Simultaneous determination of 20 food additives by high performance liquid chromatography with photo-diode array detector

An efficient and accurate analytical method was developed for the simultaneous determination of 20 synthetic food additives, including three sweeteners,seven food colorants,nine synthetic preservatives and caffeine,by high performance liquid chromatography （HPLC） with photodiode array detector（PDA）.This method permits the detection of food additives at very low concentrations（0.005-0.150μg/mL）.The applicability was verified by the determination of food additives present in various foodstuffs.

Test system of the front-end readout for an application-specific integrated circuit for the water Cherenkov detector array at the large high-altitude air shower observatory

The water Cherenkov detector array(WCDA) is an important part of the large high-altitude air shower observatory(LHAASO),which is in a research and development phase.The central scientific goal of LHAASO is to explore the origin of high-energy cosmic rays of the universe and to push forward the frontier of new physics.To simplify the WCDA's readout electronics,a prototype of a front-end readout for an application-specific integrated circuit(ASIC) is designed based on the timeover-threshold method to achieve charge-to-time conversion.High-precision time measurement and charge measurement are necessary over a full dynamic range[1-4000photoelectrons(P.E.)].To evaluate the performance of this ASIC,a test system is designed that includes the front-end ASIC test module,digitization module,and test software.The first module needs to be customized for different ASIC versions,whereas the digitization module and test software are tested for general-purpose use.In the digitization module,a field programmable gate array-based time-todigital converter is designed with a bin size of 333 ps,which also integrates an inter-integrated circuit to configure the ASIC test module,and a universal serial bus interface is designed to transfer data to the remote computer.Test results indicate that the time resolution is better than 0.5 ns,and the charge resolution is better than 30%root mean square(RMS) at 1 P.E.and 3%RMS at 4000 P.E.,which are beyond the application requirements.

The effects of beam drifts on elastic scattering measured by the large solid-angle covered detector array

A new detector array characterized by compact structure and large solid-angle coverage was designed for radioactive ion beam(RIB)experiments and measuring multi-particle correlations.A Monte Carlo simulation was performed to explore the effects of beam drifts in different directions and distances on the angular distribution of the Rutherford scattering,as measured by the detector array.The results indicate that when the beam drift distance is less than 2.0 mm,the symmetry of the detector array can maintain a count error of less than 5%.This confirms the property of the detector array for RIB experiments.Furthermore,the simulation was validated through the elastic scattering angular distributions of 6;7 Li measured by the detector array in 6;7Li t209 Bi experiments at different energies.

Silicon detector array for radioactive beam experiments at HIRFL-RIBLL

A new and innovative detector system based on a silicon strip detector dedicated to the study of the reaction induced by lighter radioactive beams is described herein.The detector system consists of five sets of three types of telescopes,which are successfully used to measure the angular distributions of both elastic scattering and breakup simultaneously, on the Radioactive Ion Beam Line in Lanzhou at Heavy Ion Research Facility in Lanzhou. This silicon detector array is used to measure the elastic scattering angular distributions of ^(11) Be on a ^(208) Pb target at E_(lab) = 140 and 209 MeV. A comparison of the Monte Carlo simulations with the experimental results shows a reasonable consistency.

Quantification of six bioactive compounds in Zhenqi Fuzheng preparation by high-performance liquid chromatography coupled with diode array detector and evaporative light scattering detector

A simple and accurate high-performance liquid chromatography（HPLC）coupled with diode array detector（DAD）and evaporative light scattering detector（ELSD）was established for the determination of six bioactive compounds in Zhenqi Fuzheng preparation（ZFP）.The monitoring wavelengths were 254,275 and 328 nm.Under the optimum conditions,good separation was achieved,and the assay was fully validated in respect of precision,repeatability and accuracy.The proposed method was successfully applied to quantify the six ingredients in 31 batches of ZFP samples and evaluate the variation by hierarchical cluster analysis（HCA）,which demonstrated significant variations on the content of these compounds in the samples from different manufacturers with different preparation procedures.The developed HPLC method can be used as a valid analytical method to evaluate the intrinsic quality of this preparation.

Reformatted method for two-dimensional detector arrays measurement data in proton pencil beam scanning

The spatial resolution of a commercial two-dimensional(2D)ionization chamber(IC)array is limited by the size of the individual detector and the center-to-center distance between sensors.For dose distributions with areas of steep dose gradients,inter-detector dose values are derived by the interpolation of nearby detector readings in the conventional mathematical interpolation of 2D IC array measurements.This may introduce significant errors,particularly in proton spot scanning radiotherapy.In this study,by combining logfile-based reconstructed dose values and detector measurements with the Laplacian pyramid image blending method,a novel method is proposed to obtain a reformatted dose distribution that provides an improved estimation of the delivered dose distribution with high spatial resolution.Meanwhile,the similarity between the measured original data and the downsampled logfilebased reconstructed dose is regarded as the confidence of the reformatted dose distribution.Furthermore,we quantify the performance benefits of this new approach by directly comparing the reformatted dose distributions with 2D IC array detector mathematically interpolated measurements and original low-resolution measurements.The result shows that this new method is better than the mathematical interpolation and achieves gamma pass rates similar to those of the original low-resolution measurements.The reformatted dose distributions generally yield a confidence exceeding 95%.

Dosimetric Comparison of Amorphous Silicon EPID and 2D Array Detector for Pre-Treatment Verification of Intensity Modulated Radiation Therapy

Purpose: To study the dosimetric characteristics of amorphous silicon Electronic Portal Imaging Device EPID and 2D array detector for dose verification of radiotherapy treatment plans, and the quality assurance QA testing of IMRT was investigated. Materials and methods: All measurements were done with Varian IX linear accelerator, aSi-1000 EPID and 2D array detector. The dose linearity, reproducibility, output factors, dose rate, SDD and response with slap phantom thickness have been measured and compared against those measured by ion chamber. Results: The characteristics of EPID and 2D array: the response of EPID agreed with 2D array and ion chamber 0.6cc. EPID and 2D array showed short-term output reproducibility with SD = 0.1%. The dose rates of 2D array SD = ±0.7%, EPID = ±0.4% compared with a 0.6 cc SD = ±0.5%. Output factor measurements for the central chamber of the EPID and 2D array showed no considerable deviation from ion chamber measurements. Measurement of beam profiles with the EPID and 2D array matched very well with the ion chamber measurements in the water phantom. The EPID is more sensitive to lower energy photons by increasing solid water phantom thickness. The mean and standard deviation passing rates (γ%≤1) for film, 2D array and EPID for 30 IMRT fields of five patients were 95.93 ± 0.96%, 99.05 ± 0.24%, and 99.37 ± 0.12%, respectively. Conclusion: The study shows that EPID and 2D array are a reliable and accurate dosimeter and a useful tool for quality assurance. We found that the EPID was more accurate compared with both 2D array and ion chamber. The gamma criterion of 3%/3 mm is the most suitable criteria for IMRT plans of QA.

CsI-bowl:an ancillary detector for exit channel selection inγ-ray spectroscopy experiments

A particle detector array designed for light-charged particles, known as the CsI-bowl, was built for exit channel selection for in-beam γ-ray spectroscopy experiments. This device is composed of 64 CsI(Tl) detectors, organized in a structure reminiscent of a tea-bowl. High quantum efficiency photodiodes, characterized by their minimal mass, were employed to collect scintillation light. Its design, construction, particle identification resolution, and its effectiveness in relation to exit channel selection are described in this paper. In source tests, the optimal figure of merit for the identification of α-particles and γ-rays using the charge comparison method was found to be 3.3 and 12.1 for CsI detectors coupled to photodiodes and avalanche photodiodes, respectively. The CsI-bowl demonstrated effectiveness in identifying particles, specifically the emission of protons and α-particles in the58Ni(19F, xpyn) fusion–evaporation reaction, thereby enabling the selection of the desired exit channels.

Performance of superconducting nanowire single-photon detector with the fan coupling antenna array

The performance of superconducting nanowire single-photon detector （SNSPD） involving niobium nitride with the fan coupling antenna array is analyzed. The SNSPD has a high detection efficiency and counting rate. Hydrogen silsesquioxane and niobium nitride are filled in the gold grating deposited on the substrate in which the fan coupling antenna arrays are embedded. By changing the position of the fan coupling antenna array, the maximum area of optical intensity is obtained and the photon collection efficiency is increased by 26.5 times. The detection efficiency of SNSPD is improved without changing the detection speed. These parameters are important for designing a practical single-photon detector,

Design and Imaging Application of Room-Temperature Terahertz Detector with Micro-Bolometer Focal Plane Array

Room-temperature terahertz （THz） detectors indicate a great potential in the imaging application because of their real-time, compact bulk, and wide spectral band responding characteristics. THz detectors with different dimensions based on a micro-bridge structure have been designed and fabricated to get optimized micro-bolometer parameters from the test results of membrane deformation. A nanostructured titanium （Ti） thin film absorber is integrated in the micro-bridge structure of the VOx micro-bolometer by a combined process of magnetron sputtering and reactive ion etching （RIE）, and its improvement of THz absorption is verified by an optical characteristics mesurement. Continuous-wave THz detection and imaging are demonstrated by using a 2.52 THz far infrared CO2 laser and a 320x240 vanadium oxide micro-bolometer focal plane array with an optimized cell structure. With this detecting system, THz imaging of metal concealed in a wiping cloth and an envelope is demonstrated, respectively.

High-Throughput Powder Diffraction Using White X-Ray Beam and a Simulated Energy-Dispersive Array Detector

High-throughput powder X-ray diffraction(XRD)with white X-ray beam and an energy-dispersive detector array is demonstrated in this work on a CeO;powder sample on a bending magnet synchrotron beamline at the Shanghai Synchrotron Radiation Facility(SSRF),using a simulated energy-dispersive array detector consisting of a spatially scanning silicon-drift detector(SDD).Careful analysis and corrections are applied to account for various experimental hardware-related and diffraction angle-related factors.The resulting diffraction patterns show that the relative strength between different diffraction peaks from energy-dispersive XRD(EDXRD)spectra is consistent with that from angle-resolved XRD(ARXRD),which is necessary for analyzing crystal structures for unknown samples.The X-ray fluorescence(XRF)signal is collected simultaneously.XRF counts from all pixels are integrated directly by energy,while the diffraction spectra are integrated by d-spacing,resulting in a much improved peak strength and signal-to-noise(S/N)ratio for the array detector.In comparison with ARXRD,the diffraction signal generated by a white X-ray beam over monochromic light under the experimental conditions is about 104 times higher.The full width at half maximum(FWHM)of the peaks in q-space is found to be dependent on the energy resolution of the detector,the angle span of the detector,and the diffraction angle.It is possible for EDXRD to achieve the same or even smaller FWHM as ARXRD under the energy resolution of the current detector if the experimental parameters are properly chosen.

Gamma-Index Passing Rates in Baseline Plans Measured with a Detector Array

Purpose: This study provides a simple protocol for validation of the gamma passing rates and to identify the optimum values of % dose and mm criteria for dose distributions measured with a detector array. Methods: We chose ArcCHECK detector array to illustrate the concepts. We used plans with uniform or quasi-uniform dose distributions along the detector array for testing in the presence of dose errors. For testing sensitivity to spatial shift we employed a plan with approximately constant dose gradient along the axis of the instrument. Results: We identified a representative set of parameters which describe performance of a detector array. We determined the minimum gamma-index acceptance criteria allowing the passing rates to reach 100% in the absence of errors, and identified the minimum fully detectable errors for such criteria. For our baseline plans delivered to ArcCHECK, 100% passing rates were obtained for 1.5% dose criterion together with ±3% minimum error detectable at 100% rate, and for 1.5 mm criterion together with the minimum fully detectable error of ±3 mm. We inspected the impact of selected program options on the passing rates. Conclusions: The protocol we developed provides a simple method of commissioning-style analysis of a detector array without a need for analysis of a large number of clinical plans.

Design and development of multi-channel front end electronics based on dual-polarity charge-to-digital converter for SiPM detector applications

With the development of silicon photomultiplier(SiPM)technology,front-end electronics for SiPM signal processing have been highly sought after in various fields.A compact 64-channel front-end electronics(FEE)system achieved by fieldprogrammable gate array-based charge-to-digital converter(FPGA-QDC)technology was built and developed.The FEE consists of an analog board and FPGA board.The analog board incorporates commercial amplifiers,resistors,and capacitors.The FPGA board is composed of a low-cost FPGA.The electronics performance of the FEE was evaluated in terms of noise,linearity,and uniformity.A positron emission tomography(PET)detector with three different readout configurations was designed to validate the readout capability of the FEE for SiPM-based detectors.The PET detector was made of a 15×15 lutetium–yttrium oxyorthosilicate(LYSO)crystal array directly coupled with a SiPM array detector.The experimental results show that FEE can process dual-polarity charge signals from the SiPM detectors.In addition,it shows a good energy resolution for 511-keV gamma photons under the dual-end readout for the LYSO crystal array irradiated by a Na-22 source.Overall,the FEE based on FPGA-QDC shows promise for application in SiPM-based radiation detectors.

Compact 16-channel integrated charge-sensitive preamplifier module for silicon strip detectors

In this study,a compact 16-channel integrated charge-sensitive preamplifier named the smart preamplifier(SPA)was developed to support the large-scale detector array used in modern nuclear physics experiments.Two types of SPA,namely SPA02 and SPA03(with external field effect transistor),have been manufactured to match silicon detectors with small and large capacitances,respectively.The characteristics of the SPA include fast response of typically less than 6 ns for pulse rising time and low equivalent noise of 1.5 keV at zero input capacitance.The energy sensitivity and pulse decay time can be easily adjusted by changing the feedback capacitance Cfand resistance Rfin various applications.A good energy resolution of 24.4 keV for 5.803-MeV alpha particles from 244 Cm was achieved using a small-sized Si-PIN detector;for the silicon strip detectors in the test with the alpha source,a typical energy resolution of 0.6–0.8%was achieved.The integrated SPA has been employed in several experiments of silicon strip detectors with hundreds of channels,and a good performance has been realized.

Design of Diode Type Un-Cooled Infrared Focal Plane Array Readout Circuit

The diode infrared focal plane array uses the silicon diodes as a sensitive device for infrared signal measurement. By the infrared radiation, the infrared focal plane can produces small voltage signals. For the traditional readout circuit structures are designed to process current signals, they cannot be applied to it. In this paper, a new readout circuit for the diode un-cooled infrared focal plane array is developed. The principle of detector array signal readout and small signal amplification is given in detail. The readout circuit is designed and simulated by using the Central Semiconductor Manufacturing Corporation （CSMC） 0.5 μm complementary metal-oxide-semiconductor transistor （CMOS） technology library. Cadence Spectre simulation results show that the scheme can be applied to the CMOS readout integrated circuit （ROIC） with a larger array, such as 320×240 size array.

Thermal and mechanical characterizations of a substrate-free focal plane array

We propose a substrate-free focal plane array （FPA） and the microcantilevers extend from a supporting frame. in this paper. The solid substrate is completely removed, Using finite element analysis, the thermal and mechanical characterizations of the substrate-free FPA are presented. Because of the large decrease in thermal conductance, the supporting frame is temperature dependent, which brings out a unique feature： the lower the thermal conductance of the supporting frame is, the higher the energy conversion efficiency in the substrate-free FPA will be. The results from the finite element analyses are consistent with our measurements： two types of substrate-free FPAs with pixel sizes of 200×200 and 60×60 um^2 are implemented in the proposed infrared detector. The noise equivalent temperature difference （NETD） values are experimentally measured to be 520 and 300 mK respectively. Further refinements are considered in various aspects, and the substrate-free FPA with a pixel size of 30×30 um^2 has a potential of achieving an NETD value of 10 mK.

Design and FPGA-Implementation of Minimum PED Based K-Best Algorithm in MIMO Detector

Minimum Partial Euclidean Distance (MPED) based K-best algorithm is proposed to detect the best signal for MIMO (Multiple Input Multiple Output) detector. It is based on Breadth-first search method. The proposed algorithm is independent of the number of transmitting/receiving antennas and constellation size. It provides a high throughput and reduced Bit Error Rate (BER) with the performance close to Maximum Likelihood Detection (MLD) method. The main innovations are the nodes that are expanded and visited based on MPED algorithm and it keeps track of finally selecting the best candidates at each cycle. It allows its complexity to scale linearly with the modulation order. Using Quadrature Amplitude Modulation (QAM) the complex domain input signals are modulated and are converted into wavelet packets and these packets are transmitted using Additive White Gaussian Noise (AWGN) channel. Then from the number of received signals the best signal is detected using MPED based K-best algorithm. It provides the exact best node solution with reduced complexity. The pipelined VLSI architecture is the best suited for implementation because the expansion and sorting cores are data driven. The proposed method is implemented targeting Xilinx Virtex 5 device for a 4 × 4, 64-QAM system and it achieves throughput of 1.1 Gbps. The results of resource utilization are tabulated and compared with the existing algorithms.

Identification and determination of the major constituents in traditional Chinese medicine Longdan Xiegan Pill by HPLC-DAD-ESI-MS

A novel and sensitive HPLC-UV method has been developed for the simultaneous determination of twelve major compounds in Longdan Xiegan Pill.The chemical profile of the twelve compounds,including geniposidic acid（1）,geniposide（2）,gentiopicroside（3）,liquiritin（4）,crocin（5）,baicalin（6）,wogonoside（7）,baicalein（8）,glycyrrhizic acid（9）,wogonin（10）,oroxylin A（11）and aristolochic acid A（12）,was acquired using high-performance liquid chromatography-diode array detector coupled with an electrospray tandem mass spectrometer（HPLC-DAD-ESI-MS）.The analysis was performed on a Dikma Platisil ODS C18 column（250 mm×4.6 mm,5 μm）with a gradient solvent system of acetonitrile-0.1% aqueous formic acid.The validation was carried out and the linearities（r〉0.9996）,repeatability（RSD〈1.8%）,intra-and inter-day precision（RSD〈1.3%）,and recoveries（ranging from 96.6% to 103.4%）were acceptable.The limits of detection（LOD）of these compounds ranged from 0.29 to 4.17 ng.Aristolochic acid A,which is the toxic ingredient,was not detected in all the batches of Longdan Xiegan Pill.Furthermore,hierarchical cluster analysis was used to evaluate the variation of the herbal prescription.The proposed method is simple,effective and suitable for the quality control of this traditional Chinese medicine（TCM）.

Multi-area detection sensitivity calculation model and detection blind areas influence analysis of photoelectric detection target

Multi-element array photoelectric detector is the core devices to form a photoelectric detection target with a large field of view.This photoelectric detection target brings about the problem of uneven detection sensitivity distribution in the detection screen.To improve the uneven detection sensitivity of this photoelectric detection target,this paper analyzes the distribution law of the uneven detection sensitivity of the photoelectric detection target using the multi-element array photoelectric detector,dissects the main factors affecting the detection sensitivity according to the photoelectric detection principle,establishes the calculation model of detection sensitivity of the photoelectric detection target in the different detection areas and proposes a method to improve the detection sensitivity by compensating the gain of each unit photoelectric detector.The analysis of simulation and experimental results show that the proposed method of photoelectric detection target can effectively improve the output signal amplitude of the projectile under the certain detection distance,in particular,the output signal amplitude of the projectile is significantly increased when the projectile passes through the detection blind area.The experimental results are consistent with the simulation results,which verify the effectiveness of the proposed improvement method.

Performance of the muon detector A under TIBET Ⅲ array

In order to observe gamma rays in the 100 TeV energy region, the 4500 m2 underground muon detector array using water Cherenkov technique is constructed, forming the TIBET Ⅲ＋MD hybrid array. Because the showers induced by primary gamma rays contain much fewer muons than those induced by primary hadrons, significant improvement of the gamma ray sensitivity for TIBET Ⅲ＋MD array is expected. In this paper, the design and performance of the MD-A detector with large Tyvek bag is reported.