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Polarizing the immune system towards neuroprotection in brain ischemia
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作者 Diana Amantea 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第1期81-82,共2页
The development of ischemic brain damage is dramatically affected by the immune system,whose activation occurs immediately after the insult and may last for several days,involving a complex interplay between soluble a... The development of ischemic brain damage is dramatically affected by the immune system,whose activation occurs immediately after the insult and may last for several days,involving a complex interplay between soluble and cellular mediators(Amantea et al.,2015).Accordingly,recent expression profiling studies have revealed that the majority of the genes modulated in the blood of stroke patients participate in the regulation of innate immune responses(Brooks et al.,2014). 展开更多
关键词 profiling innate modulated Brooks participate phenotype macrophages immediately microglia dramatically
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2D profiling of tumor chemotactic and molecular phenotype at single cell resolution using a SERS-microfluidic chip
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作者 Yizhi Zhang Lei Wu +3 位作者 Kuo Yang Shenfei Zong Zhuyuan Wang Yiping Cui 《Nano Research》 SCIE EI CSCD 2022年第5期4357-4365,共9页
Emerging single-cell technologies create new opportunities for unraveling tumor heterogeneity.However,the development of high-content phenotyping platform is still at its infancy.Here,we develop a microfluidic chip fo... Emerging single-cell technologies create new opportunities for unraveling tumor heterogeneity.However,the development of high-content phenotyping platform is still at its infancy.Here,we develop a microfluidic chip for two-dimensional(2D)profiling of tumor chemotactic and molecular features at single cell resolution.Individual cells were captured by the triangular micropillar arrays in the cell-loading channel,facilitating downstream single-cell analysis.For 2D phenotyping,the chemotactic properties of tumor cells were visualized through cellular migratory behavior in microchannels,while their protein expression was profiled with multiplex surface enhanced Raman scattering(SERS)nanovectors,in which Raman reporter-embedded gold@silver core-shell nanoparticles(Au@Ag REPs)were modified with DNA aptamers targeting cellular surface proteins.As a proof of concept,breast cancer cells with diverse phenotypes were tested on the chip,demonstrating the capability of this platform for simultaneous chemotactic and molecular analysis.The chip is expected to provide a powerful tool for investigating tumor heterogeneity and promoting clinical precision medicine. 展开更多
关键词 gold@silver nanoparticles surface enhanced Raman spectroscopy microfluidic chip single cell analysis two-dimensional(2D)phenotype profiling
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