The title compound （ethyl5-（4-（2-phenylacetamido）phenyl）-lH-pyrazole-3-carboxylate, C20H19N3O3） was synthesized by the reaction of Claisen condensation, cyclization, reduction and acylation. The structure was ch...The title compound （ethyl5-（4-（2-phenylacetamido）phenyl）-lH-pyrazole-3-carboxylate, C20H19N3O3） was synthesized by the reaction of Claisen condensation, cyclization, reduction and acylation. The structure was characterized by X-ray diffraction, MS, NMR and IR. It belongs to the monoclinic system, space group C2/c with a = 22.723（9）, b = 9.324（4）, c = 18.890（8） A, β = 114.259（6）°, V = 3649（3） A^3, Dc = 1.272 Mg·m^3, Z = 8, Mr = 349.38, p = 0.087 mm^-1, F（000） = 1472, the final R = 0.0615 and wR = 0.1643. The biological test shows that the title compound has a moderate acrosin inhibition activity.展开更多
The 7 (phenylacetamido)deacetoxycephalosporin acid was prepared by ring expansion of penicillin G sulfoxide via its trimethylsiliated intermediate(protective silylation with N,N dimethylsilylurea) using HBr 4 methy...The 7 (phenylacetamido)deacetoxycephalosporin acid was prepared by ring expansion of penicillin G sulfoxide via its trimethylsiliated intermediate(protective silylation with N,N dimethylsilylurea) using HBr 4 methylpyridine as catalyst. The effects of catal yst amount, reaction temperature and time were examined. Under optimum reaction condi tions product in 94% yield was obtained. The product has been characterized by IR and MS.展开更多
基金supported by the Science and technology support program of Jiangsu Province (2010, BE2010682)
文摘The title compound （ethyl5-（4-（2-phenylacetamido）phenyl）-lH-pyrazole-3-carboxylate, C20H19N3O3） was synthesized by the reaction of Claisen condensation, cyclization, reduction and acylation. The structure was characterized by X-ray diffraction, MS, NMR and IR. It belongs to the monoclinic system, space group C2/c with a = 22.723（9）, b = 9.324（4）, c = 18.890（8） A, β = 114.259（6）°, V = 3649（3） A^3, Dc = 1.272 Mg·m^3, Z = 8, Mr = 349.38, p = 0.087 mm^-1, F（000） = 1472, the final R = 0.0615 and wR = 0.1643. The biological test shows that the title compound has a moderate acrosin inhibition activity.
文摘The 7 (phenylacetamido)deacetoxycephalosporin acid was prepared by ring expansion of penicillin G sulfoxide via its trimethylsiliated intermediate(protective silylation with N,N dimethylsilylurea) using HBr 4 methylpyridine as catalyst. The effects of catal yst amount, reaction temperature and time were examined. Under optimum reaction condi tions product in 94% yield was obtained. The product has been characterized by IR and MS.
