Aim:The aim of this study was to evaluate the efficacy of treatment related to age in metastatic non-small cell lung cancer(NSCLC).We compared young and elders(>70)in the setting of a regional Spanish hospital.We h...Aim:The aim of this study was to evaluate the efficacy of treatment related to age in metastatic non-small cell lung cancer(NSCLC).We compared young and elders(>70)in the setting of a regional Spanish hospital.We hypothesized that elder benefit as much as younger patients from chemotherapy in stage IV NSCLC.The study was limited to performance status 0-2.Methods:Clinical and demographic characteristics were reviewed form medical records.Type of treatment was collected and compared,as well as benefit from treatment,in terms of overall survival.Results:322 patients(162 young,160 aged)Elderly patients received less active treatment(63%vs.86%,P=0.001).E lderly r eceived l ess chemotherapy,less cisplatin-doublets,more carboplatin-combinations and monotherapy(P=0.035).T he b enefits o f t reatment w ere s imilar,r egardless o f a ge.S moking s tatus demonstrated a prognosis impact for elder patients treated with chemotherapy.Those who remained active smokers had a lower overall survival in the aged group.In a multivariate analysis,the Eastern Cooperative Oncology Group,active treatment and non-smoking history were favorable prognostic factors for elder patients.Smoking had not impact on young patients.Conclusion:E lderly p atients w ere u ndertreated i n c linical p ractice.Treatment showed similar overall survival despite of age.The impact of smoking seems to be more significant in the elderly population.展开更多
文摘Aim:The aim of this study was to evaluate the efficacy of treatment related to age in metastatic non-small cell lung cancer(NSCLC).We compared young and elders(>70)in the setting of a regional Spanish hospital.We hypothesized that elder benefit as much as younger patients from chemotherapy in stage IV NSCLC.The study was limited to performance status 0-2.Methods:Clinical and demographic characteristics were reviewed form medical records.Type of treatment was collected and compared,as well as benefit from treatment,in terms of overall survival.Results:322 patients(162 young,160 aged)Elderly patients received less active treatment(63%vs.86%,P=0.001).E lderly r eceived l ess chemotherapy,less cisplatin-doublets,more carboplatin-combinations and monotherapy(P=0.035).T he b enefits o f t reatment w ere s imilar,r egardless o f a ge.S moking s tatus demonstrated a prognosis impact for elder patients treated with chemotherapy.Those who remained active smokers had a lower overall survival in the aged group.In a multivariate analysis,the Eastern Cooperative Oncology Group,active treatment and non-smoking history were favorable prognostic factors for elder patients.Smoking had not impact on young patients.Conclusion:E lderly p atients w ere u ndertreated i n c linical p ractice.Treatment showed similar overall survival despite of age.The impact of smoking seems to be more significant in the elderly population.
