A green and sustainable synthetic strategy for amide bond formation utilizing a visible light-promoted nitrone formation/rearrangement cascade was developed.This method utilized visible light as the sole and clean ene...A green and sustainable synthetic strategy for amide bond formation utilizing a visible light-promoted nitrone formation/rearrangement cascade was developed.This method utilized visible light as the sole and clean energy source without the need for an exogenous photoredox catalyst or additive.Moreover,nitrones are generated in situ,bypassing the isolation process and producing only nitrogen gas as a byproduct.The synthetic value of this protocol has potential applications in the syntheses of amides containing important natural products and drugbased complex molecules.展开更多
基金The authors acknowledge the National Natural Science Foundation of China(nos.21971001 and 21702001)the Start-up Grant from Anhui University for financial support of this work.
文摘A green and sustainable synthetic strategy for amide bond formation utilizing a visible light-promoted nitrone formation/rearrangement cascade was developed.This method utilized visible light as the sole and clean energy source without the need for an exogenous photoredox catalyst or additive.Moreover,nitrones are generated in situ,bypassing the isolation process and producing only nitrogen gas as a byproduct.The synthetic value of this protocol has potential applications in the syntheses of amides containing important natural products and drugbased complex molecules.
