A series of compounds containing oxime-ester linkage and pyrazole ring(in place of the ester linkage and the alcohol moiety in pyrethroid ester) was designed and synthesized. The structures of all the compounds prepar...A series of compounds containing oxime-ester linkage and pyrazole ring(in place of the ester linkage and the alcohol moiety in pyrethroid ester) was designed and synthesized. The structures of all the compounds prepared were confirmed by 1H NMR and MS spectroscopy as well as elemental analyses. The bioassay data of those compounds against tobacco mosaic virus(TMV), cucumber mosaic virus(CMV), potato virus X(PVX) and potato virus Y(PVY) were presented. Among them compound 6i was found to possess significant plant antiviral activities. But all the compounds showed low insecticidal and acaricidal activities.展开更多
The 1,2,3-thiadiazole-carboxylate moiety was reported to be an important pharmacophore of plant activators.In this study,a series of novel plant activators based on thieno[2,3-d]-1,2,3-thiadiazole-6-carboxylate were d...The 1,2,3-thiadiazole-carboxylate moiety was reported to be an important pharmacophore of plant activators.In this study,a series of novel plant activators based on thieno[2,3-d]-1,2,3-thiadiazole-6-carboxylate were designed and synthesized and their biological activity as plant activators was studied.The structures of the novel compounds were identifed by1H NMR,19F NMR and HRMS.The in vivo bioassay showed that these novel compounds had good effcacy against seven plant diseases.Especially,compounds 1a and 1c were more potent than the commercialized plant activator BTH.Almost no fungicidal activity was observed for the active compounds in the in vitro assay,which matched the requirements as plant activators.展开更多
According to the last World Malaria Report,there were an estimated 584 000 malaria deaths worldwide in 2013.The problem of parasite resistance towards available medicines is increasing.Natural products could play an i...According to the last World Malaria Report,there were an estimated 584 000 malaria deaths worldwide in 2013.The problem of parasite resistance towards available medicines is increasing.Natural products could play an important role to discover new antimalarial drug.The aim of the study was to highlight the anti-plasmodial properties of plants used in traditional medicine on the Mascarene Islands.85展开更多
Chagas disease is caused by the protozoan parasite Trypanosoma cruzi.This disease is also known as American trypanosomiasis and approximately 7-8 million people are currently infected(WHO,2014.Nifurtimox has been used...Chagas disease is caused by the protozoan parasite Trypanosoma cruzi.This disease is also known as American trypanosomiasis and approximately 7-8 million people are currently infected(WHO,2014.Nifurtimox has been used for over 40 years to treat Chagas disease,however,this drug is only effective during the acute phase of infection,and certain protozoan strains have developed resistance展开更多
Millions of tons of waste activated sludge(WAS) produced from biological wastewater treatment processes cause severe adverse environmental consequences. A better understanding of WAS composition is thus very critica...Millions of tons of waste activated sludge(WAS) produced from biological wastewater treatment processes cause severe adverse environmental consequences. A better understanding of WAS composition is thus very critical for sustainable sludge management. In this work, the occurrence and distribution of several fundamental sludge constituents were explored in WAS samples from nine full-scale wastewater treatment plants(WWTPs) of Beijing, China. Among all the components investigated, active heterotrophic biomass was dominant in the samples(up to 9478 mg/L), followed by endogenous residues(6736 mg/L),extracellular polymeric substances(2088 mg/L), and intracellular storage products(464 mg/L)among others. Moreover, significant differences(p 〈 0.05) were observed in composition profiles of sludge samples among the studied WWTPs. To identify the potential parameters affecting the variable fractions of sludge components, wastewater source as well as design and operational parameters of WWTPs were studied using statistical methods. The findings indicated that the component fraction of sewage sludge depends more on wastewater treatment alternatives than on wastewater characteristics among other parameters. A principal component analysis was conducted, which further indicated that there was a greater proportion of residual inert biomass in the sludge produced by the combined system of the conventional anaerobic/anoxic/oxic process and a membrane bioreactor. Additionally, a much longer solids retention time was also found to influence the sludge composition and induce an increase in both endogenous inert residues and extracellular polymeric substances in the sludge.展开更多
Started from salicylic acid(SA) and related commercialized plant activators,based on molecular threedimensional shape and pharmacophore similarity comparison(SHAFTS),a new lead compound benzotriazole was predicted...Started from salicylic acid(SA) and related commercialized plant activators,based on molecular threedimensional shape and pharmacophore similarity comparison(SHAFTS),a new lead compound benzotriazole was predicted and a series of benzotriazole derivatives were designed and synthesized.The bioassay showed that benzotriazole had high activity against a broad spectrum of diseases including fungi and oomycetes in vivo,but no activity in vitro.And the introduction of proper groups at the1'-position and 5'-position was beneficial to the activity.So,they had the potential to be exploited as novel plant activators.展开更多
The plant kingdom has provided literally thousands of natural products with widely diverse chemical structures and a vast array of biological activities.Many of them have seen subsequent application in discovery of ne...The plant kingdom has provided literally thousands of natural products with widely diverse chemical structures and a vast array of biological activities.Many of them have seen subsequent application in discovery of new druids and the pharmaceutical industry and clinical therapeutic application.展开更多
ZnO nanoparticles(ZnO NPs) were synthesized by chemical method(coprecipitation) and biological method using aqueous extracts of garlic(Allium sativum),rosemary(Rosmarinus officinalis) and basil(Ocimum basili...ZnO nanoparticles(ZnO NPs) were synthesized by chemical method(coprecipitation) and biological method using aqueous extracts of garlic(Allium sativum),rosemary(Rosmarinus officinalis) and basil(Ocimum basilicum).The influence of plant extract on the antibacterial and antioxidant activities of green synthesized nanoparticles was investigated.The X-ray diffraction studies reveal that all ZnO samples have hexagonal wurtzite structure.The particle size of ZnO NPs estimated by transmission electron microscopy analysis(between 14 and 27 nm) varies depending on the synthesis method of nanoparticles and the type of extracts from the plants used.The functional groups involved in the biosynthetic procedure were evidenced by Fourier transform infrared spectroscopy.The presence of Mn^(2+)ions,Zn vacancy complexes and oxygen vacancies in ZnO samples was highlighted by electron paramagnetic resonance spectroscopy.The green synthesized ZnO NPs have shown a good bactericidal activity against Staphylococcus aureus,Bacillus subtilis,Listeria monocytogenes,Escherichia coli,Salmonella typhimurium and Pseudomonas aeruginosa bacterial strains.ZnO NPs synthesized using extracts of the selected plant species have been found to exhibit more enhanced antibacterial and antioxidant activities as compared to chemical ZnO NPs.展开更多
基金Supported by the National Natural Science Foundation of China( No.2 9832 0 5 0 )
文摘A series of compounds containing oxime-ester linkage and pyrazole ring(in place of the ester linkage and the alcohol moiety in pyrethroid ester) was designed and synthesized. The structures of all the compounds prepared were confirmed by 1H NMR and MS spectroscopy as well as elemental analyses. The bioassay data of those compounds against tobacco mosaic virus(TMV), cucumber mosaic virus(CMV), potato virus X(PVX) and potato virus Y(PVY) were presented. Among them compound 6i was found to possess significant plant antiviral activities. But all the compounds showed low insecticidal and acaricidal activities.
基金financially supported by the National Basic Research Program of China (973 Program, No. 2010CB126100)the National High Technology Research and Development Program of China (863 Program, No. 2011AA10A207)+1 种基金the China 111 Project (No. B07023)the Fundamental Research Funds for the Central Universities.
文摘The 1,2,3-thiadiazole-carboxylate moiety was reported to be an important pharmacophore of plant activators.In this study,a series of novel plant activators based on thieno[2,3-d]-1,2,3-thiadiazole-6-carboxylate were designed and synthesized and their biological activity as plant activators was studied.The structures of the novel compounds were identifed by1H NMR,19F NMR and HRMS.The in vivo bioassay showed that these novel compounds had good effcacy against seven plant diseases.Especially,compounds 1a and 1c were more potent than the commercialized plant activator BTH.Almost no fungicidal activity was observed for the active compounds in the in vitro assay,which matched the requirements as plant activators.
文摘According to the last World Malaria Report,there were an estimated 584 000 malaria deaths worldwide in 2013.The problem of parasite resistance towards available medicines is increasing.Natural products could play an important role to discover new antimalarial drug.The aim of the study was to highlight the anti-plasmodial properties of plants used in traditional medicine on the Mascarene Islands.85
基金the Universidad Autonoma de Nuevo León(Mexico)for PAICYT grants CN-422-10 and CN-662-11
文摘Chagas disease is caused by the protozoan parasite Trypanosoma cruzi.This disease is also known as American trypanosomiasis and approximately 7-8 million people are currently infected(WHO,2014.Nifurtimox has been used for over 40 years to treat Chagas disease,however,this drug is only effective during the acute phase of infection,and certain protozoan strains have developed resistance
基金supported by the National Natural Science Foundation of China(Nos.51408589 and 51138009)State Key Joint Laboratory of Environment Simulation and Pollution Control of China(Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,No.14Z03ESPCR)Youth Innovation Promotion Association of the Chinese Academy of Sciences
文摘Millions of tons of waste activated sludge(WAS) produced from biological wastewater treatment processes cause severe adverse environmental consequences. A better understanding of WAS composition is thus very critical for sustainable sludge management. In this work, the occurrence and distribution of several fundamental sludge constituents were explored in WAS samples from nine full-scale wastewater treatment plants(WWTPs) of Beijing, China. Among all the components investigated, active heterotrophic biomass was dominant in the samples(up to 9478 mg/L), followed by endogenous residues(6736 mg/L),extracellular polymeric substances(2088 mg/L), and intracellular storage products(464 mg/L)among others. Moreover, significant differences(p 〈 0.05) were observed in composition profiles of sludge samples among the studied WWTPs. To identify the potential parameters affecting the variable fractions of sludge components, wastewater source as well as design and operational parameters of WWTPs were studied using statistical methods. The findings indicated that the component fraction of sewage sludge depends more on wastewater treatment alternatives than on wastewater characteristics among other parameters. A principal component analysis was conducted, which further indicated that there was a greater proportion of residual inert biomass in the sludge produced by the combined system of the conventional anaerobic/anoxic/oxic process and a membrane bioreactor. Additionally, a much longer solids retention time was also found to influence the sludge composition and induce an increase in both endogenous inert residues and extracellular polymeric substances in the sludge.
基金financially supported by the National Basic Research Program of China(973 Program,No.2010CB126100)the National High Technology Research and Development Program of China(863 Program,No.2011AA10A207)+1 种基金the Shanghai Leading Academic Discipline Project(B507)the Fundamental Research Funds for the Central Universities
文摘Started from salicylic acid(SA) and related commercialized plant activators,based on molecular threedimensional shape and pharmacophore similarity comparison(SHAFTS),a new lead compound benzotriazole was predicted and a series of benzotriazole derivatives were designed and synthesized.The bioassay showed that benzotriazole had high activity against a broad spectrum of diseases including fungi and oomycetes in vivo,but no activity in vitro.And the introduction of proper groups at the1'-position and 5'-position was beneficial to the activity.So,they had the potential to be exploited as novel plant activators.
文摘The plant kingdom has provided literally thousands of natural products with widely diverse chemical structures and a vast array of biological activities.Many of them have seen subsequent application in discovery of new druids and the pharmaceutical industry and clinical therapeutic application.
基金supported by the Romanian Ministry of Education and Research within the Nucleu Programme(Project PN 09-44)
文摘ZnO nanoparticles(ZnO NPs) were synthesized by chemical method(coprecipitation) and biological method using aqueous extracts of garlic(Allium sativum),rosemary(Rosmarinus officinalis) and basil(Ocimum basilicum).The influence of plant extract on the antibacterial and antioxidant activities of green synthesized nanoparticles was investigated.The X-ray diffraction studies reveal that all ZnO samples have hexagonal wurtzite structure.The particle size of ZnO NPs estimated by transmission electron microscopy analysis(between 14 and 27 nm) varies depending on the synthesis method of nanoparticles and the type of extracts from the plants used.The functional groups involved in the biosynthetic procedure were evidenced by Fourier transform infrared spectroscopy.The presence of Mn^(2+)ions,Zn vacancy complexes and oxygen vacancies in ZnO samples was highlighted by electron paramagnetic resonance spectroscopy.The green synthesized ZnO NPs have shown a good bactericidal activity against Staphylococcus aureus,Bacillus subtilis,Listeria monocytogenes,Escherichia coli,Salmonella typhimurium and Pseudomonas aeruginosa bacterial strains.ZnO NPs synthesized using extracts of the selected plant species have been found to exhibit more enhanced antibacterial and antioxidant activities as compared to chemical ZnO NPs.