Clinical and Experimental Study on Treatment of Fatty Liver of Phlegm-Dampness Stagnation Type by Zhiganle (脂肝乐) Capsule

Objective: To explore the mechanism of Zhiganle capsule (脂肝乐, ZGLC) in treating fattyliver of Phlegm-Dampness Stagnation type. Methods: One hundred and forty-six patients were treated withZGLC, the effects were observed and compared with those treated with Dongbao Gantai (DBGT, 东宝肝泰)tablets as control. The effect of ZGLC on ethionine induced hyperlipemia model rats was also observed. Results:The effect of ZGLC was obviously better than those of DBGT in relieving or removing symptoms, normalizingthe ultrasonic abnormal findings, lowering the serum levels of lipid and enzyme and improving hemorrheologicfunctions. Experimental study showed that ZGLC could reduce the blood lipids, inhibit the lipid deposition inliver. As compared with the model group, level of triglyceride in the ZGLC treatment group were much lowered(P < 0. of ) and the effect was better than those in the control group. Conclusions: ZGLC has the effect of reducing blood triglyceride level, inhibiting lipid deposition in liver and improving hemorrheologic function.Keywods: Zhiganle capsule; Phlegm--Dampness Stagnation; animal model of fatty liver

Mechanism of Guangdong Shenqu in regulating intestinal flora in mice with food stagnation and internal heat based on 16S rDNA sequencing Author links open overlay panel

Objective To investigate the effect of Guangdong Shenqu(GSQ)on intestinal flora structure in mice with food stagnation through 16S rDNA sequencing.Methods Mice were randomly assigned to control,model,GSQ low-dose(GSQL),GSQ medium-dose(GSQM),GSQ high-dose(GSQH),and lacidophilin tablets(LAB)groups,with each group containing 10 mice.A food stagnation and internal heat mouse model was established through intragastric administration of a mixture of beeswax and olive oil(1:15).The control group was administered normal saline,and the model group was administered beeswax and olive oil to maintain a state.The GSQL(2 g/kg),GSQM(4 g/kg),GSQH(8 g/kg),and LAB groups(0.625 g/kg)were administered corresponding drugs for 5 d.After administration,16S rDNA sequencing was performed to assess gut microbiota in mouse fecal samples.Results The model group exhibited significant intestinal flora changes.Following GSQ administration,the abundance and diversity index of the intestinal flora increased significantly,the number of bacterial species was regulated,andαandβdiversity were improved.GSQ administration increased the abundance of probiotics,including Clostridia,Lachnospirales,and Lactobacillus,whereas the abundance of conditional pathogenic bacteria,such as Allobaculum,Erysipelotrichaceae,and Bacteroides decreased.Functional prediction analysis indicated that the pathogenesis of food stagnation and GSQ intervention were primarily associated with carbohydrate,lipid,and amino acid metabolism,among other metabolic pathways.Conclusion The digestive mechanism of GSQ may be attributed to its role in restoring diversity and abundance within the intestinal flora,thereby improving the composition and structure of the intestinal flora in mice and subsequently influencing the regulation of metabolic pathways.

Clinical Observation of the Hot and Humid Compress Therapy of Traditional Chinese Medicine in the Treatment of Qi Stagnation and Blood Stasis Type of Lumbar Disc Herniation

Background: Although a number of studies have reported that the hot and humid compress from traditional Chinese medicine (TCM) is effective in treating lumbar disc herniation (LDH) with qi stagnation and blood stasis, clinical evidence is limited. Objective: The purpose of this study is to provide high-quality evidence to support the effectiveness of the traditional Chinese hot and humid compress in the treatment of LDH with qi stagnation and blood stasis. Methods: From October 2021 to November 2023, 86 patients with LDH of qi stagnation and blood stasis type were recruited in our hospital and divided into a control (n = 43) and an observation group (n = 43) according to the random number table method. The control group was given routine clinical treatment, and the observation group was treated with the hot and humid compress therapy for two weeks. The visual analogue scale (VAS) score, Japanese Orthopaedic Association (JOA) score, TCM syndrome score, serum interleukin-6 (IL-6), serum interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) were observed and compared between the two groups before and after treatment, and the clinical efficacy of the two groups was evaluated. Results: After treatment, the VAS score, TCM symptom score, and serum IL-6, IL-1β, and TNF-α levels decreased in both groups (P P P P P Conclusions: The hot and humid compress of traditional Chinese medicine can effectively relieve pain, restore lumbar function, improve TCM syndromes, reduce the level of inflammatory factors, and have a curative effect in treating LDH.

Clinical Efficacy of Modified Erchen Decoction on Cervical Spondylotic Vertebral Arteriopathy with Stagnation and Blockade of Phlegm-dampness Syndrome and Effects on Cerebral Blood Flow Parameters

OBJECTIVE: To observe the effect of Modified Erchen Decoction on cervical spondylotic vertebral arteriopathy with stagnation and blockade of phlegm-dampness syndrome and effects on cerebral blood flow parameters. METHODS: A total of 80 cervical spondylotic vertebral arteriopathy(CSA) patients with stagnation and blockade of phlegmdampness syndrome admitted to our hospital from October 2016 to April 2017 were selected and randomly divided into observation group and control group, with 40 cases in each group. The observation group was treated with Modified Erchen Decoction and the control group was given conventional treatment with Western medicine. After 4 weeks of treatment, the main clinical symptoms and signs(vertigo, neck and shoulder pain, headache, psychological and social adjustment, daily life and work) and cerebral blood flow parameters [the peak values of intracranial vertebral-basal artery diastolic blood flow velocity(Vd) and systolic blood flow velocity(Vp)] were compared between the 2 groups. The total clinical effective rate and adverse reactions during treatment were also compared. RESULTS: After treatment, the total effective rate of the observation group was 90.0%, which was significantly higher than that of the control group(77.5%). The difference between the two groups was statistically significant(P < 0.05). After treatment, The scores of vertigo, neck and shoulder pain, headache, psychology and society adaptation, daily life and work were significantly increased(P < 0.05), and the above scores of the observation group were increased more obviously. The difference between the groups was statistically significant(P < 0.05). After treatment, the levels of Vd and Vp were significantly increased(P < 0.05), and the increase of the above indexes was more obvious in the observation group. The difference between the 2 groups was statistically significant(P < 0.05). There were no significant abnormalities in blood routine, urine routine, liver function and renal function. There was no significant difference in the incidence of adverse reactions between the 2 groups.(P > 0.05). CONCLUSION: The treatment of vertebral artery type cervical spondylopathy with stagnation and blockade of phlegm-dampness syndrome by Modified Erchen Decoction can effectively relieve the main clinical symptoms and signs, improve cerebral blood flow parameters, and improve the peak values of vertebral-basal artery diastolic blood flow velocity(Vd) and systolic blood flow velocity(Vp), which is safe and effective, and helps to promote the recovery of cervical function.

The Effects of Thermal Radiation and Viscous Dissipation on the Stagnation Point Flow of a Micropolar Fluid over a Permeable Stretching Sheet in the Presence of Porous Dissipation

In this paper,the effects of thermal radiation and viscous dissipation on the stagnation–point flow of a micropolar fluid over a permeable stretching sheet with suction and injection are analyzed and discussed.A suitable similarity transformation is used to convert the governing nonlinear partial differential equations into a system of nonlinear ordinary differential equations,which are then solved numerically by a fourth–order Runge–Kutta method.It is found that the linear fluid velocity decreases with the enhancement of the porosity,boundary,and suction parameters.Conversely,it increases with the micropolar and injection parameters.The angular velocity grows with the boundary,porosity,and suction parameters,whereas it is reduced if the micropolar and injection parameters become larger.It is concluded that the thermal boundary layer extension increases with the injection parameter and decreases with the suction parameter.

Operational feasibility study of stagnation pressure reaction control for a mid-caliber non-spinning projectile

Controlled,guided munitions can reduce dispersion in the shot,while providing the capability of engaging both stationary and maneuvering targets.The Netherlands Organisation for Applied Scientific Research has developed a fin-less control technology called Stagnation Pressure Reaction Control(SPRC)that takes stagnation pressure air and directs it sideways to control non-spinning projectiles.In a previous study,this technology was demonstrated at Mach 2 wind-tunnel conditions to achieve up to 1.5°controllable angle of incidence for a non-spinning,aerodynamically unstable projectile-like test object.In an operational scenario,the decelerating projectile will experience a decline in control force while the simultaneous forward shift of the center of pressure increases the need for control force.Furthermore,angles of incidence exceeding 1.5°will be experienced under realistic flight conditions,especially against maneuvering targets.This work addresses these challenges and presents an operational feasibility study for a practical application of SPRC in a non-spinning mid-caliber gun-launched projectile,using experiment data on control latency and force of the earlier study.It illustrates the combined effect of the control-and stability dynamics and underlines the potential of an SPRC projectile as a precisionoperation ammunition.This research revealed that SPRC technology can stabilize and control the hypothesized projectile in a direct fire scenario against stationary and maneuvering targets.

Three-dimensional mixed convection stagnation-point fow past a vertical surface with second-order slip velocity

This study is concerned with the three-dimensional(3D)stagnation-point for the mixed convection flow past a vertical surface considering the first-order and secondorder velocity slips.To the authors’knowledge,this is the first study presenting this very interesting analysis.Nonlinear partial differential equations for the flow problem are transformed into nonlinear ordinary differential equations(ODEs)by using appropriate similarity transformation.These ODEs with the corresponding boundary conditions are numerically solved by utilizing the bvp4c solver in MATLAB programming language.The effects of the governing parameters on the non-dimensional velocity profiles,temperature profiles,skin friction coefficients,and the local Nusselt number are presented in detail through a series of graphs and tables.Interestingly,it is reported that the reduced skin friction coefficient decreases for the assisting flow situation and increases for the opposing flow situation.The numerical computations of the present work are compared with those from other research available in specific situations,and an excellent consensus is observed.Another exciting feature for this work is the existence of dual solutions.An important remark is that the dual solutions exist for both assisting and opposing flows.A linear stability analysis is performed showing that one solution is stable and the other solution is not stable.We notice that the mixed convection and velocity slip parameters have strong effects on the flow characteristics.These effects are depicted in graphs and discussed in this paper.The obtained results show that the first-order and second-order slip parameters have a considerable effect on the flow,as well as on the heat transfer characteristics.

Discussion on reprogramming of tumor energy metabolism and intervention of traditional Chinese medicine based on the theory of“collateral Q i stagnation”

The theory of stagnation of collateral Qi(Chinese medicine refers to the most fundamental and subtle substances thatconstitute the human body and maintain life activities,and also has the meaning of physiological functions)originates from the theory of collateral disease,which refers to the deficiency of Qi in the body’s collaterals,the loss of Qi and blood,and the failure of stagnation of collateral Qi,which leads to the loss of Qi,blood and body fluid,and the formation of pathological products such as deficiency,depression,phlegm,blood stasis in the local area,and ultimately damage the pathological process of collaterals.Based on the in-depth study of the pathogenesis of collateral Qi stagnation and the previous study of meridian channels,we believe that the key pathogenesis of the formation,evolution and spread of malignant tumors is“collateral Qi deficiency stagnation,collateral Qi stagnation and collateral Qi decay”.As an important energy resonance channel of the body,meridians play a key role in the process of material transformation and energy metabolism.It is believed that the small focus caused by the pathogenesis of stagnation is the cause of malignant transformation of tumor,the reprogramming of energy metabolism induced by the lesion of collateral Qi is the basis of the progress of tumor pathogenesis,and the formation of tumor microenvironment regulated by the tumor toxin vena is the root of alienation of tumor development.Guided by this theory,focusing on the correlation between collateral Qi and tumor energy metabolism,using Professor Hua Baojin's treatment method of“Regulating Qi and detoxifying”to prescribe drugs can adjust collateral Qi function,achieve the relative balance of internal environment,and then inhibit the progress of tumor.Based on the above understanding,this study tries to enlighten new diagnosis and treatment ideas under the guidance of“stagnation of collateral Qi”in traditional Chinese medicine,in order to provide some theoretical support for the intervention of traditional Chinese medicine in the process of tumor development.

Mechanism and numerical simulation of pressure stagnation during water jetting perforation

When perforating with an abrasive water jet, it is possible that the pressure in the hole （perforation） will be higher than that in the annulus because of water jet blasting against the hole wall, which also is the theoretical basis for the technology of hydro-jet fracturing. This paper analyzes the mechanism of generating pressure stagnation in water jet hole, and puts forward a new concept of hydroseal. Then, the distribution of pressure in the hole was simulated with the finite element method. The simulation results showed that the pressure in the hole was higher than that in the annulus. Also, the lower the annular pressure （confining pressure） and the higher the blasting pressure, the greater the pressure difference. An experiment indicated that the cement sample was lifted up under the pressure stagnation in the hole, which proved the finite element simulation results obviously.

A Clinical Study of Safflower Yellow Injection in Treating Coronary Heart Disease Angina Pectoris with Xin-Blood Stagnation Syndrome

Objective： To evaluate the clinical effect and safety of Safflower Yellow injection （SYI） in treating coronary heart disease angina pectoris （OHD-AP） with Xin-blood stagnation syndrome （XBSS）. Methods： Adopted was the multi-centered, randomized, positive parallel controlled method, 448 patients with CHD-AP-XBSS were enrolled and divided into two groups, 336 in the tested group treated with SYI and 112 in the control group treated with Salvia injection by intravenous dripping once a day for 14 days, so as to observe the conditions of angina, electrocardiogram, and therapeutic effect on traditinal Chinese medicine （TCM） symptoms as well as the safety of the treatment. Results： The significantly effective rate and total effective rate in the tested group were 60.06% （194/323） and 91.02 % （294/323） respectively; those in improvement of TOM symptoms were 40. 18% （129/321） and 75.23% （243/323） respectively, which were better than those in the control group （P〈0.01）. Conclusion： SYI Injection is effective and safe in treating OHD-AP-XBSS.

Change in internal energy of thermal diffusion stagnation point Maxwell nanofluid flow along with solar radiation and thermal conductivity

This paper concerns the characteristics of heat and mass transfer in upper convected Maxwell fluid flow over a linear stretching sheet with solar radiation,viscous desperation and temperature based viscosity.After boundary layer approximation,the governing equations are achieved(namely Maxwell,upper convected material derivative,thermal and concentration diffusions).By using the self-similarity transformations the governing PDEs are converted into nonlinear ODEs and solved by RK-4 method in combination with Newton Raphson(shooting technique).The effects of developed parameters on velocity,temperature,concentration,fraction factor,heat and mass diffusions are exemplified through graphs and tabular form and are deliberated in detail.Numerical values of fraction factor,heat and mass transfer rates with several parameters are computed and examined.It is noticed that the temperature is more impactable for higher values of radiative heat transport,thermal conductivity and viscous dissipation.The comparison data for some limiting case are acquired and are originated to be in good agreement with previously published articles.

Effects of variable properties on MHD heat and mass transfer flow near a stagnation point towards a stretching sheet in a porous medium with thermal radiation

The effect of variable viscosity and thermal conductivity on steady magnetohydrodynamic（MHD） heat and mass transfer flow of viscous and incompressible fluid near a stagnation point towards a permeable stretching sheet embedded in a porous medium are presented,taking into account thermal radiation and internal heat genberation/absorbtion.The stretching velocity and the ambient fluid velocity are assumed to vary linearly with the distance from the stagnation point.The Rosseland approximation is used to describe the radiative heat flux in the energy equation.The governing fundamental equations are first transformed into a system of ordinary differential equations using a scaling group of transformations and are solved numerically by using the fourth-order Rung-Kutta method with the shooting technique.A comparison with previously published work has been carried out and the results are found to be in good agreement.The results are analyzed for the effect of different physical parameters,such as the variable viscosity and thermal conductivity,the ratio of free stream velocity to stretching velocity,the magnetic field,the porosity,the radiation and suction/injection on the flow,and the heat and mass transfer characteristics.The results indicate that the inclusion of variable viscosity and thermal conductivity into the fluids of light and medium molecular weight is able to change the boundary-layer behavior for all values of the velocity ratio parameter λ except for λ = 1.In addition,the imposition of fluid suction increases both the rate of heat and mass transfer,whereas fluid injection shows the opposite effect.

An application of interacting shear flows theory: exact solution for unsteady oblique stagnation point flow

An analytical solution of the governing equations of the interacting shear flows for unsteady oblique stagnation point flow is obtained. It has the same form as that of the exact solution obtained from the complete NS equations and physical analysis and relevant discussions are then presented.

Wavelet analysis of stagnation point flow of non-Newtonian nanofluid

The wavelet approach is introduced to study the influence of the natural convection stagnation point flow of the Williamson fluid in the presence of thermophysical and Brownian motion effects. The thermal radiation effects are considered along a permeable stretching surface. The nonlinear problem is simulated numerically by using a novel algorithm based upon the Chebyshev wavelets. It is noticed that the velocity of the Williamson fluid increases for assisting flow cases while decreases for opposing flow cases when the unsteadiness and suction parameters increase, and the magnetic effect on the velocity increases for opposing flow cases while decreases for assisting flow cases. When the thermal radiation parameter, the Dufour number, and Williamson’s fluid parameter increase, the temperature increases for both assisting and opposing flow cases. Meanwhile, the temperature decreases when the Prandtl number increases. The concentration decreases when the Soret parameter increases, while increases when the Schmidt number increases. It is perceived that the assisting force decreases more than the opposing force. The findings endorse the credibility of the proposed algorithm, and could be extended to other nonlinear problems with complex nature.

Melting heat transfer effects on stagnation point flow of micropolar fluid saturated in porous medium with internal heat generation(absorption)

The effect of melting heat transfer on the two dimensional boundary layer flow of a micropolar fluid near a stagnation point embedded in a porous medium in the presence of internal heat generation/absorption is investigated. The governing non-linear partial differential equations describing the problem are reduced to a system of non-linear ordinary differential equations using similarity transformations solved numerically using the Chebyshev spectral method. Numerical results for velocity, angular velocity and temperature profiles are shown graphically and discussed for different values of the inverse Darcy number, the heat generation/absorption parameter, and the melting parameter. The effects of the pertinent parameters on the local skin-friction coefficient, the wall couple stress, and the local Nusselt number are tabulated and discussed. The results show that the inverse Darcy number has the effect of enhancing both velocity and temperature and suppressing angular velocity. It is also found that the local skin-friction coefficient decreases, while the local Nusselt number increases as the melting parameter increases.

Partial slip effect on non-aligned stagnation point nanofluid over a stretching convective surface

The present study inspects the non-aligned stagnation point nano fluid over a convective surface in the presence of partial slip. Two types of base fluids namely water and kerosene are selected with Cu nanoparticles. The governing physical problem is presented and transformed into a system of coupled nonlinear differential equations using suitable similarity transformations. These equations are then solved numerically using midpoint integration scheme along with Richardson extrapolation via Maple. Impact of relevant physical parameters on the dimensionless velocity and temperature profiles are portrayed through graphs. Physical quantities such as local skin frictions co-efficient and Nusselt numbers are tabularized.It is detected from numerical computations that kerosene-based nano fluids have better heat transfer capability compared with water-based nanofluids. Moreover it is found that water-based nanofluids offer less resistance in terms of skin friction than kerosene-based fluid. In order to authenticate our present study, the calculated results are compared with the prevailing literature and a considerable agreement is perceived for the limiting case.

Plasma L-ENK, AVP, ANP and serum gastrin in patients with syndrome of Liver-Qi-stagnation

AIM To investigate the pathophysiologic basis of syndrome of Liver Qi stagnation and parameters for clinical differentiation. METHODS Plasma L ENK, AVP, ANP and serum gastrin were determined by RIA in 84 patients with neurasthenia, mastodynia, chronic gastritis, and chronic cholecystitis presenting the same syndrome of Liver Qi stagnation in traditional Chinese medicine (TCM). Healthy subjects served as controls in comparison with patients having the same syndrome but with different diseases. RESULTS Among the patients with Liver Qi stagnation, the plasma L ENK, ANP and gastrin levels were 38 83ng/L ± 6 32ng/L , 104 11ng/L ± 29 01ng/L and 32 20ng/L ± 6 68ng/L , being significantly lower than those in the healthy controls ( t =3 34, 6 17, 4 48; P <0 01). The plasma AVP of the patient group ( 52 82ng/L ± 19 09ng/L ) was significantly higher than that of the healthy controls ( t =5 79, P <0 01). The above changes in patients having the same symptom complex but different diseases entities showed no significant differences, P >0 05. CONCLUSION The syndrome of Liver Qi stagnation is closely related to the emotional modulatory abnormality of the brain, with decrease of plasma L ENK, ANP and gastrin, and increase of plasma AVP as the important pathophysiologic basis.

Momentum and heat transfer of a special case of the unsteady stagnation-point flow

This paper investigates the unsteady stagnation-point flow and heat transfer over a moving plate with mass transfer,which is also an exact solution to the unsteady Navier-Stokes(NS)equations.The boundary layer energy equation is solved with the closed form solutions for prescribed wall temperature and prescribed wall heat flux conditions.The wall temperature and heat flux have power dependence on both time and spatial distance.The solution domain,the velocity distribution,the flow field,and the temperature distribution in the fluids are studied for different controlling parameters.These parameters include the Prandtl number,the mass transfer parameter at the wall,the wall moving parameter,the time power index,and the spatial power index.It is found that two solution branches exist for certain combinations of the controlling parameters for the flow and heat transfer problems.The heat transfer solutions are given by the confluent hypergeometric function of the first kind,which can be simplified into the incomplete gamma functions for special conditions.The wall heat flux and temperature profiles show very complicated variation behaviors.The wall heat flux can have multiple poles under certain given controlling parameters,and the temperature can have significant oscillations with overshoot and negative values in the boundary layers.The relationship between the number of poles in the wall heat flux and the number of zero-crossing points is identified.The difference in the results of the prescribed wall temperature case and the prescribed wall heat flux case is analyzed.Results given in this paper provide a rare closed form analytical solution to the entire unsteady NS equations,which can be used as a benchmark problem for numerical code validation.

Analytical solution to stagnation-point flow and heat transfer over a stretching sheet based on homotopy analysis

This paper is concerned with two-dimensional stagnation-point steady flow of an incompressible viscous fluid towards a stretching sheet whose velocity is proportional to the distance from the slit. The governing system of partial differential equations is first transformed into a system of dimensionless ordinary differential equations. Analytical solutions of the velocity distribution and dimensionless temperature profiles are obtained for different ratios of free stream velocity and stretching velocity, Prandtl number, Eckert number and dimensionality index in series forms using homotopy analysis method（HAM）. It is shown that a boundary layer is formed when the free stream velocity exceeds the stretching velocity, and an inverted boundary layer is formed when the free stream velocity is less than the stretching velocity. Graphs are presented to show the effects of different parameters.

MHD stagnation point flow towards heated shrinking surface subjected to heat generation/absorption

The magnetohydrodynamic （MHD） stagnation point flow of micropolar flu- ids towards a heated shrinking surface is analyzed. The effects of viscous dissipation and internal heat generation/absorption are taken into account. Two explicit cases, i.e., the prescribed surface temperature （PST） and the prescribed heat flux （PHF）, are discussed. The boundary layer flow and energy equations are solved by employing the homotopy analysis method. The quantities of physical interest are examined through the presenta- tion of plots/tabulated values. It is noticed that the existence of the solutions for high shrinking parameters is associated closely with the applied magnetic field.