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Spatiotemporal variations,influencing factors,and configurational promotion paths of energy efficiency in China’s cities
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作者 Ruyu Xu Keliang Wang +1 位作者 Zhuang Miao Lingxuan Sun 《Chinese Journal of Population,Resources and Environment》 2024年第1期74-86,共13页
The promotion of energy efficiency(EE)helps address energy constraints and promote environmental sustainability.This study comprehensively explores the spatiotemporal variations,influencing factors,and configuration p... The promotion of energy efficiency(EE)helps address energy constraints and promote environmental sustainability.This study comprehensively explores the spatiotemporal variations,influencing factors,and configuration promotion paths of EE in 284 Chinese cities during 2003‒2019 using the global super-efficiency minimum distance to strong efficient frontier(G-S-MinDS),exploratory spatial data analysis(ESDA),multiscale geographically weighted regression(MGWR),and fuzzy set qualitative comparative analysis(fsQCA)methods.The findings are:①China’s cities have an annual average EE of 0.658 with a growth rate of 0.53%,showing considerable promotion potential.②Industrial structure optimization,population agglomeration,economic development,and increased green coverage contribute positively,while government intervention and openness hinder China’s urban EE.③Four configurational promotion paths for enhancing China’s urban EE are identified,where among those paths population density is a core condition,while government intervention is not.This study provides valuable insights into substantially improving urban EE,emphasizing the need for targeted policies to address energy and environmental crises in China. 展开更多
关键词 Energy efficiency Spatiotemporal variations Influencing factors Configurational promotion paths
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From Inside Out:Internal Marketing as an Engine for Service Promotion-A Secondary Publication
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作者 Yermaline Ching 《Proceedings of Business and Economic Studies》 2024年第1期218-230,共13页
Focusing on“from inside out”means understanding that the driving force behind a successful service promotion campaign lies in a deep connection with the internal team,turning it into the engine that propels a positi... Focusing on“from inside out”means understanding that the driving force behind a successful service promotion campaign lies in a deep connection with the internal team,turning it into the engine that propels a positive brand perception.The University of Panama faces challenges in the effective implementation of strategies involving its internal staff,impacting the coherence and strength of its promotional messages.The research aimed to determine internal marketing strategies as an engine for service promotion at the Central Campus and CRUSAM.The applied study was descriptive,non-experimental field research,and cross-sectional.The sample consisted of 80 individuals using a quota sampling method to measure and quantify the expression of a construct or variable that is not directly observable.A selfadministered questionnaire was used to collect information,measuring variables in their various dimensions.Content validity of the questionnaire was ensured through the evaluation of three experts,and the reliability of the Likert-type instrument was assessed using Cronbach’s α coefficient,which was found to be very high(0.918).The results led to the conclusion that establishing internal marketing strategies is necessary for the transformation and innovation process in the university through service promotion. 展开更多
关键词 Internal marketing strategies Service promotion MARKETING
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Study on the Promotion of Digital Trade to Northeast Asian Regional Economy
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作者 Yating Mo Zhaoxia Zhang 《Proceedings of Business and Economic Studies》 2024年第1期162-168,共7页
Society is currently transitioning from the era of informatization and digitization to the era of intelligence.Advanced technologies such as artificial intelligence,the Internet of Things,and big data are permeating e... Society is currently transitioning from the era of informatization and digitization to the era of intelligence.Advanced technologies such as artificial intelligence,the Internet of Things,and big data are permeating every aspect of production and life.This penetration presents a rare opportunity for the development of digital trade and catalyzes innovation in traditional trade patterns.This paper first analyzes the inevitability of digital trade development in Northeast Asia.Secondly,it delves into the challenges faced by digital trade development and explores in-depth the promotion strategy for digital trade’s impact on the economic development of the Northeast Asia region,providing insights from various perspectives for reference. 展开更多
关键词 Digital trade Northeast Asian regional economy promotion
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A Multimodal Critical Discourse Analysis of Lingnan Cultural Promotional Videos on Social Media
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作者 Lu Jiang 《Journal of Contemporary Educational Research》 2024年第4期59-68,共10页
In recent years,more and more directors of culture and tourism have taken part in the promotion of local cultural tourism by cross-dressing,talent shows,and pushing their limits on self-media platforms.This study inve... In recent years,more and more directors of culture and tourism have taken part in the promotion of local cultural tourism by cross-dressing,talent shows,and pushing their limits on self-media platforms.This study investigates short videos of Lingnan culture promoted by directors general and deputy directors general of the Culture,Radio,Television,Tourism,and Sports Bureau of counties and cities in Guangdong Province on social media by the method of multimodal critical discourse analysis.The analysis of 33 videos shows that Lingnan culture is a domineering and confident culture,historical culture,graceful and elegant culture,and vibrant and active culture.Domineering and confident culture is embedded in the utterances and behaviors of the directors general or deputy directors general in the video.Historical culture is realized through the conversation with historical figures through time travel.Graceful and elegant culture is constructed in the depiction of sceneries and the depiction of characters’manners.Vibrant and active culture is represented in the depiction of the characters’actional process and analytical process. 展开更多
关键词 Lingnan culture Multimodal critical discourse analysis promotional videos TikTok WeChat
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Marketing Strategies for Reading Promotion Activities in Academic Libraries:A Case Study of the University of Shanghai for Science and Technology
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作者 Fangting Ye 《Journal of Contemporary Educational Research》 2024年第4期16-22,共7页
In the contemporary digital age,traditional reading habits have been compromised by digital media,a situation that has forced academic libraries to adopt proactive marketing approaches to promote reading among student... In the contemporary digital age,traditional reading habits have been compromised by digital media,a situation that has forced academic libraries to adopt proactive marketing approaches to promote reading among students and faculty.This article investigates the implementation of marketing strategies in promoting reading activities within academic libraries,taking the University of Shanghai for Science and Technology as a case study.The paper explores various marketing strategies employed by academic libraries,including market segmentation,utilization of new media platforms,and the creation of personalized content for readers.Drawing from an extensive literature review and real-world examples,the study establishes a framework for marketing reading promotion activities tailored to academic libraries.These findings underscore how effective marketing strategies can enhance user participation,expand library influence,and optimize resource utilization. 展开更多
关键词 University libraries Reading promotion Marketing strategies Library services Case study
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The Discourse-Historical Approach of Identity Construction in Corporate Promotional Videos for External Publicity Image
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作者 Xiaodong Wang Jing Yu 《Proceedings of Business and Economic Studies》 2024年第2期178-183,共6页
Corporate identity construction of external publicity image is an important part of the development of enterprises.Based on Wodak’s discourse-historical approach,this study takes the text of COFCO’s English promotio... Corporate identity construction of external publicity image is an important part of the development of enterprises.Based on Wodak’s discourse-historical approach,this study takes the text of COFCO’s English promotional video as the research object,analyzes the corporate brand image,media image,organizational image,and environmental image constructed by the enterprises from three steps:linguistic expression,discourse strategy,and theme to provide references for Chinese enterprises to enhance their international influence. 展开更多
关键词 Corporate promotional videos External publicity image Discourse-historical approach
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Economic Analysis and Research of New Energy Vehicle Promotion Model
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作者 Zihang Wang Xudong Wang +2 位作者 Zhenyin Zhang Shaolong Wang Chenyang Xu 《Proceedings of Business and Economic Studies》 2024年第1期169-179,共11页
New energy vehicles represent the inevitable trend of future development.Compared to traditional fuel vehicles,they are more energy-saving and environmentally friendly,effectively reducing air pollution and mitigating... New energy vehicles represent the inevitable trend of future development.Compared to traditional fuel vehicles,they are more energy-saving and environmentally friendly,effectively reducing air pollution and mitigating excessive exploitation of oil resources,a stance strongly supported by governments.However,new energy vehicles possess certain drawbacks in terms of price and usability compared to traditional counterparts.Therefore,external support is imperative for their development.This paper delineates four main sections:the background of new energy vehicle promotion and application,a comparative analysis of domestic and foreign promotion models,specific promotion suggestions,and future development prospects.By leveraging insights from economic analysis,the optimal promotion model for new energy vehicles is elucidated. 展开更多
关键词 New energy vehicle engineering promotion model Economic analysis Sustainable development
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Implementation Research on the Effects and Results of a National Health Promotion Project
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作者 Linda Dalbom Miia Tuominen +1 位作者 Eliisa Löyttyniemi Päivi Rautava 《Health》 2023年第6期695-709,共15页
The purpose of this study was to describe the implementation of the Finnish government’s 2017-2018 key project titled “Effective lifestyle counselling for social and health care cross-functionally” (VESOTE) in prim... The purpose of this study was to describe the implementation of the Finnish government’s 2017-2018 key project titled “Effective lifestyle counselling for social and health care cross-functionally” (VESOTE) in primary health care organizations in Southwest Finland. The study also aimed to illustrate the project’s impacts on nursing practices in primary health care organizations in terms of lifestyle counselling. Data were collected from all of the primary health care organizations in Southwest Finland by using a questionnaire. The data were analyzed qualitatively and by using descriptive statistics. The participants considered the VESOTE project important in terms of its contents. However, only individual measures of the project were adopted into practice. Organizations require tools to monitor the implementation of a new operating model. This should be taken into account when launching national projects. 展开更多
关键词 Evaluation Lifestyle Counselling IMPLEMENTATION Health promotion
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Exercise and oncology:The role of physical activity in disease prevention and health promotion
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作者 Zan Gao Linda Trinh 《Journal of Sport and Health Science》 SCIE CAS CSCD 2023年第6期651-652,F0003,共3页
The field of exercise-oncology has evolved significantly over the past 30 years.Numerous studies have examined the role of structured exercise interventions—often incorporating aerobic or resistance training at moder... The field of exercise-oncology has evolved significantly over the past 30 years.Numerous studies have examined the role of structured exercise interventions—often incorporating aerobic or resistance training at moderate-to-vigorous intensities,sometimes in conjunction with multi-modal strategies—for individuals living with and beyond cancer. 展开更多
关键词 PREVENTION promotion ONCOLOGY
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Promotion effects of alkali metals on iron molybdate catalysts for CO_(2)catalytic hydrogenation
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作者 Yong Zhou Aliou Sadia Traore +9 位作者 Deizi V.Peron Alan J.Barrios Sergei A.Chernyak Massimo Corda Olga V.Safonova Achim Iulian Dugulan Ovidiu Ersen Mirella Virginie Vitaly V.Ordomsky Andrei Y.Khodakov 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2023年第10期291-300,I0009,共11页
CO_(2)hydrogenation is an attractive way to store and utilize carbon dioxide generated by industrial processes,as well as to produce valuable chemicals from renewable and abundant resources.Iron catalysts are commonly... CO_(2)hydrogenation is an attractive way to store and utilize carbon dioxide generated by industrial processes,as well as to produce valuable chemicals from renewable and abundant resources.Iron catalysts are commonly used for the hydrogenation of carbon oxides to hydrocarbons.Iron-molybdenum catalysts have found numerous applications in catalysis,but have been never evaluated in the CO_(2)hydrogenation.In this work,the structural properties of iron-molybdenum catalysts without and with a promoting alkali metal(Li,Na,K,Rb,or Cs)were characterized using X-ray diffraction,hydrogen temperatureprogrammed reduction,CO_(2)temperature-programmed desorption,in-situ^(57)Fe Mossbauer spectroscopy and operando X-ray adsorption spectroscopy.Their catalytic performance was evaluated in the CO_(2)hydrogenation.During the reaction conditions,the catalysts undergo the formation of an iron(Ⅱ)molybdate structure,accompanied by a partial reduction of molybdenum and carbidization of iron.The rate of CO_(2)conversion and product selectivity strongly depend on the promoting alkali metals,and electronegativity was identified as an important factor affecting the catalytic performance.Higher CO_(2)conversion rates were observed with the promoters having higher electronegativity,while low electronegativity of alkali metals favors higher light olefin selectivity. 展开更多
关键词 CO_(2)utilization Iron molybdate catalysts promotion Alkali metals Light olefins In-situ characterization
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‘Nihao!China’the Yellow River Tourism Overseass Promotion Season 2023 in Brazil
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作者 Lu Feng 《China & The World Cultural Exchange》 2023年第9期28-29,共2页
On August 8,2023,as the first offline Chinese tourism promotion event held in Brazil after the pandemic,with the strong support of the Chinese Embassy in Brazil,the Chinese Consulate General in Sao Paulo and the Sao P... On August 8,2023,as the first offline Chinese tourism promotion event held in Brazil after the pandemic,with the strong support of the Chinese Embassy in Brazil,the Chinese Consulate General in Sao Paulo and the Sao Paulo State Travel and Tourism Secretariat,"Nihao!China"the Yellow River Tourism Overseas Promotion Season 2023 in Brazil jointly sponsored by the Network of International Culturalink Entities and Shandong. 展开更多
关键词 jointly Brazil promotion
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Investment Promotion for Development Zones in China:Underlying Rationale and Policy Options
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作者 Chen Qiangyuan Zhao Haoyun Ye Yang 《China Economist》 2023年第5期98-123,共26页
Development zones(DZs)have emerged as a significant policy initiative for promoting regional coordination and facilitating resources allocation.They serve as an organizational framework for fostering industrial agglom... Development zones(DZs)have emerged as a significant policy initiative for promoting regional coordination and facilitating resources allocation.They serve as an organizational framework for fostering industrial agglomeration and driving high-quality development.DZs attract and accommodate resource factors,firms,and projects,thereby functioning as a central catalyst for economic growth.This study utilizes data collected at the“DZ,City and Countrycountry”levels through manual compilation,textual analysis,and innovation measurement.It aims to empirically examine the theoretical rationale and practical preferences for promoting business and investment in China’s DZs.This study considers several factors such as industry attribute,firm attribute,agglomeration theory,and industrial chain layout.Based on our research findings,DZs exhibit distinct preferences.First,industry attribute:DZs align with both national and regional strategic planning and adhere to the industrial endowments of the respective areas.Second,firm attribute:DZs prioritize attracting firms that are productive and innovative,and have an international presence,rather than those that primarily contribute to taxes and job creation.Third,DZs are guided by the agglomeration theory,which suggests that they prefer firms that generate strong agglomeration externalities.Lastly,DZs also consider the industrial chain layout,aiming to attract firms that not only align with their existing industrial strengths but also extend to the upstream and downstream supply chain links.These conclusions are substantiated by the performance of robustness test.The success of DZs in China can be attributed to the five key principles:Adherence to national and regional strategic planning,prioritizing the actual industrial foundation,incorporating the theory of agglomeration externalities,strengthening corporate competitiveness,and expanding industrial chains. 展开更多
关键词 Investment promotion by development zones basic rationale policy options agglomeration externalities spatial allocation of resources
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Language-socialization-based Analysis of Putonghua Promotion’s Influences on Tujia Cultural Identity-A Case Study of Enshi Tujia and Miao Autonomous Prefecture
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作者 HUANG Jiao 《Journal of Literature and Art Studies》 2023年第2期100-103,共4页
Language functions as a carrier of culture,playing a crucial role in individual socialization into his cultural community,thus it is inextricably interconnected with individual cultural identity.Language acquisition a... Language functions as a carrier of culture,playing a crucial role in individual socialization into his cultural community,thus it is inextricably interconnected with individual cultural identity.Language acquisition and language ability development require necessary sociocultural interactions and practices.China boasts 55 ethnic minorities which have their own distinctive cultures and language varieties.But some of them are experiencing loss of languages and cultural identity.This paper is dedicated to examining the influences of Putonghua Promotion on Tujia cultural identity from the perspectives of Language Socialization. 展开更多
关键词 Putonghua promotion Tujia cultural identity INFLUENCES language socialization
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Drinking Water from the Same River, Close ass One Family——The Lancang-Mekong Tourism Cooperation Promotion
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作者 Chen Bin 《China & The World Cultural Exchange》 2023年第12期24-27,共4页
The promotion of Lancang-Mekong Tourism Cooperation was held in Sydney,Australia recently.The event aims to promote the development of"multi-destination"services and products in various provinces of China an... The promotion of Lancang-Mekong Tourism Cooperation was held in Sydney,Australia recently.The event aims to promote the development of"multi-destination"services and products in various provinces of China and the Mekong countries.It is the first time that the six countries have jointly promoted the event since the launch of the Lancang-Mekong Cooperation Mechanism seven years ago. 展开更多
关键词 jointly SYDNEY promotion
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Enhanced extracellular production of alpha-lactalbumin from Bacillus subtilis through signal peptide and promoter screening
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作者 Yuqi Zhu Pengdong Sun +6 位作者 Chunjian Li Yu Zhang Yu Wang Jingyuan Li Yanfeng Liu Jian Chen Yang Deng 《Food Science and Human Wellness》 SCIE CAS CSCD 2024年第4期2310-2316,共7页
Alpha-lactalbumin(α-LA)is a major whey protein found in breast milk and plays a crucial role in the growth and development of infants.In this study,Bacillus subtilis RIK1285 harboring AprE signal peptide(SP)was selec... Alpha-lactalbumin(α-LA)is a major whey protein found in breast milk and plays a crucial role in the growth and development of infants.In this study,Bacillus subtilis RIK1285 harboring AprE signal peptide(SP)was selected as the original strain for the production ofα-LA.It was found thatα-LA was identified in the pellet after ultrasonic disruption and centrifugation instead of in the fermentation supernatant.The original strain most likely only producedα-LA intracellular,but not extracellular.To improve the expression and secretion ofα-LA in RIK1285,a library of 173 homologous SPs from the B.subtilis 168 genome was fused with target LALBA gene in the pBE-S vector and expressed extracellularly in RIK1285.SP YjcN was determined to be the best signal peptide.Bands in supernatant were observed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and purified by nickel column to calculate the highest yield signal peptide.In addition,different promoters(P_(aprE),P_(43),and P_(glv))were compared and applied.The results indicated that the strain RIK1285-pBE-P_(glv)-YjcN-LALBA had the highestα-LA yield,reaching 122.04μg/mL.This study demonstrates successful expression and secretion of humanα-LA in B.subtilis and establishes a foundation for simulating breast milk for infant formulas and developing bioengineered milk. 展开更多
关键词 Bacillus subtilis ALPHA-LACTALBUMIN Bioengineering milk Signal peptide promoter screening
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Molecular cloning,characterization and promoter analysis of LbgCWIN1 and its expression profiles in response to exogenous sucrose during in vitro bulblet initiation in lily
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作者 Cong Gao Shiqi Li +4 位作者 Yunchen Xu Yue Liu Yiping Xia Ziming Ren Yun Wu 《Horticultural Plant Journal》 SCIE CAS CSCD 2024年第2期545-555,共11页
Lily(Lilium spp.) is an important ornamental flower, which is mainly propagated by bulbs. Cell wall invertases(CWINs), which catalyze the irreversibly conversion of sucrose into glucose and fructose in the extracellul... Lily(Lilium spp.) is an important ornamental flower, which is mainly propagated by bulbs. Cell wall invertases(CWINs), which catalyze the irreversibly conversion of sucrose into glucose and fructose in the extracellular space, are key enzymes participating in sucrose allocation in higher plants. Previous studies have shown that CWINs play an essential role in bulblet initiation process in bulbous crops, but the underlying molecular mechanism remains unclear. Here, a CWIN gene of Lilium brownii var. giganteum(Lbg) was identified and amplified from genomic DNA. Quantitative RT-PCR assays revealed that the expression level of LbgCWIN1 was highly upregulated exactly when the endogenous starch degraded in non-sucrose medium during in vitro bulblet initiation in Lbg. Phylogenetic relationship, motif, and domain analysis of LbgCWIN1 protein and CWINs in other plant species showed that all sequences of these CWIN proteins were highly conserved. The promoter sequence of LbgCWIN1 possessed a number of alpha-amylase-, phytohormone-, light-and stress-responsive cis-elements. Meanwhile, β-glucuronidase(GUS) assay showed that the 459 bp upstream fragment from the translational start site displayed maximal promoter activity. These results revealed that LbgCWIN1 might function in the process of in vitro bulblet initiation and be in the response to degradation of endogenous starch. 展开更多
关键词 Lilium brownii var.giganteum LbgCWIN1 Phylogenetic analysis promoter analysis Bulblet initiation
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Research on the Connotation, Characteristics, and Promotion Path of Teacher Leadership in Higher Vocational Colleges
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作者 Nana Qin 《Journal of Contemporary Educational Research》 2023年第4期91-96,共6页
In vocational education,teacher leadership is an important factor in promoting school development and improving teaching quality.Enhancing teacher leadership has practical significance for the connotative development ... In vocational education,teacher leadership is an important factor in promoting school development and improving teaching quality.Enhancing teacher leadership has practical significance for the connotative development of vocational colleges.It involves improving education and teaching quality,cultivating high-skilled talents,building excellent teaching teams,enhancing school governance systems,and other areas.The core elements include professional knowledge,teaching innovation,teamwork,and communication skills.The enhancement of teacher leadership can effectively enhance teachers’enthusiasm to participate in educational and teaching reforms as well as promote the overall efficiency of vocational colleges.In order to enhance teacher leadership in vocational colleges,it is necessary to achieve a breakthrough in institutional barriers,combine personal and external factors,strengthen institutionalized teacher leadership construction through a top-down design,and strengthen evaluation and feedback mechanisms to establish a scientific leadership evaluation system and improve teacher leadership cognition. 展开更多
关键词 Vocational college teachers Leadership CONNOTATION CHARACTERISTICS promotion path Online publication:April 27 2023
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Pueraria isoflavones inhibit XOD and GLUT9 to decrease uric acid production and promote uric acid excretion, respectively
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作者 LI Tong LIANG Bao-yue +7 位作者 LIU Han FANG Shao-ting ZHANG Ming-jie LUO Jing CHEN Pin-nuo SONG Ji-chi CHU Xiao HUANG Chun-xia 《Journal of Hainan Medical University》 CAS 2024年第2期13-13,共1页
Objective: To analyze the possible mechanism of Pueraria isoflavones inhibiting XOD and GLUT9 to reduce uric acid production and promote uric acid excretion. Methods: August 2021-April 2022, a total of forty SPF male ... Objective: To analyze the possible mechanism of Pueraria isoflavones inhibiting XOD and GLUT9 to reduce uric acid production and promote uric acid excretion. Methods: August 2021-April 2022, a total of forty SPF male Kunming mice were divided into the healthy group (carboxymethylcellulose sodium at a dose of 250 mg/kg), the model group (HUA mice were given carboxymethylcellulose sodium at a dose of 250 mg/kg), the low group (HUA mice were given pueraria isoflavone at a dose of 125 mg/kg), HUA mice were given pueraria isoflavones at a dose of 250 mg/kg once d frequency)and the high group (HUA mice were given pueraria isoflavones at a dose of 500 mg/kg once d frequency) dosage groups, with 8 mice in each group. The contents of uric acid (SUA), urea nitrogen (BUN) and creatinine (SCr) in serum and urine of each group were compared before and after intervention (30 d). Statistical differences of xanthine oxidase (XOD) and human glucose transporter 9(GLUT9), cy- clooxygenase- 2(COX-2), tumor necrosis factor (TNF-α) and interleukin-1 (IL-1β) contents in renal tissues of each group after intervention (30 d) were compared. Results: After intervention, kidney inflammatory factors (COX-2, TNF-α and IL-1β) in the model group were compared. Blood and urine indexes (SUA, BUN, SCr);The contents of XOD and GLUT9 were higher than those of healthy group(P<0.05). Renal inflammatory cytokines (COX-2, TNF-α and IL-1β) in low, medium and high dose groups;Blood and urine indexes (SUA, BUN, SCr);The contents of XOD and GLUT9 were lower than those of model group, and there were low > medium > high dose groups, the comparison between the two groups had statistical significance(P< 0.05). After intervention, the contents of 3 indicators in blood or urine(COX-2, TNF-α and IL-1β) all decreased compared with before intervention, and the differences in intra-group comparison were statistically significant (P<0.05). Conclusion: Pueraria isoflavones can treat HUA mice by inhibiting the expression of XOD and GLUT9, and then play a role in reducing uric acid pro- duction and promoting uric acid excretion, as well as alleviating the degree of disease inflammation. 展开更多
关键词 Kudzu root ISOFLAVONE HYPERURICEMIA Xanthine oxidase Human glucose transporter 9 Inflammation Reduce generation promote excretion
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Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters
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作者 Biola M Javierre 《四川生理科学杂志》 2024年第4期860-860,共1页
Long-range interactions between regulatory elements and gene promoters play key roles in transcriptional regulation.The vast majority of interactions are uncharted,constituting a major missing link in understanding ge... Long-range interactions between regulatory elements and gene promoters play key roles in transcriptional regulation.The vast majority of interactions are uncharted,constituting a major missing link in understanding genome control.Here,we use promoter capture Hi-C to identify interacting regions of 31,253 promoters in 17 human primary hematopoietic cell types.We show that promoter interactions are highly cell type specific and enriched for links between active promoters and epigenetically marked enhancers.Promoter interactomes reflect lineage relationships of the hematopoietic tree,consistent with dynamic remodeling of nuclear architecture during differentiation.Interacting regions are enriched in genetic variants linked with altered expression of genes they contact,highlighting their functional role.We exploit this rich resource to connect non-coding disease variants to putative target promoters,prioritizing thousands of disease-candidate genes and implicating disease pathways.Our results demonstrate the power of primary cell promoter interactomes to reveal insights into genomic regulatory mechanisms underlying common diseases. 展开更多
关键词 promotER enriched insight
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Promotional Effect of Bismuth as Dopant in Bi-Doped Vanadyl Pyrophosphate Catalysts for Selective Oxidation of n-Butane to Maleic Anhydride 被引量:7
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作者 Y.H.Taufiq-Yap Y.Kamiya K.P.Tan 《Journal of Natural Gas Chemistry》 EI CAS CSCD 2006年第4期297-302,共6页
Bismuth-promoted (1% and 3%) vanadyl pyrophosphate catalysts were prepared by refluxing Bi(NO3)4.5H2O and VOPO4.2H2O in isobutanol. The incorporation of Bi into the catalysts lattice increased the surface area and... Bismuth-promoted (1% and 3%) vanadyl pyrophosphate catalysts were prepared by refluxing Bi(NO3)4.5H2O and VOPO4.2H2O in isobutanol. The incorporation of Bi into the catalysts lattice increased the surface area and lowered the overall V oxidation state. Profiles of temperature programmed reduction (TPR) in H2 show a significant shift of the maxima of major reduction peaks to lower temperatures for the Bi-promoted catalysts. A new peak was also observed at the low temperature region for the catalyst with 3% of Bi dopant. The addition of Bi also increased the total amount of oxygen removed from the catalysts. The reduction pattern and reactivity information provide fundamental insight into the catalytic properties of the catalysts. Bi-promoted catalysts were found to be highly active (71% and 81% conversion for 1% and 3% Bi promoted catalysts, respectively, at 703 K), as compared to the unpromoted material (47% conversion). The higher activity of the Bi-promoted catalysts is due to that these catalysts possess highly active and labile lattice oxygen. The better catalytic performance can also be attributed to the larger surface area. 展开更多
关键词 BISMUTH promotER vanadyl pyrophosphate n-butane oxidation
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