GRAPHICAL COMPUTING METHOD ON FOUR-BAR LINKAGE(1)——Inflexion Circle,Focal Axis,Ball's Point,Centering-point Curve and Circling-point Curve For Four ISPs,Coupler Curves Based on Ball's Points——

By means of programs GTMPAC based- on generalized triangle method,analysis and synthesis of mechanism design in accordance with absolutely graphicalmethod( absolutely germetrical method) are developed.In this paper,we make aspecial study about centering- point curve and circling- point curve and couplercurves based on Ball’s points.

Simulation Model of Mechanical Properties of Point - Bonded Nonwovens

A computer model for studying the mechanical properties of point - bonded nonwovens is established. The simulation tensile curve of a nonwoven fabric may be obtained based on relaxation procedure when the mechanical properties of fibers, the arrangement of bond points in the fibrous web and specimen size are inputted into the computer. Relaxation method and relevant algorithms of computer simulation are described in detail. The validity of the model is also demonstrated.

Coupled Fixed Point for (<i>&alpha;</i>, <i>&Psi;</i>)-Contractive in Partially Ordered Metric Spaces Using Compatible Mappings

In this paper, first we introduce notions of (α, Ψ)-contractive and (α)-admissible for a pair of map and prove a coupled coincidence point theorem for compatible mappings using these notions. Our work extends and generalizes the results of Mursaleen et al. [1]. At the end, we will provide an example in support of our result.

Epidemio-Clinical, Therapeutic and Evolutive Aspects of Pulmonary Embolism in Young Subject in the Cardiology Department in Point “G” Hospital University Center Bamako

Objective: The purpose of this work was to determine the epidemiological, clinical and evolutionary aspects of the pulmonary embolism of the young person in the cardiology department of the University Hospital Center (CHU) Point G in Bamako-Mali. Methodology: This was an analytical study from January 01, 2018 to December 31, 2018 in the CHU Point G cardiology department, including all patients hospitalized during this period. Results: Of 1379 hospitalized patients, 19 patients were concerned by pulmonary embolism of the young person. The prevalence of pulmonary embolism of the young person was 1.37%. The most affected age group was 21 - 30 (47.4%) of patients. The predominance was female (89.47%) with a gender ratio of 0.11 in favour of women. The average age in the series was 29.79 years with extremes of 16 years and 40 years. Factors predisposing to pulmonary embolism were dominated by peri partum, cardiomyopathy and obesity with 47.3%, 31.57% and 21.1%, respectively. The dominant signs were chest pain and dyspnea in 94.7% and 89.5% of cases respectively. Pulmonary embolism was unlikely in 60.52% according to the Geneva and Wells score simplified. At the thoracic angioscanner, the embolism was bilateral in 52.6% of cases and distal in 36.8% of patients;in 10 patients who performed cardiac ultrasound, pulmonary arterial hypertension (70%), dilation of the right ventricle (20%) and left ventricular dilation (40%). Hyper leucocytosis (47.4%), anemia and low prothrombin rate (TP) (22.2%) were the most found biological abnormalities. More than 2/3 (68.5%) our patients had an intermediate mortality risk according to the PESI (Pulmonary Embolism Severity Index) score. The average hospital stay was 10 days. Hospital mortality was 10.5%. Conclusion: The pulmonary embolism of the young person is a frequent, serious and multifactorial pathology and the female sex is most affected especially during peri partum periods, hence the need for preventive measures. Clinical signs are not specific and based on the assessment of clinical probability. Pulmonary angioscanner remains the confirmation review in our context.

Cross-Correlation Detection of Point Sources in the WMAP First Year Data

We apply a Cross-Correlation （CC） method developed previously for detecting gamma-ray point sources to the WMAP first year data by using the Point-Spread Function of WMAP and obtain a full sky CC coefficient map. We find that the CC method is a powerful tool to examine the WMAP foreground residuals which can be further cleaned accord- ingly. Evident foreground signals are found in the WMAP foreground cleaned maps and the Tegmark cleaned map. In this process 101 point sources are detected, and 26 of them are new sources additional to the originally listed WMAP 208 sources. We estimate the flux of these new sources and verify them by another method. As a result, a revised mask file based on the WMAP first year data is produced by including these new sources.

CAS 132-2006 Standard for Flat Panel Display TV Set Installation Service Formulating and Enforcing Main Point Explanation and Analysis

CAS 132-2006 formulation background and work courses Flat panel display technology is maturing alongside the development of science and technology. The prices of flat panel display TV sets are becoming lower and lower. Flat panel display TV sets have begun entering the mainstream and are now the first choice of some consumers when making new TV purchases.Display TV Set Installation Service Point Explanation and AnalysisRepair, Retreat and Change Duty Stipulations. Peculiar use conditions, usage environments, and the practical circumstances of user consumption service requirements, etc., were also taken into account on the basis of extensive investigation, testing, and verification.……

Study on the method of optimal location on explosion events at near-source site

IntroductionEarthquake location is one of the inverse problems in seismology. The accurate earthquake source location is the basis of studies of earthquake images, the relation analysis between seismicity and tectonics, and the important parameters of earthquakes. It is also the basic data used to study the space distribution of aftershocks after a strong earthquake. The earthquake location accuracy mainly depends on reliability of the velocity models for the earth￠s crust, the reasonable design of the seismograph network, the accuracy of arrival time, and the location method used (ZHAO, 1983; ZHU, ZHAO, 1997; LI, et al, 1999). The reliability of the velocity model directly influences loca-tion results. The reasonable seismograph network design can improve the location accuracy; otherwise it will in-troduce ill-conditioned equations and large location error. If arrival time is not accurate, for example, if the seismic phase is wrongly identified or the time service is inaccurate, large arrival time error will be produced, and the location results and real hypocenters will be discordant. Different location algorithms adopted will produce differ-ent location errors. The residual criterion chosen has influence on location results. Besides, whether the event is correctly associated also influences the location quality. In practice, it can often be seen that large location devia-tion introduced by wrong event association.

“秩边透水道”针法对子宫内膜异位症大鼠Beclin-1、LC3调节作用的研究

目的观察“秩边透水道”针法对子宫内膜异位症(EMS)大鼠Bclin-1、LC3表达的影响,探讨此针法治疗EMS的可能机制。方法50只雌性SD大鼠随机分为模型组、假手术组、针刺组、激动剂组、针刺加抑制剂组,每组10只。假手术组不造模,不干预,其余各组造模成功后,分别处理。针刺组大鼠予以“秩边透水道”针刺干预;激动剂组予以雷帕霉素(rapamycin)腹腔注射;针刺加抑制剂组在针刺组干预基础上,同时予以3-甲基腺嘌呤(3-methyladenine,3-MA)腹腔注射;模型组和假手术组动物常规饲养。各组均干预3周。取各组大鼠子宫在位、异位内膜组织,苏木素-伊红(HE)染色观察病理学变化;透射电镜观察自噬小体变化;RT-qPCR、Western blot法检测Beclin-1、LC3 mRNA和蛋白的表达。结果HE染色结果显示大鼠子宫内膜上皮都出现萎缩,并伴随纤维组织的增生和毛细血管的减少,其中针刺组和激动剂组变化最为明显。透射电镜结果显示模型组自噬泡减少;针刺组自噬泡较多;激动剂组大鼠子宫内膜细胞中自噬泡较多;针刺加抑制剂组有少量的自噬泡。无论在各组大鼠子宫在位还是异位内膜中,模型组LC3、Beclin-1 mRNA及蛋白表达均明显低于假手术组(P<0.05);各干预组LC3、Beclin-1 mRNA及蛋白表达均明显高于模型组(P<0.05);针刺组、激动剂组LC3、Beclin-1 mRNA及蛋白表达均明显高于针刺加抑制剂组(P<0.05)。结论“秩边透水道”针法可上调大鼠子宫内膜组织内Beclin-1、LC3的表达,改善大鼠子宫内膜细胞防护效应机制。

A new calibration model for pointing a radio telescope that considers nonlinear errors in the azimuth axis

A new calibration model of a radio telescope that includes pointing error is presented, which considers nonlinear errors in the azimuth axis. For a large radio telescope, in particular for a telescope with a turntable, it is difficult to correct pointing errors using a traditional linear calibration model, because errors produced by the wheel-on-rail or center bearing structures are generally nonlinear. Fourier expansion is made for the oblique error and parameters describing the inclination direction along the azimuth axis based on the linear calibration model, and a new calibration model for pointing is derived. The new pointing model is applied to the 40 m radio telescope administered by Yunnan Observatories, which is a telescope that uses a turntable. The results show that this model can significantly reduce the residual systematic errors due to nonlinearity in the azimuth axis compared with the linear model.

Population Spatial Distribution Based on Luojia 1-01 Nighttime Light Image:A Case Study of Beijing

With the continuous development of urbanization in China,the country’s growing population brings great challenges to urban development.By mastering the refined population spatial distribution in administrative units,the quantity and agglomeration of population distribution can be estimated and visualized.It will provide a basis for a more rational urban planning.This paper takes Beijing as the research area and uses a new Luojia1-01 nighttime light image with high resolution,land use type data,Points of Interest(POI)data,and other data to construct the population spatial index system,establishing the index weight based on the principal component analysis.The comprehensive weight value of population distribution in the study area was then used to calculate the street population distribution of Beijing in 2018.Then the population spatial distribution was visualize using GIS technology.After accuracy assessments by comparing the result with the WorldPop data,the accuracy has reached 0.74.The proposed method was validated as a qualified method to generate population spatial maps.By contrast of local areas,Luojia 1-01 data is more suitable for population distribution estimation than the NPP/VIIRS(Net Primary Productivity/Visible infrared Imaging Radiometer)nighttime light data.More geospatial big data and mathematical models can be combined to create more accurate population maps in the future.

A New Thioamide Derivative for Separation and Preconcentration of Multi Elements in Aquatic Environment by Cloud Point Extraction

2-(pyridine-2-yl)-N-p-chlorohydrazinecarbothioamide (HCPTS) was synthesized, characterized and successfully applied for the preconcentration of Cu(II), Ni(II), Zn(II), Cd(II), Co(II), Pb(II), Fe(II), and Hg(II) in water, blood, and urine samples prior to graphite furnace atomic absorption determination (GFAAS);Hg was determined by cold vapor technique. Under the optimum experimental conditions (i.e. pH = 8, 10–4 M of HCPTS, 0.05% w/v of Triton X-114), calibration graphs were linear in the range of 0.02 to 200 ng?mL–1 for Co(II), Cd(II), Pb(II) and Ni(II);0.03 to 200 ng?mL–1 for Cu(II);0.07 to 200 ng?mL–1 for Fe(II) and Zn(II) and 0.02 to 150 ng?mL–1 for Hg(II). The enrichment factors were 43, 51, 41, 46, 54, 40, 45 and 52 for Cu(II), Ni(II),Zn (II), Cd(II), Co(II), Pb(II), Fe(II), and Hg(II), respectively. The limit of detection were found to be 0.019, 0.094, 0.0514, 0.052, 0.0165, 0.047, 0.068 and 0.041 ng?mL–1 for Cu(II), Ni(II), Zn(II), Cd(II), Co(II), Pb(II), Fe(II), and Hg(II), respectively. The developed method was applied to the determination of these metal ions in water, blood and urine samples with satisfactory results.

Observation of a diverse deviation from macropore-formation theory in silicon electrochemistry

Via anodizing patterned and unpatterned samples with a high HF concentration （[HF]）, the degree of deviation from pore-formation theory was found to be markedly different. Based on the analysis of scanning electron microscope （SEM） micrographs and current-voltage （I - V） curves, the variation of physical and chemical parameters of patterned and unpatterned substrates was found to be crucial to the understanding of the observations. Our results indicate that the initial surface morphology of samples can have a considerable influence upon pore formation. The electric-field effect as well as current-burst-model was employed to interpret the underlying mechanism.

Fixed Point Theorems of the Iterated Function Systems

In this paper, we present some fixed point theorems of iterated function systems consisting of α-ψ-contractive type mappings in Fractal space constituted by the compact subset of metric space and iterated function systems consisting of Banach contractive mappings in Fractal space constituted by the compact subset of generalized metric space, which is Mso extensively applied in topological dynamic system.

A New Critical Value Concerning the Genealogy of Long Period Families at L_4 in the Restricted Three-body Problem

We found another critical mass ratio value -↑μ between μ4 and μ5 concerning the genealogy of the long period family around the equilateral equilibrium point L4 in the restricted three-body problem. This value has not been pointed out before. We used numerical computations to show how the long period family evolves around this critical value. The case is similar to that of the critical values between μ2 and μ4, with slight difference in evolution details.

Study on the relationship between relieving energy crisis in myofascial trigger points with An-Pressing manipulation and AMPK/PGC-1α pathway activation

Objective To explore the mechanism of An-Pressing manipulation in relieving energy crisis in chronic myofascial trigger points(MTrPs)by observing the effects of An-Pressing manipulation on adenosine triphosphate(ATP),adenosine 5′-monophosphate(AMP)-activated protein kinase(AMPK)/peroxisome proliferator-activated receptorγcoactivator 1α(PGC-1α)pathway and mitochondrial ultrastructure of skeletal muscle cells in MTrPs rats.Methods Forty-eight male Sprague-Dawley rats were randomly divided into a blank group,a model group,a lidocaine group,and an An-Pressing manipulation group,with 12 rats in each group.The model group,lidocaine group and An-Pressing manipulation group were used to replicate the MTrPs rat model by blunt shock and centrifugal motion method.After modeling,the An-Pressing manipulation group was subjected to 7 times An-Pressing manipulation,once every other day;the lidocaine group was treated with 3 times of injection of lidocaine at the MTrPs,once every 6 d.The blank group and the model group were fed normally without intervention.After the intervention,local muscle tissue was taken to detect the content of ATP and the expression of AMPK,phosphorylated AMPK(phospho-AMPK),PGC-1α,and glucose transporter 4(GluT4),and the ultrastructure of mitochondria was observed under an electron microscope.Results Compared with the blank group,the ATP content in the model group was decreased(P<0.05),the protein expression levels of phospho-AMPK,PGC-1α,and GluT4 and the ratio of phospho-AMPK to AMPK were decreased(P<0.05);under the electron microscope,the number of mitochondria decreased,and they were deformed,small in volume,and had deformed cristae.Compared with the model group,the ATP contents in the An-Pressing manipulation group and the lidocaine group were increased(P<0.05),and the protein expression levels of phospho-AMPK,PGC-1α,and GluT4 and the ratio of phospho-AMPK to AMPK were increased(P<0.05);under the electron microscope,the number of mitochondria increased,the shape and size of the mitochondria were basically normal,and the cristae could be seen.Compared with the lidocaine group,phospho-AMPK and the ratio of phospho-AMPK to AMPK in the An-Pressing manipulation group were increased(P<0.05);under the electron microscope,the numbers of mitochondria were similar,and the shape and size of the mitochondria were basically normal without swelling,and the cristae could be observed.Conclusion An-Pressing manipulation can increase the ATP content in MTrPs tissue,improve the expression levels of PGC-1α and GluT4 proteins and the ratio of phospho-AMPK to AMPK;its mechanism may relate to the activation of AMPK/PGC-1α signaling pathway to promote the repair of mitochondrial damages.

摩腹联合电针透穴法对失眠大鼠生物钟相关基因及神经递质表达的影响

目的探讨摩腹联合电针透穴法对失眠大鼠生物钟基因Clock、BMAL1、PER1表达及神经递质乙酰胆碱(ACh)、谷氨酸(Glu)含量的影响及可能的作用机制。方法50只SD雄性大鼠随机分为正常组、模型组、摩腹组、电针透穴组和联合组,每组10只。除正常组外,采用腹腔注射对氯苯丙氨酸建立失眠大鼠模型。摩腹组进行腹部按摩,电针透穴组采用平刺法,百会透神庭、三阴交透阴陵泉(双侧)、神门透内关(双侧),电针仪疏密波,频率1Hz/20Hz,联合组摩腹后进行电针透穴治疗,各组均1次/d,连续7d,正常组和模型组不予干预。HE染色观察下丘脑组织神经元细胞形态变化,RT-qPCR检测下丘脑组织Clock、BMAL1、PER1 mRNA表达,免疫组化染色检测下丘脑组织Clock、BMAL1、PER1表达,Western blot检测下丘脑组织Clock、BMAL1、PER1蛋白表达,ELISA检测血清ACh、Glu含量。结果与正常组比较,模型组大鼠入睡潜伏期延长,睡眠持续时间缩短,下丘脑组织细胞结构破坏严重、呈空泡样变化,神经元细胞数量减少,下丘脑组织Clock、BMAL1mRNA和蛋白表达升高,PER1mRNA和蛋白表达降低,血清ACh、Glu含量增加,差异均有统计学意义(P<0.05);与模型组比较,摩腹组、电针透穴组和联合组均能缩短入睡潜伏期,延长睡眠持续时间,改善下丘脑神经元细胞形态,降低下丘脑组织Clock、BMAL1mRNA和蛋白表达,上调PER1mRNA和蛋白表达,减少血清ACh、Glu含量,差异均有统计学意义(P<0.05),以联合组作用最显著(P<0.05)。结论摩腹联合电针透穴法能改善大鼠失眠状况,其机制可能与调控生物钟基因Clock、BMAL1、PER1mRNA和蛋白表达及神经递质含量有关。

头部电针透穴治疗脑卒中后抑郁症临床观察

目的:研究头部电针透穴疗法治疗脑卒中后抑郁症(PSD)的临床疗效及作用机理。方法:108例PSD患者随机分为电针透穴组(38例)、非透穴组(36例)和西药组(34例)。电针透穴组选用悬颅透悬厘、脑户透强间、头临泣透阳白等穴;非透穴组选用百会、印堂、四神聪等穴;西药组采用氟西汀口服。治疗28天后,分别对3组疗效、治疗前后HAMD抑郁量表评分、SDS自评量表评分和血浆中5-羟色胺(5-HT)含量进行对比观察。结果:电针透穴组有效率为86.84%,明显优于非透穴组的63.89%和西药组的67.65%(P<0.01,P<0.05)。电针透穴组能明显提高血浆中5-HT含量,与非透穴组相比差异有非常显著性意义(P<0.01),与西药组相比差异有显著性意义(P<0.05)。结论:头部电针透穴疗法能明显提高病人血浆中5-HT含量,治疗PSD的疗效明显优于非透穴组和西药组。

秩边透水道针法治疗慢性前列腺炎的解剖学基础

目的 :为“秩边透水道”针法治疗慢性前列腺炎提供形态学依据。 方法 :在 2 4具 (48例 )成年男性尸体上解剖、测量了针体穿过的途径与针尖抵达部位的有关数据。 结果 :针体逐层穿经皮肤、浅筋膜、臀大肌、梨状肌与骶丛达小骨盆上口中心冠状面后 1 77± 16 6 4mm ,小骨盆上口平面下 4 0 6 0± 17 86mm ,小骨盆侧壁内侧 18 13± 14 2 3mm。结论 :针尖抵达的部位恰在盆丛 ,表明其治病的机理可能是通过刺激盆丛所含的交感。

透针疗法治疗中风偏瘫痉挛状态临床观察

目的 :探寻治疗偏瘫痉挛状态的有效手段。方法 :运用患肢阴阳经相透针法治疗中风偏瘫痉挛状态 2 9例 ,与常规针刺组 (头针 +体针 ) 2 2例、药物治疗组 (口服妙纳 ) 2 7例比较。 结果 :治疗组治疗前后肌张力累积差值差异大 ,肌张力降低明显 ;在降低肌张力、髋内收肌张力上与常规针刺组、药物治疗组对照差异有显著性意义 (P <0 0 5 )。结论 :透针疗法治疗中风肢体痉挛有较好疗效。

头穴透刺配合溶栓治疗急性脑梗塞的临床机理研究

本题选择 111例急性脑梗塞患者 ,根据治疗方法和发病时间顺序将其分为 8组。采用临床疗效观察、神经功能评分等为指标 ,进行治疗前后连续性检测。结果 :发现单纯溶栓组溶栓后血管虽然再通 ,脑血流也得到改善 ,但常常不能使神经功能等临床状况获得明显的恢复 ,这可能主要与溶栓再灌注中自由基损害有关。而针刺配合溶栓组的这种现象较少 ,与单纯溶栓组比较差异有显著性意义 (P <0 0 5) ,从而间接证明针刺可能减轻溶栓再灌注损伤 。