Objective:To study the effect of ultrasound-guided serratus anterior plane block on the pain, inflammation and oxidation after radical mastectomy.Methods: Patients who underwent radical mastectomy in Qinghai Provincia...Objective:To study the effect of ultrasound-guided serratus anterior plane block on the pain, inflammation and oxidation after radical mastectomy.Methods: Patients who underwent radical mastectomy in Qinghai Provincial People's Hospital between March 2015 and December 2017 were selected as the research subjects and randomly divided into the experimental group who accepted ultrasound-guided serratus anterior plane block combined with general anesthesia and the control group who accepted general anesthesia. The pain mediators, inflammatory molecules and oxidative stress molecules were measured before surgery and 3 d after surgery.Results: Compared with those of same group before surgery, serum NPY, SP, PGE2, CGRP, IL-1β, IL-18, TNF-α, MDA and 8-iso-PGF2 levels as well as peripheral blood NF-κB, NLRP3, NOX4 and MPO expression intensity of both groups of patients were increasing whereas serum SOD levels were decreasing after surgery, and serum NPY, SP, PGE2, CGRP, IL-1β, IL-18, TNF-α, MDA and 8-iso-PGF2 levels as well as peripheral blood NF-κB, NLRP3, NOX4 and MPO expression intensity of experimental group after surgery were lower than those of control group whereas serum SOD level was higher than that of control group.Conclusion:Ultrasound-guided serratus anterior plane block has significant inhibitory effect on the pain, inflammation and oxidation degree after radical mastectomy.展开更多
Objective This study aimed to compare the postoperative analgesia and recovery of ultrasound-guided erector spinae plane block combined with serratus anterior plane block(ESPB combined with SAPB)versus thoracic parave...Objective This study aimed to compare the postoperative analgesia and recovery of ultrasound-guided erector spinae plane block combined with serratus anterior plane block(ESPB combined with SAPB)versus thoracic paravertebral block(PVB)after thoracoscopic surgery.Methods Ninety-two patients who underwent video-assisted thoracoscopic surgery(VATS)were randomly divided into group S(n=46)and group P(n=46).After anesthesia induction,the same anesthesiologist performed ultrasound-guided ESPB at T5 and T7 levels combined with SAPB at the level of the fifth rib in the midaxillary line in group S and ultrasound-guided PVB at T5 and T7 levels in group P.Patients in both groups were given 40 mL of 0.4%ropivacaine.Eighty-six patients completed the study(group S,n=44;group P,n=42).The morphine consumption,visual analogue scale(VAS)scores at rest and coughing,and frequency of remedial analgesia were recorded at 1,2,4,8,and 24 h postoperatively.Pulmonary function parameters were recorded at 1,4,and 24 h postoperatively,and the quality of recovery(QoR)-15 score at 24 h postoperatively.The adverse effects,duration of chest tube drainage and length of stay were also recorded.Results The morphine consumption at postoperative 4 and 8 h and the incidence of ipsilateral shoulder pain(ISP)were significantly lower in group S than in group P.The QoR-15 questionnaire score at postoperative 24 h was significantly lower in group P than in group S(P<0.05).The morphine consumption was lower at 24 h postoperatively in group S than in group P,with no significant difference found yet.The morphine consumption at other observed times,VAS scores,pulmonary function parameters,frequency of remedial analgesia,duration of chest tube drainage,length of stay,and incidence of other adverse events were comparable between group S and group P.Conclusion Ultrasound-guided ESPB combined with SAPB is non-inferior to PVB in terms of morphine consumption at postoperative 24 h and postoperative recovery.But,this approach can significantly reduce morphine consumption in the early postoperative period(0–8 h)after thoracoscopy with lower incidence of ISP.It is a simpler and safer operation.展开更多
目的探讨丙泊酚微量泵输注联合前锯肌平面阻滞对老年胃癌根治术患者麻醉药物用量、术后谵妄及躁动影响。方法前瞻性选取2021年1月至2023年12月临汾市人民医院收治的80例老年胃癌患者作为研究对象,按照抽签法分为观察组与对照组,每组各4...目的探讨丙泊酚微量泵输注联合前锯肌平面阻滞对老年胃癌根治术患者麻醉药物用量、术后谵妄及躁动影响。方法前瞻性选取2021年1月至2023年12月临汾市人民医院收治的80例老年胃癌患者作为研究对象,按照抽签法分为观察组与对照组,每组各40例。所有患者均择期实施胃癌根治术治疗,对照组患者实施单纯全身静脉麻醉,术中采取丙泊酚微量泵注维持麻醉,观察组在对照组基础上增加前锯肌平面阻滞。对比两组麻醉效果,麻醉前(T1)、麻醉后2 min(T2)、手术开始即刻(T3)及手术结束即刻(T4)平均动脉压、血氧饱和度及心率水平变化,对比两组麻醉药物总用量,术后1、6及12 h疼痛及镇静情况,最后对比其谵妄及躁动发生率。结果观察组麻醉效果Ⅰ级患者比率为65.00%,高于对照组(37.50%),观察组麻醉效果Ⅲ级患者比率为2.50%,低于对照组(15.00%),差异均有统计学意义(P<0.05)。观察组T2、T3、T4时MAP水平分别为(80.94±6.26)、(83.37±6.52)、(92.39±5.18)mmHg,均高于对照组[(74.33±4.85)、(76.21±4.42)、(83.72±11.22)mmHg],观察组T2、T3时血氧饱和度分别为(98.84±1.67)%、(98.95±1.56)%,均高于对照组[(93.52±2.52)%、(93.12±1.53)%],观察组T2时心率为(80.36±9.27)次/min,低于对照组[(86.28±7.22)次/min],差异均有统计学意义(P<0.05)。两组患者瑞芬太尼用量比较,差异无统计学意义(P>0.05),观察组患者舒芬太尼、丙泊酚用量分别为(43.32±5.12)μg、(251.63±42.52)mg,均明显低于对照组[(46.02±7.25)μg、(281.68±56.12)mg],差异均有统计学意义(P<0.05)。观察组术后1、6、12 h Ramsay评分(1.62±0.28)、(1.08±0.15)、(0.73±0.16)级,均低于对照组[(2.81±0.31)、(1.52±0.12)、(1.03±0.12)级];观察组术后1、6、12 h VAS评分(3.41±1.23)、(2.44±0.21)、(2.17±0.31)分,均低于对照组[(4.39±1.38)、(3.57±0.11)、(3.03±0.25)分],差异均有统计学意义(P<0.05)。观察组术后谵妄及躁动发生率分别为5.00%、2.50%,均明显低于对照组(22.50%、17.50%),差异均有统计学意义(P<0.05)。结论丙泊酚微量泵输注联合前锯肌平面阻滞可提升老年胃癌根治术患者麻醉效果,稳定术中生命体征,减少麻醉药物用量,同时可提升术后镇痛及镇静效果,降低躁动及谵妄发生率。展开更多
基金Projects of Qinghai Provincial Natural Science Foundation No:132810045101230.
文摘Objective:To study the effect of ultrasound-guided serratus anterior plane block on the pain, inflammation and oxidation after radical mastectomy.Methods: Patients who underwent radical mastectomy in Qinghai Provincial People's Hospital between March 2015 and December 2017 were selected as the research subjects and randomly divided into the experimental group who accepted ultrasound-guided serratus anterior plane block combined with general anesthesia and the control group who accepted general anesthesia. The pain mediators, inflammatory molecules and oxidative stress molecules were measured before surgery and 3 d after surgery.Results: Compared with those of same group before surgery, serum NPY, SP, PGE2, CGRP, IL-1β, IL-18, TNF-α, MDA and 8-iso-PGF2 levels as well as peripheral blood NF-κB, NLRP3, NOX4 and MPO expression intensity of both groups of patients were increasing whereas serum SOD levels were decreasing after surgery, and serum NPY, SP, PGE2, CGRP, IL-1β, IL-18, TNF-α, MDA and 8-iso-PGF2 levels as well as peripheral blood NF-κB, NLRP3, NOX4 and MPO expression intensity of experimental group after surgery were lower than those of control group whereas serum SOD level was higher than that of control group.Conclusion:Ultrasound-guided serratus anterior plane block has significant inhibitory effect on the pain, inflammation and oxidation degree after radical mastectomy.
文摘Objective This study aimed to compare the postoperative analgesia and recovery of ultrasound-guided erector spinae plane block combined with serratus anterior plane block(ESPB combined with SAPB)versus thoracic paravertebral block(PVB)after thoracoscopic surgery.Methods Ninety-two patients who underwent video-assisted thoracoscopic surgery(VATS)were randomly divided into group S(n=46)and group P(n=46).After anesthesia induction,the same anesthesiologist performed ultrasound-guided ESPB at T5 and T7 levels combined with SAPB at the level of the fifth rib in the midaxillary line in group S and ultrasound-guided PVB at T5 and T7 levels in group P.Patients in both groups were given 40 mL of 0.4%ropivacaine.Eighty-six patients completed the study(group S,n=44;group P,n=42).The morphine consumption,visual analogue scale(VAS)scores at rest and coughing,and frequency of remedial analgesia were recorded at 1,2,4,8,and 24 h postoperatively.Pulmonary function parameters were recorded at 1,4,and 24 h postoperatively,and the quality of recovery(QoR)-15 score at 24 h postoperatively.The adverse effects,duration of chest tube drainage and length of stay were also recorded.Results The morphine consumption at postoperative 4 and 8 h and the incidence of ipsilateral shoulder pain(ISP)were significantly lower in group S than in group P.The QoR-15 questionnaire score at postoperative 24 h was significantly lower in group P than in group S(P<0.05).The morphine consumption was lower at 24 h postoperatively in group S than in group P,with no significant difference found yet.The morphine consumption at other observed times,VAS scores,pulmonary function parameters,frequency of remedial analgesia,duration of chest tube drainage,length of stay,and incidence of other adverse events were comparable between group S and group P.Conclusion Ultrasound-guided ESPB combined with SAPB is non-inferior to PVB in terms of morphine consumption at postoperative 24 h and postoperative recovery.But,this approach can significantly reduce morphine consumption in the early postoperative period(0–8 h)after thoracoscopy with lower incidence of ISP.It is a simpler and safer operation.
文摘目的探讨丙泊酚微量泵输注联合前锯肌平面阻滞对老年胃癌根治术患者麻醉药物用量、术后谵妄及躁动影响。方法前瞻性选取2021年1月至2023年12月临汾市人民医院收治的80例老年胃癌患者作为研究对象,按照抽签法分为观察组与对照组,每组各40例。所有患者均择期实施胃癌根治术治疗,对照组患者实施单纯全身静脉麻醉,术中采取丙泊酚微量泵注维持麻醉,观察组在对照组基础上增加前锯肌平面阻滞。对比两组麻醉效果,麻醉前(T1)、麻醉后2 min(T2)、手术开始即刻(T3)及手术结束即刻(T4)平均动脉压、血氧饱和度及心率水平变化,对比两组麻醉药物总用量,术后1、6及12 h疼痛及镇静情况,最后对比其谵妄及躁动发生率。结果观察组麻醉效果Ⅰ级患者比率为65.00%,高于对照组(37.50%),观察组麻醉效果Ⅲ级患者比率为2.50%,低于对照组(15.00%),差异均有统计学意义(P<0.05)。观察组T2、T3、T4时MAP水平分别为(80.94±6.26)、(83.37±6.52)、(92.39±5.18)mmHg,均高于对照组[(74.33±4.85)、(76.21±4.42)、(83.72±11.22)mmHg],观察组T2、T3时血氧饱和度分别为(98.84±1.67)%、(98.95±1.56)%,均高于对照组[(93.52±2.52)%、(93.12±1.53)%],观察组T2时心率为(80.36±9.27)次/min,低于对照组[(86.28±7.22)次/min],差异均有统计学意义(P<0.05)。两组患者瑞芬太尼用量比较,差异无统计学意义(P>0.05),观察组患者舒芬太尼、丙泊酚用量分别为(43.32±5.12)μg、(251.63±42.52)mg,均明显低于对照组[(46.02±7.25)μg、(281.68±56.12)mg],差异均有统计学意义(P<0.05)。观察组术后1、6、12 h Ramsay评分(1.62±0.28)、(1.08±0.15)、(0.73±0.16)级,均低于对照组[(2.81±0.31)、(1.52±0.12)、(1.03±0.12)级];观察组术后1、6、12 h VAS评分(3.41±1.23)、(2.44±0.21)、(2.17±0.31)分,均低于对照组[(4.39±1.38)、(3.57±0.11)、(3.03±0.25)分],差异均有统计学意义(P<0.05)。观察组术后谵妄及躁动发生率分别为5.00%、2.50%,均明显低于对照组(22.50%、17.50%),差异均有统计学意义(P<0.05)。结论丙泊酚微量泵输注联合前锯肌平面阻滞可提升老年胃癌根治术患者麻醉效果,稳定术中生命体征,减少麻醉药物用量,同时可提升术后镇痛及镇静效果,降低躁动及谵妄发生率。
