Exposure to phthalate acid esters(PAEs)has been found to have adverse effects on reproduction of human and animal.However,the effects on the semen quality are controversial.In this study,we have collected paired blood...Exposure to phthalate acid esters(PAEs)has been found to have adverse effects on reproduction of human and animal.However,the effects on the semen quality are controversial.In this study,we have collected paired blood and sperm samples from patients(n=103)at a medical clinic in Guangzhou,China,to determine the concentrations of eight phthalate metabolites∑8m-PAEs).The concentration ranges of P8m-PAEs were 2.7-55 and 0.99-17 ng/mL in blood and semen samples,respectively.MEHP(median,3.6 ng/mL in blood and 0.55 ng/mL in semen)and MnOP(median,3.4 ng/mL in blood and 0.69 ng/mL in semen)were the predominant analytes in both blood and semen samples.However,analytes were not correlated in paired blood and semen.Semen motility was significantly associated to the concentrations of∑8m-PAEs in semen,but it did not associate to the concentrations of PAEs in blood.Multi-linear regression analysis,including concentrations of PAEs in both blood and semen,as well as BMI,occupation,living habits,suggested that exposure to PAEs at current environmental levels had very limited effects on semen quality of population in Guangzhou,China.展开更多
Phthalates(PAEs)are synthetic chemicals widely used in industrial and personal consumer products as adhesives or plasticizers.PAEs have been demonstrated to have toxic effects on the human body.However,biological moni...Phthalates(PAEs)are synthetic chemicals widely used in industrial and personal consumer products as adhesives or plasticizers.PAEs have been demonstrated to have toxic effects on the human body.However,biological monitoring data for the internal PAE exposure levels of Chinese rural residents are still limited.The present study investigated the exposure levels of ten phthalate metabolites(mPAEs)of rural residents in Northwest China.The results showed that mPAEs were wildly prevalent in urine and the geometric mean concentration ofΣ10mPAEs was 957.02 ng mL^(–1)(adjusted by specific gravity).Mono-n-butyl phthalate(MBP)and metabolites of di(2-ethylhexyl)-phthalate(DEHP)were the most dominant mPAEs in urine,with specific gravity adjusted median concentrations of 174.67 and 156.30 ng mL^(–1),respectively.Urinary concentrations of mPAEs were significantly associated with age,body mass index and economic level(p<0.05).By calculating the percentage and relative conversion rate of DEHP metabolites,it was found that the degree of oxidative metabolism of DEHP in children was significantly higher than that in adults(p<0.05),indicating that the pathway and degree of DEHP oxidation were age-related.The risk assessment showed that 59.12%of rural residents may have a noncancer risk from PAE exposure.This study provides important basis for assessing the occurrence and exposure of urinary phthalate metabolites among rural residents in China.展开更多
基金the 2011 Education Department Breeding Project of Guangdong,China(LYM11011),the Third Affiliated Hospital of Sun Yat-sen University and the Open Fund of Guangdong Provincial Key Laboratory of Petrochemical Pollution Process and Control,Guangdong University of Petrochemical Technology(No.2018B030322017)China Postdoctoral Science Foundation(2018M643670).
文摘Exposure to phthalate acid esters(PAEs)has been found to have adverse effects on reproduction of human and animal.However,the effects on the semen quality are controversial.In this study,we have collected paired blood and sperm samples from patients(n=103)at a medical clinic in Guangzhou,China,to determine the concentrations of eight phthalate metabolites∑8m-PAEs).The concentration ranges of P8m-PAEs were 2.7-55 and 0.99-17 ng/mL in blood and semen samples,respectively.MEHP(median,3.6 ng/mL in blood and 0.55 ng/mL in semen)and MnOP(median,3.4 ng/mL in blood and 0.69 ng/mL in semen)were the predominant analytes in both blood and semen samples.However,analytes were not correlated in paired blood and semen.Semen motility was significantly associated to the concentrations of∑8m-PAEs in semen,but it did not associate to the concentrations of PAEs in blood.Multi-linear regression analysis,including concentrations of PAEs in both blood and semen,as well as BMI,occupation,living habits,suggested that exposure to PAEs at current environmental levels had very limited effects on semen quality of population in Guangzhou,China.
基金The authors gratefully acknowledge financial support from the National Natural Science Foundation of China(42177412)Ministry of Education of China(B17025).
文摘Phthalates(PAEs)are synthetic chemicals widely used in industrial and personal consumer products as adhesives or plasticizers.PAEs have been demonstrated to have toxic effects on the human body.However,biological monitoring data for the internal PAE exposure levels of Chinese rural residents are still limited.The present study investigated the exposure levels of ten phthalate metabolites(mPAEs)of rural residents in Northwest China.The results showed that mPAEs were wildly prevalent in urine and the geometric mean concentration ofΣ10mPAEs was 957.02 ng mL^(–1)(adjusted by specific gravity).Mono-n-butyl phthalate(MBP)and metabolites of di(2-ethylhexyl)-phthalate(DEHP)were the most dominant mPAEs in urine,with specific gravity adjusted median concentrations of 174.67 and 156.30 ng mL^(–1),respectively.Urinary concentrations of mPAEs were significantly associated with age,body mass index and economic level(p<0.05).By calculating the percentage and relative conversion rate of DEHP metabolites,it was found that the degree of oxidative metabolism of DEHP in children was significantly higher than that in adults(p<0.05),indicating that the pathway and degree of DEHP oxidation were age-related.The risk assessment showed that 59.12%of rural residents may have a noncancer risk from PAE exposure.This study provides important basis for assessing the occurrence and exposure of urinary phthalate metabolites among rural residents in China.
