The probe-assisted integration of imaging and therapy into a single modality offers significant advantages in bio-applications. As a newly developed photoacoustic （PA） mechanism, plasmon-mediated nanocavitation, whe...The probe-assisted integration of imaging and therapy into a single modality offers significant advantages in bio-applications. As a newly developed photoacoustic （PA） mechanism, plasmon-mediated nanocavitation, whereby photons are effectively converted into PA shockwaves, has excellent advantages for image-guided therapy. In this study, by simulating the laser absorption, temperature field, and nanobubble dynamics using both finite-element analysis and computational fluid dynamics, we quantified the cavitation-induced PA conversion efficiency of a water-immersed gold nanosphere, revealing new insights. Interestingly, sequential multi-bubble emission accompanied by high PA signal production occur under a single high-dose pulse of laser irradiation, enabling a cavitation-induced PA conversion efficiency up to 2%, which is -50 times higher than that due to thermal expansion. The cavitation-induced PA signal has unique frequency characteristics, which may be useful for a new approach for in vivo nanoparticle tracking. Our work offers theoretical guidance for accurate diagnosis and controllable therapy based on plasmon-mediated nanocavitation.展开更多
As a frontier imaging technique for biomedical applications,photoacoustic(PA)imaging has been developed rapidly.The development of new design strategies and excellent PA imaging reagents to boost PA conversion is eage...As a frontier imaging technique for biomedical applications,photoacoustic(PA)imaging has been developed rapidly.The development of new design strategies and excellent PA imaging reagents to boost PA conversion is eagerly desirable for high quality PA imaging but complicated to realize.Herein,we develop a new strategy in which PA imaging reagents with better properties can be easily optimized by polymerization.A series of new PA imaging reagents were designed and synthesized.The polymerization strategy can effectively promote the PA signal by specifically increasing the thermal-to-acoustic conversion efficiency.As these materials shared the same building units,the optimized effectiveness of polymerization strategy in terms of near-infrared light-harvesting capacity and thermal-to-acoustic conversion efficiency are discussed,rationally.The polymers with intense intramolecular motion exhibit an amplified PA signal by elevating thermal-to-acoustic conversion and its higher light-harvesting capability at redshifted region.The simultaneously strong PA signal and photothermal conversion efficiency of p-TTmB NPs enable precise PA imaging and effective photothermal therapy.This work highlights a simple and available design guideline of polymerization for amplifying the PA effect and optimizing existing materials.展开更多
文摘The probe-assisted integration of imaging and therapy into a single modality offers significant advantages in bio-applications. As a newly developed photoacoustic （PA） mechanism, plasmon-mediated nanocavitation, whereby photons are effectively converted into PA shockwaves, has excellent advantages for image-guided therapy. In this study, by simulating the laser absorption, temperature field, and nanobubble dynamics using both finite-element analysis and computational fluid dynamics, we quantified the cavitation-induced PA conversion efficiency of a water-immersed gold nanosphere, revealing new insights. Interestingly, sequential multi-bubble emission accompanied by high PA signal production occur under a single high-dose pulse of laser irradiation, enabling a cavitation-induced PA conversion efficiency up to 2%, which is -50 times higher than that due to thermal expansion. The cavitation-induced PA signal has unique frequency characteristics, which may be useful for a new approach for in vivo nanoparticle tracking. Our work offers theoretical guidance for accurate diagnosis and controllable therapy based on plasmon-mediated nanocavitation.
基金supported by the National Key R&D Program of China (Intergovernmental Cooperation Project, 2017YFE0132200)the National Natural Science of Fundation of China (Nos.51961160730, 51873092, and 81921004)+1 种基金the Fundamental Research Funds for the Central Universitiesthe Tianjin Science Fund for Distinguished Young Scholars (19JCJQJC61200)
文摘As a frontier imaging technique for biomedical applications,photoacoustic(PA)imaging has been developed rapidly.The development of new design strategies and excellent PA imaging reagents to boost PA conversion is eagerly desirable for high quality PA imaging but complicated to realize.Herein,we develop a new strategy in which PA imaging reagents with better properties can be easily optimized by polymerization.A series of new PA imaging reagents were designed and synthesized.The polymerization strategy can effectively promote the PA signal by specifically increasing the thermal-to-acoustic conversion efficiency.As these materials shared the same building units,the optimized effectiveness of polymerization strategy in terms of near-infrared light-harvesting capacity and thermal-to-acoustic conversion efficiency are discussed,rationally.The polymers with intense intramolecular motion exhibit an amplified PA signal by elevating thermal-to-acoustic conversion and its higher light-harvesting capability at redshifted region.The simultaneously strong PA signal and photothermal conversion efficiency of p-TTmB NPs enable precise PA imaging and effective photothermal therapy.This work highlights a simple and available design guideline of polymerization for amplifying the PA effect and optimizing existing materials.
