BACKGROUND We describe a case of relentless placoid chorioretinitis(RPC)that progressed despite administration of peribulbar and systemic corticosteroids,and was resolved by systemic combined with intravitreal methotr...BACKGROUND We describe a case of relentless placoid chorioretinitis(RPC)that progressed despite administration of peribulbar and systemic corticosteroids,and was resolved by systemic combined with intravitreal methotrexate.CASE SUMMARY A 16-year-old male reported painless blurred vision and a temporal scotoma in his right eye for one week.Due to widespread distribution and continuous enlargement,multimodal imaging of the lesions led to the diagnosis of RPC.Lesions in the right eye extended despite peribulbar injection of triamcinolone acetonide,but the progression was immediately terminated by a single dose of intravitreal methotrexate.A new fresh lesion occurred in the contralateral eye despite systemic prednisolone but was resolved by oral methotrexate.CONCLUSION Systemic immunosuppressants should be given upon RPC diagnosis.Intravitreal methotrexate immediately halted progression and may be considered for sightthreatening cases as part of the initial therapy.展开更多
Dear Editor,Primary vitreoretinal lymphoma（PVRL）is a rare form of ocular malignancy and it is usually considered as a subset of primary central nervous system lymphoma（PCNSL）.An insidious onset associated with del...Dear Editor,Primary vitreoretinal lymphoma（PVRL）is a rare form of ocular malignancy and it is usually considered as a subset of primary central nervous system lymphoma（PCNSL）.An insidious onset associated with delays in diagnosis iscommon.展开更多
A new subsoiler with placoid scale microstructure bionic surface was proposed which mimicked shark skin to reduce tillage resistance and soil adhesion during subsoiling cultivation.The contour curves of placoid scale ...A new subsoiler with placoid scale microstructure bionic surface was proposed which mimicked shark skin to reduce tillage resistance and soil adhesion during subsoiling cultivation.The contour curves of placoid scale microstructure on shark skin were fitted,and two kinds of bionic subsoiler with continuous and discontinuous microstructures were designed and fabricated,respectively.The effects of different bionic surfaces on tillage resistance were investigated by finite element simulation and experiment.The results indicated that the bionic subsoiler with discontinuous microstructure reduced the horizontal and vertical force by 21.3%and 24.8%,respectively.The subsoiler with discontinuous microstructure surface can prevent the adhesion between the soil and subsoiler surface more efficiently.展开更多
基金the National Natural Science Foundation of China,No.81800847and the Tenth“Academic Star”project of Peking University People's Hospital,No.RS2018-05.
文摘BACKGROUND We describe a case of relentless placoid chorioretinitis(RPC)that progressed despite administration of peribulbar and systemic corticosteroids,and was resolved by systemic combined with intravitreal methotrexate.CASE SUMMARY A 16-year-old male reported painless blurred vision and a temporal scotoma in his right eye for one week.Due to widespread distribution and continuous enlargement,multimodal imaging of the lesions led to the diagnosis of RPC.Lesions in the right eye extended despite peribulbar injection of triamcinolone acetonide,but the progression was immediately terminated by a single dose of intravitreal methotrexate.A new fresh lesion occurred in the contralateral eye despite systemic prednisolone but was resolved by oral methotrexate.CONCLUSION Systemic immunosuppressants should be given upon RPC diagnosis.Intravitreal methotrexate immediately halted progression and may be considered for sightthreatening cases as part of the initial therapy.
文摘Dear Editor,Primary vitreoretinal lymphoma（PVRL）is a rare form of ocular malignancy and it is usually considered as a subset of primary central nervous system lymphoma（PCNSL）.An insidious onset associated with delays in diagnosis iscommon.
基金This work was financially supported by Natural Science Basic Research Program of Shaanxi(Program No.2021JQ-173)Innovation and Entrepreneurship Training Program of Northwest A&F University(Program No.201910712134).
文摘A new subsoiler with placoid scale microstructure bionic surface was proposed which mimicked shark skin to reduce tillage resistance and soil adhesion during subsoiling cultivation.The contour curves of placoid scale microstructure on shark skin were fitted,and two kinds of bionic subsoiler with continuous and discontinuous microstructures were designed and fabricated,respectively.The effects of different bionic surfaces on tillage resistance were investigated by finite element simulation and experiment.The results indicated that the bionic subsoiler with discontinuous microstructure reduced the horizontal and vertical force by 21.3%and 24.8%,respectively.The subsoiler with discontinuous microstructure surface can prevent the adhesion between the soil and subsoiler surface more efficiently.
