Key advances in multifunctional magnetic nanoparticles （MNPs） for magnetic resonance （MR） image-guided pho- tothermal therapy of cancer are reviewed. We briefly outline the design and fabrication of such multifunc...Key advances in multifunctional magnetic nanoparticles （MNPs） for magnetic resonance （MR） image-guided pho- tothermal therapy of cancer are reviewed. We briefly outline the design and fabrication of such multifunctional MNPs. Bimodal image-guided photothermal therapies （MR/fluorescence and MR/ultrasound） are also discussed.展开更多
WS2 nanosheets were prepared by the solvent-thermal method in the presence of n-butyl lithium, then the exfoliation under the condition of ultrasound. The formed WS2 nanosheets were conjugated with thiol-modified poly...WS2 nanosheets were prepared by the solvent-thermal method in the presence of n-butyl lithium, then the exfoliation under the condition of ultrasound. The formed WS2 nanosheets were conjugated with thiol-modified polyethylene glycol （PEG-SH） to improve the biocompatibility. The nanosheets （WS2- PEG） were able to inhibit the growth of a model HeLa cancer cell line in vitro due to the high photothermal conversion efficiency of ~35% irradiated by an 808 nm laser （1 W/cm^2）. As a proof of concept, WS2-PEG nanosheets with the better X-ray attenuation property than the clinical computed tomography （CT） contrast agent （lohexol） could be performed for CT imaging of the lymph vessel.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.81371580 and 21273014)the State Key Program of the National Natural Science Foundation of China(Grant No.81230036)the National Natural Science Foundation for Distinguished Young Scholars(Grant No.81225011)
文摘Key advances in multifunctional magnetic nanoparticles （MNPs） for magnetic resonance （MR） image-guided pho- tothermal therapy of cancer are reviewed. We briefly outline the design and fabrication of such multifunctional MNPs. Bimodal image-guided photothermal therapies （MR/fluorescence and MR/ultrasound） are also discussed.
基金partially supported by National Natural Science Foundation of China (Nos.21271130,21371122,and 11275050)Program for Changjiang Scholars and Innovative Research Team in University (No.IRT1269)+4 种基金Shanghai Science and Technology Development Fund (Nos.12ZR1421800 and 13520502800)Shanghai Pujiang Program (No.13PJ1406600)Shanghai Municipal Education Commission (No.13ZZ110)Shanghai Normal University (Nos.DXL122 and SK201339)International Joint Laboratory on Resource Chemistry (IJLRC)
文摘WS2 nanosheets were prepared by the solvent-thermal method in the presence of n-butyl lithium, then the exfoliation under the condition of ultrasound. The formed WS2 nanosheets were conjugated with thiol-modified polyethylene glycol （PEG-SH） to improve the biocompatibility. The nanosheets （WS2- PEG） were able to inhibit the growth of a model HeLa cancer cell line in vitro due to the high photothermal conversion efficiency of ~35% irradiated by an 808 nm laser （1 W/cm^2）. As a proof of concept, WS2-PEG nanosheets with the better X-ray attenuation property than the clinical computed tomography （CT） contrast agent （lohexol） could be performed for CT imaging of the lymph vessel.
