POEMS(polyneuropathy,organomegaly,endocrinopathy,M-protein and skin changes)综合征是一种单克隆浆细胞异常增殖的副肿瘤综合征,患病率约为0.3/10万[1]。该病累积神经、内分泌、骨骼、免疫及造血等系统,临床上诊断需要2个基本要素...POEMS(polyneuropathy,organomegaly,endocrinopathy,M-protein and skin changes)综合征是一种单克隆浆细胞异常增殖的副肿瘤综合征,患病率约为0.3/10万[1]。该病累积神经、内分泌、骨骼、免疫及造血等系统,临床上诊断需要2个基本要素:多发性周围神经病和单克隆浆细胞病[2]。周围神经病变是超过60%的POEMS综合征患者的首发症状,不少患者早期就诊于神经内科并被误诊为慢性炎性脱髓鞘性多发性神经根神经病(chronic inflammatory demyelinating polyneuropathy,CIDP)等原发性神经系统疾病[3]。由于神经病变进展缓慢、致残率高,多数患者就诊时症状严重且已造成神经不可逆性损伤,给患者生活带来极大不便,因此早识别、早诊断、及时治疗至关重要。本文报告1例采用达雷妥尤单抗(Daratumumab,Dara)联合方案治疗伴有严重周围神经病变的POEMS综合征,分析了神经病变的发病机制,并强调了POEMS综合征诊断的复杂性以及Daratumumab作为新一代药物在治疗中的潜在优势。展开更多
Zong Baihua’s aesthetic character and the creative philosophy of small poems are integrated and intertwined with each other,with distinctive aesthetic characteristics and unique artistic concepts.Whether it is his“r...Zong Baihua’s aesthetic character and the creative philosophy of small poems are integrated and intertwined with each other,with distinctive aesthetic characteristics and unique artistic concepts.Whether it is his“rounded and integrated aesthetics centered on Chinese art”,“vivid and charming natural cosmology”,or“personality aesthetics that mutually mirrors with the nature universe”,they all have extraordinary inspirations and guidance for us today to explore the reform of new literature and art,the reform of new poems,and even the contemplation of the cosmos,society,and life,with positive and profound significance.展开更多
Qiaoxi Poems is an influential collection of poetry that reflects the integration of the Zhuang and Han ethnic groups in China.It has collected a considerable number of Zhuang and Han Chinese poems on an unprecedented...Qiaoxi Poems is an influential collection of poetry that reflects the integration of the Zhuang and Han ethnic groups in China.It has collected a considerable number of Zhuang and Han Chinese poems on an unprecedented scale,featuring poems that blend ancient Zhuang and Han characters,showing the historical memory of exchanges and integration between the Zhuang and Han people,and reflecting their common spiritual home.Qiaoxi poetry has spread to the United States,where it is collected in the Harvard-Yenching Library and the East Asia Library at Columbia University.This is a reflection of its widespread spread.Qiaoxi Poems are of great value to the study of the development of Chinese poetry in Guangxi during the Ming and Qing Dynasties.展开更多
文摘Zong Baihua’s aesthetic character and the creative philosophy of small poems are integrated and intertwined with each other,with distinctive aesthetic characteristics and unique artistic concepts.Whether it is his“rounded and integrated aesthetics centered on Chinese art”,“vivid and charming natural cosmology”,or“personality aesthetics that mutually mirrors with the nature universe”,they all have extraordinary inspirations and guidance for us today to explore the reform of new literature and art,the reform of new poems,and even the contemplation of the cosmos,society,and life,with positive and profound significance.
文摘Qiaoxi Poems is an influential collection of poetry that reflects the integration of the Zhuang and Han ethnic groups in China.It has collected a considerable number of Zhuang and Han Chinese poems on an unprecedented scale,featuring poems that blend ancient Zhuang and Han characters,showing the historical memory of exchanges and integration between the Zhuang and Han people,and reflecting their common spiritual home.Qiaoxi poetry has spread to the United States,where it is collected in the Harvard-Yenching Library and the East Asia Library at Columbia University.This is a reflection of its widespread spread.Qiaoxi Poems are of great value to the study of the development of Chinese poetry in Guangxi during the Ming and Qing Dynasties.
