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Intravascular photoacoustic and optical coherence tomography imaging dual-mode system for detecting spontaneous coronary artery dissection: A feasibility study 被引量:1
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作者 Yongwei Wang Yuyang Wan Zhongjiang Chen 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2024年第1期77-86,共10页
In this work,we present an intravascular dual-mode endoscopic system capable of both intravascular photoacoustic imaging(IVPAI)and intravascular optical coherence tomography(IVOCT)for recognizing spontaneous coronary ... In this work,we present an intravascular dual-mode endoscopic system capable of both intravascular photoacoustic imaging(IVPAI)and intravascular optical coherence tomography(IVOCT)for recognizing spontaneous coronary artery dissection(SCAD)phantoms.IVPAI provides high-resolution and high-penetration images of intramural hematoma(IMH)at different depths,so it is especially useful for imaging deep blood clots associated with imaging phantoms.IVOCT can readily visualize the double-lumen morphology of blood vessel walls to identify intimal tears.We also demonstrate the capability of this dual-mode endoscopic system using mimicking phantoms and biological samples of blood clots in ex vivo porcine arteries.The results of the experiments indicate that the combined IVPAI and IVOCT technique has the potential to provide a more accurate SCAD assessment method for clinical applications. 展开更多
关键词 Spontaneous coronary artery dissection(SCAD) intravascular optical coherence tomography(IVOCT) intravascular photoacoustic imaging(IVPAI)
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Isoindigo nanoparticles for photoacoustic imaging-guided tumor photothermal therapy
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作者 Yao Pei Ran Wang +9 位作者 Xiang Rong Xiang Xia Hexiang Wang Zongwei Zhang Tian Qiu Saran Long Jianjun Du Jiangli Fan Wen Sun Xiaojun Peng 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2024年第8期19-25,共7页
The key factor in photothermal therapy lies in the selection of photothermal agents.Traditional photothermal agents generally have problems such as poor photothermal stability and low photothermal conversion efficienc... The key factor in photothermal therapy lies in the selection of photothermal agents.Traditional photothermal agents generally have problems such as poor photothermal stability and low photothermal conversion efficiency.Herein,we have designed and synthesized an isoindigo(IID)dye.We used isoindigo as the molecular center and introduced common triphenylamine and methoxy groups as rotors.In order to improve the photothermal stability and tumor targeting ability,we encapsulated IID into nanoparticles.As a result,the nanoparticles exhibited high photothermal stability and photothermal conversion efficiency(67%)upon 635 nm laser irradiation.Thus,the nanoparticles demonstrated a significant inhibitory effect on live tumors in photothermal therapy guided by photoacoustic imaging and provided a viable strategy to overcome the treatment challenges. 展开更多
关键词 Photothermal therapy Isoindigo NANOPARTICLES photoacoustic imaging
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Photoacoustic elastography based on laser-excited shear wave
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作者 Yang Liu Ruoyi Shi +1 位作者 Gang Li Mingjian Sun 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2024年第3期56-72,共17页
Elastography can be used as a diagnostic method for quantitative characterization of tissue hardness information and thus,differential changes in pathophysiological states of tissues.In this study,we propose a new met... Elastography can be used as a diagnostic method for quantitative characterization of tissue hardness information and thus,differential changes in pathophysiological states of tissues.In this study,we propose a new method for shear wave elastography(SWE)based on laser-excited shear wave,called photoacoustic shear wave elastography(PASWE),which combines photoacoustic(PA)technology with ultrafast ultrasound imaging.By using a focused laser to excite shear waves and ultrafast ultrasonic imaging for detection,high-frequency excitation of shear waves and noncontact elastic imaging can be realized.The laser can stimulate the tissue with the light absorption characteristic to produce the thermal expansion,thus producing the shear wave.The frequency of shear wave induced by laser is higher and the frequency band is wider.By tracking the propagation of shear wave,Young’s modulus of tissue is reconstructed in the whole shear wave propagation region to further evaluate the elastic information of tissue.The feasibility of the method is verified by experiments.Compared with the experimental results of supersonic shear imaging(SSI),it is proved that the method can be used for quantitative elastic imaging of the phantoms.In addition,compared with the SSI method,this method can realize the noncontact excitation of the shear wave,and the frequency of the shear wave excited by the laser is higher than that of the acoustic radiation force(ARF),so the spatial resolution is higher.Compared to the traditional PA elastic imaging method,this method can obtain a larger imaging depth under the premise of ensuring the imaging resolution,and it has potential application value in the clinical diagnosis of diseases requiring noncontact quantitative elasticity. 展开更多
关键词 ELASTOGRAPHY shear wave photoacoustic Young's modulus
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Microwave-induced thermoacoustic elastic imaging:A simulation study
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作者 Lin Huang Zheng Liang +1 位作者 Shuaiqi Qiao Weipeng Wang 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2024年第2期1-11,共11页
Microwave-induced thermoacoustic imaging(MTI)has the advantages of high resolution,high contrast,non-ionization,and non-invasive.Recently,MTI was used in the¯eld of breast cancer screening.In this paper,based on ... Microwave-induced thermoacoustic imaging(MTI)has the advantages of high resolution,high contrast,non-ionization,and non-invasive.Recently,MTI was used in the¯eld of breast cancer screening.In this paper,based on the¯nite element method(FEM)and COMSOL Multiphysics software,a three-dimensional breast cancer model suitable for exploring the MTI process is proposed to investigate the in°uence of Young's modulus(YM)of breast cancer tissue on MTI.It is found that the process of electromagnetic heating and initial pressure generation of the entire breast tissue is earlier in time than the thermal expansion process.Besides,compared with normal breast tissue,tumor tissue has a greater temperature rise,displacement,and pressure rise.In particular,YM of the tumor is related to the speed of thermal expansion.In particular,the larger the YM of the tumor is,the higher the heating and contraction frequency is,and the greater the maximum pressure is.Di®erent Young's moduli correspond to di®erent thermoacoustic signal spectra.In MTI,this study can be used to judge di®erent degrees of breast cancer based on elastic imaging.In addition,this study is helpful in exploring the possibility of microwave-induced thermoacoustic elastic imaging(MTAE). 展开更多
关键词 thermoacoustic imaging breast cancer multi-physics simulation elastic imaging
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Triple-path feature transform network for ring-array photoacoustic tomography image reconstruction
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作者 Lingyu Ma Zezheng Qin +1 位作者 Yiming Ma Mingjian Sun 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2024年第3期23-40,共18页
Photoacoustic imaging(PAI)is a noninvasive emerging imaging method based on the photoacoustic effect,which provides necessary assistance for medical diagnosis.It has the characteristics of large imaging depth and high... Photoacoustic imaging(PAI)is a noninvasive emerging imaging method based on the photoacoustic effect,which provides necessary assistance for medical diagnosis.It has the characteristics of large imaging depth and high contrast.However,limited by the equipment cost and reconstruction time requirements,the existing PAI systems distributed with annular array transducers are difficult to take into account both the image quality and the imaging speed.In this paper,a triple-path feature transform network(TFT-Net)for ring-array photoacoustic tomography is proposed to enhance the imaging quality from limited-view and sparse measurement data.Specifically,the network combines the raw photoacoustic pressure signals and conventional linear reconstruction images as input data,and takes the photoacoustic physical model as a prior information to guide the reconstruction process.In addition,to enhance the ability of extracting signal features,the residual block and squeeze and excitation block are introduced into the TFT-Net.For further efficient reconstruction,the final output of photoacoustic signals uses‘filter-then-upsample’operation with a pixel-shuffle multiplexer and a max out module.Experiment results on simulated and in-vivo data demonstrate that the constructed TFT-Net can restore the target boundary clearly,reduce background noise,and realize fast and high-quality photoacoustic image reconstruction of limited view with sparse sampling. 展开更多
关键词 Deep learning feature transformation image reconstruction limited-view measurement photoacoustic tomography.
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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis
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作者 Xiao Liang Xingping Quan +6 位作者 Xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi Zhen Yuan Ping Wang Bin Liu 《Neural Regeneration Research》 SCIE CAS 2025年第7期2029-2037,共9页
To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral cortex.However,these me... To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral cortex.However,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly age-related.In this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed laser.We observed the molding process in mice of different ages and presented age-dependent vascular embolism differentiation.Moreover,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a stroke.Our imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes. 展开更多
关键词 AGE-DEPENDENT cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy PHOTOTHROMBOSIS vascular imaging
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In vivo tumor detection with com bined MR-Photoacoustic-Thermoacoustic imaging 被引量:3
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作者 Lin Huang Wei Cai +7 位作者 Yuan Zhao Dan Wu Lei Wang Yuqing Wang Dakun Lai Jian Rong Fabao Gao Huabei Jiang 《Journal of Innovative Optical Health Sciences》 SCIE EI CAS 2016年第5期38-47,共10页
Here,we report a new method using combined magnetic resonance(MR)-Photoacoustic(PA)-Thermoacoustic(TA)imaging techmiques,and demonstrate its unique ability for in vrivo cancer detection using tumor-bearing mice.Circul... Here,we report a new method using combined magnetic resonance(MR)-Photoacoustic(PA)-Thermoacoustic(TA)imaging techmiques,and demonstrate its unique ability for in vrivo cancer detection using tumor-bearing mice.Circular scanning TA and PA imaging systems were used to recover the dielectric and optical property dist ributions of three colon carcinoma bearing mice While a 7.0-T magnetic resonance imaging(MRI)unit with a mouse body volume coil was utilized for high resolution structural imaging of the same mice.Three plastic tubes flled with soybean sauce were used as fiducial markers for the co-registration of MR,PA and TA images.The resulting fused images provided both enhanced tumor margin and contrast relative to the surrounding normal tissues.In particular,some finger-like protrusions extending into the surrounding tissues were revealed in the MR/TA infused images.These results show that the tissue functional optical and dielectric properties provided by PA and TA images along with the anatomical structure by MRI in one picture make accurate tumor identification easier.This combined MR-PA-TA-imaging strategy has the potential to offer a dinically useful triple-modality tool for accurate cancer detection and for intraoper ative surgical navigation. 展开更多
关键词 thermoacoustic photoacoustic MRI in vivo tumor detection
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Prospects of microwave-induced thermoacoustic imaging
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作者 Xing-Hua Wang Huan Qin 《Journal of Electronic Science and Technology》 EI CAS CSCD 2023年第3期21-37,共17页
Microwave-induced thermoacoustic imaging(MTAI)has advantages including the large imaging depth,high imaging resolution,high imaging contrast,and fast imaging speed.The thermoacoustic(TA)group of South China Normal Uni... Microwave-induced thermoacoustic imaging(MTAI)has advantages including the large imaging depth,high imaging resolution,high imaging contrast,and fast imaging speed.The thermoacoustic(TA)group of South China Normal University has dedicated to developing TA imaging for more than a decade and has made many breakthroughs.This review introduces these breakthroughs from two aspects including the improvement in techniques and the exploration of applications.On the technological level,there are ultrashort microwave pulse(USMP)-inducedTA imaging that can improve the imaging resolution,nonlinear thermoacoustic imaging(NTAI)that can improve the imaging contrast,polarized microwave-inducedthermoacoustic imaging(P-MTAI)that can obtain cellular-level alignment information,and more convenient and accurate handheld and multimodal probes.On the application side,the optimization and expansion have been carried out,mainly concentrating on breast and myocardial imaging.Finally,several current research directions are introduced,including the application of P-MTAI on joint imaging and research on whole-body imaging of small animals. 展开更多
关键词 Applications in biomedical field Microwave-induced thermoacoustic imaging(MTAI) Nonlinear thermoacoustic imaging(NTAI) Polarized microwave-induced thermoacoustic imaging(P-MTAI) Ultrashort microwave pulse (USMP)-induced thermoacoustic IMAGING
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High Efficiency and Anomalous Photoacoustic Behavior in Vertical CNTs Array
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作者 Jiapu Li Ziyu Wang +7 位作者 Laiming Jiang Zechuan Yu Xu Ge Jun Ouyang Xiaofei Yang Xiaobao Tian He Tian Benpeng Zhu 《Energy & Environmental Materials》 SCIE EI CAS CSCD 2023年第1期105-110,共6页
Miniaturized sound generators are attractive to realize intriguing functions.Thermoacoustic device’s application is seriously limited due to the frequency-doubling phenomenon.To address this issue,photoacoustic sound... Miniaturized sound generators are attractive to realize intriguing functions.Thermoacoustic device’s application is seriously limited due to the frequency-doubling phenomenon.To address this issue,photoacoustic sound generator is considered as a promising alternative.Here,based on vertical single-wall carbon nanotubes(CNTs)array,we introduce a photoacoustic sound generator with internal nano-Helmholtz cavity.Different from traditional device that generates sound by periodically heating up the open space air around material,this sound generator produces an audio signal by forming a forced vibration of the air inside the CNTs.Interestingly,anomalous photoacoustic behavior is observed that the sound pressure level(SPL)curve has a resonance peak,the corresponding frequency of which is inversely proportional to the CNTs array’s height.Furthermore,the energy conversion efficiency of this photoacoustic device is 1.64 times as large as that of a graphene sponge-based photoacoustic device.Most importantly,this device can be employed for music playing,bringing a new clew for the development of musical instruments in the future. 展开更多
关键词 anomalous photoacoustic behavior CNTs array Nano-Helmholtz Cavity photoacoustic sound generator
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Microwave-induced thermoacoustic imaging with functional nanoparticles
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作者 Xiaoyu Tang Jia Fu Huan Qin 《Journal of Innovative Optical Health Sciences》 SCIE EI CAS CSCD 2023年第2期92-107,共16页
As an emerging hybrid imaging modality,microwave-induced thermoacoustic imaging(MTAI),using microwaves as the excitation source and ultrasonic signals as the information carrier for combining the characteristics of hi... As an emerging hybrid imaging modality,microwave-induced thermoacoustic imaging(MTAI),using microwaves as the excitation source and ultrasonic signals as the information carrier for combining the characteristics of high contrast of electromagnetic imaging and high resolution of ultrasound imaging,has shown broad prospects in biomedical and clinical applications.The imaging contrast depends on the microwave-absorption coe±cient of the endogenous imaged tissue and the injected MTAI contrast agents.With systemically introduced functional nanoparticles,MTAI contrast and sensitivity can be further improved,and enables visualization of biological processes in vivo.In recent years,functional nanoparticles for MTAI have been developed to improve the performance and application range of MTAI in biomedical applications.This paper reviews the recent progress of functional nanoparticles for MTAI and their biomedical applications.The challenges and future directions of microwave thermoacoustic imaging with functional nanoparticles in theeld of translational medicine are discussed. 展开更多
关键词 Microwave thermoacoustic imaging NANOMATERIALS NANOPROBE
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Developing microwave-induced thermoacoustic tomography:System,application,and reconstruction
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作者 Shuang-Li Liu Wan-Ting Peng +4 位作者 Xiao-Zhang Zhu Jian Song Xin Shang Hua Zhang Zhi-Qin Zhao 《Journal of Electronic Science and Technology》 EI CSCD 2023年第4期1-19,共19页
A microwave-induced thermoacoustic imaging(MITAT)system is a non-destructive physical medical imaging method that combines the advantages of the high contrast of microwave imaging and the high resolution of ultrasound... A microwave-induced thermoacoustic imaging(MITAT)system is a non-destructive physical medical imaging method that combines the advantages of the high contrast of microwave imaging and the high resolution of ultrasound imaging.It uses the microwave as the excitation source and ultrasound as the information carrier.When different kinds of biological tissue absorb electromagnetic energy,it results in localized temperature rises.The thermal expansion will induce ultrasonic signals(i.e.,thermoacoustic signals),known as the thermoacoustic effect.The microwave absorption image of the sample can be reconstructed by algorithm processing.The MITAT contrast depends on different dielectric parameters of different kinds of tissue.We introduce the developed system and its application.In addition,the challenges and prospects of MITAT for further development are discussed. 展开更多
关键词 APPLICATION Microwave-induced thermoacoustic tomography(MITAT) RECONSTRUCTION SYSTEM
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Thermoacoustic imaging:From single-element scanning to portable and array-based imaging
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作者 Yi-Jie Huang Qi-Kai-Yu Feng Lin Huang 《Journal of Electronic Science and Technology》 EI CAS CSCD 2023年第3期1-20,共20页
The microwave-induced thermoacoustic imaging(TAI)technology has both the advantages of high contrast of microwave imaging and high resolution of ultrasound imaging(UI),so it has carried out exploratory application res... The microwave-induced thermoacoustic imaging(TAI)technology has both the advantages of high contrast of microwave imaging and high resolution of ultrasound imaging(UI),so it has carried out exploratory application research in various areas,such as the early detection of breast tumors and cerebrovascular diseases.However,the microwave generator used in the traditional TAI technology is huge and expensive,and the temporal resolution is also too low due to the single-element scanning mechanism.Thus,it is difficult to meet the needs of clinical applications.In this paper,the iterative process and the analysis of related application scenarios from single-element scanning to portable and array-based TAI,such as the miniaturized microwave generator,handheld antenna,multi-channel data acquisition,and UI/TAIdual-modality imaging,are reviewed,and the future trends of this technology are discussed.This review helps researchers in the field of TAI learn the technological development process and future trends.It also deepens clinicians’understanding of TAI so as to put forward more application requirements. 展开更多
关键词 Array-based PORTABLE Single-element scanning thermoacoustic imaging(TAI)
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Microwave-induced thermoacoustic imaging of joints
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作者 Zi-Hui Chi Shuang Du +3 位作者 Yang Wang Lin Huang Dan Wu Hua-Bei Jiang 《Journal of Electronic Science and Technology》 EI CAS CSCD 2023年第2期1-13,共13页
Due to the complexity of joint structures and the diversity of disorders in the joints,the diagnosis of joint diseases is challenging.Current clinical diagnostic techniques for evaluating joint diseases,such as arthri... Due to the complexity of joint structures and the diversity of disorders in the joints,the diagnosis of joint diseases is challenging.Current clinical diagnostic techniques for evaluating joint diseases,such as arthritis,have strengths and weaknesses.New imaging techniques need to be developed for the diagnosis or auxiliary diagnosis of arthritis.As an emerging nonintrusive low-cost imaging method,microwave-induced thermoacoustic imaging(TAI)can present tissue morphology while providing the tissue microwave energy absorption density distribution related to dielectric properties.TAI is currently in development to potentially visualize joint anatomic structures and to detect arthritis.Here,we offer a mini review to summarize the status of research on TAI of joints and present an outlook to the future development of TAI in the detection of joint diseases. 展开更多
关键词 Arthritis detection Joint structures thermoacoustic imaging(TAI)
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Photoacoustic microscopy based on transparent piezoelectric ultrasound transducers
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作者 Hangbing Peng Zhongwen Cheng +1 位作者 Lvming Zeng Xuanrong Ji 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2023年第5期77-92,共16页
Photoacoustic microscopy(PAM),due to its deep penetration depth and high contrast,is playing an increasingly important role in biomedical imaging.PAM imaging systems equipped with conventional ultrasound transducers h... Photoacoustic microscopy(PAM),due to its deep penetration depth and high contrast,is playing an increasingly important role in biomedical imaging.PAM imaging systems equipped with conventional ultrasound transducers have demonstrated excellent imaging performance.However,these opaque ultrasonic transducers bring some constraints to the further development and application of PAM,such as complex optical path,bulky size,and difficult to integrate with other modalities.To overcome these problems,ultrasonic transducers with high optical transparency have appeared.At present,transparent ultrasonic transducers are divided into optical-based and acoustic-based sensors.In this paper,we mainly describe the acoustic-based piezoelectric transparent transducers in detail,of which the research advances in PAM applications are reviewed.In addition,the potential challenges and developments of transparent transducers in PAM are also demonstrated. 展开更多
关键词 photoacoustic microscopy transparent ultrasound transducer LiNbO_(3) PMN-PT PVDF CMUT
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Effects of Light Stress on Oxygen Evolution and Photochemical Energy Stor age of Hybrid Poplar Clones Determined by Photoacoustic Technique 被引量:1
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作者 张守仁 高荣孚 《Acta Botanica Sinica》 CSCD 2000年第8期818-823,共6页
The oxygen evolution, thermal dissipation, and photochemical energy storage of three hybrid poplar clones, namely the triploid clone B342, the diploid clone B11 [(Populus alba×P. glandulosa)×(P.tomentosa... The oxygen evolution, thermal dissipation, and photochemical energy storage of three hybrid poplar clones, namely the triploid clone B342, the diploid clone B11 [(Populus alba×P. glandulosa)×(P.tomentosa×P.bolleana)], and the triploid clone B346 [(P.tomentosa×P. bolleana)×(P. alba×P.glandulosa)], under light stress were studied using photoacoustics. The oxygen evolution signal and photochemical energy storage varied negatively with the pretreatment_PFD (photon flux density), whereas the thermal signal varied positively with the pretreatment_PFD. Photochemical energy storage was reallocated to PSⅡ more than to PSⅠ, while the photochemical energy storage in PSⅠ was more stable than that in PSⅡ when subjected to light stress. The inhibitors streptomycin (SM), dithiothreitol (DTT) and sodium fluoride (NaF) could all affect the oxygen evolution signal. Clones B11 and B342 were more resistant to light stress than clone B346. 展开更多
关键词 hybrid poplar clones light stress oxygen evolution signal photochemical energy storage photoacousticS INHIBITORS
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Two-Dimensional Photoacoustic Imaging of Blood Vessel Networks within Biological Tissues 被引量:12
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作者 苏翼雄 王瑞康 +1 位作者 张帆 姚建铨 《Chinese Physics Letters》 SCIE CAS CSCD 2006年第2期512-515,共4页
Photoacoustic tomography (PAT) is a powerful imaging merits and most compelling features of light and sound, technique for medical diagnosis because it combines the We describe a PAT experimental system constructed ... Photoacoustic tomography (PAT) is a powerful imaging merits and most compelling features of light and sound, technique for medical diagnosis because it combines the We describe a PAT experimental system constructed in our laboratory which consists of a Q-switched Nd:YAG pulse laser operating at 532nm with a 8-ns pulse width to generate the photoacoustic signals from a biological sample. Two-dimensional photoacoustic imaging of blood vessel networks lcm below the tissue surface is achieved, We also successfully demonstrate that the system is capable of imaging the blood vessels over the ex vivo rat brain with skull and skin intact. 展开更多
关键词 TIME-DOMAIN RECONSTRUCTION thermoacoustic TOMOGRAPHY
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Highly Sensitive MoS_2–Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site 被引量:11
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作者 Chengbo Liu Jingqin Chen +9 位作者 Ying Zhu Xiaojing Gong Rongqin Zheng Ningbo Chen Dong Chen Huixiang Yan Peng Zhang Hairong Zheng Zonghai Sheng Liang Song 《Nano-Micro Letters》 SCIE EI CAS 2018年第3期115-126,共12页
Photoacoustic technology in combination with molecular imaging is a highly effective method for accurately diagnosing brain glioma. For glioma detection at a deeper site, contrast agents with higher photoacoustic imag... Photoacoustic technology in combination with molecular imaging is a highly effective method for accurately diagnosing brain glioma. For glioma detection at a deeper site, contrast agents with higher photoacoustic imaging sensitivity are needed. Herein, we report a MoS_2–ICG hybrid with indocyanine green(ICG) conjugated to the surface of MoS_2 nanosheets. The hybrid significantly enhanced photoacoustic imaging sensitivity compared to MoS_2 nanosheets. This conjugation results in remarkably high optical absorbance across a broad near-infrared spectrum, redshifting of the ICG absorption peak and photothermal/photoacoustic conversion efficiency enhancement of ICG. A tumor mass of 3.5 mm beneath the mouse scalp was clearly visualized by using MoS_2–ICG as a contrast agent for the in vivo photoacoustic imaging of orthotopic glioma, which is nearly twofold deeper than the tumors imaged in our previous report using MoS_2 nanosheet. Thus, combined with its good stability and high biocompatibility, the MoS_2–ICG hybrid developed in this study has a great potential for high-efficiency tumor molecular imaging in translational medicine. 展开更多
关键词 MoS2–ICG hybrid Orthotopic brain glioma photoacoustic imaging Molecular imaging
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Recent advances in photoacoustic endoscopy 被引量:5
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作者 Tae-Jong Yoon Young-Seok CHo 《World Journal of Gastrointestinal Endoscopy》 CAS 2013年第11期534-539,共6页
Imaging based on photoacoustic effect relies on illuminating with short light pulses absorbed by tissue absorbers, resulting in thermoelastic expansion, giving rise to ultrasonic waves. The ultrasonic waves are then d... Imaging based on photoacoustic effect relies on illuminating with short light pulses absorbed by tissue absorbers, resulting in thermoelastic expansion, giving rise to ultrasonic waves. The ultrasonic waves are then detected by detectors placed around the sample. Photoacoustic endoscopy(PAE) is one of four major implementations of photoacoustic tomography that have been developed recently. The prototype PAE was based on scanning mirror system that deflected both the light and the ultrasound. A recently developed mini-probe was further miniaturized, and enabled simultaneous photoacoustic and ultrasound imaging. This PAE-endoscopic ultrasound(EUS) system can offer high-resolution vasculature information in the gastrointestinal(GI) tract and display differences between optical and mechanical contrast compared with single-mode EUS. However, PAE for endoscopic GI imaging is still at the preclinical stage. In this commentary, we describe the technological improvements in PAE for possible clinical application in endoscopic GI imaging. In addition, we discuss thetechnical details of the ultrasonic transducer incorporated into the photoacoustic endoscopic probe. 展开更多
关键词 photoacoustic techniques TOMOGRAPHY ENDOSCOPY ENDOSONOGRAPHY GASTROINTESTINAL NEOPLASM
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Study on F-F Transitions of Powdered Neodymium Compounds by Photoacoustic Spectroscopy 被引量:5
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作者 杨跃涛 苏庆德 +1 位作者 赵贵文 张淑仪 《Journal of Rare Earths》 SCIE EI CAS CSCD 2002年第1期10-14,共5页
Photoacoustic (PA) spectra of powdered neodymium oxide (Nd 2O 3 (A type)), neodymium hydrated chloride (NdCl 3·6H 2O) and neodymium fluoride (NdF 3) were reported. PA band shifts as compared to their positio... Photoacoustic (PA) spectra of powdered neodymium oxide (Nd 2O 3 (A type)), neodymium hydrated chloride (NdCl 3·6H 2O) and neodymium fluoride (NdF 3) were reported. PA band shifts as compared to their positions in aqueous Nd 3+ are used to calculate the nephelauxetic parameters of the compounds. The variation of these parameters and correlation with the nature of metal ligand bonding were discussed. A novel method is introduced to determine the relative values of oscillator strengths and Judd Ofelt parameters of powdered samples using PA spectroscopy. It is found that a linear correlation exists between relative values of τ 2 and oscillator strengths of hypersensitive transitions of the title compounds. It is hopetul that the new method of PA technique may serve for the Judd Ofelt quantitative analysis of powdered rare earth compounds. 展开更多
关键词 rare earths photoacoustic spectroscopy NEODYMIUM f f transition oscillator strength
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Thermal diffusivity of light-emitting diode packaging material determined by photoacoustic piezoelectric technique 被引量:5
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作者 孙启明 高椿明 +1 位作者 赵斌兴 饶海波 《Chinese Physics B》 SCIE EI CAS CSCD 2010年第11期673-677,共5页
Thermal property is one of the most important properties of light-emitting diode (LED). Thermal property of LED packaging material determines the heat dissipations of the phosphor and the chip surface, accordingly h... Thermal property is one of the most important properties of light-emitting diode (LED). Thermal property of LED packaging material determines the heat dissipations of the phosphor and the chip surface, accordingly having an influence on the light-emitting efficiency and the life-span of the device. In this paper, photoacoustic piezoelectric (PAPE) technique has been employed to investigate the thermal properties of polyvinyl alcohol (]?VA) and silicon dioxide, which are the new and the traditional packaging materials in white LED, respectively. Firstly, the theory of PAPE technique has been developed for two-layer model in order to investigate soft materials; secondly, the experimental system has been set up and adjusted by measuring the reference sample; thirdly, the thermal diffusivities of PVA and silicon dioxide are measured and analysed. The experimental results show that PVA has a higher thermal diffusivity than silicon dioxide and is a better packaging material in the sense of thermal diffusivity for white LED. 展开更多
关键词 thermal diffusivity photoacoustic piezoelectric technique two-layer model LED packaging material
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