done with zero energy! Both twinning and structural phase-transition onsets and normalized phase-transition energies are now calculated without iterations but with physically correct closed arithmetic equations. These are reported for Berkovich and cubecorner indentations, including their comparison on geometric grounds and an indentation standard without mechanical twinning is proposed. Characteristic data are reported. This is the first detection of the indentation twinning of aluminium at room temperature and the mechanical twinning of fused quartz is also new. Their disqualification as indentation standards is established. Also, the again found higher load phase-transitions disqualify aluminium and fused quartz as ISO-ASTM 14577 (International Standardization Organization and American Society for Testing and Materials) standards for the contact depth “hc” iterations. The incorrect and still world-wide used black-box values for H- and Er-values (the latter are still falsely called “Young’s moduli” even though they are not directional) and all mechanical properties that depend on them. They lack relation to bulk moduli from compression experiments. Experimentally obtained and so published force vs depth parabolas always follow the linear FN = kh3/2 + Fa equation, where Fa is the axis-cut before and after the phase-transition branches (never “h2” as falsely enforced and used for H, Er and giving incorrectly calculated parameters). The regression slopes k are the precise physical hardness values, which for the first time allow for precise calculation of the mechanical qualities by indentation in relation to the geometry of the indenter tip. Exactly 20% of the applied force and thus energy is not available for the indentation depth. Only these scientific k-values must be used for AI-advises at the expense of falsely iterated indentation hardness H-values. Any incorrect H-ISO-ASTM and also the iterated Er-ISO-ASTM modulus values of technical materials in artificial intelligence will be a disaster for the daily safety. The AI must be told that these are unscientific and must therefore be replaced by physical data. Iterated data (3 and 8 free parameters!) cannot be transformed into physical data. One has to start with real experimental loading curves and an absolute ZerodurR standard that must be calibrated with standard force and standard length to create absolute indentation results. .

Transforming Molecules into Medicines: Role of CDMOS in Phase-Appropriate Technology Transfers in Advancing Pharmaceutical Innovation

CDMOs are emerging as critical drivers of innovation within the pharmaceutical and biotech industries. As the pharmaceutical industry continues to evolve, we can expect to see CDMOs play an increasingly important role in drug development and manufacturing. Many companies within these sectors are now leveraging the expertise of CDMOs through technology transfers to foster innovation and enhance the development of new drug products. In the extensive field of drug development, technology transfer plays a crucial role at multiple stages, ranging from preclinical phases to commercialization. By working closely with drug developers, CDMOs can ensure that technologies are transferred seamlessly between phases of drug development, allowing for a more efficient and cost-effective development process. CDMOs also bring a wealth of experience in various areas of drug development, including process development, analytical testing, quality control, and manufacturing. This expertise, combined with a focus on innovation, can help drug developers to overcome technical challenges and optimize their drug development programs. CDMOs can provide drug developers with various manufacturing capabilities, from small-scale clinical trials to large-scale commercial production. This flexibility allows drug developers to focus on their core competencies while relying on CDMOs to provide the necessary infrastructure and support for drug manufacturing. The critical role of CDMOs in advancing pharmaceutical innovation in phase-appropriate technology transfer where there will be a lot of effort and patience with strong technical expertise is required. This article explores the various types of Technology transfer from preclinical to commercial stages and successful strategies to foster innovation.

Microwave-Assisted Au and Ag Nanoparticle Synthesis: An Energy Phase-Space Projection Analysis

Microwave-assisted synthesis of gold and silver nanoparticles, as a function of Green Chemistry, non Green Chemistry, and four applicator types are reported. The applicator types are Domestic microwave ovens, commercial temperature controlled microwave chemistry ovens (TCMC), digesters, and axial field helical antennae. For each of these microwave applicators the process energy budget where estimated (Watts multiplied by process time = kJ) and energy density (applied energy divided by suspension volume = kJ·ml-1) range between 180 ± 176.8 kJ, and 79.5 ± 79 kJ·ml-1, respectively. The axial field helical field an-tenna applicator is found to be the most energy efficient (0.253 kJ·m-1 per kJ, at 36 W). Followed by microwave ovens (4.47 ± 3.9 kJ·ml-1 per 76.83 ± 39 kJ), and TCMC ovens (2.86 ± 2.3 kJ·m-1 per 343 ± 321.5 kJ). The digester applicators have the least energy efficiency (36.2 ± 50.7 kJ·m-1 per 1010 ± 620 kJ). A comparison with reconstructed ‘non-thermal’ microwave oven inactivation microorganism experiments yields a power-law signature of n = 0.846 (R2 = 0.7923) four orders of magnitude. The paper provides a discussion on the Au and Ag nanoparticle chemistry and bio-chemistry synthesis aspects of the microwave applicator energy datasets and variation within each dataset. The visual and analytical approach within the energy phase-space projection enables a nanoparticle synthesis route to be systematically characterized, and where changes to the synthesis are to be mapped and compared directly with historical datasets. In order to help identify lower cost nanoparticle synthesis, in addition to potentially reduce synthesis energy to routes informed changes to potentially reduce synthesis energy budget, along with nanoparticle morphology and yield.

Phase-Transitions at High, Very High, and Very Low Temperatures upon Nano-Indentations: Onset Forces and Transition Energies

This paper describes the phase-transition energies from published loading curves on the basis of the physically deduced FN = k-h3/2 law that does not violate the energy law by assuming h2 instead, as still do ISO-ASTM 14,577 standards. This law is valid for all materials and all “one-point indentation” temperatures. It detects initial surface effects and phase-transition kink-unsteadiness. Why is that important? The mechanically induced phase-transitions form polymorph interfaces with increased risk of crash nucleation for example at the pickle forks of airliners. After our published crashing risk, as nucleated within microscopic polymorph-interfaces via pre-cracks, had finally appeared (we presented microscopic images (5000×) from a model system), 550 airliners were all at once grounded for 18 months due to such microscopic pre-cracks at their pickle forks (connection device for wing to body). These pre-cracks at phase-transition interfaces were previously not complained at the (semi)yearlycheckups of all airliners. But materials with higher compliance against phase- transitions must be developed for everybody’s safety, most easily by checking with nanoindentations, using their physically correct analyses. Unfortunately, non-physical analyses, as based on the after all incredible exponent 2 on h for the FN versus h loading curve are still enforced by ISO-ASTM standards that cannot detect phase-transitions. These standards propagate that all of the force, as applied to the penetrating cone or pyramid shall be used for the depth formation, but not also in part for the pressure to the indenter environment. However, the remaining part of pressure (that was not consumed for migrations, etc.) is always used for the elastic modulus detection routine. That severely violates the energy-law! Furthermore, the now physically analyzed published loading curves contain the phase-transition onsets and energies information, because these old-fashioned authors innocently (?) published (of course correct) experimental loading curves. These follow as ever the physically deduced FN = k-h3/2 relation that does not violate the energy law. Nevertheless, the old-fashioned authors stubbornly assume h2instead of h3/2 as still do ISO-ASTM 14,577 standards according to an Oliver-Pharr publication of 1992 and textbooks. The present work contributes to understanding the temperature dependence of phase-transitions under mechanical load, not only for aviation and space flights, which is important. The physical calculations use exclusively regressions and pure algebra (no iterations, no fittings, and no simulations) in a series of straightforward steps by correcting for unavoidable initial effects from the axis cuts of the linear branches from the above equation exhibiting sharp kink unsteadiness at the onset of phase transitions. The test loading curves are from Molybdenum and Al 7075 alloy. The valid published loading curves strictly follow the FN = k-h3/2 relation. Full applied work, conversion work, and conversion work per depth unit show reliable overall comparable order of magnitude values at temperature increase by 150°C (Al 7075) and 980°C (Mo) when also considering different physical hardnesses and penetration depths. It turns out how much the normalized endothermic phase-transition energy decreases upon temperature increase. For the only known 1000°C indentation we provide reason that the presented loading curves changes are only to a minor degree caused by the thermal expansion. The results with Al 7075 up to 170°C are successfully compared. Al 7075 alloy is also checked by indentation with liquid nitrogen cooling (77 K). It gives two endothermic and one very prominent exothermic phase transition with particularly high normalized phase-transition energy. This indentation loading curve at liquid nitrogen temperature reveals epochal novelties. The energy requiring endothermic phase transitions (already seen at 20°C and above) at 77 K is shortly after the start of the second polymorph (sharply at 19.53 N loading force) followed by a strongly exothermic phase-transition by producing (that is losing) energy-content. Both processes at 77 K are totally unexpected. The produced energy per depth unit is much higher energy than the one required for the previous endothermic conversions. This exothermic phase-transition profits from the inability to provide further energy for the formation of the third polymorph as endothermic obtained at 70°C and above. That is only possible because the very cold crystal can no longer support endothermic events but supports exothermic ones. Both endothermic and exothermic phase-transitions at 77 K under load are unprecedented and were not expected before. While the energetic support at 77 K for endothermic processes under mechanical load is unusual but still understandable (there are also further means to produce lower temperatures). But strongly exothermicphase-transition under mechanical load for the production of new modification with negative energy content (less than the energy content of the ambient polymorph) at very low temperature is an epochal event here on earth. It leads to new global thinking and promises important new applications. The energy content of strongly exothermic transformed material is less than the thermodynamic standard zero energy-content on earth. And it can only be reached when there is no possibility left to produce an endothermic phase-transition. Such less than zero-energy-content materials should be isolated, using appropriate equipment. Their properties must be investigated by chemists, crystallographers, and physicists for cosmological reasons. It could be that such materials will require cooling despite their low energy content (higher stability!) and not survive at ambient temperatures and pressures on earth, but only because we do not know of such negative-energy-content materials with our arbitrary thermodynamic standard zeros on earth. At first one will have to study how far we can go up with temperature for keeping them stable. Thus, the apparently never before considered unprecedented result opens up new thinking for the search of new polymorphs that can, of course, not be reached by heating. Various further applications including cosmology and space flight explorations are profiting from it.

A non-monotone Phase-1 method in linear programming

To gain superior computational efficiency, it might be necessary to change the underlying philosophy of the simplex method. In this paper, we propose a Phase-1 method along this line. We relax not only the conventional condition that some function value increases monotonically, but also the condition that all feasible variables remain feasible after basis change in Phase-1. That is, taking a purely combinatorial approach to achieving feasibility. This enables us to get rid of ratio test in pivoting, reducing computational cost per iteration to a large extent. Numerical results on a group of problems are encouraging.

混合自动机的多项式phase-portrait近似

抽象近似是验证混合系统安全性的主要方法,模型转换是构造一个可判定的(或半判定的)混合自动机来近似原混合自动机。本文将线性phase-portrait近似推广到多项式phase-portrait近似,叙述了如何自动构造多项式phase-portrait近似自动机及如何精化近似模型。

定性推理在矩形phase-portrait近似中的应用

抽象近似是验证混合系统安全性的主要方法,矩形phase-portrait近似是通过构造简单的线性混合自动机来近似原混合自动机。phase-portrait近似的关键步骤是如何划分状态空间。本文采用定性推理的方法,叙述了如何根据系统动态特征来划分状态空间及如何精化抽象模型。

Phase-type分布在随机退化模型中的应用

Phase-type分布是一类应用广泛的分布,主要用在随机模型领域,例如:通讯、金融、排队论、可靠性和生存分析.本研究的目的在于针对随机退化模型,利用Phase-type分布的形式,建立了有限状态空间的马氏过程.同时假设维修时间和失效时间的分布是Phase-type分布,研究了几类特殊的具有两元件的随机退化模型,并给出各模型的Q矩阵及其他感兴趣的量.

基于定性推理的矩形phase-portrait近似

矩形phase-portrait近似的关键是控制模态的有效划分.本文提出了基于定性推理的phase-portrait近似,给出了一种基于向量场、感兴趣多项式及其李导数动态特性的模态空间划分方法,并进一步给出了基于精化多项式的抽象模型精化方法.实验结果表明,基于定性推理划分的phase-portrait近似验证明显地减少了模态空间的划分数目,提高了验证的效率.

一类离散时间的Phase-Type分布的逆问题

该文从条件分布向量序列出发研究离散时间的Phase Type分布的逆问题。利用矩阵分析的方法 ,在已知Markov链首达时间的条件分布向量序列的前提下 。

The correlation between stochastic resonance and the average phase-synchronization time of a bistable system driven by colour-correlated noises

This paper investigates the correlation between stochastic resonance （SR） and the average phase-synchronization time which is between the input signal and the output signal in a bistable system driven by colour-correlated noises. The results show that the output signal-to-noise ratio can reach a maximum with the increase of the average phase- synchronization time, which may be helpful for understanding the principle of SR from the point of synchronization; however, SR and the maximum of the average phase-synchronization time appear at different optimal noise level, moreover, the effects on them of additive and multiplicative noise are different.

多元马氏模型下的Phase-Type分布及其数学期望

在多元马尔可夫模型下研究了Phase-Type分布.根据多元马氏模型状态的转移特征,在确定模型中各随机序列的瞬时状态集转移到吸收态集的首达时间的条件下,结合传统Phase-Type分布的定义,提出多元马氏模型下Phase-Type分布的概念,并给出该分布的分布列和数学期望.

Predicting Net Cross-Shore Total Load Transport: A Phase-Averaging, Quasi-Steady Approach Incorporating Undertow Contribution

Wave shapes that induce velocity skewness and acceleration asymmetry are usually responsible for onshore sediment transport, whereas undertow and bottom slope effect normally contribute to offshore sediment transport. By incorporating these counteracting driving forces in a phase-averaged manner, the theoretically-based quasi-steady formula of Wang （2007） is modified to predict the magnitude and direction of net cross-shore total load transport under the coaction of wave and current. The predictions show an excellent agreement with the measurement data on medium and fine sand collected by Dohmen-Janssen and Hanes （2002） and Schretlen （2012） in a full-scale wave flume at the Coastal Research Centre in Hannover, Germany. The modified formula can predict the net onshore transport of fine sand in sheet flows. In particular, it can predict the net offshore transport of medium sand in rippled beds through enlarged bed roughness, as well as the net offshore transport of fine-to-coarse sand in sheet flows with the aid of a new criterion to judge the occurrence of net offshore transport.

多元马氏模型Phase-type分布的反问题

本文在多元马尔可夫模型下研究Phase-Type分布的反问题.在确定模型中各随机序列的瞬时状态集转移到吸收态集的首达时间的条件下,根据多元马氏模型的首达时间的条件分布向量序列,针对PhaseType分布的反问题,求出多元马氏模型瞬时状态集的转移概率矩阵.

Cerebral blood flow volume measurements of the carotid artery and ipsilateral branches using two-dimensional phase-contrast magnetic resonance angiography

The optimal velocity encoding of phase-contrast magnetic resonance angiography （PC MRA） in measuring cerebral blood flow volume （BFV） ranges from 60 to 80 cm/s. To verify the accuracy of two-dimensional （2D） PC MRA, the present study localized the region of interest at blood vessels of the neck using PC MRA based on three-dimensional time-of-flight sequences, and the velocity encoding was set to 80 cm/s. Results of the measurements showed that the error rate was 7.0±6.0% in the estimation of BFV in the internal carotid artery, the external carotid artery and the ipsilateral common carotid artery. There was no significant difference, and a significant correlation in BFV between internal carotid artery ＋ external carotid artery and ipsilateral common carotid artery. In addition, the BFV of the common carotid artery was correlated with that of the ipsilateral internal carotid artery. The main error was attributed to the external carotid artery and its branches. Therefore, after selecting the appropriate scanning parameters and protocols, 2D PC MRA is more accurate in the determination of BFV in the carotid arteries.

Information Encryption Based on Using Arbitrary Two-Step Phase-Shift Interferometry

A deterministic phase-encoded encryption system is proposed. A lenticular lens array (LLA) sheet with a particular LPI (lenticular per inch) number is chosen as a modulator (key) instead of the random phase molator. The suggested encryption scheme is based on arbitrary two-step phase-shift interferometry (PSI), using an unknown phase step. The encryption and decryption principle is based on an LLA in arbitrary unknown two-step PSI. Right key holograms can be used to theoretically show that the object wavefront is the only one left in the hologram plane and that all accompanying undesired terms are eliminated. The encrypted image can therefore be numerically and successfully decrypted with the right key in the image plane. The number of degrees of freedom of the encryption scheme increases with the distance from the object and the LLA to the CCD, and also with the unknown phase-step and the LLA LPI number. Computer simulations are performed to verify the encryption and decryption principles without a key, with the wrong key and with the right key. Optical experiments are also performed to validate them.

受内反馈控制的Phase-Field系统的稳定性

该文证明了受内反馈控制的 phase- field系统的解在某些条件下是稳定的 .

Highly selective ethylbenzene production through alkylation of dilute ethylene with gas phase-liquid phase benzene and transalkylation feed

A novel industrial process was designed for the highly selective production of ethylbenzene. It comprised of a reactor vessel, vapor phase ethylene feed stream, benzene and transalkylation feed stream. Especially the product stream containing ethylbenzene was used to heat the reactor vessel, which consisted of an alkylation section, an upper heat exchange section, and a bottom heat exchange section. In such a novel reactor, vapor phase benzene and liquid phase benzene were coexisted due to the heat produced by isothermal reaction between the upper heat exchange section and the bottom heat exchange section. The process was demonstrated by the thermodynamic analysis and experimental results. In fact, during the 1010 hour-life-test of gas phase ethene with gas phase-liquid phase benzene alkylation reaction, the ethene conversion was above 95%, and the ethylbenzene selectivity was above 83% （only benzene feed） and even higher than 99% （benzene plus transalkylation feed）. At the same time, the xylene content in the ethylbenzene was less than 100 ppm when the reaction was carried out under the reaction conditions of 140-185℃ of temperature, 1.6-2.1 MPa of pressure, 3.0-5.5 of benzene/ethylene mole ratio, 4-6 v% of transalkylation feed/（benzene＋transalkylation feed）, 0.19-0.27 h^-1 of ethene space velocity, and 1000 g of 3998 catalyst loaded. Thus, compared with the conventional ethylbenzene synthesis route, the transalkylation reactor could be omitted in this novel industrial process.