Objective To investigate the correlations of plasma homocysteine(Hcy)level and apolipoprotein E gene polymorphism with Alzheimer’s disease(AD)and mild cognitive impairment(MCI).Methods A case-control study in 66 AD p...Objective To investigate the correlations of plasma homocysteine(Hcy)level and apolipoprotein E gene polymorphism with Alzheimer’s disease(AD)and mild cognitive impairment(MCI).Methods A case-control study in 66 AD patients(AD group),64 MCI patients(MCI group)and 54 healthy controls(control group)was conducted.Plasma Hcy level and Apo E polymorphism展开更多
Objective:The aim of this study is to assess the correlation between traditional cardiovascular risk factors and elevated plasma tHcy level in Nigerian hypertensive.Methods:Thirty-six hypertensive patients were recrui...Objective:The aim of this study is to assess the correlation between traditional cardiovascular risk factors and elevated plasma tHcy level in Nigerian hypertensive.Methods:Thirty-six hypertensive patients were recruited with 36 age and sex-matched controls.The age,sex and anthropometric measurements including height,weight and body mass index(BMI)were taken.Plasma total cholesterol,low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),triglycerides and tHcy were analyzed.The results of the two groups were compared.Results:The mean total cholesterol and LDL-C were significantly higher in the subjects than in the controls(P=0.01 and 0.03 respectively).On the other hand,means of HDL-C and triglycerides were not significantly different between the two groups(P=0.06 and 0.68 respectively).Mean total plasma tHcy was(12.95±4.9)μmol/L in hypertensive patients when compared with(11.29±3.6)μmol/L in the controls(P=0.09),however the mean tHcy was significantly higher in hypertensive patients who had stroke or myocardial infarction than those without these complications(one way Anova F=3.63,P=0.04).Significant positive correlation was seen between tHcy and systolic blood pressure,diastolic blood pressure,BMI and LDL-C.Conclusion:The study suggests that elevated plasma tHcy may predict occurrence of cardiovascular complications in hypertensive individuals.展开更多
Objective This study aimed to investigate the effects of N,N-dimethylglycine(DMG) on the concentration and metabolism of plasma homocysteine(pHcy) in folate-sufficient and folate-deficient rats.Methods In this study, ...Objective This study aimed to investigate the effects of N,N-dimethylglycine(DMG) on the concentration and metabolism of plasma homocysteine(pHcy) in folate-sufficient and folate-deficient rats.Methods In this study, 0.1% DMG was supplemented in 20% casein diets that were either folatesufficient(20 C) or folate-deficient(20 CFD). Blood and liver of rats were subjected to assays of Hcy and its metabolites. Hcy and its related metabolite concentrations were determined using a liquid chromatographic system.Results Folate deprivation significantly increased pHcy concentration in rats fed 20 C diet(from 14.19 ±0.39 μmol/L to 28.49 ± 0.50 μmol/L;P < 0.05). When supplemented with DMG, pHcy concentration was significantly decreased(12.23 ± 0.18 μmol/L) in rats fed 20 C diet but significantly increased(31.56 ±0.59 μmol/L) in rats fed 20 CFD. The hepatic methionine synthase activity in the 20 CFD group was significantly lower than that in the 20 C group;enzyme activity was unaffected by DMG supplementation regardless of folate sufficiency. The activity of hepatic cystathionine β-synthase(CBS) in the 20 CFD group was decreased but not in the 20 C group;DMG supplementation enhanced hepatic CBS activity in both groups, in which the effect was significant in the 20 C group but not in the other group.Conclusion DMG supplementation exhibited hypohomocysteinemic effects under folate-sufficient conditions. By contrast, the combination of folate deficiency and DMG supplementation has deleterious effect on pHcy concentration.展开更多
目的探讨血浆同型半胱氨酸(Hcy)水平与动态血压的关系。方法选择2009年10月—2012年12月在首都医科大学附属北京安贞医院健康体检中心体检者1 078例,符合1999年WHO/ISH制定的原发性高血压病诊断标准者402例(高血压组),其余676例为非高...目的探讨血浆同型半胱氨酸(Hcy)水平与动态血压的关系。方法选择2009年10月—2012年12月在首都医科大学附属北京安贞医院健康体检中心体检者1 078例,符合1999年WHO/ISH制定的原发性高血压病诊断标准者402例(高血压组),其余676例为非高血压组。在服用降压药物前,检测受试者血糖(GLU)、肌酐(Cr)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C);并采用循环酶法测定血浆Hcy水平。采用血压监测仪进行24h动态血压监测,记录受试者24 h收缩压(SBP)、24 h舒张压(DBP)、24 h脉压和心率、SBP变化、DBP变化、心率变化、日间和夜间血压负荷,以及24 h、日间和夜间SBP变化速率。采用Pearson相关分析血浆Hcy与动态血压的关系,同时采用多元线性回归分析影响血浆Hcy水平的因素。结果两组性别、BMI、GLU、Cr、LDL-C、24 h心率、DBP变化、心率变化、DBP负荷、日间SBP变化速率和夜间SBP变化速率比较,差异均无统计学意义(P>0.05);高血压组年龄、SBP变化、HDL-C低于非高血压组,总胆固醇、三酰甘油、Hcy、SBP、DBP、24 h SBP、24 h DBP、24 h脉压、SBP负荷、24 h SBP变化速率高于非高血压组(P<0.05)。高血压组Hcy与诊室SBP、24 h SBP、24 h脉压、SBP负荷、DBP负荷、24 h SBP变化速率、日间SBP变化速率、夜间SBP变化速率呈正相关(P<0.01);非高血压组Hcy水平与24 h SBP、SBP负荷、DBP负荷和日间SBP变化速率呈正相关(P<0.05)。多元线性回归分析结果显示,高血压组诊室血压、24 h SBP、SBP负荷、DBP负荷、24h SBP变化速率、日间SBP变化速率、夜间SBP变化速率为Hcy的影响因素(P<0.05);非高血压组24 h SBP、SBP负荷和DBP负荷为Hcy的影响因素(P<0.05)。结论血浆Hcy水平与动态血压指标间相关。展开更多
文摘Objective To investigate the correlations of plasma homocysteine(Hcy)level and apolipoprotein E gene polymorphism with Alzheimer’s disease(AD)and mild cognitive impairment(MCI).Methods A case-control study in 66 AD patients(AD group),64 MCI patients(MCI group)and 54 healthy controls(control group)was conducted.Plasma Hcy level and Apo E polymorphism
文摘Objective:The aim of this study is to assess the correlation between traditional cardiovascular risk factors and elevated plasma tHcy level in Nigerian hypertensive.Methods:Thirty-six hypertensive patients were recruited with 36 age and sex-matched controls.The age,sex and anthropometric measurements including height,weight and body mass index(BMI)were taken.Plasma total cholesterol,low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),triglycerides and tHcy were analyzed.The results of the two groups were compared.Results:The mean total cholesterol and LDL-C were significantly higher in the subjects than in the controls(P=0.01 and 0.03 respectively).On the other hand,means of HDL-C and triglycerides were not significantly different between the two groups(P=0.06 and 0.68 respectively).Mean total plasma tHcy was(12.95±4.9)μmol/L in hypertensive patients when compared with(11.29±3.6)μmol/L in the controls(P=0.09),however the mean tHcy was significantly higher in hypertensive patients who had stroke or myocardial infarction than those without these complications(one way Anova F=3.63,P=0.04).Significant positive correlation was seen between tHcy and systolic blood pressure,diastolic blood pressure,BMI and LDL-C.Conclusion:The study suggests that elevated plasma tHcy may predict occurrence of cardiovascular complications in hypertensive individuals.
基金supported by the National Natural Science Foundation of China under the Grant No. 81973048a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Culture, Sports and Technology of Japan [JSPS-C-21580137]。
文摘Objective This study aimed to investigate the effects of N,N-dimethylglycine(DMG) on the concentration and metabolism of plasma homocysteine(pHcy) in folate-sufficient and folate-deficient rats.Methods In this study, 0.1% DMG was supplemented in 20% casein diets that were either folatesufficient(20 C) or folate-deficient(20 CFD). Blood and liver of rats were subjected to assays of Hcy and its metabolites. Hcy and its related metabolite concentrations were determined using a liquid chromatographic system.Results Folate deprivation significantly increased pHcy concentration in rats fed 20 C diet(from 14.19 ±0.39 μmol/L to 28.49 ± 0.50 μmol/L;P < 0.05). When supplemented with DMG, pHcy concentration was significantly decreased(12.23 ± 0.18 μmol/L) in rats fed 20 C diet but significantly increased(31.56 ±0.59 μmol/L) in rats fed 20 CFD. The hepatic methionine synthase activity in the 20 CFD group was significantly lower than that in the 20 C group;enzyme activity was unaffected by DMG supplementation regardless of folate sufficiency. The activity of hepatic cystathionine β-synthase(CBS) in the 20 CFD group was decreased but not in the 20 C group;DMG supplementation enhanced hepatic CBS activity in both groups, in which the effect was significant in the 20 C group but not in the other group.Conclusion DMG supplementation exhibited hypohomocysteinemic effects under folate-sufficient conditions. By contrast, the combination of folate deficiency and DMG supplementation has deleterious effect on pHcy concentration.
文摘目的探讨血浆同型半胱氨酸(Hcy)水平与动态血压的关系。方法选择2009年10月—2012年12月在首都医科大学附属北京安贞医院健康体检中心体检者1 078例,符合1999年WHO/ISH制定的原发性高血压病诊断标准者402例(高血压组),其余676例为非高血压组。在服用降压药物前,检测受试者血糖(GLU)、肌酐(Cr)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C);并采用循环酶法测定血浆Hcy水平。采用血压监测仪进行24h动态血压监测,记录受试者24 h收缩压(SBP)、24 h舒张压(DBP)、24 h脉压和心率、SBP变化、DBP变化、心率变化、日间和夜间血压负荷,以及24 h、日间和夜间SBP变化速率。采用Pearson相关分析血浆Hcy与动态血压的关系,同时采用多元线性回归分析影响血浆Hcy水平的因素。结果两组性别、BMI、GLU、Cr、LDL-C、24 h心率、DBP变化、心率变化、DBP负荷、日间SBP变化速率和夜间SBP变化速率比较,差异均无统计学意义(P>0.05);高血压组年龄、SBP变化、HDL-C低于非高血压组,总胆固醇、三酰甘油、Hcy、SBP、DBP、24 h SBP、24 h DBP、24 h脉压、SBP负荷、24 h SBP变化速率高于非高血压组(P<0.05)。高血压组Hcy与诊室SBP、24 h SBP、24 h脉压、SBP负荷、DBP负荷、24 h SBP变化速率、日间SBP变化速率、夜间SBP变化速率呈正相关(P<0.01);非高血压组Hcy水平与24 h SBP、SBP负荷、DBP负荷和日间SBP变化速率呈正相关(P<0.05)。多元线性回归分析结果显示,高血压组诊室血压、24 h SBP、SBP负荷、DBP负荷、24h SBP变化速率、日间SBP变化速率、夜间SBP变化速率为Hcy的影响因素(P<0.05);非高血压组24 h SBP、SBP负荷和DBP负荷为Hcy的影响因素(P<0.05)。结论血浆Hcy水平与动态血压指标间相关。
