The redox cofactor𝛽-nicotinamide adenine dinucleotide(NAD)has been revealed to serve as a building block for the biosynthesis of an alkaloid natural product,altemicidin.The biosynthetic pathway investigation i...The redox cofactor𝛽-nicotinamide adenine dinucleotide(NAD)has been revealed to serve as a building block for the biosynthesis of an alkaloid natural product,altemicidin.The biosynthetic pathway investigation identified a unique pyridoxal pyrophosphate(PLP)-dependent enzyme that utilizes NAD and S-adenosylmethionine(SAM)to build the bicyclic alkaloid scaffold,opening the door for biosynthetic studies of NAD-derived natural products.展开更多
基金supported by the National Natural Science Foundation of China(22177092,82003631)the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2020R01004)to L.Z.
文摘The redox cofactor𝛽-nicotinamide adenine dinucleotide(NAD)has been revealed to serve as a building block for the biosynthesis of an alkaloid natural product,altemicidin.The biosynthetic pathway investigation identified a unique pyridoxal pyrophosphate(PLP)-dependent enzyme that utilizes NAD and S-adenosylmethionine(SAM)to build the bicyclic alkaloid scaffold,opening the door for biosynthetic studies of NAD-derived natural products.
