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Flexible fiber-laser ultrasound sensor for multiscale photoacoustic imaging 被引量:6
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作者 Bai-Ou Guan Long Jin +2 位作者 Jun Ma Yizhi Liang Xue Bai 《Opto-Electronic Advances》 SCIE 2021年第8期16-29,共14页
Photoacoustic imag ing(PAI)is a nonin vasive biomedical imag ing tech no logy capable of multiscale imag ing of biological samples from orga ns dow n to cells.Multiscale PAI requires differe nt ultraso und tra nsducer... Photoacoustic imag ing(PAI)is a nonin vasive biomedical imag ing tech no logy capable of multiscale imag ing of biological samples from orga ns dow n to cells.Multiscale PAI requires differe nt ultraso und tra nsducers that are flat or focused because the current widely-used piezoelectric transducers are rigid and lack the flexibility to tune their spatial ultrasound responses.Inspired by the rapidly-developing flexible photonics,we exploited the inherent flexibility and low-loss features of optical fibers to develop a flexible fiber-laser ultrasound sensor(FUS)for multiscale PAI.By simply bending the fiber laser from straight to curved geometry,the spatial ultraso und resp onse of the FUS can be tuned for both wide-view optical-resolution photoacoustic microscopy at optical diffraction-limited depth(~1 mm)and photoacoustic computed tomography at optical dissipation-limited depth of several centimeters.A radio-frequency demodulation was employed to get the readout of the beat frequency variation of two orthogonal polarization modes in the FUS output,which ensures low-noise and stable ultrasound detection.Compared to traditional piezoelectrical transducers with fixed ultrasound responses once manufactured,the flexible FUS provides the freedom to design multiscale PAI modalities including wearable microscope,intravascular endoscopy,and portable tomography system,which is attractive to fundamental biologic-al/medical studies and clinical applications. 展开更多
关键词 flexible ultrasound transducer fiber-laser ultrasound sensor multiscale photoacoustic imaging photoacoustic microscopy photoacoustic computed tomography
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Recent advances in applications of multimodal ultrasound-guided photoacoustic imaging technology
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作者 Shanshan Wang Yunfeng Zhao Ye Xu 《Visual Computing for Industry,Biomedicine,and Art》 2020年第1期266-277,共12页
Photoacoustic imaging(PAI)is often performed simultaneously with ultrasound imaging and can provide functional and cellular information regarding the tissues in the anatomical markers of the imaging.This paper describ... Photoacoustic imaging(PAI)is often performed simultaneously with ultrasound imaging and can provide functional and cellular information regarding the tissues in the anatomical markers of the imaging.This paper describes in detail the basic principles of photoacoustic/ultrasound(PA/US)imaging and its application in recent years.It includes near-infrared-region PA,photothermal,photodynamic,and multimode imaging techniques.Particular attention is given to the relationship between PAI and ultrasonic imaging;the latest high-frequency PA/US imaging of small animals,which involves not only B-mode,but also color Doppler mode,power Doppler mode,and nonlinear imaging mode;the ultrasonic model combined with PAI,including the formation of multimodal imaging;the preclinical imaging methods;and the most effective detection methods for clinical research for the future. 展开更多
关键词 photoacoustic/ultrasound imaging The second near-infrared photoacoustic Photothermal therapy Photodynamic therapy Multi-mode imaging
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Optically-excited simultaneous photoacoustic and ultrasound imaging based on aflexible gold-PDMS film
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作者 Dandan Cui Zhenhui Zhang Yujiao Shi 《Journal of Innovative Optical Health Sciences》 SCIE EI CAS 2020年第4期10-19,共10页
We constructed a flexible gold-polydimethylsiloxane(gold-PDMS)nanocomposites film with controllable thickness and light transmittance,to realize optically-excited simultaneous photo-acoustic(PA)and ultrasound(US)imagi... We constructed a flexible gold-polydimethylsiloxane(gold-PDMS)nanocomposites film with controllable thickness and light transmittance,to realize optically-excited simultaneous photo-acoustic(PA)and ultrasound(US)imaging under a single laser pulse irradiation.Benefiting from the excellent thermoelastic properties,the gold-PDMS film absorbs part of the incident laser energy and produces a high-intensity US,which is used to realize US imaging.Meanwhile,the partly transmitted light is used to excite samples for PA imaging.By controlling the thickness of the gold-PDMS,we can control the center frequency in the US imaging.We experimentally analyzed the frequency of the produced US signal by the gold-PDMSfilm and compared it with the finite element analysis(FEA)method,where the experiments agree with the FEA results.This method is demonstrated by the experiments on phantoms and a mouse model.Our work provides a cost-effective methodology for simultaneous PA and US imaging. 展开更多
关键词 photoacoustic and ultrasound imaging Gold-polydimethylsiloxane(gold-PDMS)nanocomposites film finite element analysis(FEA)
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Recovery of photoacoustic images based on accurate ultrasound positioning
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作者 Yinhao Pan Ningbo Chen +3 位作者 Liangjian Liu Chengbo Liu Zhiqiang Xu Jianhui Zhang 《Visual Computing for Industry,Biomedicine,and Art》 EI 2021年第1期63-69,共7页
Photoacoustic microscopy is an in vivo imaging technology based on the photoacoustic effect.It is widely used in various biomedical studies because it can provide high-resolution images while being label-free,safe,and... Photoacoustic microscopy is an in vivo imaging technology based on the photoacoustic effect.It is widely used in various biomedical studies because it can provide high-resolution images while being label-free,safe,and harmless to biological tissue.Polygon-scanning is an effective scanning method in photoacoustic microscopy that can realize fast imaging of biological tissue with a large field of view.However,in polygon-scanning,fluctuations of the rotating motor speed and the geometric error of the rotating mirror cause image distortions,which seriously affect the photoacoustic-microscopy imaging quality.To improve the image quality of photoacoustic microscopy using polygon-scanning,an image correction method is proposed based on accurate ultrasound positioning.In this method,the photoacoustic and ultrasound imaging data of the sample are simultaneously obtained,and the angle information of each mirror used in the polygon-scanning is extracted from the ultrasonic data to correct the photoacoustic images.Experimental results show that the proposed method can significantly reduce image distortions in photoacoustic microscopy,with the image dislocation offset decreasing from 24.774 to 10.365μm. 展开更多
关键词 photoacoustic microscopy Polygon-scanning image correction ultrasound positioning
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Noncontact ultrasound sensing based on Mach-Zehnder homodyne interferometer for photoacoustic imaging
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作者 龙星 胡毅成 +1 位作者 王一冰 李长辉 《Chinese Optics Letters》 SCIE EI CAS CSCD 2024年第3期101-106,共6页
We present a novel noncontact ultrasound(US)and photoacoustic imaging(PAI)system,overcoming the limitations of traditional coupling media.Using a long coherent length laser,we employ a homodyne free-space Mach-Zehnder... We present a novel noncontact ultrasound(US)and photoacoustic imaging(PAI)system,overcoming the limitations of traditional coupling media.Using a long coherent length laser,we employ a homodyne free-space Mach-Zehnder setup with zero-crossing triggering,achieving a noise equivalent pressure of 703 Pa at 5 MHz and a-6 dB bandwidth of 1 to8.54 MHz.We address the phase uncertainty inherent in the homodyne method.Scanning the noncontact US probe enables photoacoustic computed tomography(PACT).Phantom studies demonstrate imaging performance and system stability,underscoring the potential of our system for noncontact US sensing and PAI. 展开更多
关键词 noncontact ultrasound sensing photoacoustic imaging Mach–Zehnder interferometer
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Concurrent photoacoustic and ultrasound microscopy with a coaxial dual-element ultrasonic transducer 被引量:1
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作者 Yuqi Tang Wei Liu +2 位作者 Yang Li Qifa Zhou Junjie Yao 《Visual Computing for Industry,Biomedicine,and Art》 2018年第1期18-23,共6页
Simultaneous photoacoustic and ultrasound(PAUS)imaging has attracted increasing attention in biomedical research to probe the optical and mechanical properties of tissue.However,the resolution for majority of the exis... Simultaneous photoacoustic and ultrasound(PAUS)imaging has attracted increasing attention in biomedical research to probe the optical and mechanical properties of tissue.However,the resolution for majority of the existing PAUS systems is on the order of 1 mm as the majority are designed for clinical use with low-frequency US detection.Here we developed a concurrent PAUS microscopy that consists of optical-resolution photoacoustic microscopy(OR-PAM)and high-frequency US pulse-echo imaging.This dual-modality system utilizes a novel coaxial dual-element ultrasonic transducer(DE-UST)and provides anatomical and functional information with complementary contrast mechanisms,achieving a spatial resolution of 7μm for PA imaging and 106μm for US imaging.We performed phantom studies to validate the system’s performance.The vasculature of a mouse’s hind paw was imaged to demonstrate the potential of this hybrid system for biomedical applications. 展开更多
关键词 photoacoustic microscopy ultrasound microscopy Concurrent imaging Coaxial dual-element ultrasonic transducer
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Combating acoustic heterogeneity in photoacoustic computed tomography:A review 被引量:3
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作者 Tong Wang Wen Liu Chao Tian 《Journal of Innovative Optical Health Sciences》 SCIE EI CAS 2020年第3期32-47,共16页
Based on the energy conversion of light into sound,photoacoustic computed tomography(PACT)is an emerging biomedical imaging modality and has unique applications in a range of biomedical fields.In PACT,image formation ... Based on the energy conversion of light into sound,photoacoustic computed tomography(PACT)is an emerging biomedical imaging modality and has unique applications in a range of biomedical fields.In PACT,image formation relies on a process called acoustic inversion from received photoacoustic signals.While most PACT systems perform this inversion with a basic assumption that biological tissues are acoustically homogeneous,the community gradually rea-lizes that the intrinsic acoustic heterogeneity of tissues could pose distortions and artifacts to finally formed images.This paper surveys the most recent research progress on acoustic het-erogeneity correction in PACT.Four major strategies are reviewed in detail,including half-time or partial-time reconstruction,autofocus reconstruction by optimizing sound speed maps,joint reconstruction of optical absorption and sound speed maps,and ultrasound computed tomog-raphy(USCT)enhanced reconstruction.The correction of acoustic heterogeneity helps improve the imaging performance of PACT. 展开更多
关键词 photoacoustic computed tomography image reconstruction acoustic heterogeneity ultrasound computed tomography speed of sound
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Multimodal intravascular imaging technology for characterization of atherosclerosis
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作者 Yan Li Jason Chen Zhongping Chen 《Journal of Innovative Optical Health Sciences》 SCIE EI CAS 2020年第1期82-96,共15页
Early detection of vulnerable plaques is the critical step in the prevention of acute coronary events.Morphology,composition,and mechanical property of a coronary artery have been demonstrated to be the key characteri... Early detection of vulnerable plaques is the critical step in the prevention of acute coronary events.Morphology,composition,and mechanical property of a coronary artery have been demonstrated to be the key characteristics for the identification of vulnerable plaques.Several intravascular multimodal imaging technologies providing co-registered simultaneous images have been developed and applied in clinical studies to improve the characterization of atherosclerosis.In this paper,the authors review the present system and probe designs of representative intra-vascular multimodal techniques.In addition,the scientific innovations,potential limitations,and future directions of these technologies are also discussed. 展开更多
关键词 MULTIMODAL intravascular imaging photoacoustic ultrasound optical coherence tomography near-infrared fluorescence spectroscopy ATHEROSCLEROSIS imaging probe
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An encapsulated optical microsphere sensor for ultrasound detection and photoacoustic imaging 被引量:4
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作者 Jialve Sun Jia-Wei Meng +1 位作者 Shui-Jing Tang Changhui Li 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS CSCD 2022年第2期44-49,共6页
Optical whispering-gallery microresonators have attracted considerable interest for ultrasensitive ultrasound detection and photoacoustic imaging because of the combination of high quality factors and small cavity siz... Optical whispering-gallery microresonators have attracted considerable interest for ultrasensitive ultrasound detection and photoacoustic imaging because of the combination of high quality factors and small cavity sizes.In the last decade,ultrasonic sensors with on-chip microcavities have been extensively developed;however,they are unsuitable for the near-field photoacoustic microscopy of micro/nanoscale objects in complex biological environments and endoscopic imaging.In this work,we developed ultrasonic sensors using two types of encapsulated microsphere resonators with different cavity materials.A noise equivalent pressure of as low as 160 Pa at 20 MHz was achieved with the acoustic response up to 70 MHz at-6 d B.Furthermore,the microsensor was used for photoacoustic microscopy in which we successfully performed 3 D imaging of hairs and leaf veins.The microsphere ultrasonic sensor has considerable potential as a probe-type ultrasonic detector for near-field photoacoustic microscopy of micro/nanoscale objects such as subcellular structures and high-resolution endoscopic photoacoustic imaging with its high sensitivity and wide bandwidth. 展开更多
关键词 optical whispering gallery micro-resonators ultrasound sensing photoacoustic imaging
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Ultrasound-propelled Janus Au NR-mSiO_(2) nanomotor for NIR-II photoacoustic imaging guided sonodynamic-gas therapy of large tumors 被引量:3
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作者 Jiamin Ye Qinrui Fu +8 位作者 Luntao Liu Lanlan Chen Xuan Zhang Qingqing Li Zhi Li Lichao Su Rong Zhu Jibin Song Huanghao Yang 《Science China Chemistry》 SCIE EI CSCD 2021年第12期2218-2229,共12页
Varieties of contrast agents have been developed for photoacoustic(PA)and ultrasound(US)imaging of cancers in vivo.However,access of traditional contrast agents into the sites of tumors has been principally through pa... Varieties of contrast agents have been developed for photoacoustic(PA)and ultrasound(US)imaging of cancers in vivo.However,access of traditional contrast agents into the sites of tumors has been principally through passive infiltration without any external force,preventing their deep penetration into the tissues of the tumors,and hindering the use of PA and US for deep tumor imaging.The concept of micro/nanomotors has been the focus of increasing attention as active theranostic agents due to their active movement in particular fluids,thereby conducting assigned tasks.Herein,US-propelled Janus mesoporous SiO_(2)partially coated gold nanorods(Au NR-mSiO_(2))were fabricated for deep tumor NIR-II PA imaging and synergistic sonodynamic-gas therapy.Following US irradiation,2,2-azobis[2-(2-imidazolin-2-yl)propane]dihydrochloride(AIPH)loaded in mSiO_(2)(Au NR-mSiO_(2)/AIPH)generated N_(2)microbubbles with high efficiency to achieve nanomotor drive.Due to the deep penetration of US,the nanomotors exhibited a capability to travel deep within sites of tumors,providing enhanced PA/US imaging inside the tumors.Furthermore,the nanomotor based cancer therapy was demonstrated through synergistic N_(2)gas and sonodynamic therapy.The US-propelled nanomotors demonstrated a novel strategy for the simultaneous PA/US dual imaging deep within tumor tissues and precise therapy of large tumors. 展开更多
关键词 NANOMOTOR NIR-Ⅱphotoacoustic imaging ultrasound sonodynamic therapy gas therapy
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Color-coded perfluorocarbon nanodroplets for multiplexed ultrasound and photoacoustic imaging
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作者 Daniela Y. Santiesteban Kristina A. Hallam +1 位作者 Steven K. Yarmoska Stanislav Y. Emelianov 《Nano Research》 SCIE EI CAS CSCD 2019年第4期741-747,共7页
Laser-activated perfluorocarb on n anodroplets are an emerging class of phase-cha nge, dual-c ontrast age nts that can be utilized in ultraso und and photoacoustic imaging. Through the ability to differe ntiate subpop... Laser-activated perfluorocarb on n anodroplets are an emerging class of phase-cha nge, dual-c ontrast age nts that can be utilized in ultraso und and photoacoustic imaging. Through the ability to differe ntiate subpopulations of nano droplets via laser activatio n at differe nt wavelengths of n ear-infrared light, optically-triggered color-coded perfluorocarb on nano droplets prese nt themselves as an attractive tool for multiplexed ultrasound and photoacoustic imaging. In particular, laser-activated droplets can be used to provide quantitative spatiotemporal information regarding distinct biological targets, allowing for their potential use in a wide range of diagnostic and therapeutic applications. In the work prese nted, laser-activated color-coded perfluorocarb on nan odroplets are syn thesized to selectively resp ond to laser irradiati on at corresp on ding wavele ngths. The dyn amic ultraso und and photoacoustic signals produced by laser-activated perfluorocarbon nano droplets are evaluated in situ prior to implementation in a murine model. In vivo, these particles are used to distinguish unique particle trafficking mechanisms and are show n to provide ultraso und and photoacoustic contrast for up to 72 hours within lymphatics. Overall, the con ducted studies show that laser-activated color-coded perfluorocarbo n nano droplets are a promising agent for multiplexed ultraso und and photoacoustic imaging. 展开更多
关键词 multiplexed imaging PERFLUOROCARBON NANODROPLETS photoacoustic imaging ultrasound imaging molecular targets
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双模态成像仿生纳米粒对甲状腺髓样癌的声动力治疗
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作者 朱炜薇 凡正超 +2 位作者 胥莹 夏纪筑 赵香芝 《中国组织工程研究》 CAS 北大核心 2025年第16期3410-3419,共10页
背景:声动力疗法作为一种新型抗肿瘤治疗手段具有非侵入性和时空可控性的特点,在甲状腺髓样癌无创性治疗中具有广阔的应用前景。目的:制备具有双模态成像能力的仿生癌细胞膜涂层脂质纳米粒,检测纳米粒的理化性质、靶向能力、成像效果、... 背景:声动力疗法作为一种新型抗肿瘤治疗手段具有非侵入性和时空可控性的特点,在甲状腺髓样癌无创性治疗中具有广阔的应用前景。目的:制备具有双模态成像能力的仿生癌细胞膜涂层脂质纳米粒,检测纳米粒的理化性质、靶向能力、成像效果、细胞毒性和抗迁移能力。方法:以二棕榈酰磷脂酰胆碱、二棕榈酰磷脂酰甘油、二硬脂酰磷脂酰乙醇胺-聚乙二醇2000、胆固醇、血卟啉单甲醚、全氟己烷为原料,通过薄膜水合-超声振荡法制备脂质纳米粒HP@LNP,其中血卟啉单甲醚装载于脂质纳米结构的疏水层,全氟己烷装载于脂质纳米结构的亲水核心层内;将甲状腺髓样癌细胞膜包覆于脂质纳米粒HP@LNP表面,构建具有主动靶向甲状腺髓样癌细胞能力的仿生脂质纳米粒MHP@LNP。表征纳米粒MHP@LNP的理化性质、靶向能力、免疫逃逸能力、成像效果、细胞毒性和抗迁移能力。结果与结论:①脂质纳米粒MHP@LNP呈现典型的核壳结构,粒径为131.06 nm,平均电位为-30.59 mV,凝胶电泳结果显示脂质纳米粒MHP@LNP与癌细胞膜蛋白图谱相符合,荧光共定位结果显示脂质纳米粒MHP@LNP与癌细胞膜的荧光信号显著重合。脂质纳米粒MHP@LNP纳米粒内血卟啉单甲醚的包封率为87.8%,载药率为14.6%。在低强度聚焦超声刺激下,脂质纳米粒MHP@LNP可发生相变产生微泡,在4 min时超声信号强度达到最大值。在激光照射下,脂质纳米粒MHP@LNP的光声信号强度与其质量浓度呈现线性相关。脂质纳米粒MHP@LNP具有同源细胞靶向能力和免疫逃逸能力。未经低强度聚焦超声照射前的脂质纳米粒MHP@LNP具有良好的生物相容性,而经低强度聚焦超声照射后产生具有细胞毒性的活性氧,有效杀伤甲状腺髓样癌细胞,并抑制甲状腺髓样癌细胞的迁移能力。②结果表明,脂质纳米粒MHP@LNP能够在超声和光声双模态成像引导下实现声动力治疗,用于治疗甲状腺髓样癌。 展开更多
关键词 脂质纳米粒 声动力疗法 低强度聚焦超声 声敏剂 活性氧 癌细胞膜 同源靶向 纳米医学 光声成像 双模态成像
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光声成像评价靶向纳米粒联合LIFU对小鼠乳腺癌的治疗研究
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作者 黎鹏 方辉 +2 位作者 缪婉婷 范雪莲 董海霞 《医学影像学杂志》 2023年第12期2278-2282,共5页
目的制备叶酸修饰的红细胞膜伪装的载青蒿素(ART)多功能靶向仿生纳米粒,并应用光声成像(PAI)评价其联合低强度聚焦超声(LIFU)治疗小鼠乳腺癌的价值。方法选用聚乳酸-羟基乙酸共聚物(PLGA)作为纳米粒的载体材料,以全氟己烷(PFH)、Fe_(3)O... 目的制备叶酸修饰的红细胞膜伪装的载青蒿素(ART)多功能靶向仿生纳米粒,并应用光声成像(PAI)评价其联合低强度聚焦超声(LIFU)治疗小鼠乳腺癌的价值。方法选用聚乳酸-羟基乙酸共聚物(PLGA)作为纳米粒的载体材料,以全氟己烷(PFH)、Fe_(3)O_(4)、ART作为纳米粒的内核,再以红细胞膜(EM)包覆该纳米粒,最后EM表面经叶酸(FA)修饰为靶向分子,制备多功能靶向仿生纳米粒(PFH/ART@PLGA/Fe_(3)O_(4)-eFA)。激光扫描共聚焦显微镜(LSCM)观察纳米粒的FA连靶率。应用PAI观察纳米粒在小鼠乳腺癌组织内的靶向聚集程度。电感耦合等离子体发射光谱(ICP)检测纳米粒在血液中的代谢情况。纳米粒联合LIFU协同治疗肿瘤,并记录肿瘤大小变化。结果LSCM分析显示纳米粒mander重叠系数为83.7%。PAI结果显示合成的PFH/ART@PLGA/Fe_(3)O_(4)-eFA纳米粒在体外及体内均有良好的光学成像效果。PFH/ART@PLGA/Fe_(3)O_(4)-eFA组小鼠乳腺癌组织内光声信号强度显著高于PFH/ART@PLGA/Fe_(3)O_(4)组。ICP结果显示PFH/ART@PLGA/Fe_(3)O_(4)-eFA组血液中Fe2+浓度显著高于PFH/ART@PLGA/Fe_(3)O_(4)组;PFH/ART@PLGA/Fe_(3)O_(4)-eFA组小鼠肝脏及脾脏内的Fe2+显著低于PFH/ART@PLGA/Fe_(3)O_(4)组;且PFH/ART@PLGA/Fe_(3)O_(4)-eFA组小鼠乳腺癌组织内的Fe2+显著高于PFH/ART@PLGA/Fe_(3)O_(4)组。体内治疗结果显示,PFH/ART@PLGA/Fe_(3)O_(4)-eFA组小鼠乳腺癌体积显著小于其他各组。结论本研究成功制备包封PFH、Fe_(3)O_(4)、ART的多功能靶向仿生纳米粒,具有良好的体内外光声成像效果,初步证实可用于小鼠乳腺癌的靶向诊断,联合LIFU可以协同治疗小鼠乳腺癌。 展开更多
关键词 乳腺癌 青蒿素 纳米粒 低强度聚焦 超声诊断 光声成像
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载IR780/PFH纳米粒双模态成像及增效高强度聚焦超声消融牛肝的实验研究
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作者 杜燕 唐瑜 +5 位作者 欧霞 林丽 张中 汪瑶台 罗勇 邹建中 《临床超声医学杂志》 CSCD 2023年第6期417-422,共6页
目的 制备载IR780/全氟己烷(PFH)的脂质体纳米粒(IR780-CLs),评估其体外超声成像、光声成像和靶向肿瘤的能力,以及协同高强度聚焦超声(HIFU)消融牛肝的效果,探讨其增效HIFU的机制。方法 采用薄膜水化法制备IR780-CLs,检测其基本理化性质... 目的 制备载IR780/全氟己烷(PFH)的脂质体纳米粒(IR780-CLs),评估其体外超声成像、光声成像和靶向肿瘤的能力,以及协同高强度聚焦超声(HIFU)消融牛肝的效果,探讨其增效HIFU的机制。方法 采用薄膜水化法制备IR780-CLs,检测其基本理化性质,并观察其与4TI乳腺癌细胞的结合情况。体外超声成像即使用120 W、30 s的能量辐照PBS和IR780-CLs溶液,比较辐照前后二维超声和超声造影回声信号灰度变化值的差异;体外光声成像即将IR780-CLs分别配置成不同浓度(20、40、60、80μg/ml)溶液,获取其对应的光声信号值。通过离体牛肝实验评估IR780-CLs增效HIFU的作用,行被动空化检测并取宽带噪声信号幅度的均方根值(RMS)随时间变化曲线反映实时空化信号,比较牛肝内注入PBS(PBS组)和IR780-CLs溶液(IR780-CLs组)后RMS的差异。结果 成功制备的IR780-CLs呈均匀的球形,平均电位为(34.5±3.2)mV,平均粒径为(246.5±12.4)nm,包封率为88%,其能高效靶向4TI乳腺癌细胞。体外超声成像显示,IR780-CLs辐照前后二维超声回声信号的灰度变化值分别为42.09±0.35和48.25±0.93,超声造影回声信号的灰度变化值分别为45.10±0.74和87.30±1.76,两者辐照前后回声信号的灰度变化值比较差异均有统计学意义(均P<0.001);体外光声成像显示,浓度为20、40、60、80μg/ml的IR780-CLs溶液对应的光声信号值分别为0.476、0.864、1.378、1.996 a.u.。离体牛肝实验表明,IR780-CLs具有显著增效HIFU的作用;被动空化检测结果显示,IR780-CLs组RMS高于PBS组。结论 本实验成功制备IR780-CLs,其具有良好的体外超声、光声双模态成像能力和靶向肿瘤的能力,并能显著提高HIFU消融牛肝的效率,其增效HIFU的主要机制为空化效应。 展开更多
关键词 高强度聚焦超声 纳米粒 光声成像 空化效应
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磁共振/光声双模态分子影像探针的研究进展
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作者 徐男 郭效宾 +2 位作者 柯腾飞 廖承德 杨军 《中国CT和MRI杂志》 2023年第7期172-173,184,共3页
多模态成像技术可以对同一生物体进行多方面的成像,克服单一成像的局限性,是一种非常有前景的生物医学成像方法。磁共振/光声(MR/PA)双模态分子探针结合MRI和光声成像的特点,突破原有成像研究限制,拓宽成像技术的应用范围。本文对MR/PA... 多模态成像技术可以对同一生物体进行多方面的成像,克服单一成像的局限性,是一种非常有前景的生物医学成像方法。磁共振/光声(MR/PA)双模态分子探针结合MRI和光声成像的特点,突破原有成像研究限制,拓宽成像技术的应用范围。本文对MR/PA双模态分子探针类别以及临床应用前景进行综述。 展开更多
关键词 MRI 光声成像 双模态成像 分子探针
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骨骼肌肉系统的光声成像应用进展 被引量:1
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作者 刁宗平 赵佳琦 《海军军医大学学报》 CAS CSCD 北大核心 2023年第2期150-154,共5页
光声成像兼具结构与功能成像的特点,是目前医学影像技术研究的新热点,研究方向涵盖了微观的细胞分子和宏观的组织器官。光声成像可通过直接定量评估肌红蛋白血氧饱和度反映受损肌肉的修复状态,亦可在2D和3D模式下清晰显示关节软骨、滑... 光声成像兼具结构与功能成像的特点,是目前医学影像技术研究的新热点,研究方向涵盖了微观的细胞分子和宏观的组织器官。光声成像可通过直接定量评估肌红蛋白血氧饱和度反映受损肌肉的修复状态,亦可在2D和3D模式下清晰显示关节软骨、滑膜、血管和骨组织的结构形态。在关节炎症检测中,光声成像可无创地评估软骨受损程度,并通过抗体与光声造影剂偶联精准地分辨炎症分子标志物分布的空间信息,有助于关节炎的诊断和进展分期。 展开更多
关键词 光声成像 骨骼肌 软组织损伤 关节炎 肌骨超声
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A molecular probe carrying anti-tropomyosin 4 for early diagnosis of cerebral ischemia/reperfusion injury
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作者 Teng-Fei Yu Kun Wang +5 位作者 Lu Yin Wen-Zhe Li Chuan-Ping Li Wei Zhang Jie Tian Wen He 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第6期1321-1324,共4页
In vivo imaging of cerebral ischemia/reperfusion injury remains an important challenge.We injected porous Ag/Au@SiO_(2) bimetallic hollow nanoshells carrying anti-tropomyosin 4 as a molecular probe into mice with cere... In vivo imaging of cerebral ischemia/reperfusion injury remains an important challenge.We injected porous Ag/Au@SiO_(2) bimetallic hollow nanoshells carrying anti-tropomyosin 4 as a molecular probe into mice with cerebral ischemia/reperfusion injury and observed microvascular changes in the brain using photoacoustic imaging with ultrasonography.At each measured time point,the total photoacoustic signal was significantly higher on the affected side than on the healthy side.Twelve hours after reperfusion,cerebral perfusion on the affected side increased,cerebrovascular injury worsened,and anti-tropomyosin 4 expression increased.Twenty-four hours after reperfusion and later,perfusion on the affected side declined slowly and stabilized after 1 week;brain injury was also alleviated.Histopathological and immunohistochemical examinations confirmed the brain injury tissue changes.The nanoshell molecular probe carrying anti-tropomyosin 4 has potential for use in early diagnosis of cerebral ischemia/reperfusion injury and evaluating its progression. 展开更多
关键词 cerebral ischemia/reperfusion injury diagnosis dynamic monitoring ischemic stroke middle cerebral artery occlusion molecular probe NANOSHELLS photoacoustic imaging tropomyosin 4 ultrasound
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光声成像及其在生物医学中的应用 被引量:20
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作者 谷怀民 杨思华 向良忠 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2006年第5期431-437,共7页
光声成像是一种新近迅速发展起来、基于生物组织内部光学吸收差异、以超声作媒介的无损生物光子成像方法,它结合了纯光学成像的高对比度特性和纯超声成像的高穿透深度特性的优点,以超声探测器探测光声波代替光学成像中的光子检测,从原... 光声成像是一种新近迅速发展起来、基于生物组织内部光学吸收差异、以超声作媒介的无损生物光子成像方法,它结合了纯光学成像的高对比度特性和纯超声成像的高穿透深度特性的优点,以超声探测器探测光声波代替光学成像中的光子检测,从原理上避开了光学散射的影响,可以提供高对比度和高分辨率的组织影像,为研究生物组织的结构形态、生理特征、代谢功能、病理特征等提供了重要手段,在生物医学临床诊断以及在体组织结构和功能成像领域具有广泛的应用前景.对光声成像技术的机理、光声成像技术和方法、光声图像重建算法以及光声成像在生物医学上的应用情况作一个简单介绍,希望有助于推动我国在该领域的科研和开发应用工作的迅速发展. 展开更多
关键词 光声成像 超声探测 图像重建 医学成像 肿瘤诊断 光学散射
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超声引导下肝癌热消融治疗的现状与进展 被引量:12
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作者 李鑫 梁萍 《临床肝胆病杂志》 CAS 北大核心 2021年第3期510-514,共5页
肝癌是临床上常见的恶性肿瘤,影像引导下热消融治疗为早期肝癌根治性治疗手段,为中晚期肝癌的姑息减瘤及联合系统治疗的主要手段之一。超声技术以其显像实时、引导准确、操作简便、移动便捷、费用低廉、无辐射损伤及高效节能等优势在肝... 肝癌是临床上常见的恶性肿瘤,影像引导下热消融治疗为早期肝癌根治性治疗手段,为中晚期肝癌的姑息减瘤及联合系统治疗的主要手段之一。超声技术以其显像实时、引导准确、操作简便、移动便捷、费用低廉、无辐射损伤及高效节能等优势在肝癌热消融治疗术前规划、术中引导、术后评估及长期随访中发挥重要作用,尤其随着超声与影像融合技术的进步以及与光声成像为代表的功能影像技术的发展,使超声引导下热消融走在肝癌精准治疗的最前沿,并保持持久发展,向更微创、精准、安全、有效的诊疗模式发展。 展开更多
关键词 肝细胞 消融技术 超声 多模态影像融合 光声成像
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载吲哚菁绿和液态氟碳的光致相变型纳米粒的制备及增强体内成像的实验研究 被引量:5
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作者 宫玉萍 陈澄 +1 位作者 孙阳 王志刚 《临床超声医学杂志》 2016年第4期217-220,共4页
目的制备一种光致相变型液态氟碳纳米粒,研究其体外相变及体内增强光声、超声成像能力。方法采用三步乳化技术制备出以聚乳酸-羟基乙酸共聚物(PLGA)为载体,液态氟碳(PFH)和吲哚菁绿(ICG)为内核的纳米粒,检测该纳米粒的粒径和电位,然后... 目的制备一种光致相变型液态氟碳纳米粒,研究其体外相变及体内增强光声、超声成像能力。方法采用三步乳化技术制备出以聚乳酸-羟基乙酸共聚物(PLGA)为载体,液态氟碳(PFH)和吲哚菁绿(ICG)为内核的纳米粒,检测该纳米粒的粒径和电位,然后体外激光辐照激发纳米粒相变,体内观察该纳米粒增强超声及光声成像的能力。结果成功制备出包裹PFH和ICG的光致相变型纳米粒,该纳米粒平均粒径(599.2±134.3)nm,平均电位(-24.10±4.09)m V。激光辐照后,纳米粒可发生相变转变成微米级的微泡,体内增强了裸鼠移植瘤的光声及超声信号。结论制备的光致相变型纳米粒在激光作用下发生相变,并可增强体内超声、光声成像,为临床疾病的诊断提供了新的思路。 展开更多
关键词 吲哚菁绿 液态氟碳 光致相变 超声成像 光声成像
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