To study the changes of thrombomodulin(TM) in both plasma and tissue extracts of cancer patients for evaluating its clinical significance. Methods: PlasmaTM levels were measured by enzyme-linked immunosorbent assay (E...To study the changes of thrombomodulin(TM) in both plasma and tissue extracts of cancer patients for evaluating its clinical significance. Methods: PlasmaTM levels were measured by enzyme-linked immunosorbent assay (ELISA) in both plasma of 188 cancer patients and 24 cancer tissue extractsincluding their adjacent non-cancer tissues. Results:The plasma TM levels both in cancer patients and in metastasis patients were significantly higher than that in controls [(33.4714.25)mg/L, (41.6816.96)mg/L, vs(20.40 7.22) mg/L,P<0.01]. The plasma TM levels incancer patients after operation decreased obviously thanthat before operation [(18.459.96)mg/L, vs (28.2911.74)mg/L, P<0.01], whereas, the plasma TM levels in patientswith recurrence and metastasis after operation increasedobviously [(34.5012.57)mg/L]. Among the types of cancer,the plasma TM levels in metastasis lung cancers, gastric cancers and pancreatic cancers were significantly higherthan that in non-metastasis respective cancers. Nosignificant differences were found between controls andnon-metastasis cancers including gastric cancers,pancreatic cancers, nasopharyngeal cancers, large intestine cancers and laryngeal cancers (P>0.05). The TM levels incancer tissue extracts were significantly lower than that intheir adjacent non-cancer tissue extracts [(647.71317.51)mg/L vs (1455.63772.22)mg/L, P<0.01]. On the contrary, the plasma TM levels in these cancers were significantly higher than that in controls. Conclusion: The rise of plasma TMlevels in cancer patients was associated with metastasis and diffusion of cancers. The TM levels can be served as ansensitive index for judging progression and metastasis of展开更多
目的探讨妊娠11~14周孕妇血清中PAPP-A水平值在胎盘早剥中的预测价值,以及联合检测孕妇血清中CA125、TM水平对早期诊断胎盘早剥的临床价值。方法前瞻性选取2014年1月到2015年8月,孕11~14周时行Ⅰ期唐氏筛查的孕妇,孕周大于20周后有阴道...目的探讨妊娠11~14周孕妇血清中PAPP-A水平值在胎盘早剥中的预测价值,以及联合检测孕妇血清中CA125、TM水平对早期诊断胎盘早剥的临床价值。方法前瞻性选取2014年1月到2015年8月,孕11~14周时行Ⅰ期唐氏筛查的孕妇,孕周大于20周后有阴道出血、子宫体压痛、腰背痛、不明原因胎儿窘迫及宫缩过频、子宫张力过高等怀疑胎盘早剥的孕妇100例作为研究对象,产后检查是否有胎盘早剥再分为早剥组66例、无早剥组34例;同期选择在该院产检并正常分娩的100例孕妇为对照组,分别登记其PAPP-A值,并行CA125、TM检测,B超检查和产后胎盘检查,比较三组检测结果的差异。应用ROC曲线和约登指数评判各血清学指标在胎盘早剥诊断中的价值,并确定PAPP-A和TM相应的诊断界值。结果妊娠11~14周血清PAPP-A值,胎盘早剥组明显低于无胎盘早剥组和正常对照组（P〈0.05）,胎盘早剥组CA-125、TM水平明显高于无胎盘早剥组和正常对照组,均有统计学意义（P〈0.05）。将PAPP-A、TM作为检验变量得出诊断胎盘早剥的界值,PAPP-A〈2 028 m U/L、TM〉55μg/L时预测价值最高。结论妊娠11~14周低水平的血清PAPP-A值对胎盘早剥有预测作用;高水平的血清CA-125和高TM值对胎盘早剥的早期诊断具有较高的临床应用价值。展开更多
文摘To study the changes of thrombomodulin(TM) in both plasma and tissue extracts of cancer patients for evaluating its clinical significance. Methods: PlasmaTM levels were measured by enzyme-linked immunosorbent assay (ELISA) in both plasma of 188 cancer patients and 24 cancer tissue extractsincluding their adjacent non-cancer tissues. Results:The plasma TM levels both in cancer patients and in metastasis patients were significantly higher than that in controls [(33.4714.25)mg/L, (41.6816.96)mg/L, vs(20.40 7.22) mg/L,P<0.01]. The plasma TM levels incancer patients after operation decreased obviously thanthat before operation [(18.459.96)mg/L, vs (28.2911.74)mg/L, P<0.01], whereas, the plasma TM levels in patientswith recurrence and metastasis after operation increasedobviously [(34.5012.57)mg/L]. Among the types of cancer,the plasma TM levels in metastasis lung cancers, gastric cancers and pancreatic cancers were significantly higherthan that in non-metastasis respective cancers. Nosignificant differences were found between controls andnon-metastasis cancers including gastric cancers,pancreatic cancers, nasopharyngeal cancers, large intestine cancers and laryngeal cancers (P>0.05). The TM levels incancer tissue extracts were significantly lower than that intheir adjacent non-cancer tissue extracts [(647.71317.51)mg/L vs (1455.63772.22)mg/L, P<0.01]. On the contrary, the plasma TM levels in these cancers were significantly higher than that in controls. Conclusion: The rise of plasma TMlevels in cancer patients was associated with metastasis and diffusion of cancers. The TM levels can be served as ansensitive index for judging progression and metastasis of
文摘目的探讨妊娠11~14周孕妇血清中PAPP-A水平值在胎盘早剥中的预测价值,以及联合检测孕妇血清中CA125、TM水平对早期诊断胎盘早剥的临床价值。方法前瞻性选取2014年1月到2015年8月,孕11~14周时行Ⅰ期唐氏筛查的孕妇,孕周大于20周后有阴道出血、子宫体压痛、腰背痛、不明原因胎儿窘迫及宫缩过频、子宫张力过高等怀疑胎盘早剥的孕妇100例作为研究对象,产后检查是否有胎盘早剥再分为早剥组66例、无早剥组34例;同期选择在该院产检并正常分娩的100例孕妇为对照组,分别登记其PAPP-A值,并行CA125、TM检测,B超检查和产后胎盘检查,比较三组检测结果的差异。应用ROC曲线和约登指数评判各血清学指标在胎盘早剥诊断中的价值,并确定PAPP-A和TM相应的诊断界值。结果妊娠11~14周血清PAPP-A值,胎盘早剥组明显低于无胎盘早剥组和正常对照组（P〈0.05）,胎盘早剥组CA-125、TM水平明显高于无胎盘早剥组和正常对照组,均有统计学意义（P〈0.05）。将PAPP-A、TM作为检验变量得出诊断胎盘早剥的界值,PAPP-A〈2 028 m U/L、TM〉55μg/L时预测价值最高。结论妊娠11~14周低水平的血清PAPP-A值对胎盘早剥有预测作用;高水平的血清CA-125和高TM值对胎盘早剥的早期诊断具有较高的临床应用价值。
