Reformatted method for two-dimensional detector arrays measurement data in proton pencil beam scanning

The spatial resolution of a commercial two-dimensional(2D)ionization chamber(IC)array is limited by the size of the individual detector and the center-to-center distance between sensors.For dose distributions with areas of steep dose gradients,inter-detector dose values are derived by the interpolation of nearby detector readings in the conventional mathematical interpolation of 2D IC array measurements.This may introduce significant errors,particularly in proton spot scanning radiotherapy.In this study,by combining logfile-based reconstructed dose values and detector measurements with the Laplacian pyramid image blending method,a novel method is proposed to obtain a reformatted dose distribution that provides an improved estimation of the delivered dose distribution with high spatial resolution.Meanwhile,the similarity between the measured original data and the downsampled logfilebased reconstructed dose is regarded as the confidence of the reformatted dose distribution.Furthermore,we quantify the performance benefits of this new approach by directly comparing the reformatted dose distributions with 2D IC array detector mathematically interpolated measurements and original low-resolution measurements.The result shows that this new method is better than the mathematical interpolation and achieves gamma pass rates similar to those of the original low-resolution measurements.The reformatted dose distributions generally yield a confidence exceeding 95%.

Achieving Directionality and Transmit Diversity via Integrating Beam Pattern Scanning (BPS) Antenna Arrays and OFDM

In this paper, we introduce a novel merger of antenna arrays with scanning beam patterns, and Orthogonal Frequency Division Multiplexing (OFDM) systems. Controlled time varying phase shifts are applied to the antenna array elements mounted at the base station with beam patterns directed toward the desired user. This creates a small beam pattern movement called Beam Pattern Scanning (BPS). In rich scattering environments BPS creates a time varying environment leading to time diversity exploitable at the receiver enhances its probability-of-error performance. Here, we apply OFDM signals to BPS antenna arrays, and we achieve: (1) directionality, which supports Space Division Multiple Access (SDMA);and (2) a time diversity gain, which leads to high performance. We discuss the structure of the base station antenna array and the OFDM receiver that exploits time diversity. We also introduce the merger of BPS and multi-carrier OFDM (MC-OFDM) systems. In MC-OFDM each bit is transmitted over all sub-carriers after serial to parallel conversion. BPS/ MC-OFDM receiver exploits both time diversity inherent in BPS, and frequency diversity inherent in MC-OFDM transmission technique. Simulation results show high Probability-of-error performance is achie- vable via BPS/OFDM and BPS/MC-OFDM schemes comparing to the traditional OFDM and MC-OFDM, respectively. Simulations also reveal that MC-OFDM system as well as its merger with BPS is capable of mitigating large Peak-to-Average Ratio (PAPR) problem in traditional OFDM system. In addition, performance simulations with coded OFDM (COFDM) and coded MC-OFDM (MC-COFDM) and their merger with BPS are studied.

Study of Beam Scan with Variable Linear Polarisation Directions of Antenna Arrays Using MMIC T/R Modules

The beam scan with variable linear polarization directions of antenna arrays using MM/C transmit-receive (T/R) modules is explored. It is shown that the beam scan and the polarizations of electric fields can be controlled simultaneously if the forms of module arrangement are chosen properly and the amplitudes and the phases of array excitation are determined by the method presented in this article. Moreover, the calculations of the amplitudes and the phases of array excitation are simplified greatly while using the bounded conditions properly, and the desired beam sweep rate is achieved.

Ultrasonic focusing and scanning with multiple waves

This paper presents a new focusing and scanning method which focuses multiple waves on a target. The key of the method is to control excitation pulses for each element of the transducer array. The excitation pulse on each array element is obtained by time reversing the signal received by the same element, which is generated by an imaginary source at the target. The excitation pulses from all array elements are transmitted and arrive at the target simultaneously, and focusing is achieved. The performance of the two methods is compared in numerical examples, and it is demonstrated that the proposed method achieves a satisfactory focusing and a good signal-to-noise ratio no matter where the target location is.

Imaging oxygen microenvironment in hydrogel microwell array

Hydrogel microwell arrays (HMAs) have been wildly used for engineering cell microenvironment by providing well-controlled biophysical and biochemical cues (e.g., three dimensional (3D) physical boundary, biomolecule coating) for cells. Among these cues, the oxygen microenvironment has shown great effect on the cellular physiological processes. However, it is currently technically challenging to characterize the local oxygen microenvironment within HMAs. Here, we prepared HMAs with different crosslinking concentrations to adjust the structural and physical properties of HMAs. Then we introduced a scanning electrochemical microscopy (SECM)-based electrochemical method to map the surface topography and oxygen microenvironment around HMAs. The SECM results show both the 3D topography and the oxygen permeability of HMAs in aqueous solution. The obtained oxygen permeability of HMAs increases with increasing the crosslinking concentration, and the microwell boundaries show the highest oxygen permeability throughout HMAs. This work demonstrates that SECM offers a high spatial resolution and in-situ method for characterization of the topography and the local oxygen permeability of HMAs, which can provide useful information for better engineering cell microenvironment through optimizing HMAs design.

Feature Extraction of Sectorial Scan Image of Thick-Walled Electron Beam Welding Seam Based on Principal Component Analysis

A feature extraction method was proposed to sectorial scan image of Ti-6Al-4V electron beam welding seam based on principal component analysis to solve problem of high-dimensional data resulting in timeconsuming in defect recognition. Seven features were extracted from the image and represented 87. 3% information of the original data. Both the extracted features and the original data were used to train support vector machine model to assess the feature extraction performance in two aspects: recognition accuracy and training time. The results show that using the extracted features the recognition accuracy of pore,crack,lack of fusion and lack of penetration are 93%,90.7%,94.7% and 89.3%,respectively,which is slightly higher than those using the original data. The training time of the models using the extracted features is extremely reduced comparing with those using the original data.

Optical tomography based on nonredundant array scanning holography

A novel technique termed nonredundant array scanning holography based on the principle of optical heterodyne scanning holography and the tomographic technique of coded aperture imaging is proposed. The system designed in terms of this technique codes an object optically and decodes its coded image digitally. It can realize optical tomograms of three-dimensional objects. It also has potentially practical value due to its compact structure. The computer simulations present the principle of the technique. Some experiments at the proof-principle level are performed to test the principle.

Computer generated hologram from full-parallax 3D image data captured by scanning vertical camera array(Invited Paper)

Full-parallax light-field is captured by a small-scale 3D image scanning system and applied to holographic display. A vertical camera array is scanned horizontally to capture full-parallax imagery, and the vertical views between cameras are interpolated by depth image-based rendering technique. An improved technique for depth estimation reduces the estimation error and high-density light-field is obtained. The captured data is employed for the calculation of computer hologram using ray-sampling plane. This technique enables high-resolution display even in deep 3D scene although a hologram is calculated from ray information, and thus it makes use of the important advantage of holographic 3D display.

A Review of Wideband Wide-Angle Scanning 2-D Phased Array and Its Applications in Satellite Communication

In this review,research progress on the wideband wide-angle scanning two-dimensional phased arrays is summarized.The importance of the wideband and the wide-angle scanning characteristics for satellite communication is discussed.Issues like grating lobe avoidance,active reflection coefficient suppression and gain fluctuation reduction are emphasized in this review.Besides,techniques to address these issues and methods to realize the wideband wide-angle scanning phased array are reviewed.

烟雾病免疫相关基因研究

目的通过分析烟雾(moyamoya)病患者外周血液淋巴细胞和正常人外周血液淋巴细胞免疫相关基因表达的差异,探讨烟雾病的发病机制。方法分别采集烟雾病患者和正常人血液标本各22份,提取烟雾病患者和正常人外周血液淋巴细胞的总RNA,将mRNA逆转录为cDNA,用Cy5和Cy3标记作为探针,与含有492个基因的自身免疫和炎症反应基因芯片进行杂交。以ScanArray4000荧光扫描仪扫描芯片上两种荧光信号,用计算机进行处理和分析。结果烟雾病患者外周血液淋巴细胞和正常人血液淋巴细胞比较,差异表达2倍以上的基因共有32个,其中19个基因表达增加,13个基因表达降低。结论烟雾病发生与患者的免疫相关基因异常有关。

Numerical study on scanning radiation acoustic field in formations generated from a borehole

Numerical study on scanning radiation acoustic field in formations generated by linear phased array transmitters in a fluid-filled borehole is carried out using a real axis integration (RAI) method. The main lobe width of the acoustic beams and the incident angle on the borehole wall can be controlled by means of adjusting parameters, such as the element number and the delay time between the neighboring array elements of linear phased array transmitter. The steered angle of longitudinal waves generated in the formation satisfies the Snell’s law for plane waves when the incident angle on the borehole wall is less than the first critical angle. When the lobe width of the acoustic beams is narrow and the steered angle is less than the first critical angle, the acoustic field in the formation can be approximately calculated given that the linear phased array is put in the formation without borehole. The technique of scanning radiation acoustic field can be applied to enhancing investigation resolution and signal-to-noise ratio in crosswell seismic survey and borehole acoustic reflection imaging.

Fast fluorescence lifetime imaging techniques:A review on challenge and development

Fluorescence lifetime imaging microscopy(FLIM)is increasingly used in biomedicine,material science,chemistry,and other related research fields,because of its advantages of high specificity and sensitivity in monitoring cellular microenvironments,studying interaction between proteins,metabolic state,screening drugs and analyzing their efficacy,characterizing novel materials,and diagnosing early cancers.Understandably,there is a large interest in obtaining FLIM data within an acquisition time as short as possible.Consequently,there is currently a technology that advances towards faster and faster FLIM recording.However,the maximum speed of a recording technique is only part of the problerm.The acquisition time of a FLIM image is a complex function of many factors.These include the photon rate that can be obtained from the sample,the amount of information a technique extracts from the decay functions,the fficiency at which it determines fluorescence decay parameters from the recorded photons,the demands for the accuracy of these parameters,the number of pixels,and the lateral and axial resolutions that are obtained in biological materials.Starting from a discussion of the parameters which determine the acquisition time,this review will describe existing and emerging FLIM techniques and data analysis algo-rithms,and analyze their performance and recording speed in biological and biomedical applications.

Terahertz Transmission Imaging with 2.52 THz Continuous Wave

In this article, two terahertz transmission imaging systems are built with a 2.52 THz continuous wave laser and two types of sensors. One is array scanning system using a 124×124 pyro-electric array camera as the detector; the other is a point-wise scanning system utilizing a Golay cell as the detector. The imaging speed and quality is briefly analyzed. Terahertz （THz） imaging results demonstrate that the array scanning system has higher imaging speed with lower resolution. The point-wise scanning system has higher imaging quality with lower speed.

Signal Acquisition and Processing Method Using Sector SSPA

Self scanning photodiode array (SSPA) is a kind of solid state imaging sensor. The signal processing method using a special sector SSPA was investigated. Based on the principle and characteristics of SSPA, a signal acquisition and processing method controlled by computer was introduced. The amplification of weak signal, the matching of time sequence, the fast peak holding with low leakage, the high speed A/D conversion and nonlinear correction were discussed. This method can acquire the peak signal of every ring of sector SSPA with high accuracy and in real time. It can be used to detect the distribution of space light energy.

Design of 2D-Bootlace Lens with Five Focal Feed for Multiple Beam Forming

Utility of microwave bootlace lens is well established. For broadband and wide scanning network, it is required to op-timize and use features of this lens for better communication and scanning device. This report presents the design of a compact 2D bootlace lens with five focal feed for multiple beam forming. This design will help in reducing phase error and will provide power efficiency and better resolution during target tracking. This design will provide better aperture efficiency and scanning angle.

Beam-pointing error compensation method of phased array radar seeker with phantom-bit technology

A phased array radar seeker（PARS） must be able to effectively decouple body motion and accurately extract the line-of-sight（LOS） rate for target missile tracking.In this study,the realtime two-channel beam pointing error（BPE） compensation method of PARS for LOS rate extraction is designed.The PARS discrete beam motion principium is analyzed,and the mathematical model of beam scanning control is finished.According to the principle of the antenna element shift phase,both the antenna element shift phase law and the causes of beam-pointing error under phantom-bit conditions are analyzed,and the effect of BPE caused by phantom-bit technology（PBT） on the extraction accuracy of the LOS rate is examined.A compensation method is given,which includes coordinate transforms,beam angle margin compensation,and detector dislocation angle calculation.When the method is used,the beam angle margin in the pitch and yaw directions is calculated to reduce the effect of the missile body disturbance and to improve LOS rate extraction precision by compensating for the detector dislocation angle.The simulation results validate the proposed method.