Identification of a mitochondria-targeting fluorescent small molecule for dual phototherapy

Phototherapy,mainly induding photodynamic therapy(PDT)and photothermal therapy(PTT),is a noninvasive and effective approach for cancer treatment.Since integration of PDT and PTT for simultaneous synergistic PDT/PTT treatment enables us to improve phototherapeutic eficacy significantly,it has been attracting a lot of investigations in current days.Here,we introduce IR-52,a new mitochondria-targeting near infrared(NIR)fAuorescent small molecule,which possesses structure inherent PTT and PDT synergistic photother apeutic effects wit hout conjugation to specific ligands.After NIR light irradiation(808 nm,2 W/cm^(2),5min),both the hyperthermia and excessive singlet oaxygen levels were determined when dis-solving IR-52 in aqueous sohutions.In vitro photoinduced cytotoxicity studies showed signifcant lower cell viabilities and higher necrotic/apoptotic rates when cancer cells were treated with IR-52 and irradiation,and its'mitochondrial localization in cancer cells would partially explain its high cytotoxicity.Further in vivo synergetic PDT and PTT effects were demonstrated by high tumor surface temperature and sigmificant inhibition of tumor growth.Our results strongly suggest that IR-52,which possesses excellent photosensitivity,may provide a promising strategy for tumor treatment with decreased side effects.

有机小分子纳米粒子的光学诊疗应用

癌症严重威胁着人类健康,因此,急需开发高效的诊断和治疗方法.基于光敏剂和近红外激光的光学诊疗将诊断和治疗集于一体,与传统的手术治疗和化学治疗相比,光学诊疗显示出无创性和高空间选择性的优点.有机小分子染料具有确定且易于修饰的化学结构、良好的重现性和优异的生物相容性,与无机和聚合物材料相比,它是一类具有前景的可用于光学诊疗的光敏剂.本文总结了基于传统小分子染料、给体-受体(D-A)共轭小分子和聚集诱导发光(AIE)分子等有机小分子的纳米粒子在光学诊疗中的应用.此外,对于光学诊疗用有机小分子染料纳米粒子未来的挑战和前景也进行了展望.

基于黑磷的药物递送系统在肿瘤诊疗中的研究进展

黑磷作为二维材料的新成员,因具有良好的生物降解性、生物相容性、随层数可调的直接带隙、超大的比表面积等优良特性,在光声成像、光热光动力治疗、药物装载等领域中展现出良好的应用前景。由于黑磷具有易氧化、易降解的特点,利用相对稳定的脂质材料或聚合物材料对其进行包被,构建基于黑磷的药物递送系统,在肿瘤治疗和诊断中显示出较大的潜力,成为药物递送研究中的新热点。本文详细介绍了黑磷在肿瘤诊疗中的作用,并重点归纳了近年来基于黑磷的药物递送系统的设计及其在肿瘤诊疗中的研究进展,以期为黑磷的研究和应用提供参考和思路。