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A micro-crosslinked amphoteric hydrophobic association copolymer as high temperature-and salt-resistance fluid loss reducer for water-based drilling fluids
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作者 Jian Li Yu-Xi Ji +3 位作者 Xiao-Xiao Ni Kai-He Lv Xian-Bin Huang Jin-Sheng Sun 《Petroleum Science》 SCIE EI CAS CSCD 2024年第3期1980-1991,共12页
During ultradeep oil and gas drilling,fluid loss reducers are highly important for water-based drilling fluids,while preparing high temperature-and salt-resistance fluid loss reducers with excellent rheology and filtr... During ultradeep oil and gas drilling,fluid loss reducers are highly important for water-based drilling fluids,while preparing high temperature-and salt-resistance fluid loss reducers with excellent rheology and filtration performance remains a challenge.Herein,a micro-crosslinked amphoteric hydrophobic association copolymer(i.e.,DADC)was synthesized using N,N-dimethyl acrylamide,diallyl dimethyl ammonium chloride,2-acrylamido-2-methylpropane sulfonic acid,hydrophobic monomer,and pentaerythritol triallyl ether crosslinker.Due to the synergistic effects of hydrogen bonds,electrostatic interaction,hydrophobic association,and micro-crosslinking,the DADC copolymer exhibited outstanding temperature-and salt-resistance.The rheological experiments have shown that the DADC copolymer had excellent shear dilution performance and a certain degree of salt-responsive viscosity-increasing performance.The DADC copolymer could effectively adsorb on the surface of bentonite particles through electrostatic interaction and hydrogen bonds,which bring more negative charge to the bentonite,thus improving the hydration and dispersion of bentonite particles as well as the colloidal stability of the drilling fluids.Moreover,the drilling fluids constructed based on the DADC copolymer exhibited satisfactory rheological and filtration properties(FLHTHP=12 m L)after aging at high temperatures(up to200℃)and high salinity(saturated salt)environments.Therefore,this work provided new insights into designing and fabricating high-performance drilling fluid treatment agents,demonstrating good potential applications in deep and ultradeep drilling engineering. 展开更多
关键词 Fluid loss reducer Temperature-and salt-resistance Hydrophobic association AMPHOTERIC Micro-crosslinking
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Distribution and dynamics of niche and interspecific association of dominant phytoplankton species in the Feiyun River basin,Zhejiang,China
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作者 Shengnan ZHU Zengchuan DONG +6 位作者 Guobin FU Shujun WU Jinyu MENG Weilin LIU Yupeng LIU Xun CUI Yuejiao ZHOU 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2024年第4期1157-1172,共16页
To investigate the dominant species and interspecific association in the phytoplankton community of the Feiyun River basin in Zhejiang Province,East China,the main stream and the Shanxi Zhaoshandu Reservoir in the dow... To investigate the dominant species and interspecific association in the phytoplankton community of the Feiyun River basin in Zhejiang Province,East China,the main stream and the Shanxi Zhaoshandu Reservoir in the downstream were chosen as the study area,for which 22 sampling sites were designated.Sampling was conducted in September 2021,January,May,and July 2022.Phytoplankton species were identified from both quantitative samples and in-vivo observations.Phytoplankton was quantified by direct counting.Results show that there were 98 species belonging to 6 phyla and 78 genera.In addition,to clarify the niches of the dominant phytoplankton species and their interspecific association,the dominance index was calculated,and a comprehensive analysis was conducted including niche width,niche overlap value,ecological response rate,overall association,chi-square test,and the stability.The phytoplankton community exhibited characteristics of a Cyanobacteria-Chlorophyta-Diatom type community,showing higher diversity in spring and lower diversity in summer.Among 11 dominants phytoplankton species from 3 phyla,both frequency and dominance degree varied seasonally,of which Microcystis sp.was the dominant species in Spring,Autumn,and Winter.The niche widths of the dominant species ranged from 0.234 to 0.933,and were categorized into three groups.The niche overlap values of the 11 dominant species ranged from 0.359 to 0.959,exhibiting significant seasonal differences-highest in winter followed by autumn,spring,and summer in turn.The overall correlation among dominant species in all four seasons revealed a non-significant negative association,resulting in an unstable community structure.A significant portion(84.2%)of species pairs displayed positive associations,suggesting a successional pattern where Diatoms dominated while other dominant species shared resources and space.Despite this pattern,stability measurements indicated that the dominant species community remained unstable.Therefore,careful monitoring is recommended for potential water environment issues arising from abnormal proliferation of dominant species in the watershed during winter.This research built a theoretical foundation with a data support to the early warning of eutrophication and provided a reference for water resources management in similar watersheds along the eastern coast of China. 展开更多
关键词 PHYTOPLANKTON dominant species NICHE interspecific association Feiyun River basin
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Strengthening Active Aging through Older People’s Association and Economic Activity of the Older People in Nepal
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作者 Hom Nath Chalise James Brightman 《Advances in Aging Research》 CAS 2024年第2期15-24,共10页
Aging is a natural lifelong process ending in death. Many older people are living in poverty. Older people are generally considered dependent on others as they grow older. The purpose of this article is to explore the... Aging is a natural lifelong process ending in death. Many older people are living in poverty. Older people are generally considered dependent on others as they grow older. The purpose of this article is to explore the entrepreneurship activities of Nepalese older adults. Data for this study were collected from the project Help Age International (HAI) implemented in Nepal. Qualitative data observations and interviews were used to collect data. The findings of this study show the formation of the Older People’s Association (OPA) has supported many older people to participate outside the home in various social activities. Moreover, regular deposits through OPAs offer little help. OPAs support older people in their need of financial support to implement minor entrepreneurship. Older people who received support were pleased and were actively involved in their activities and also regularly deposited money in them. Subsequently, older people’s participation in social activities has increased and also helped to lower elderly abuse, loneliness, and depression. Local governments should promote such activities which will help with healthy aging. 展开更多
关键词 Aging in Nepal Active Aging Older People’s association Older People Healthy Aging
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THAPE: A Tunable Hybrid Associative Predictive Engine Approach for Enhancing Rule Interpretability in Association Rule Learning for the Retail Sector
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作者 Monerah Alawadh Ahmed Barnawi 《Computers, Materials & Continua》 SCIE EI 2024年第6期4995-5015,共21页
Association rule learning(ARL)is a widely used technique for discovering relationships within datasets.However,it often generates excessive irrelevant or ambiguous rules.Therefore,post-processing is crucial not only f... Association rule learning(ARL)is a widely used technique for discovering relationships within datasets.However,it often generates excessive irrelevant or ambiguous rules.Therefore,post-processing is crucial not only for removing irrelevant or redundant rules but also for uncovering hidden associations that impact other factors.Recently,several post-processing methods have been proposed,each with its own strengths and weaknesses.In this paper,we propose THAPE(Tunable Hybrid Associative Predictive Engine),which combines descriptive and predictive techniques.By leveraging both techniques,our aim is to enhance the quality of analyzing generated rules.This includes removing irrelevant or redundant rules,uncovering interesting and useful rules,exploring hidden association rules that may affect other factors,and providing backtracking ability for a given product.The proposed approach offers a tailored method that suits specific goals for retailers,enabling them to gain a better understanding of customer behavior based on factual transactions in the target market.We applied THAPE to a real dataset as a case study in this paper to demonstrate its effectiveness.Through this application,we successfully mined a concise set of highly interesting and useful association rules.Out of the 11,265 rules generated,we identified 125 rules that are particularly relevant to the business context.These identified rules significantly improve the interpretability and usefulness of association rules for decision-making purposes. 展开更多
关键词 association rule learning POST-PROCESSING PREDICTIVE machine learning rule interpretability
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Epistasis-aware genome-wide association studies provide insights into the efficient breeding of high-yield and high-quality rice
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作者 Xiaogang He Zirong Li +6 位作者 Sicheng Guo Xingfei Zheng Chunhai Liu Zijie Liu Yongxin Li Zheming Yuan Lanzhi Li 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第8期2541-2556,共16页
Marker-assisted selection(MAS)and genomic selection(GS)breeding have greatly improved the efficiency of rice breeding.Due to the influences of epistasis and gene pleiotropy,ensuring the actual breeding effect of MAS a... Marker-assisted selection(MAS)and genomic selection(GS)breeding have greatly improved the efficiency of rice breeding.Due to the influences of epistasis and gene pleiotropy,ensuring the actual breeding effect of MAS and GS is still a difficult challenge to overcome.In this study,113 indica rice varieties(V)and their 565 testcross hybrids(TC)were used as the materials to investigate the genetic basis of 12 quality traits and nine agronomic traits.The original traits and general combining ability of the parents,as well as the original traits and midparent heterosis of TC,were subjected to genome-wide association analysis.In total,381 primary significantly associated loci(SAL)and 1,759 secondary SALs that had epistatic interactions with these primary SALs were detected.Among these loci,322 candidate genes located within or nearby the SALs were screened,204 of which were cloned genes.A total of 39 MAS molecular modules that are beneficial for trait improvement were identified by pyramiding the superior haplotypes of candidate genes and desirable epistatic alleles of the secondary SALs.All the SALs were used to construct genetic networks,in which 91 pleiotropic loci were investigated.Additionally,we estimated the accuracy of genomic prediction in the parent V and TC by incorporating either no SALs,primary SALs,secondary SALs or epistatic effect SALs as covariates.Although the prediction accuracies of the four models were generally not significantly different in the TC dataset,the incorporation of primary SALs,secondary SALs,and epistatic effect SALs significantly improved the prediction accuracies of 5(26%),3(16%),and 11(58%)traits in the V dataset,respectively.These results suggested that SALs and epistatic effect SALs identified based on an additive genotype can provide considerable predictive power for the parental lines.They also provide insights into the genetic basis of complex traits and valuable information for molecular breeding in rice. 展开更多
关键词 rice genome-wide association study EPISTASIS gene pleiotropy maker-associated selection genome selection
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Demography and Socio-Economic Aspects on Irrigated Smallholder Agricultural Enterprises and Their Association with the Cultivation of Maize (Zea mays L.) as a Selected Field Crop
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作者 Tsumbedzo Jutas Mavhungu Azwihangwisi Edward Nesamvuni +2 位作者 Khathutshelo Alfred Tshikolomo Ndivhudzannyi Sylvestor Mpandeli Johan Adriaan van Niekerk 《Agricultural Sciences》 2024年第7期729-741,共13页
The purpose of this study is to correlate demography and socio-economic aspects at Irrigated Smallholder Agricultural Enterprises and their association with the Cultivation of Maize in order to determine its positive ... The purpose of this study is to correlate demography and socio-economic aspects at Irrigated Smallholder Agricultural Enterprises and their association with the Cultivation of Maize in order to determine its positive impacts at irrigated smallholders’ agricultural entrepreneurs’ household. Chi-square test was used as descriptive analysis method. The Fischer Exact tests were employed to test demography (gender, age, education, and income) in winter and summer production season of irrigated smallholder agricultural enterprises and their association with the cultivation of selected field crop (i.e. maize). The results show that gender results were not being statistically significant, as measured by the Phi measure of effect size, φ = 0.149, p = 0.011, and φ = 0.05, p = 0.392 in summer. As far as age is concern, it appears to be a statistically significant association between cultivating maize and age in winter, φ = 0.046, p = 0.730 in winter and φ = 0.172, p = 0.013. Education winter result not being statistically significant, the effect size showed a weak association, as measured by the Phi measure of effect size, φ = 0.112, p = 0.305 and φ = 0.035, p = 0.948 in summer. Income result not being statistically significant, as measured by the Phi measure of effect size, φ = 0.049, p = 0.399 and φ = 0.081, p = 0.166 in summer. In conclusion, the study shows that the development of best management practices must be based on a comprehensive analysis of the livelihoods and irrigated smallholder agricultural enterprise farming styles of participating irrigated smallholder agricultural entrepreneurs. 展开更多
关键词 MAIZE association Irrigated Smallholder Agricultural Enterprises DEMOGRAPHY Livelihoods
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Association between Placental Malaria and Severe Pre-Eclampsia in Two University Hospitals of Yaounde City
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作者 Ayissi Gregory Astrid Ruth Ndolo Kondo +10 位作者 Ndoumba Afouba Alice Noa Ndoua Claude Cyrille Essiben Félix Meka Esther Belinga Etienne Metogo Junie Engo Engo Samuel Désiré Bodo Edmond Lemaire Tchente Nguefack Charlotte Foumane Pascal Mboudou Emile Télésphore 《Open Journal of Obstetrics and Gynecology》 2024年第9期1488-1511,共24页
Context: Pre-eclampsia and placental malaria, are two diseases that share pathophysiological similarities, such as placental ischemia, endothelial dysfunction and production of pro-inflammatory cytokines. Objective: T... Context: Pre-eclampsia and placental malaria, are two diseases that share pathophysiological similarities, such as placental ischemia, endothelial dysfunction and production of pro-inflammatory cytokines. Objective: The objective of our study was to investigate the association between placental malaria lesions and severe pre-eclampsia. Methodology: We conducted a prospective analytical cross-sectional study in two University Hospitals in the city of Yaounde (Yaounde Central Hospital and the Gynaecological Obstetrics and Paediatrics Hospital), and in the laboratory of the Centre Pasteur in Yaounde over an eight-month period (1st January 2021 – 1st September 2021). All patients with pre-eclampsia diagnosed according to the criteria of the International Society for the Study of Hypertension (ISSHP) and free of chronic metabolic or infectious pathology were included in this study. The patients were divided into two groups: group 1 (mild pre-eclampsia) and group 2: severe pre-eclampsia. Socio-demographic, clinical and histopathological characteristics specific to pre-eclampsia and placental malaria were investigated. Statistical analysis was performed with SPSS 23.0 software, Chi 2 was used to compare categorical variables, Student t-test was used to compare means, and logistic regression was used to assess the association between placental malaria lesions and PES. Results: The mean age of our study population was 29.93 ± 7.36 years versus 28.28 ± 7.18 years in patients with mild and severe pre-eclampsia respectively. Pre-eclampsia placental lesions (accelerated villous maturation, infarction) were significantly greater in patients with severe pre-eclampsia (p Conclusion: Placental malaria lesions were significantly associated with severe pre-eclampsia and increased the risk of developing severe pre-eclampsia placental lesions by a factor of 10. 展开更多
关键词 Mild Pre-Eclampsia Severe Pre-Eclampsia MALARIA Placental Lesions association
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Leveraging the potential of big genomic and phenotypic data for genome-wide association mapping in wheat
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作者 Moritz Lell Yusheng Zhao Jochen C.Reif 《The Crop Journal》 SCIE CSCD 2024年第3期803-813,共11页
Genome-wide association mapping studies(GWAS)based on Big Data are a potential approach to improve marker-assisted selection in plant breeding.The number of available phenotypic and genomic data sets in which medium-s... Genome-wide association mapping studies(GWAS)based on Big Data are a potential approach to improve marker-assisted selection in plant breeding.The number of available phenotypic and genomic data sets in which medium-sized populations of several hundred individuals have been studied is rapidly increasing.Combining these data and using them in GWAS could increase both the power of QTL discovery and the accuracy of estimation of underlying genetic effects,but is hindered by data heterogeneity and lack of interoperability.In this study,we used genomic and phenotypic data sets,focusing on Central European winter wheat populations evaluated for heading date.We explored strategies for integrating these data and subsequently the resulting potential for GWAS.Establishing interoperability between data sets was greatly aided by some overlapping genotypes and a linear relationship between the different phenotyping protocols,resulting in high quality integrated phenotypic data.In this context,genomic prediction proved to be a suitable tool to study relevance of interactions between genotypes and experimental series,which was low in our case.Contrary to expectations,fewer associations between markers and traits were found in the larger combined data than in the individual experimental series.However,the predictive power based on the marker-trait associations of the integrated data set was higher across data sets.Therefore,the results show that the integration of medium-sized to Big Data is an approach to increase the power to detect QTL in GWAS.The results encourage further efforts to standardize and share data in the plant breeding community. 展开更多
关键词 Big Data Genome-wide association study Data integration Genomic prediction WHEAT
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Tree mycorrhizal associations determine how biodiversity,large trees,and environmental factors drive aboveground carbon stock in temperate forests
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作者 Yue Chen Zikun Mao +2 位作者 Jonathan A.Myers Jinghua Yu Xugao Wang 《Forest Ecosystems》 SCIE CSCD 2024年第4期448-456,共9页
Biodiversity,large trees,and environmental conditions such as climate and soil have important effects on forest carbon stocks.However,recent studies in temperate forests suggest that the relative importance of these f... Biodiversity,large trees,and environmental conditions such as climate and soil have important effects on forest carbon stocks.However,recent studies in temperate forests suggest that the relative importance of these factors depends on tree mycorrhizal associations,whereby large-tree effects may be driven by ectomycorrhizal(EM)trees,diversity effects may be driven by arbuscular mycorrhizal(AM)trees,and environment effects may depend on differential climate and soil preferences of AM and EM trees.To test this hypothesis,we used forest-inventory data consisting of over 80,000 trees from 631 temperate-forest plots(30 m×30 m)across Northeast China to examine how biodiversity(species diversity and ecological uniqueness),large trees(top 1%of tree diameters),and environmental factors(climate and soil nutrients)differently regulate aboveground carbon stocks of AM trees,EM trees,and AM and EM trees combined(i.e.total aboveground carbon stock).We found that large trees had a positive effect on both AM and EM tree carbon stocks.However,biodiversity and environmental factors had opposite effects on AM vs.EM tree carbon stocks.Specifically,the two components of biodiversity had positive effects on AM tree carbon stocks,but negative effects on EM tree carbon stocks.Environmental heterogeneity(mean annual temperature and soil nutrients)also exhibited contrasting effects on AM and EM tree carbon stocks.Consequently,for the total carbon stock,the positive large-tree effect far surpasses the diversity and environment effect.This is mainly because when integrating AM and EM tree carbon stock into total carbon stock,the opposite diversity-effect(also environment-effect)on AM vs.EM tree carbon stock counteracts each other while the consistent positive large-tree effect on AM and EM tree carbon stock is amplified.In summary,this study emphasized a mycorrhizal viewpoint to better understand the determinants of overarching aboveground carbon profile across regional forests. 展开更多
关键词 BIODIVERSITY Ecological uniqueness Environment heterogeneity Large trees Mycorrhizal associations Tree carbon stock
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Genome-Wide Association Study of Cooked Rice Textural Attributes and Starch Physicochemical Properties in indica Rice
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作者 DENG Bowen ZHANG Yanni +4 位作者 ZHANG Fan WANG Wensheng XU Jianlong ZHANG Yu BAO Jinsong 《Rice science》 SCIE CSCD 2024年第3期300-316,I0018-I0041,共41页
Rice cooking and eating qualities(CEQ)are mainly determined by cooked rice textural parameters and starch physicochemical properties.However,the genetic bases of grain texture and starch properties in rice have not be... Rice cooking and eating qualities(CEQ)are mainly determined by cooked rice textural parameters and starch physicochemical properties.However,the genetic bases of grain texture and starch properties in rice have not been fully understood.We conducted a genome-wide association study for apparent amylose content(AAC),starch pasting viscosities,and cooked rice textural parameters using 279 indica rice accessions from the 3000 Rice Genome Project.We identified 26 QTLs in the whole population and detected single nucleotide polymorphisms(SNPs)with the lowest P-value at the Waxy(Wx)locus for all traits except pasting temperature and cohesiveness.Additionally,we detected significant SNPs at the SUBSTANDARD STARCH GRAIN6(SSG6)locus for AAC,setback(SB),hardness,adhesiveness,chewiness(CHEW),gumminess(GUM),and resilience.We subsequently divided the population using a SNP adjacent to the Waxy locus,and identified 23 QTLs and 12 QTLs in two sub-panels,WxT and WxA,respectively.In these sub-panels,SSG6 was also identified to be associated with pasting parameters,including peak viscosity,hot paste viscosity,cold paste viscosity,and consistency viscosity.Furthermore,a candidate gene encoding monosaccharide transporter 5(OsMST5)was identified to be associated with AAC,breakdown,SB,CHEW,and GUM.In total,39 QTLs were co-localized with known genes or previously reported QTLs.These identified genes and QTLs provide valuable information for genetic manipulation to improve rice CEQ. 展开更多
关键词 cooking and eating quality genome-wide association study RICE Waxy gene
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Genome-wide association study of seedling nitrogen-use efficiency-associated traits in common wheat(Triticum aestivum L.)
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作者 Huawei Shi Weichong Wang +14 位作者 Lifeng Gao Jirong Wu Chengmei Hu Huishu Yan Yugang Shi Ning Li Youzhi Ma Yongbin Zhou Zhaoshi Xu Jun Chen Wensi Tang Kai Chen Daizhen Sun Yuxiang Wu Ming Chen 《The Crop Journal》 SCIE CSCD 2024年第1期222-231,共10页
Nitrogen(N)fertilizer application is essential for crop-plant growth and development.Identifying genetic loci associated with N-use efficiency(NUE)could increase wheat yields and reduce environmental pollution caused ... Nitrogen(N)fertilizer application is essential for crop-plant growth and development.Identifying genetic loci associated with N-use efficiency(NUE)could increase wheat yields and reduce environmental pollution caused by overfertilization.We subjected a panel of 389 wheat accessions to N and chlorate(a nitrate analog)treatments to identify quantitative trait loci(QTL)controlling NUE-associated traits at the wheat seedling stage.Genotyping the panel with a 660K single-nucleotide polymorphism(SNP)array,we identified 397 SNPs associated with N-sensitivity index and chlorate inhibition rate.These SNPs were merged into 49 QTL,of which eight were multi-environment stable QTL and 27 were located near previously reported QTL.A set of 135 candidate genes near the 49 QTL included TaBOX(F-box family protein)and TaERF(ethylene-responsive transcription factor).A Tabox mutant was more sensitive to low-N stress than the wild-type plant.We developed two functional markers for Hap 1,the favorable allele of TaBOX. 展开更多
关键词 WHEAT NUE Genome-wide association study Nitrogen sensitive index Chlorate inhibition rate
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Learning-based user association and dynamic resource allocation in multi-connectivity enabled unmanned aerial vehicle networks
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作者 Zhipeng Cheng Minghui Liwang +3 位作者 Ning Chen Lianfen Huang Nadra Guizani Xiaojiang Du 《Digital Communications and Networks》 SCIE CSCD 2024年第1期53-62,共10页
Unmanned Aerial Vehicles(UAvs)as aerial base stations to provide communication services for ground users is a flexible and cost-effective paradigm in B5G.Besides,dynamic resource allocation and multi-connectivity can ... Unmanned Aerial Vehicles(UAvs)as aerial base stations to provide communication services for ground users is a flexible and cost-effective paradigm in B5G.Besides,dynamic resource allocation and multi-connectivity can be adopted to further harness the potentials of UAVs in improving communication capacity,in such situations such that the interference among users becomes a pivotal disincentive requiring effective solutions.To this end,we investigate the Joint UAV-User Association,Channel Allocation,and transmission Power Control(J-UACAPC)problem in a multi-connectivity-enabled UAV network with constrained backhaul links,where each UAV can determine the reusable channels and transmission power to serve the selected ground users.The goal was to mitigate co-channel interference while maximizing long-term system utility.The problem was modeled as a cooperative stochastic game with hybrid discrete-continuous action space.A Multi-Agent Hybrid Deep Reinforcement Learning(MAHDRL)algorithm was proposed to address this problem.Extensive simulation results demonstrated the effectiveness of the proposed algorithm and showed that it has a higher system utility than the baseline methods. 展开更多
关键词 UAV-user association Multi-connectivity Resource allocation Power control Multi-agent deep reinforcement learning
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Casual associations between blood metabolites and colon cancer
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作者 Ke-Yue Hu Yi-Quan Cheng +2 位作者 Zhi-Long Shi Fu-Peng Ren Gang-Feng Xiao 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第5期1995-2005,共11页
BACKGROUND Limited knowledge exists regarding the casual associations linking blood metabolites and the risk of developing colorectal cancer.AIM To investigate causal associations between blood metabolites and colon c... BACKGROUND Limited knowledge exists regarding the casual associations linking blood metabolites and the risk of developing colorectal cancer.AIM To investigate causal associations between blood metabolites and colon cancer.METHODS The study utilized a two-sample Mendelian randomization(MR)analysis to investigate the causal impact of 486 blood metabolites on colorectal cancer.The primary method of analysis used was the inverse variance weighted model.To further validate the results several sensitivity analyses were performed,including Cochran's Q test,MR-Egger intercept test,and MR robust adjusted profile score.These additional analyses were conducted to ensure the reliability and robustness of the findings.RESULTS After rigorous selection for genetic variation,486 blood metabolites were included in the MR analysis.We found Mannose[odds ratio(OR)=2.09(1.10-3.97),P=0.024],N-acetylglycine[OR=3.14(1.78-5.53),P=7.54×10^(-8)],X-11593-O-methylascorbate[OR=1.68(1.04-2.72),P=0.034],1-arachidonoylglycerophosphocholine[OR=4.23(2.51-7.12),P=6.35×10^(-8)]and 1-arachidonoylglycerophosphoethanolamine 4[OR=3.99(1.17-13.54),P=0.027]were positively causally associated with colorectal cancer,and we also found a negative causal relationship between Tyrosine[OR=0.08(0.01-0.63),P=0.014],Urate[OR=0.25(0.10-0.62),P=0.003],N-acetylglycine[0.73(0.54-0.98),P=0.033],X-12092[OR=0.89(0.81-0.99),P=0.028],Succinylcarnitine[OR=0.48(0.27-0.84),P=0.09]with colorectal cancer.A series of sensitivity analyses were performed to confirm the rigidity of the results.CONCLUSION This study showed a causal relationship between 10 blood metabolites and colorectal cancer,of which 5 blood metabolites were found to be causal for the development of colorectal cancer and were confirmed as risk factors.The other five blood metabolites are protective factors. 展开更多
关键词 METABOLITES Colon cancer Mendelian randomization Genome-wide association studies Casual
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Reform of the Irrigation Sector and Creation of Functional and Sustainable Irrigation Water Users Associations (AUEI) in Niger: Capitalization of the Experience of the Konni AHA
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作者 Saidou Abdoulkarimou Illou Mahamadou 《Agricultural Sciences》 2024年第2期209-229,共21页
During the 1980s, as part of a policy of liberalization, following budgetary cuts linked to the implementation of structural adjustment programs, management responsibilities for AHAs were transferred from ONAHA to coo... During the 1980s, as part of a policy of liberalization, following budgetary cuts linked to the implementation of structural adjustment programs, management responsibilities for AHAs were transferred from ONAHA to cooperatives concerned. Due to lack of financial resources, but also because of poor management, everywhere in Niger we are witnessing an accelerated deterioration of the irrigation infrastructure of hydro-agricultural developments. Institutional studies carried out on this situation led the State of Niger to initiate a reform of the governance of hydro-agricultural developments, by streng-thening the status of ONAHA, by creating an Association of Irrigation Water Users (AUEI) and by restructuring the old cooperatives. Indeed, this research aims to analyze the creation of functional and sustainable Irrigation Water User Associations (AUEI) in Niger in a context of reform of the irrigation sector, and based on the experience of the Konni AHA. It is based on a methodological approach which takes into account documentary research and the collection of data from 115 farmers, selected by reasoned choice and directly concerned by the management of the irrigated area. The data collected was analyzed and the results were analyzed using the systemic approach and the diagnostic process. The results show that the main mission of the AUEI is to ensure better management of water, hydraulic equipment and infrastructure on the hydro-agricultural developments of Konni. The creation of the Konni AUEI was possible thanks to massive support from the populations and authorities in the implementation process. After its establishment, the AUEI experienced a certain lethargy for some time due to the rehabilitation work of the AHA but currently it is functional and operational in terms of associative life and governance. Thus, the constraints linked to the legal system, the delay in the completion of the work, the uncertainties of access to irrigation water but also the problems linked to the change in mentality of certain ONAHA agents constitute the challenges that must be resolved in the short term for the operationalization of the Konni AUEI. 展开更多
关键词 Konni (Niger) Hydro-Agricultural Developments association of Irrigation Water Users GOVERNANCE
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Genome-wide association mapping and genomic prediction of stalk rot in two mid-altitude tropical maize populations
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作者 Junqiao Song Angela Pacheco +7 位作者 Amos Alakonya Andrea S.Cruz-Morales Carlos Muoz-Zavala Jingtao Qu Chunping Wang Xuecai Zhang Felix San Vicente Thanda Dhliwayo 《The Crop Journal》 SCIE CSCD 2024年第2期558-568,共11页
Maize stalk rot reduces grain yield and quality.Information about the genetics of resistance to maize stalk rot could help breeders design effective breeding strategies for the trait.Genomic prediction may be a more e... Maize stalk rot reduces grain yield and quality.Information about the genetics of resistance to maize stalk rot could help breeders design effective breeding strategies for the trait.Genomic prediction may be a more effective breeding strategy for stalk-rot resistance than marker-assisted selection.We performed a genome-wide association study(GWAS)and genomic prediction of resistance in testcross hybrids of 677 inbred lines from the Tuxpe?o and non-Tuxpe?o heterotic pools grown in three environments and genotyped with 200,681 single-nucleotide polymorphisms(SNPs).Eighteen SNPs associated with stalk rot shared genomic regions with gene families previously associated with plant biotic and abiotic responses.More favorable SNP haplotypes traced to tropical than to temperate progenitors of the inbred lines.Incorporating genotype-by-environment(G×E)interaction increased genomic prediction accuracy. 展开更多
关键词 Maize stalk rot Genome-wide association mapping Haplotype analysis Genomic prediction G×E interaction
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Causal association between 731 immunocyte phenotypes and liver cirrhosis: A bidirectional two-sample mendelian randomization analysis
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作者 Ying Li Xin Quan +3 位作者 Yang Tai Yu-Tong Wu Bo Wei Hao Wu 《World Journal of Hepatology》 2024年第8期1156-1166,共11页
BACKGROUND Liver cirrhosis is a progressive hepatic disease whose immunological basis has attracted increasing attention.However,it remains unclear whether a concrete causal association exists between immunocyte pheno... BACKGROUND Liver cirrhosis is a progressive hepatic disease whose immunological basis has attracted increasing attention.However,it remains unclear whether a concrete causal association exists between immunocyte phenotypes and liver cirrhosis.AIM To explore the concrete causal relationships between immunocyte phenotypes and liver cirrhosis through a mendelian randomization(MR)study.METHODS Data on 731 immunocyte phenotypes were obtained from genome-wide assoc-iation studies.Liver cirrhosis data were derived from the Finn Gen dataset,which included 214403 individuals of European ancestry.We used inverse variable weighting as the primary analysis method to assess the causal relationship.Sensitivity analyses were conducted to evaluate heterogeneity and horizontal pleiotropy.RESULTS The MR analysis demonstrated that 11 immune cell phenotypes have a positive association with liver cirrhosis[P<0.05,odds ratio(OR)>1]and that 9 immu-nocyte phenotypes were negatively correlated with liver cirrhosis(P<0.05,OR<1).Liver cirrhosis was positively linked to 9 immune cell phenotypes(P<0.05,OR>1)and negatively linked to 10 immune cell phenotypes(P<0.05;OR<1).None of these associations showed heterogeneity or horizontally pleiotropy(P>0.05).CONCLUSION This bidirectional two-sample MR study demonstrated a concrete causal association between immunocyte phenotypes and liver cirrhosis.These findings offer new directions for the treatment of liver cirrhosis. 展开更多
关键词 Liver cirrhosis Immune cell Immunocyte phenotype Mendelian analysis Causal association
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Genome-wide and candidate gene association studies identify BnPAP17 as conferring the utilization of organic phosphorus in oilseed rape
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作者 Ping Xu Hao Li +6 位作者 Haiyuan Li Ge Zhao Shengjie Dai Xiaoyu Cui Zhenning Liu Lei Shi Xiaohua Wang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第4期1134-1149,共16页
Phosphorus(P)is essential for living plants,and P deficiency is one of the key factors limiting the yield in rapeseed production worldwide.As the most important organ for plants,root morphology traits(RMTs)play a key ... Phosphorus(P)is essential for living plants,and P deficiency is one of the key factors limiting the yield in rapeseed production worldwide.As the most important organ for plants,root morphology traits(RMTs)play a key role in P absorption.To investigate the genetic variability of RMT under low P availability,we dissected the genetic structure of RMTs by genome-wide association studies(GWAS),linkage mapping and candidate gene association studies(CGAS).A total of 52 suggestive loci were associated with RMTs under P stress conditions in 405 oilseed rape accessions.The purple acid phosphatase gene BnPAP17 was found to control the lateral root number(LRN)and root dry weight(RDW)under low P stress.The expression of BnPAP17 was increased in shoot tissue in P-efficient cultivars compared to root tissue and P-inefficient cultivars in response to low P stress.Moreover,the haplotype of BnPAP17^(Hap3)was detected for the selective breeding of P efficiency in oilseed rape.Over-expression of the BnPAP17^(Hap3)could promote the shoot and root growth with enhanced tolerance to low P stress and organic phosphorus(Po)utilization in oilseed rape.Collectively,these findings increase our understanding of the mechanisms underlying BnPAP17-mediated low P stress tolerance in oilseed rape. 展开更多
关键词 genome-wide association studies(GWAS) root morphology traits(RMTs) organic phosphorus(Po) oilseed rape BnPAP17
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How Group Leaders Build Stable Community Buying Groups:A Perspective Based on the Differential Mode of Association
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作者 SI Xiang 《Psychology Research》 2024年第1期30-35,共6页
Since 2016,community group buying has grown significantly in China,largely driven by its efficient logistics,supply chains,low prices,and convenience.This model has been further popularized during the COVID-19 pandemi... Since 2016,community group buying has grown significantly in China,largely driven by its efficient logistics,supply chains,low prices,and convenience.This model has been further popularized during the COVID-19 pandemic due to its effectiveness in meeting daily needs while minimizing human-to-human contact.A key component of this business model is the“group leaders”-influential individuals within a community responsible for managing group buying activities,which include order collection,supplier liaison,and goods distribution.Their primary task is to form and sustain a reliable community group buying consortium,a task that demands excellent organizational and interpersonal skills.This paper examines this phenomenon using the lens of the differential mode of association,a theoretical model explaining interpersonal relationships in traditional Chinese society.The research indicates that group leaders,through regular interaction with consumers,are able to alter their social network position,increase their influence,understand consumer needs,provide satisfying services,and enhance trust,thereby transforming consumers into loyal group buying participants.This transformation not only brings stability to group buying activities but also reinforces the community influence of group leaders,thus fostering the growth of community group buying. 展开更多
关键词 Community group buying China Group leaders The differential mode of association
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From Differential Mode of Association to Tianxia Worldview:A Study on Chinese Entrepreneurial Spirit
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作者 Chao Gang Qian Chen Wang Lei 《China Economist》 2024年第4期58-88,共31页
China has made significant strides in economic and social development since reform and opening up over the past four decades.This process has been influenced by the exceptional innovation and entrepreneurship of Chine... China has made significant strides in economic and social development since reform and opening up over the past four decades.This process has been influenced by the exceptional innovation and entrepreneurship of Chinese business leaders,as well as their profound sentiments of compassion for the world and their country.It is of great significance to foster and promote an entrepreneurial spirit with distinctive Chinese characteristics.Not only is such spirit essential to the high-quality development of enterprises and the economy,but it is also a critical impetus for achieving Chinese modernization.Nevertheless,there is still a paucity of adequate theoretical discourse on the cultural origins and entrepreneurial spirit of outstanding Chinese business leaders.This paper employs the classical grounded theory method to conduct a 10-year follow-up research on 11 representative entrepreneurs and their enterprises.The results indicate that these entrepreneurs exhibit an evolving worldview along the paths of“self-cultivation and moral conduct”,“assisting employees to achieve”,“multilateral symbiosis”,and“the oneness of existence”when interacting with themselves,employees,partners,the general public,and all things in nature.Such entrepreneurial spirit is embodied in this paper as the“Tianxia(all-under-heaven)worldview”.Through theoretical construction,this study defines the concept of“Tianxia worldview”and extensively examines the distinctions and connections between the broadminded“Tianxia worldview”and the kinship-centered“differential mode of association”in terms of internal structure,value orientation,and applicable groups.It is posited that the transition from the former to the latter is a continuous process of transcendence and evolution of the individual mindset.This study has theoretical significance in the context of advancing the research on the Chinese entrepreneurial spirit,transcending the constraints of the management approach based on the“differential mode of association”,and enhancing the research on social responsibility from the perspective of“benefit corporations”.It also has practical value in overcoming the trust dilemma and development impediment of family businesses,ensuring that enterprises consciously fulfill their social responsibilities in a broader social context,and achieving common prosperity and progress for both enterprises and society. 展开更多
关键词 Tianxia worldview differential mode of association Chinese entrepreneurial spirit corporate social responsibility grounded theory method
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Structural Characteristics and Influencing Factors of Carbon Emission Spatial Association Network:A Case Study of Yangtze River Delta City Cluster,China
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作者 BI Xi SUN Renjin +2 位作者 HU Dongou SHI Hongling ZHANG Han 《Chinese Geographical Science》 SCIE CSCD 2024年第4期689-705,共17页
City cluster is an effective platform for encouraging regionally coordinated development.Coordinated reduction of carbon emissions within city cluster via the spatial association network between cities can help coordi... City cluster is an effective platform for encouraging regionally coordinated development.Coordinated reduction of carbon emissions within city cluster via the spatial association network between cities can help coordinate the regional carbon emission management,realize sustainable development,and assist China in achieving the carbon peaking and carbon neutrality goals.This paper applies the improved gravity model and social network analysis(SNA)to the study of spatial correlation of carbon emissions in city clusters and analyzes the structural characteristics of the spatial correlation network of carbon emissions in the Yangtze River Delta(YRD)city cluster in China and its influencing factors.The results demonstrate that:1)the spatial association of carbon emissions in the YRD city cluster exhibits a typical and complex multi-threaded network structure.The network association number and density show an upward trend,indicating closer spatial association between cities,but their values remain generally low.Meanwhile,the network hierarchy and network efficiency show a downward trend but remain high.2)The spatial association network of carbon emissions in the YRD city cluster shows an obvious‘core-edge’distribution pattern.The network is centered around Shanghai,Suzhou and Wuxi,all of which play the role of‘bridges’,while cities such as Zhoushan,Ma'anshan,Tongling and other cities characterized by the remote location,single transportation mode or lower economic level are positioned at the edge of the network.3)Geographic proximity,varying levels of economic development,different industrial structures,degrees of urbanization,levels of technological innovation,energy intensities and environmental regulation are important influencing factors on the spatial association of within the YRD city cluster.Finally,policy implications are provided from four aspects:government macro-control and market mechanism guidance,structural characteristics of the‘core-edge’network,reconfiguration and optimization of the spatial layout of the YRD city cluster,and the application of advanced technologies. 展开更多
关键词 carbon emission spatial association network social network analysis(SNA) quadratic assignment procedure(QAP)model Yangtze River Delta city cluster China
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