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Influence of Physico-Chemical Factors, Zooplankton Species Biodiversity and Seasonal Abundance in Anzali International Wetland, Iran
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作者 Delaram Golmarvi Maryam Fallahi Kapourchali +2 位作者 Ali Mashinchian Moradi Mohammadreza Fatemi Rezvan Mousavi Nadoshan 《Open Journal of Marine Science》 2017年第1期91-99,共9页
Anzali International wetland is located in the south coast of the Caspian Sea. Physicochemical analysis and zooplankton survey of the wetland were carried out on monthly basis for the period of one year from January 2... Anzali International wetland is located in the south coast of the Caspian Sea. Physicochemical analysis and zooplankton survey of the wetland were carried out on monthly basis for the period of one year from January 2012 to December 2013 at 9 different stations of Anzali wetland and its related channel to the Caspian Sea. Water temperature of the wetland followed more or less similar trend as that of air temperature. pH determined alkaline nature of the wetland ranging between 7.05 to 9.47, dissolved oxygen was recorded in the range of 3.36 mg/l to 10.51 mg/l while other parameters recorded were water temperature (10 to 23 C), Nitrate (0.48 to 4.36 mg/l), Total Phosphates (0.15 to 0.67 mg/l), Salinity (220 to 692 mg/l), Electrical Conductivity (235 to 1369 μs/cm), TDS (246 to 1971 mg/l), BOD (2 to 36 mg/l) and COD (4 to 74 mg/l). During study period, total 60 species of zooplankton were identified in four main groups such as Protozoa (22 sp.), Rotifera (29 sp.), Copepoda (5 sp.) and Cladocera (4 sp.). The highest numbers of zooplankton were recorded in summer months and lowest in winter which is the second rainy season of this area. The water body is receiving domestic discharge, agricultural run-off and industrial wastes leading to large amount of nutrient inputs to the ecosystem which indicates the eutrophic statue of the wetland. The aim of present study was to investigate the interrelationship between physicochemical factors and zooplankton population in context of their seasonal abundance. 展开更多
关键词 PHYSICOCHEMICAL factors ZOOPLANKTON Population SEASONAL ABUNDANCE Anzali WETLAND
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Physico-Chemical Analysis of Soils Used for Pineapple Cultivation in the Sub-Prefectures of Maferinyah and Friguiagbé (Prefectures of Forécariah and Kindia) Republic of Guinea 被引量:1
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作者 Sâa Gerard Tolno Saran Camara +2 位作者 Amadou Sylla Adama Moussa Sakho Lounceny Traore 《Journal of Agricultural Chemistry and Environment》 2024年第3期251-262,共12页
Over the years, pineapple production in the Republic of Guinea has become less competitive in the West African sub-region, with a world ranking of 144th. It is therefore only natural to review certain parameters in or... Over the years, pineapple production in the Republic of Guinea has become less competitive in the West African sub-region, with a world ranking of 144th. It is therefore only natural to review certain parameters in order to improve this ranking. To do this, certain physico-chemical parameters of soil samples from Friguiagbé and Maferinyah (in the Kindia and Forécariah prefectures) were taken and analysed using the following techniques: Pipette de Robinson, Anne, Bray II, Kapen HICDVITZ, Mc. Lead (1982). The analytical results show that the soils at Friguiagbé in Kindia and Maferinyah in Forécariah are acidic, with pH values of 4.4 and 4.7 (fields I and II) and 4.8 and 4.7 (fields I and II) respectively. The soils have a silty-sandy texture. This study could therefore serve as a guide for the Ministry of Agriculture of the Republic of Guinea. 展开更多
关键词 Soil Pineapple Crop physico-chemical Analysis
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Physico-Chemical and Nutritional Properties of a Food Broth Based on Nere (Parkia biglobosa)
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作者 Lassana Bamba Gervais Melaine M’Boh +5 位作者 N’Gbésso Amos Ekissi Kipré Laurent Séri Gnogbo Alexis Bahi Koffi Pierre Valery Niaba Allico Joseph Djaman Grah Avit Maxwell Beugre 《Food and Nutrition Sciences》 CAS 2024年第5期377-389,共13页
Purpose: Diet and eating habits are major risk factors for the health and the development of disease, such as, for example, metabolic disorder leading to cardiovascular pathology and cancer, decreased immunity exposin... Purpose: Diet and eating habits are major risk factors for the health and the development of disease, such as, for example, metabolic disorder leading to cardiovascular pathology and cancer, decreased immunity exposing to infections. This study of the physico-chemical and nutritional properties of a soumara-based food broth was carried out with the aim of promoting the consumption of organic broth made from nere seeds (soumara). That is to alleviate certain metabolic diseases, which is a matter of food safety, and also to limit the risk for the health about the consumption of some cooking stocks on the market. Methods: Several natural ingredients such as nere seeds (soumara), ginger, black pepper, parsley and garlic were used to create a nere-based stock. All these ingredients were freeze-dried and the powder obtained was used to make the broth, regarding their physical and chemical properties. Results: The broth had a good protein content of 17.41 ± 0.367 g/100g, a lipid content of 16.80 ± 0.08 g/100g and a fiber content of 8.66 ± 0.04 g/100g. In terms of nutritional values, the broth showed good levels of calcium 184.21 ± 0.09 mg/100g, potassium 50.04 ± 1.45 mg/100g and iron and zinc. In terms of antioxidant activity, the broth also showed good antioxidant activity. Conclusion: Regarding the properties of our food broth, whose composition is based on natural ingredients, could be recommended for consumption and, its properties, could play an important role in preventing and combating certain metabolic diseases. 展开更多
关键词 Food Broth Nere physico-chemical Properties NUTRITION Food Safety
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Physico-Chemical Properties of Soils from Diguel and Koudalwa Tchad,and Phytoremediation Potentials of Acasia and Kinkeliba Plants in Removing Cr and Cu from These Soils
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作者 Dieudonne Caleb Dahaina Jean Claude Doumnang Mbaigane +1 位作者 Bobet Ouanmini Cornelius Tsamo 《Journal of Environmental Science and Engineering(A)》 CAS 2024年第5期165-177,共13页
The aim of this study to investigate the physico-chemical properties of soils from Diguel and Koudalwa Tchad,and phytoremediation potentials of acasia and kinkeliba plants in removing Cr and Cu from these soils.Soil w... The aim of this study to investigate the physico-chemical properties of soils from Diguel and Koudalwa Tchad,and phytoremediation potentials of acasia and kinkeliba plants in removing Cr and Cu from these soils.Soil was sampled from the tannery plant in Diguel and agricultural land around crude oil activities in Koudalwa.Soils were characterized by the following properties:pH,(Electrical Conductivity),TDS(Total Dissolved Solids),salinity,bulk density,OM(Organic Matter),nitrate,phosphate,clay,silt,sand,and textural class.The acasia and kinkeliba plants were used to decontaminate Cu and Cr from sample soils for 30 days period.The bulk density of all the soil samples from Kouldawa was higher compared to Diguil,ranging from 1.421 to 1.64 g/cm^(3)compared to 1.21 to 1.51 g/cm^(3)for Diguel.Most of the soils in Kouldawa are mineral soils,while those of Diguel are mostly mineral soil with some organics.Diguel soils are richer in nitrate(577.9 to 2,687.32 mg/kg in Diguel and 33.64 to 197.64 mg/kg in Kouldawa)and phosphate than soils from Kouldawa.Soils from the studied areas are not saline except for a subsurface soil in Diguel(salinity,4.21;EC,4.280 dS/m;TDS,3,040 mg/L).The highest amount of Cr and Cu removed by acasia is 78%and 53.12%compared to 73.8%and 52.21%by kinkeliba.Diguel soil can be very suitable for agriculture and Kouldawa soils for construction.Acasia and kinkeliba can be effectively used to decontaminate the studied soils from heavy metal pollution. 展开更多
关键词 SOIL physico-chemical properties PHYTOREMEDIATION heavy metals Tchad.
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Physico-Chemical and Structural Assessment of Akono Riparian Forest Watershed, Tributary of the Nyong Basin (Centre-Cameroon) at Different Stages of Degradation
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作者 Nwamo Roland Didier Gordon Nwutih Ajonina +1 位作者 Ndzougou Nkodo Colette Rose Tomedi Eyango Minette 《Journal of Environmental Protection》 2024年第5期552-571,共20页
Freshwater bodies are natural resources that should be exploited to the fullest, while maintaining the sustainability of ecosystems and ecosystem services which they support. Riparian forests are more important as the... Freshwater bodies are natural resources that should be exploited to the fullest, while maintaining the sustainability of ecosystems and ecosystem services which they support. Riparian forests are more important as they contain rivers which are vital sources of fresh water for local populations. However, the quality and quantity of water issued from the watershed depend on the structural state of these forests. The aim of this work was to assess the physico-chemical and structural state of the Akono gallery forest. To achieve this, fieldwork consisted of selecting six major streams of the watershed including Ndjolong, Menyeng adzap, Emomodo, Mvila, Negbe and Ossoé kobok. On each of these, two stations, one intact and one degraded, were marked by transects. The method involved measuring Hydrometric parameters (depth, length, width) of the stream and Physico-chemical parameters of water in the streams while dendrometric parameters were measured along 100 m-transects laid using the point-centred quarter method modified for water bodies to collect tree, shrub and palm variables such as trunk diameter, crown diameter and height. Macrophytes and species identification were carried out using standard botanical procedures. Results showed that, the majority of physico-chemical parameters measured differed significantly between intact and degraded stations (P Pentachletra mancrophylla, whereas on degraded sites, this index was low and characterized by the relative dominance of species Piptadeniastrum africanum. Sorensen’s index (0.56) and CFA showed that the different stands were homogeneous. We can affirm that the riparian forests of Akono watershed are towards a state of stability notwithstanding the perpetuation of anthropological actions. 展开更多
关键词 Akono Gallery Forest physico-chemical Parameters Floristic Diversity Dendrometric Parameters
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Assessment of Groundwater Physico-Chemical Quality in the Ouémé Delta (Southern-Benin)
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作者 Aoulatou Alassane Zakari Dadja Toyou Masamaéya Gnazou +5 位作者 Abdoukarim Alassane Kodjo Apelete Raoul Kpegli Ousmane Touré Boukari Bio Guidah Chabi Bénito Didier Koukpohounsi Daouda Mama 《Journal of Environmental Protection》 2024年第3期298-317,共20页
Groundwater resources are the main sources of water used to supply drinking water to the population of the Ouémé Delta via the Continental Terminal aquifer. Urbanization, population growth, and agricultural ... Groundwater resources are the main sources of water used to supply drinking water to the population of the Ouémé Delta via the Continental Terminal aquifer. Urbanization, population growth, and agricultural and industrial activities have resulted in a deterioration in the quality of these resources. To assess the quality of the delta’s groundwater and its suitability for human consumption and irrigation, a total of fourteen (14) physico-chemical parameters were analyzed in some forty existing water points between September 2020 and March 2021, using standard water analysis techniques. The values obtained were compared with the potability standards recommended by the World Health Organization (WHO) and the Republic of Benin and were subjected to statistical analysis (principal component analysis (PCA)). In addition, methods for determining the suitability of water for irrigation were used. The results showed that the waters are acidic to slightly neutral and influenced by ambient temperature. In addition, the waters are moderately mineralized, with conductivities (24 - 1205 μS/cm) in line with WHO standards. A comparison of the analytical results of the WHO (2017) and Benin (2001) standards indicates that the majority of the waters studied are of good quality for all the chemical parameters considered. Nevertheless, some samples show levels of nitrates (21%), potassium (14% to 16%), calcium (13%), ammonium (12%), nitrites (8%) and bicarbonates (10%) over their respective standards. The Wilcox and Riverside diagrams indicate that the majority of waters (90%) have excellent suitability for irrigation and no negative effect on soil fertilization. 展开更多
关键词 BENIN OuéméDelta GROUNDWATER physico-chemical Quality Consumption IRRIGATION
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Physico-Chemical Characterization of Some Honeys from the Savannah-Gallery Forest Complex and Primary Forest in Gabon
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作者 Charline Obone Madi Guirema Abaker +3 位作者 Silas Davy Mbadinga Boubala Estelle Dumont Gino Boussiengui-Boussiengui Alexis Nicaise Lepengue 《Open Journal of Applied Sciences》 2024年第7期1904-1917,共14页
Honey harvesting throughout beekeeping is a technology recently introduced in Gabon comparing to the other African countries well known in international honey trade. The purpose of this study is to contribute to the k... Honey harvesting throughout beekeeping is a technology recently introduced in Gabon comparing to the other African countries well known in international honey trade. The purpose of this study is to contribute to the knowledge of the quality of multi-flower honeys from the savannah-gallery forest complex and primary forest not well documented in Gabon. Physical and chemical parameters of different honeys were analyzed using the official methods of analysis of the Association of Official Analytical Chemists. The results of physico-chemical analysis show variations in pH (3.4 to 3.9), free acidity (37.12 to 76.65 meq∙kg−1), water content (17.49% to 21.21%), electrical conductivity (0.64 to 1.24 mS∙cm−1), density (1.02 to 1.03) and total sugar content (77% to 82%). These variations were significantly different (p < 0.05) between certain honeys, but independent of the type of ecosystem considered. The pH values confirmed the botanical origin of the five honeys. The physico-chemical parameters of the honeys show significant correlations (p < 0.05). Moisture content is negatively correlated with conductivity (r = −0.628), pH (r = −0.631), density (r = −0.552) and total sugar content (r = −0.890). Conductivity is positively correlated with free acidity (r = 0.688) and total sugar content (r = 0.776), and negatively correlated with water content (r = −0.628). All honeys were in line with Codex Alimentarius standards, except for 3 types of honey (M1, M2 and M4) for free acidity and electrical conductivity, showing possible fermentation of these honeys. 展开更多
关键词 physico-chemical Parameters HONEY GABON Codex Alimentarius
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Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology
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作者 Yiyang Qin Wenzhen Zhu +6 位作者 Tingting Guo Yiran Zhang Tingting Xing Peng Yin Shihua Li Xiao-Jiang Li Su Yang 《Neural Regeneration Research》 SCIE CAS 2025年第9期2655-2666,共12页
Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto r.The mutant androgen r... Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto r.The mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy patients.These aggregates alter protein-protein interactions and compromise transcriptional activity.In this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic factor.Overexpressio n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor aggregation.Conversely.knocking down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor aggregation.Our findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy. 展开更多
关键词 androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model NEURODEGENERATION neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor
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Functions of nuclear factor Y in nervous system development,function and health
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作者 Pedro Moreira Roger Pocock 《Neural Regeneration Research》 SCIE CAS 2025年第10期2887-2894,共8页
Nuclear factor Y is a ubiquitous heterotrimeric transcription factor complex conserved across eukaryotes that binds to CCAAT boxes,one of the most common motifs found in gene promoters and enhancers.Over the last 30 y... Nuclear factor Y is a ubiquitous heterotrimeric transcription factor complex conserved across eukaryotes that binds to CCAAT boxes,one of the most common motifs found in gene promoters and enhancers.Over the last 30 years,research has revealed that the nuclear factor Y complex controls many aspects of brain development,including differentiation,axon guidance,homeostasis,disease,and most recently regeneration.However,a complete understanding of transcriptional regulatory networks,including how the nuclear factor Y complex binds to specific CCAAT boxes to perform its function remains elusive.In this review,we explore the nuclear factor Y complex’s role and mode of action during brain development,as well as how genomic technologies may expand understanding of this key regulator of gene expression. 展开更多
关键词 axon guidance CCAAT boxes neuronal degeneration neuronal differentiation neuronal regeneration nuclear factor Y complex transcription factor transcriptional regulation
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The effects of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents:a meta-analysis
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作者 Xueyun Shao Longfei He Yangyang Liu 《Neural Regeneration Research》 SCIE CAS 2025年第5期1513-1520,共8页
Brain-derived neurotrophic factor is a crucial neurotrophic factor that plays a significant role in brain health. Although the vast majority of meta-analyses have confirmed that exercise interventions can increase bra... Brain-derived neurotrophic factor is a crucial neurotrophic factor that plays a significant role in brain health. Although the vast majority of meta-analyses have confirmed that exercise interventions can increase brain-derived neurotrophic factor levels in children and adolescents, the effects of specific types of exercise on brain-derived neurotrophic factor levels are still controversial. To address this issue, we used meta-analytic methods to quantitatively evaluate, analyze, and integrate relevant studies. Our goals were to formulate general conclusions regarding the use of exercise interventions, explore the physiological mechanisms by which exercise improves brain health and cognitive ability in children and adolescents, and provide a reliable foundation for follow-up research. We used the Pub Med, Web of Science, Science Direct, Springer, Wiley Online Library, Weipu, Wanfang, and China National Knowledge Infrastructure databases to search for randomized controlled trials examining the influences of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents. The extracted data were analyzed using Review Manager 5.3. According to the inclusion criteria, we assessed randomized controlled trials in which the samples were mainly children and adolescents, and the outcome indicators were measured before and after the intervention. We excluded animal experiments, studies that lacked a control group, and those that did not report quantitative results. The mean difference(MD;before versus after intervention) was used to evaluate the effect of exercise on brain-derived neurotrophic factor levels in children and adolescents. Overall, 531 participants(60 children and 471 adolescents, 10.9–16.1 years) were included from 13 randomized controlled trials. Heterogeneity was evaluated using the Q statistic and I^(2) test provided by Review Manager software. The meta-analysis showed that there was no heterogeneity among the studies(P = 0.67, I^(2) = 0.00%). The combined effect of the interventions was significant(MD = 2.88, 95% CI: 1.53–4.22, P < 0.0001), indicating that the brain-derived neurotrophic factor levels of the children and adolescents in the exercise group were significantly higher than those in the control group. In conclusion, different types of exercise interventions significantly increased brain-derived neurotrophic factor levels in children and adolescents. However, because of the small sample size of this meta-analysis, more high-quality research is needed to verify our conclusions. This metaanalysis was registered at PROSPERO(registration ID: CRD42023439408). 展开更多
关键词 adolescents brain-derived neurotrophic factor CHILDREN EXERCISE META-ANALYSIS randomized controlled trials
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Telencephalic stab wound injury induces regenerative angiogenesis and neurogenesis in zebrafish:unveiling the role of vascular endothelial growth factor signaling and microglia
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作者 Danielle Fernezelian Philippe Rondeau +1 位作者 Laura Gence Nicolas Diotel 《Neural Regeneration Research》 SCIE CAS 2025年第10期2938-2954,共17页
After brain damage,regenerative angiogenesis and neurogenesis have been shown to occur simultaneously in mammals,suggesting a close link between these processes.However,the mechanisms by which these processes interact... After brain damage,regenerative angiogenesis and neurogenesis have been shown to occur simultaneously in mammals,suggesting a close link between these processes.However,the mechanisms by which these processes interact are not well understood.In this work,we aimed to study the correlation between angiogenesis and neurogenesis after a telencephalic stab wound injury.To this end,we used zebrafish as a relevant model of neuroplasticity and brain repair mechanisms.First,using the Tg(fli1:EGFP×mpeg1.1:mCherry)zebrafish line,which enables visualization of blood vessels and microglia respectively,we analyzed regenerative angiogenesis from 1 to 21 days post-lesion.In parallel,we monitored brain cell proliferation in neurogenic niches localized in the ventricular zone by using immunohistochemistry.We found that after brain damage,the blood vessel area and width as well as expression of the fli1 transgene and vascular endothelial growth factor(vegfaa and vegfbb)were increased.At the same time,neural stem cell proliferation was also increased,peaking between 3 and 5 days post-lesion in a manner similar to angiogenesis,along with the recruitment of microglia.Then,through pharmacological manipulation by injecting an anti-angiogenic drug(Tivozanib)or Vegf at the lesion site,we demonstrated that blocking or activating Vegf signaling modulated both angiogenic and neurogenic processes,as well as microglial recruitment.Finally,we showed that inhibition of microglia by clodronate-containing liposome injection or dexamethasone treatment impairs regenerative neurogenesis,as previously described,as well as injury-induced angiogenesis.In conclusion,we have described regenerative angiogenesis in zebrafish for the first time and have highlighted the role of inflammation in this process.In addition,we have shown that both angiogenesis and neurogenesis are involved in brain repair and that microglia and inflammation-dependent mechanisms activated by Vegf signaling are important contributors to these processes.This study paves the way for a better understanding of the effect of Vegf on microglia and for studies aimed at promoting angiogenesis to improve brain plasticity after brain injury. 展开更多
关键词 ANGIOGENESIS cerebral damage inflammation NEUROGENESIS stab wound TELENCEPHALON vascular endothelial growth factor ZEBRAFISH
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Age-related driving mechanisms of retinal diseases and neuroprotection by transcription factor EB-targeted therapy
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作者 Samuel Abokyi Dennis Yan-yin Tse 《Neural Regeneration Research》 SCIE CAS 2025年第2期366-377,共12页
Retinal aging has been recognized as a significant risk factor for various retinal disorders,including diabetic retinopathy,age-related macular degeneration,and glaucoma,following a growing understanding of the molecu... Retinal aging has been recognized as a significant risk factor for various retinal disorders,including diabetic retinopathy,age-related macular degeneration,and glaucoma,following a growing understanding of the molecular underpinnings of their development.This comprehensive review explores the mechanisms of retinal aging and investigates potential neuroprotective approaches,focusing on the activation of transcription factor EB.Recent meta-analyses have demonstrated promising outcomes of transcription factor EB-targeted strategies,such as exercise,calorie restriction,rapamycin,and metformin,in patients and animal models of these common retinal diseases.The review critically assesses the role of transcription factor EB in retinal biology during aging,its neuroprotective effects,and its therapeutic potential for retinal disorders.The impact of transcription factor EB on retinal aging is cell-specific,influencing metabolic reprogramming and energy homeostasis in retinal neurons through the regulation of mitochondrial quality control and nutrient-sensing pathways.In vascular endothelial cells,transcription factor EB controls important processes,including endothelial cell proliferation,endothelial tube formation,and nitric oxide levels,thereby influencing the inner blood-retinal barrier,angiogenesis,and retinal microvasculature.Additionally,transcription factor EB affects vascular smooth muscle cells,inhibiting vascular calcification and atherogenesis.In retinal pigment epithelial cells,transcription factor EB modulates functions such as autophagy,lysosomal dynamics,and clearance of the aging pigment lipofuscin,thereby promoting photoreceptor survival and regulating vascular endothelial growth factor A expression involved in neovascularization.These cell-specific functions of transcription factor EB significantly impact retinal aging mechanisms encompassing proteostasis,neuronal synapse plasticity,energy metabolism,microvasculature,and inflammation,ultimately offering protection against retinal aging and diseases.The review emphasizes transcription factor EB as a potential therapeutic target for retinal diseases.Therefore,it is imperative to obtain well-controlled direct experimental evidence to confirm the efficacy of transcription factor EB modulation in retinal diseases while minimizing its risk of adverse effects. 展开更多
关键词 age-related macular degeneration anti-aging interventions autophagy calorie restriction diabetic retinopathy exercise glaucoma NEUROMODULATION PHAGOCYTOSIS photoreceptor outer segment degradation retinal aging transcription factor EB
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Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination
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作者 Josep Tomàs Víctor Cilleros-Mañé +7 位作者 Laia Just-Borràs Marta Balanyà-Segura Aleksandra Polishchuk Laura Nadal Marta Tomàs Carolina Silvera-Simón Manel M.Santafé Maria A.Lanuza 《Neural Regeneration Research》 SCIE CAS 2025年第2期394-401,共8页
During the development of the nervous system,there is an overproduction of neurons and synapses.Hebbian competition between neighboring nerve endings and synapses performing different activity levels leads to their el... During the development of the nervous system,there is an overproduction of neurons and synapses.Hebbian competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or strengthening.We have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse consolidation.The purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this process.In particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental competition.The dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific endings.We describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon terminals.The downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary synapses.Finally,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to reduce transmitter release and promote withdrawal of the most unfavorable nerve terminals during elimination(the weakest in acetylcholine release and those that have already become silent).The main findings contribute to a better understanding of punishment-rewarding interactions between nerve endings during development.Identifying the molecular targets and signaling pathways that allow synapse consolidation or withdrawal of synapses in different situations is important for potential therapies in neurodegenerative diseases. 展开更多
关键词 acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB
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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease
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作者 Shengyang Zhou Ting Li +8 位作者 Wei Zhang Jian Wu Hui Hong Wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen 《Neural Regeneration Research》 SCIE CAS 2025年第8期2361-2372,共12页
Interferon regulatory factor 7 plays a crucial role in the innate immune response.However,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains unknown.Here we report... Interferon regulatory factor 7 plays a crucial role in the innate immune response.However,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains unknown.Here we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial cells.Both the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 phenotype.In addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and YM1.Taken together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease. 展开更多
关键词 cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease NEUROINFLAMMATION Parkinson’s disease RU521 STING type I interferon
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Physico-Chemical Properties of Flour, Starch, and Modified Starch of Two Rice Varieties 被引量:5
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作者 LIN Qin-lu XIAO Hua-xi +3 位作者 FU Xiang-jin TIAN Wei LI Li-hui YU Feng-xiang 《Agricultural Sciences in China》 CAS CSCD 2011年第6期960-968,共9页
The physical and chemical properties of the flours, starches, and modified starches of indica rice and japonica rice were investigated in this paper. Results showed that the swelling powers of flour, starch, and phosp... The physical and chemical properties of the flours, starches, and modified starches of indica rice and japonica rice were investigated in this paper. Results showed that the swelling powers of flour, starch, and phosphate starch [substitution degree (DS)=0.065] of japonica rice were significantly higher than those (DS=0.065) of indica rice. The transmittance of modified starches was highest; and that of flours was lowest. The pasting property investigated with rapid visco analyzer (RVA) indicated that the peak viscosity and breakdown value of paste with high swelling power were high. Furthermore, the effect of protein and amylose content on pasting property were investigated. The results of rheological properties determined using rheological rheometer showed that at the same temperature, the storage modulus (G′ of flour, starch, and modified starch of indica rice was higher than that of japonica rice. For each variety, the G′of flour was the highest, while the G′of modified starch was the lowest. 展开更多
关键词 RICE STARCH viscosity physico-chemical properties RHEOLOGY
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Physico-Chemical Properties and Enzyme Activities of the Arable Soils in Lhasa,Tibet,China 被引量:5
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作者 WEI Yai ZHOU Zhonghao LIU Gangcai 《Journal of Mountain Science》 SCIE CSCD 2012年第4期558-569,共12页
An understanding of the physical,chemical,and biological properties of a soil provides a basis for soil use and management.This paper reports the major physico-chemical properties and enzyme activities of the soils of... An understanding of the physical,chemical,and biological properties of a soil provides a basis for soil use and management.This paper reports the major physico-chemical properties and enzyme activities of the soils of Lhasa's main arable lands and the factors that influence these soil properties.Composite and core samples were taken from the three main arable soil types(alluvial soil,subalpine arable steppe soil,and subalpine arable meadow soil) and were analysed using standard methods.The bulk density and the ventilation porosity ratio of the soils were close to the recommended values for arable lands,and the dominant soil texture was sandy.The soil moisture release rates were arable steppe soil > alluvial soil > arable meadow soil.Soil organic matter content,Cation-Exchange Capacity(CEC),total and available nitrogen content,and catalase activity of the arable meadow soil were higher than those of the alluvial and the arable steppe soils,while soil pH in the arable meadow was lower.Most of the measured properties did not show a significant variance among these three soils.However,the measured indices(apart from the total potassium) indicate that there are notable differences among the three types of soil.The results implied that the utilisation patterns of the arable soil or human activities,such as tillage practices and fertiliser applications,have a substantialeffect on the soil properties in this region.Our results suggest that the cultivation practices in the region have apparently positive impact on the soil organic matter,nutrient contents and bulk density probably due to the sound fertiliser management such as the applications of farmyard manure and chemical fertilisers.However,intense cultivation practices lowered the activity of most soil enzymes.The results demonstrate that the choice of soil management strategy had a significant impact on the soil physicochemical and biological properties in the region studied. 展开更多
关键词 Arable land Enzyme activity Land use physico-chemical property
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Soil Physico-Chemical Properties and Microflora as Influenced by Bispyribac Sodium 10% SC in Transplanted Kharif Rice 被引量:4
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作者 S.BERA R.K.GHOSH 《Rice science》 SCIE 2013年第4期298-302,共5页
The effects of bispyribac sodium 10% SC and butachlor 50% SC on soil physico-chemical properties and microflora in transplanted kharifrice were investigated over two seasons (2010 and 2011 ) Effects of the herbicide... The effects of bispyribac sodium 10% SC and butachlor 50% SC on soil physico-chemical properties and microflora in transplanted kharifrice were investigated over two seasons (2010 and 2011 ) Effects of the herbicide on bulk density, water holding capacity, moisture content, soil pH, organic matter content, electrical conductivity, as well as total nitrogen, available phosphorus and available potassium contents were analyzed along with microflora population (total bacteria, actinomycetes and fungi). No significant changes in soil physico-chemical properties were observed. Herbicide treatments resulted in decreases in microbial counts initially. With the degradation of applied herbicides within a considerable time, the microflora populations even exceeded the initial count at 60 d after application of the herbicide. 展开更多
关键词 HERBICIDE bispyribac sodium physico-chemical property SOIL microflora population RICE
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Heavy metal contamination, physico-chemical and microbial evaluation of water samples collected from chromite mine environment of Sukinda, India 被引量:5
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作者 S. DAS S. C. PATNAIK +3 位作者 H. K. SAHU A. CHAKRABORTY M. SUDARSHAN H. N. THATOI 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2013年第2期484-493,共10页
Water samples from chromite mine quarry of Sukinda and its adjacent areas were analyzed for their heavy metal contamination along with physico-chemical and microbial contents. The chromite mine water samples possessed... Water samples from chromite mine quarry of Sukinda and its adjacent areas were analyzed for their heavy metal contamination along with physico-chemical and microbial contents. The chromite mine water samples possessed high concentrations of heavy metals in the order of Cr〉Fe〉Zn〉Ni〉Co〉Mn while ground water did not show any heavy metal contamination except Fe. Physico-chemical parameters of mine water samples showed deviation from those of normal water. Mine water harboured low microbial populations of bacteria, fungi and actinomycetes in comparison with mine adjacent water samples. The correlation of data between metals with physico-chemical parameters showed both positive and negative responses while that of metal and microbial population exhibited negative correlation. Bacterial strains isolated from chromite mine water exhibited high tolerance towards chromium and other heavy metals as well as antibiotics which could be used as an indicator of heavy metal pollution. 展开更多
关键词 BIOREMEDIATION hexavalent chromium physico-chemical properties mine water pollution microbial population chromium tolerant bacteria
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Effects of Plant Types on Physico-chemical Properties of Reclaimed Mining Soil in Inner Mongolia,China 被引量:4
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作者 FU Yao LIN Changcun +1 位作者 MA Jianjun ZHU Tingcheng 《Chinese Geographical Science》 SCIE CSCD 2010年第4期309-317,共9页
A field experiment was conducted in Jungar Banner,Inner Mongolia,China to study the effects of plant types on the physical structure and chemical properties of open-cast mining soils reclaimed for 15 years,and to anal... A field experiment was conducted in Jungar Banner,Inner Mongolia,China to study the effects of plant types on the physical structure and chemical properties of open-cast mining soils reclaimed for 15 years,and to analyze the triggering factors of the soil formation.Results indicate that plant types affect soil-forming process especially in the upper layer (0-20 cm),and the spatial structure of reclaimed plant is the main reason for variability of the soil-forming process.In the upper soil layer at the site reclaimed with mixed plants,the concentrations of soil organic matter (SOM) and soil organic carbon (SOC) are the highest,and they were significantly higher at the sites reclaimed with Leymus chinensis,Caragana sinica,which is mainly due to a large amount of litter fall and root exudation in herbages and shrubs.However,the concentrations of SOM and SOC in the soils at the reclaimed sites are quite low comparing with those in local primary soil,which indicates the importance of using organic amendments during the ecological restoration in the study area. 展开更多
关键词 open-cast coal mining mining reclamation soil physico-chemical property soil organic matter soil organic carbon
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The Physico-Chemical Quality of Effluents of Selected Sewage Treatment Plants Draining into River Rwizi, Mbarara Municipality, Uganda 被引量:2
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作者 Jeninah Atwebembeire Morgan Andama +3 位作者 Jane Yatuha Julius Bunny Lejju Grace Kagoro Rugunda Joel Bazira 《Journal of Water Resource and Protection》 2019年第1期20-36,共17页
As population increases in urban areas, the domestic and industrial activities increase resulting in an increase in the volumes of wastewater and anthropogenic pollution, hence posing a threat to public health and env... As population increases in urban areas, the domestic and industrial activities increase resulting in an increase in the volumes of wastewater and anthropogenic pollution, hence posing a threat to public health and environment. This study assessed the physical chemical quality of two main sewage plant effluents discharging into River Rwizi. Effluent water samples were analyzed for dissolved oxygen, colour, turbidity, total suspended solid, total iron, phosphates, alkalinity, magnesium, calcium carbonate, temperature, pH, ammonium, electrical conductivity, chloride and nitrates. Parameters were analyzed following standard methods of APHA (1985). The values obtained were compared with EPA (2001), NWSC (2015) and NEMA (1999) standards for waste water. Results showed that the mean values most of the parameters tested were higher than the recommended EPA, NWSC and NEMA standards. The mean colour was 1627.67°C and 1414.33°C in Kakoba and Taso sewage effluents respectively compared to EPA (20-150), NWSC (500) and NEMA (300) standards (p > 0.05). The mean alkalinity was 1390.17 mg/l and 1308.33 mg/l for Kakoba and Taso respectively compared with EPA (400) and NWSC (800) standards. DO had a mean concentration of 68.27 mg/l and 63.03 mg/l in Taso and Kakoba respectively compared to EPA and NEMA standard of 5 mg/l. Mg was 243.29 mg/l and 246.49 mg/l in Kakoba and Taso sewage effluents respectively compared to NEMA standard for waste water of 100 mg/l (p > 0.05). The mean pH was 8.26 and 8.16 in Taso and Kakoba sewage effluents respectively compared to NWSC and NEMA standard of 6.0 - 8.0. Phosphate mean concentration levels were 32.2 mg/l and 27.11 mg/l for Taso and Kakoba respectively compared to standards of EPA (0.5 - 0.7 mg/l) and NEMA (10 mg/l). NO3 was 10 mg/l and 5.83 mg/l in Kakoba and Taso sewage effluents respectively compared to NWSC maximum permissible limit of 5 mg/l. The mean NH4 concentration was 385.33 mg/l (Kakoba) and 50.0 mg/l (Taso) compared to the EPA guideline range (0.2 - 4 mg/l). Chloride (Cl) had a mean of 833.33 mg/l in Kakoba compared to EPA (250 mg/l), NWSC and NEMA (500 mg/l) standards. Therefore the study recommends for effective treatment of waste effluents from Kakoba and Taso sewage treatment plants before recycling in order to avoid pollution of river Rwizi. 展开更多
关键词 physico-chemical EFFLUENTS SEWAGE RIVER Rwizi Mbarara MUNICIPALITY
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