Trapping unstable intermediates for elucidating reaction mechanisms in chemistry presents a formidable challenge.There has long been a lack of direct evidence for key intermediates like the highly reactive phlorin lea...Trapping unstable intermediates for elucidating reaction mechanisms in chemistry presents a formidable challenge.There has long been a lack of direct evidence for key intermediates like the highly reactive phlorin leading to porphyrin.Here,we report a molecular-strain engineering(MSE)strategy that harnesses intramolecular strain to trap the native phlorin during porphyrin synthesis.By mechanically constraining its periphery,a phlorin stable towards oxidation was captured as an isolable intermediate and fully characterized.展开更多
基金from the National Natural Science Foundation of China(grant nos.22171232 and 21971211)the Natural Science Foundation of Zhejiang Province(grant no.2022XHSJJ007)the Qiantang River Talent Foundation(grant no.QJD1902029).
文摘Trapping unstable intermediates for elucidating reaction mechanisms in chemistry presents a formidable challenge.There has long been a lack of direct evidence for key intermediates like the highly reactive phlorin leading to porphyrin.Here,we report a molecular-strain engineering(MSE)strategy that harnesses intramolecular strain to trap the native phlorin during porphyrin synthesis.By mechanically constraining its periphery,a phlorin stable towards oxidation was captured as an isolable intermediate and fully characterized.
