目的探讨血小板压积(plateletcrit,PCT)联合收缩压(systolic blood pressure,SBP)和急性生理与慢性健康评分(Acute Physiology and Chronic Health Evaluation,APACHEⅡ评分)对脓毒性休克的预测价值。方法入选2018年1月~2021年12月山西...目的探讨血小板压积(plateletcrit,PCT)联合收缩压(systolic blood pressure,SBP)和急性生理与慢性健康评分(Acute Physiology and Chronic Health Evaluation,APACHEⅡ评分)对脓毒性休克的预测价值。方法入选2018年1月~2021年12月山西省人民医院收治的131例脓毒症患者作为研究对象,记录患者基线资料和临床数据。根据是否发生脓毒性休克,将131例患者分为脓毒症组(n=68)和脓毒性休克组(n=63)。比较两组临床资料,采用二元Logistic回归模型分析发生脓毒性休克的独立危险因素。采用受试者工作特征(receiver operating characteristic,ROC)曲线评价PCT、SBP和APACHEⅡ评分及三者联合对脓毒性休克的预测价值。结果两组患者年龄、性别、C反应蛋白、血小板分布宽度和白细胞计数等比较,差异无统计学意义(P>0.05)。与脓毒症组比较,脓毒性休克组收缩压、舒张压、血小板计数、血小板压积和嗜酸性粒细胞计数显著降低;心率、D二聚体、降钙素原、序贯器官衰竭评估(sequential organ failure assessment,SOFA)评分和APACHEⅡ评分升高,差异有统计学意义(P<0.05)。Logistic回归分析显示,低PCT、低SBP和APACHEⅡ评分是脓毒症休克的独立危险因素。ROC曲线分析显示,PCT、SBP和APACHEⅡ预测脓毒症发生的曲线下面积(area under the curve,AUC)分别为0.653、0.665和0.692,而三者联合后,曲线下面积为0.794。结论血小板压积可作为预测脓毒性休克的指标,与收缩压及APACHEⅡ评分联合能够提高预测脓毒性休克的准确性。展开更多
Objective: To explore the change of platelet indices namely plateletcrit, platelet distribution width and mean platelet volume among patients with recurrent pregnancy loss (RPL). Methods: The medical records of 45 wom...Objective: To explore the change of platelet indices namely plateletcrit, platelet distribution width and mean platelet volume among patients with recurrent pregnancy loss (RPL). Methods: The medical records of 45 women with a history of RPL and 45 women who gave birth without RPL were reviewed retrospectively from three governmental hospitals in Yemen. The personal, obstetric and complete blood count reports were analyzed. Results: Platelets' count and indices were significantly higher among RPL patients when compared to the control and the receiver operating characteristic curve for each platelet index showed significant area under the curve, with higher area for plateletcrit followed by platelet distribution width and then mean platelet volume. While the multiple logistic regression analysis for all platelets indices revealed that the platelet distribution width was the significant predictor for RPL in this study. Conclusions: The use of platelet indices may help gynecologists in predicting high risk pregnancy (pregnancy loss) in the low resources areas inYemen.展开更多
Introduction: Immune thrombocytopenic purpura (ITP) is an acquired disorder characterized by isolated thrombocytopenia. There is no “gold standard” test that can establish the diagnosis of primary ITP. Therefore, th...Introduction: Immune thrombocytopenic purpura (ITP) is an acquired disorder characterized by isolated thrombocytopenia. There is no “gold standard” test that can establish the diagnosis of primary ITP. Therefore, the diagnosis is one of exclusion and is based on patient history, physical examination, complete blood count, and blood smear review. Platelet indices are biomarkers of platelet activation, allowing extensive investigations focusing on the diagnostic and prognostic values in various diseases without extra-costs. Mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT) were investigated aiming at evaluating the correlation between pre- and post-treatment values in ITP patients. The sensitivity and specificity of platelet indices for assessment of their predictive value for treatment response were also evaluated. Methods: Fifty newly diagnosed primary ITP patients were selected from the Hematology Clinics of Ain Shams University Hospitals and classified into pediatric and adult groups. Platelet count, MPV, PDW, PCT have been recorded for all pre and post-treatment CBC samples using Beckman Coulter LH750 analyzer. Results: In pediatrics post-treatment MPV and PDW were significantly decreased while PCT was increased when compared to their values at the time of presentation (P < 0.01). The same results were obtained in adult patients, except for PDW which did not attain any significance. A significant correlation was found between pre-treatment values of these platelet indices and treatment response in pediatrics, while no significance was found between pre-treatment PDW and treatment response in adults. Conclusion: Increased pre-treatment MPV and PDW, and decreased PCT can provide diagnostic and predictive value for treatment response in ITP patients.展开更多
文摘目的探讨血小板压积(plateletcrit,PCT)联合收缩压(systolic blood pressure,SBP)和急性生理与慢性健康评分(Acute Physiology and Chronic Health Evaluation,APACHEⅡ评分)对脓毒性休克的预测价值。方法入选2018年1月~2021年12月山西省人民医院收治的131例脓毒症患者作为研究对象,记录患者基线资料和临床数据。根据是否发生脓毒性休克,将131例患者分为脓毒症组(n=68)和脓毒性休克组(n=63)。比较两组临床资料,采用二元Logistic回归模型分析发生脓毒性休克的独立危险因素。采用受试者工作特征(receiver operating characteristic,ROC)曲线评价PCT、SBP和APACHEⅡ评分及三者联合对脓毒性休克的预测价值。结果两组患者年龄、性别、C反应蛋白、血小板分布宽度和白细胞计数等比较,差异无统计学意义(P>0.05)。与脓毒症组比较,脓毒性休克组收缩压、舒张压、血小板计数、血小板压积和嗜酸性粒细胞计数显著降低;心率、D二聚体、降钙素原、序贯器官衰竭评估(sequential organ failure assessment,SOFA)评分和APACHEⅡ评分升高,差异有统计学意义(P<0.05)。Logistic回归分析显示,低PCT、低SBP和APACHEⅡ评分是脓毒症休克的独立危险因素。ROC曲线分析显示,PCT、SBP和APACHEⅡ预测脓毒症发生的曲线下面积(area under the curve,AUC)分别为0.653、0.665和0.692,而三者联合后,曲线下面积为0.794。结论血小板压积可作为预测脓毒性休克的指标,与收缩压及APACHEⅡ评分联合能够提高预测脓毒性休克的准确性。
文摘Objective: To explore the change of platelet indices namely plateletcrit, platelet distribution width and mean platelet volume among patients with recurrent pregnancy loss (RPL). Methods: The medical records of 45 women with a history of RPL and 45 women who gave birth without RPL were reviewed retrospectively from three governmental hospitals in Yemen. The personal, obstetric and complete blood count reports were analyzed. Results: Platelets' count and indices were significantly higher among RPL patients when compared to the control and the receiver operating characteristic curve for each platelet index showed significant area under the curve, with higher area for plateletcrit followed by platelet distribution width and then mean platelet volume. While the multiple logistic regression analysis for all platelets indices revealed that the platelet distribution width was the significant predictor for RPL in this study. Conclusions: The use of platelet indices may help gynecologists in predicting high risk pregnancy (pregnancy loss) in the low resources areas inYemen.
文摘Introduction: Immune thrombocytopenic purpura (ITP) is an acquired disorder characterized by isolated thrombocytopenia. There is no “gold standard” test that can establish the diagnosis of primary ITP. Therefore, the diagnosis is one of exclusion and is based on patient history, physical examination, complete blood count, and blood smear review. Platelet indices are biomarkers of platelet activation, allowing extensive investigations focusing on the diagnostic and prognostic values in various diseases without extra-costs. Mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT) were investigated aiming at evaluating the correlation between pre- and post-treatment values in ITP patients. The sensitivity and specificity of platelet indices for assessment of their predictive value for treatment response were also evaluated. Methods: Fifty newly diagnosed primary ITP patients were selected from the Hematology Clinics of Ain Shams University Hospitals and classified into pediatric and adult groups. Platelet count, MPV, PDW, PCT have been recorded for all pre and post-treatment CBC samples using Beckman Coulter LH750 analyzer. Results: In pediatrics post-treatment MPV and PDW were significantly decreased while PCT was increased when compared to their values at the time of presentation (P < 0.01). The same results were obtained in adult patients, except for PDW which did not attain any significance. A significant correlation was found between pre-treatment values of these platelet indices and treatment response in pediatrics, while no significance was found between pre-treatment PDW and treatment response in adults. Conclusion: Increased pre-treatment MPV and PDW, and decreased PCT can provide diagnostic and predictive value for treatment response in ITP patients.
