Currently,the mortality rate of malignant tumors ranks second globally,surpassed only by cardiovascular and cerebrovascular diseases.The treatment of malignant tumors poses a formidable challenge to both modern medici...Currently,the mortality rate of malignant tumors ranks second globally,surpassed only by cardiovascular and cerebrovascular diseases.The treatment of malignant tumors poses a formidable challenge to both modern medicine and traditional Chinese medicine(TCM).To date,TCM has developed a substantial foundational theoretical understanding and accumulated significant clinical experience in combating tumors.According to TCM foundational theories,"Qi deficiency"is a critical symptom associated with cancer,and"fortifying the body's vitality while expelling pathogens"is the cornerstone of TCM's approach to tumor treatment and bodily balance.Codonopsis pilosula(CP),a Qi-invigorating herb,is known to invigorat the spleen,benefit the lungs,nourish the blood,and promote bodily fluids.It is often employed as a substitute for ginseng in clinical settings.Prolonged clinical observations have identified key active constituents of CP,such as Codonopsis polysaccharides,isoimperatorin,saponins,lobetyolin,sesquiterpene lactones,and muscone.These ingredients exhibit various therapeutic properties,including anti-tumor,immunomodulatory,anti-infective,antioxidant,and hematopoiesis-enhancing effects.Additionally,when CP is combined with other TCM herbs like Astragalus and Atractylodes macrocephala,it bolsters the body's vital energy and rejuvenates both Qi and blood.CP can be used in combination with chemotherapy agents to mitigate the adverse effects of radiotherapy and chemotherapy.Moreover,CP demonstrates potential in preventing precancerous lesions.This review summarizes recent research findings on the anti-tumor properties of CP,elucidates the anti-tumor effects and molecular mechanisms of its active components,provides a basis for promoting the utilization of CP resources and its active constituents,and offers insights for the research and development of new anti-tumor drugs.展开更多
目的对党参中的糖蛋白(即党参总糖蛋白,CGP)进行分离、纯化、结构表征和抗炎药效研究。方法使用Tris-HCL缓冲溶液在39℃水浴提取CGP,采用Q-Sepharose Fast Flow强阴离子交换层析和SDS-PAGE法对CGP进行分离纯化。使用紫外光谱、圆二色谱...目的对党参中的糖蛋白(即党参总糖蛋白,CGP)进行分离、纯化、结构表征和抗炎药效研究。方法使用Tris-HCL缓冲溶液在39℃水浴提取CGP,采用Q-Sepharose Fast Flow强阴离子交换层析和SDS-PAGE法对CGP进行分离纯化。使用紫外光谱、圆二色谱等方法,对纯品组分的结构及组成进行研究。以脂多糖(LPS)诱导的RAW 264.7为炎症模型,验证CGP的抗炎药效。结果得到分子量分别为35 kDa和25 kDa的两种纯品组分CGP1和CGP2,其结构均为O-糖肽键连接的糖蛋白,并证明5 mg·mL^(-1)的CGP抗炎效与槲皮素相当。结论CGP有望成为一种具有抗炎功效的潜在物质成分,为党参的药食同源应用提供了科研依据。展开更多
目的对党参多糖相关文献的研究现状、热点和趋势进行可视化分析。方法检索1987年1月1日至2023年7月9日Web of Science核心合集、中国知网、万方数据知识服务平台和维普网收录的党参多糖相关文献,应用VOSviewer 6.1.19等软件进行可视化...目的对党参多糖相关文献的研究现状、热点和趋势进行可视化分析。方法检索1987年1月1日至2023年7月9日Web of Science核心合集、中国知网、万方数据知识服务平台和维普网收录的党参多糖相关文献,应用VOSviewer 6.1.19等软件进行可视化分析。结果纳入研究的文献共411篇;涉及255个机构、1110位作者、208种期刊。International Journal of BiologicaI Macromolecules杂志发文量最多,《党参多糖对小鼠免疫和造血功能的影响》被引用量第一,发表论文最多的作者是山西医科大学的高建平。共有1288个关键词,主要形成8个关键聚类,主要关键词为提取工艺、抗氧化、抗肿瘤、免疫功能等。结论党参多糖的研究热度呈上升趋势,制备工艺及药理学研究是党参多糖的研究热点。展开更多
基金support of the National Natural Science Foundation of China(Grant No.82204696)the Natural Science Foundation project of Nanjing University of Chinese Medicine(Grant No.XPT82204696).
文摘Currently,the mortality rate of malignant tumors ranks second globally,surpassed only by cardiovascular and cerebrovascular diseases.The treatment of malignant tumors poses a formidable challenge to both modern medicine and traditional Chinese medicine(TCM).To date,TCM has developed a substantial foundational theoretical understanding and accumulated significant clinical experience in combating tumors.According to TCM foundational theories,"Qi deficiency"is a critical symptom associated with cancer,and"fortifying the body's vitality while expelling pathogens"is the cornerstone of TCM's approach to tumor treatment and bodily balance.Codonopsis pilosula(CP),a Qi-invigorating herb,is known to invigorat the spleen,benefit the lungs,nourish the blood,and promote bodily fluids.It is often employed as a substitute for ginseng in clinical settings.Prolonged clinical observations have identified key active constituents of CP,such as Codonopsis polysaccharides,isoimperatorin,saponins,lobetyolin,sesquiterpene lactones,and muscone.These ingredients exhibit various therapeutic properties,including anti-tumor,immunomodulatory,anti-infective,antioxidant,and hematopoiesis-enhancing effects.Additionally,when CP is combined with other TCM herbs like Astragalus and Atractylodes macrocephala,it bolsters the body's vital energy and rejuvenates both Qi and blood.CP can be used in combination with chemotherapy agents to mitigate the adverse effects of radiotherapy and chemotherapy.Moreover,CP demonstrates potential in preventing precancerous lesions.This review summarizes recent research findings on the anti-tumor properties of CP,elucidates the anti-tumor effects and molecular mechanisms of its active components,provides a basis for promoting the utilization of CP resources and its active constituents,and offers insights for the research and development of new anti-tumor drugs.
文摘目的对党参多糖相关文献的研究现状、热点和趋势进行可视化分析。方法检索1987年1月1日至2023年7月9日Web of Science核心合集、中国知网、万方数据知识服务平台和维普网收录的党参多糖相关文献,应用VOSviewer 6.1.19等软件进行可视化分析。结果纳入研究的文献共411篇;涉及255个机构、1110位作者、208种期刊。International Journal of BiologicaI Macromolecules杂志发文量最多,《党参多糖对小鼠免疫和造血功能的影响》被引用量第一,发表论文最多的作者是山西医科大学的高建平。共有1288个关键词,主要形成8个关键聚类,主要关键词为提取工艺、抗氧化、抗肿瘤、免疫功能等。结论党参多糖的研究热度呈上升趋势,制备工艺及药理学研究是党参多糖的研究热点。
