Twenty-eight compounds,including flavones(2,4-5,7-11),flavonols(1,3,6,21,22),flavanones(12-18),isoflavones(19,20),chalcones(23,24),phenylpropanoids(25,26),and others(27,28)were isolated from the ethanol extract of the...Twenty-eight compounds,including flavones(2,4-5,7-11),flavonols(1,3,6,21,22),flavanones(12-18),isoflavones(19,20),chalcones(23,24),phenylpropanoids(25,26),and others(27,28)were isolated from the ethanol extract of the seeds of Pongamia pinnata(L.)Pierre and identified on the basis of physic-chemical constants and spectral analysis(NMR,ECD,[α]^20 D).Among them,compounds 16,18,21,23,25 and 26 were obtained from the genus for the first time.The cytotoxicities of the purified flavonoids against H292 cells were evaluated using MTT assays.As a result,compounds 14 and 15 displayed moderate cytotoxicities.展开更多
Objective:To evaluate the mosquito larvicidal activity of Pongamia pinnata(P.pinnata)extracts against three mosquito vectors.Methods:The methanol and hydroalcohol extracts of bark part of P.pinnata L were tested again...Objective:To evaluate the mosquito larvicidal activity of Pongamia pinnata(P.pinnata)extracts against three mosquito vectors.Methods:The methanol and hydroalcohol extracts of bark part of P.pinnata L were tested against fourth instar larvae of Culex quinqnefasciatus,Aedes aegypti and Anopheles stephensi.The mortality was observed 24 h and 48 h after treatment,data was subjected to probit analysis to determine lethal concentration(LC_(50)and LC_(90))to kill 50 and 90 percent of treated larvae of tested species.Results:The larval mortality was found in both methanol and hydroalcohol extracts of P.pinnata against Culex quinquefascialus,Aedes aegypti and Anopheles stephensi with LC_(50)values of 84.8,118.2 and 151.7 ppm;97.7,128.3 and 513 ppm.The highest larval mortality was found in methanol extract of P.pinnala when comparable to the hydroalcohol extract.Conclusions:These results suggest that both methanol and hyrdoalcohol extracts have the potential to be used as an ideal ecofriendly approach for the control of disease vectors.This could lead to isolation of novel natural larvicidal compounds.展开更多
基金This work was fin an cially supported by National Natural Science Foundation of China(Grant No.81872768,81673323,U1903122)Liaoning Revitalization Talents Program(XLYC1807118)Liaoning BaiQianWan Talents Program(2018).
文摘Twenty-eight compounds,including flavones(2,4-5,7-11),flavonols(1,3,6,21,22),flavanones(12-18),isoflavones(19,20),chalcones(23,24),phenylpropanoids(25,26),and others(27,28)were isolated from the ethanol extract of the seeds of Pongamia pinnata(L.)Pierre and identified on the basis of physic-chemical constants and spectral analysis(NMR,ECD,[α]^20 D).Among them,compounds 16,18,21,23,25 and 26 were obtained from the genus for the first time.The cytotoxicities of the purified flavonoids against H292 cells were evaluated using MTT assays.As a result,compounds 14 and 15 displayed moderate cytotoxicities.
基金Foundation Name and Grant No:AICTE/QIP/09/2009/059
文摘Objective:To evaluate the mosquito larvicidal activity of Pongamia pinnata(P.pinnata)extracts against three mosquito vectors.Methods:The methanol and hydroalcohol extracts of bark part of P.pinnata L were tested against fourth instar larvae of Culex quinqnefasciatus,Aedes aegypti and Anopheles stephensi.The mortality was observed 24 h and 48 h after treatment,data was subjected to probit analysis to determine lethal concentration(LC_(50)and LC_(90))to kill 50 and 90 percent of treated larvae of tested species.Results:The larval mortality was found in both methanol and hydroalcohol extracts of P.pinnata against Culex quinquefascialus,Aedes aegypti and Anopheles stephensi with LC_(50)values of 84.8,118.2 and 151.7 ppm;97.7,128.3 and 513 ppm.The highest larval mortality was found in methanol extract of P.pinnala when comparable to the hydroalcohol extract.Conclusions:These results suggest that both methanol and hyrdoalcohol extracts have the potential to be used as an ideal ecofriendly approach for the control of disease vectors.This could lead to isolation of novel natural larvicidal compounds.
