The SSRF phase-Ⅱ beamline project was launched in 2016. Its major goal was to establish a systematic state-of-the-art experimental facility for third-generation synchrotron radiation to solve problems in cutting-edge...The SSRF phase-Ⅱ beamline project was launched in 2016. Its major goal was to establish a systematic state-of-the-art experimental facility for third-generation synchrotron radiation to solve problems in cutting-edge science and technology.Currently, the construction is fully completed. All 16 newly built beamlines with nearly 60 experimental methods passed acceptance testing by the Chinese Academy of Sciences and are in operation.展开更多
CDMOs are emerging as critical drivers of innovation within the pharmaceutical and biotech industries. As the pharmaceutical industry continues to evolve, we can expect to see CDMOs play an increasingly important role...CDMOs are emerging as critical drivers of innovation within the pharmaceutical and biotech industries. As the pharmaceutical industry continues to evolve, we can expect to see CDMOs play an increasingly important role in drug development and manufacturing. Many companies within these sectors are now leveraging the expertise of CDMOs through technology transfers to foster innovation and enhance the development of new drug products. In the extensive field of drug development, technology transfer plays a crucial role at multiple stages, ranging from preclinical phases to commercialization. By working closely with drug developers, CDMOs can ensure that technologies are transferred seamlessly between phases of drug development, allowing for a more efficient and cost-effective development process. CDMOs also bring a wealth of experience in various areas of drug development, including process development, analytical testing, quality control, and manufacturing. This expertise, combined with a focus on innovation, can help drug developers to overcome technical challenges and optimize their drug development programs. CDMOs can provide drug developers with various manufacturing capabilities, from small-scale clinical trials to large-scale commercial production. This flexibility allows drug developers to focus on their core competencies while relying on CDMOs to provide the necessary infrastructure and support for drug manufacturing. The critical role of CDMOs in advancing pharmaceutical innovation in phase-appropriate technology transfer where there will be a lot of effort and patience with strong technical expertise is required. This article explores the various types of Technology transfer from preclinical to commercial stages and successful strategies to foster innovation.展开更多
To gain superior computational efficiency, it might be necessary to change the underlying philosophy of the simplex method. In this paper, we propose a Phase-1 method along this line. We relax not only the conventiona...To gain superior computational efficiency, it might be necessary to change the underlying philosophy of the simplex method. In this paper, we propose a Phase-1 method along this line. We relax not only the conventional condition that some function value increases monotonically, but also the condition that all feasible variables remain feasible after basis change in Phase-1. That is, taking a purely combinatorial approach to achieving feasibility. This enables us to get rid of ratio test in pivoting, reducing computational cost per iteration to a large extent. Numerical results on a group of problems are encouraging.展开更多
This paper investigates the correlation between stochastic resonance （SR） and the average phase-synchronization time which is between the input signal and the output signal in a bistable system driven by colour-corr...This paper investigates the correlation between stochastic resonance （SR） and the average phase-synchronization time which is between the input signal and the output signal in a bistable system driven by colour-correlated noises. The results show that the output signal-to-noise ratio can reach a maximum with the increase of the average phase- synchronization time, which may be helpful for understanding the principle of SR from the point of synchronization; however, SR and the maximum of the average phase-synchronization time appear at different optimal noise level, moreover, the effects on them of additive and multiplicative noise are different.展开更多
In this study was to investigate, by phase-transfer catalysis, the activity of single and mixed ammonium and phosphonium salts grafted on a 揼el-type?styrene-7% divinylbenzene copolymer in the oxidation of benzyl alco...In this study was to investigate, by phase-transfer catalysis, the activity of single and mixed ammonium and phosphonium salts grafted on a 揼el-type?styrene-7% divinylbenzene copolymer in the oxidation of benzyl alcohol with hydrogen peroxide. A wide variety of catalysts with different quaternary groups and different quaternary chain length substituents were examined. The activity of single 搊nium?salts increases as a consequence of the association of ammonium and phosphonium salts grafted on the same polymeric support. The activity of polymer-supported ammonium and phosphonium salts increases with the number of carbon atoms contained in the alkyl radicals of the onium and of the functionalization degree with phosphonium groups.展开更多
基于Windows Media技术的流媒体同步控制需要ASF的支持。现有方法要求直接修改ASF文件的头对象而不易编程实现。通过对比研究,提出了一种基于Windows Media Encoder编码器后处理过程间接修改ASF文件的方法,并探讨了该方法的基本原理。...基于Windows Media技术的流媒体同步控制需要ASF的支持。现有方法要求直接修改ASF文件的头对象而不易编程实现。通过对比研究,提出了一种基于Windows Media Encoder编码器后处理过程间接修改ASF文件的方法,并探讨了该方法的基本原理。实际系统中的成功应用证明了该方法能有效降低编程难度并易于集成,对实现流媒体同步控制具有一定的参考价值。展开更多
文摘The SSRF phase-Ⅱ beamline project was launched in 2016. Its major goal was to establish a systematic state-of-the-art experimental facility for third-generation synchrotron radiation to solve problems in cutting-edge science and technology.Currently, the construction is fully completed. All 16 newly built beamlines with nearly 60 experimental methods passed acceptance testing by the Chinese Academy of Sciences and are in operation.
文摘CDMOs are emerging as critical drivers of innovation within the pharmaceutical and biotech industries. As the pharmaceutical industry continues to evolve, we can expect to see CDMOs play an increasingly important role in drug development and manufacturing. Many companies within these sectors are now leveraging the expertise of CDMOs through technology transfers to foster innovation and enhance the development of new drug products. In the extensive field of drug development, technology transfer plays a crucial role at multiple stages, ranging from preclinical phases to commercialization. By working closely with drug developers, CDMOs can ensure that technologies are transferred seamlessly between phases of drug development, allowing for a more efficient and cost-effective development process. CDMOs also bring a wealth of experience in various areas of drug development, including process development, analytical testing, quality control, and manufacturing. This expertise, combined with a focus on innovation, can help drug developers to overcome technical challenges and optimize their drug development programs. CDMOs can provide drug developers with various manufacturing capabilities, from small-scale clinical trials to large-scale commercial production. This flexibility allows drug developers to focus on their core competencies while relying on CDMOs to provide the necessary infrastructure and support for drug manufacturing. The critical role of CDMOs in advancing pharmaceutical innovation in phase-appropriate technology transfer where there will be a lot of effort and patience with strong technical expertise is required. This article explores the various types of Technology transfer from preclinical to commercial stages and successful strategies to foster innovation.
文摘To gain superior computational efficiency, it might be necessary to change the underlying philosophy of the simplex method. In this paper, we propose a Phase-1 method along this line. We relax not only the conventional condition that some function value increases monotonically, but also the condition that all feasible variables remain feasible after basis change in Phase-1. That is, taking a purely combinatorial approach to achieving feasibility. This enables us to get rid of ratio test in pivoting, reducing computational cost per iteration to a large extent. Numerical results on a group of problems are encouraging.
文摘This paper investigates the correlation between stochastic resonance （SR） and the average phase-synchronization time which is between the input signal and the output signal in a bistable system driven by colour-correlated noises. The results show that the output signal-to-noise ratio can reach a maximum with the increase of the average phase- synchronization time, which may be helpful for understanding the principle of SR from the point of synchronization; however, SR and the maximum of the average phase-synchronization time appear at different optimal noise level, moreover, the effects on them of additive and multiplicative noise are different.
文摘In this study was to investigate, by phase-transfer catalysis, the activity of single and mixed ammonium and phosphonium salts grafted on a 揼el-type?styrene-7% divinylbenzene copolymer in the oxidation of benzyl alcohol with hydrogen peroxide. A wide variety of catalysts with different quaternary groups and different quaternary chain length substituents were examined. The activity of single 搊nium?salts increases as a consequence of the association of ammonium and phosphonium salts grafted on the same polymeric support. The activity of polymer-supported ammonium and phosphonium salts increases with the number of carbon atoms contained in the alkyl radicals of the onium and of the functionalization degree with phosphonium groups.
文摘基于Windows Media技术的流媒体同步控制需要ASF的支持。现有方法要求直接修改ASF文件的头对象而不易编程实现。通过对比研究,提出了一种基于Windows Media Encoder编码器后处理过程间接修改ASF文件的方法,并探讨了该方法的基本原理。实际系统中的成功应用证明了该方法能有效降低编程难度并易于集成,对实现流媒体同步控制具有一定的参考价值。
