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Electrochemical biosensors for point-of-care testing 被引量:1
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作者 Jinsol Kim Juho Jeong Seung Hwan Ko 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2024年第4期548-565,共18页
Point-of-care testing(POCT)is the practice of diagnosing and monitoring diseases where the patient is located,as opposed to traditional treatment conducted solely in a medical laboratory or other clinical setting.POCT... Point-of-care testing(POCT)is the practice of diagnosing and monitoring diseases where the patient is located,as opposed to traditional treatment conducted solely in a medical laboratory or other clinical setting.POCT has been less common in the recent past due to a lack of portable medical devices capable of facilitating effective medical testing.However,recent growth has occurred in this field due to advances in diagnostic technologies,device miniaturization,and progress in wearable electronics.Among these developments,electrochemical sensors have attracted interest in the POCT field due to their high sensitivity,compact size,and affordability.They are used in various applications,from disease diagnosis to health status monitoring.In this paper we explore recent advancements in electrochemical sensors,the methods of fabricating them,and the various types of sensing mechanisms that can be used.Furthermore,we delve into methods for immobilizing specific biorecognition elements,including enzymes,antibodies,and aptamers,onto electrode surfaces and how these sensors are used in real-world POCT settings. 展开更多
关键词 point-of-care testing(poct) Electrochemical sensor ENZYME ANTIBODY Health care
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Process of Designing Robust, Dependable, Safe and Secure Software for Medical Devices: Point of Care Testing Device as a Case Study
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作者 Sivanesan Tulasidas Ruth Mackay +3 位作者 Pascal Craw Chris Hudson Voula Gkatzidou Wamadeva Balachandran 《Journal of Software Engineering and Applications》 2013年第9期1-13,共13页
This paper presents a holistic methodology for the design of medical device software, which encompasses of a new way of eliciting requirements, system design process, security design guideline, cloud architecture desi... This paper presents a holistic methodology for the design of medical device software, which encompasses of a new way of eliciting requirements, system design process, security design guideline, cloud architecture design, combinatorial testing process and agile project management. The paper uses point of care diagnostics as a case study where the software and hardware must be robust, reliable to provide accurate diagnosis of diseases. As software and software intensive systems are becoming increasingly complex, the impact of failures can lead to significant property damage, or damage to the environment. Within the medical diagnostic device software domain such failures can result in misdiagnosis leading to clinical complications and in some cases death. Software faults can arise due to the interaction among the software, the hardware, third party software and the operating environment. Unanticipated environmental changes and latent coding errors lead to operation faults despite of the fact that usually a significant effort has been expended in the design, verification and validation of the software system. It is becoming increasingly more apparent that one needs to adopt different approaches, which will guarantee that a complex software system meets all safety, security, and reliability requirements, in addition to complying with standards such as IEC 62304. There are many initiatives taken to develop safety and security critical systems, at different development phases and in different contexts, ranging from infrastructure design to device design. Different approaches are implemented to design error free software for safety critical systems. By adopting the strategies and processes presented in this paper one can overcome the challenges in developing error free software for medical devices (or safety critical systems). 展开更多
关键词 point of care testing System Architecture Safety CRITICAL Systems SOFTWARE Development
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Point-of-Care Testing Using Three Dimensional Optical Biosensor Based on Microfluidic Technology
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作者 Chunxiu Liu Haoyuan Cai +4 位作者 Jian Jia Tianyang Cao Tong Li Tianjun Ma Chang Liu 《Journal of Biosciences and Medicines》 2016年第12期56-61,共6页
We have presented a three dimensional optical protein chip that fulfills the demanding for point-of-care diagnostics in terms of ease-of-use (one step assay), miniaturization (5 μl). The artful combination of magneti... We have presented a three dimensional optical protein chip that fulfills the demanding for point-of-care diagnostics in terms of ease-of-use (one step assay), miniaturization (5 μl). The artful combination of magnetic nanoparticles on chip and total internal reflection imaging (TIRI) technology permits the sensitive and rapid detection of hs-CRP (high-sensitivity C-reactive protein). The whole test was complete within 10 min using “all in one step” assay with a limit of detection of 0.1 ng/mL hs-CRP. The measuring range for hs-CRP could be extended to 10 ng/mL. The chip can also be used to detect more parameters in blood samples. 展开更多
关键词 point-of-care testing (poct) Three Dimensional Optical Chip HS-CRP
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Point-of-Care Testing vs. Laboratory Testing during High Patient Volume Situations
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作者 Jonathan McCoy Robert Eisenstein +5 位作者 Channing Hui Greg Corcoran Chris Kilker Pamela Ohman-Strickland Mark Merlin Clifton Lacy 《Open Journal of Emergency Medicine》 2019年第4期49-56,共8页
Introduction: Our aim was to determine what patient volume, if any, in-laboratory testing provides results faster than Point-of-Care-Testing (POCT). Methods: To evaluate POCT effectiveness during high volume situation... Introduction: Our aim was to determine what patient volume, if any, in-laboratory testing provides results faster than Point-of-Care-Testing (POCT). Methods: To evaluate POCT effectiveness during high volume situations, POCT was compared to in-laboratory testing during busy periods with large numbers of patients. Our setting was an urban level 1 trauma center with an academic emergency medicine department (ED) and annual patient volume of 70,000. Patients seen requiring laboratory testing during peak volume between 11 a.m. and 7 p.m. were enrolled over a five-week period. One tube of blood was sent to the laboratory and the other tube was run in the ED using POCT. Turnaround time was recorded as time from when the tube was received to when the result was available. We also completed a time-motion study to assess the number of POCT machines that would be needed to process the entire average hourly hospital laboratory volume. Results: We collected 539 hematology and chemistry specimens. The POCT group was significantly faster than in-laboratory testing, with mean POCT [complete blood count (CBC) and chemistry] 3.5 minutes compared to in-laboratory CBC test time of 30.9 minutes and chemistry test time of 55 minutes. As the volume of samples peaked, there was a slight but insignificant decrease in POCT turnaround time. If POCT was used to process the entire average hospital laboratory volume which approached 54 samples an hour, 3 POCT machines would be necessary to maintain turnaround times. Conclusion: Even during ED high volume situations, POCT provided results significantly faster than in-laboratory testing. 展开更多
关键词 point-OF-care testing EMERGENCY DEPARTMENT DISASTER MEDICINE
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Evaluation of a Plasma hCG Method for Point of Care Testing with the Aim of Shortening Test-Turnaround-Times
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作者 Anna-Karin Wikstrom Magnus Hagmar +1 位作者 Goran Ronquist Anders Larsson 《Open Journal of Obstetrics and Gynecology》 2015年第6期341-343,共3页
Objective: To examine the correlation between plasma hCG results obtained with the new i-STAT&reg hCG point of care test with those concomitantly obtained from the central hospital laboratory utilizing the same pa... Objective: To examine the correlation between plasma hCG results obtained with the new i-STAT&reg hCG point of care test with those concomitantly obtained from the central hospital laboratory utilizing the same patient samples. Methods: Prospective cross-sectional laboratory test evaluation. We compared plasma hCG results obtained with the i-STAT&reg hCG test (Abbott Point of Care, Princeton, NJ, USA) with Architect Ci8200 (Abbott Laboratories, Abbott Park, IL, USA). We also calculated the total coefficient of variation (CV) for the i-STAT&reg method. Results: The two methods showed a good linear correlation (R2 = 0.994;slope 1.03) and CV for the i-STAT&reg method was 2.1% - 5.2%. Conclusion: We suggest that the i-STAT&reg hCG blood assay could be used as a complement to urine hCG assays in clinical situations when rapid test results are needed and urine is not available. 展开更多
关键词 Human Chorionic Gonadotropin PREGNANCY Method Evaluation point of care test
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14台POCT血气分析仪与中心实验室检测结果的一致性分析
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作者 凌明智 张江峰 +2 位作者 胡彪 袁有华 万震 《检验医学与临床》 CAS 2024年第10期1420-1424,共5页
目的分析14台床旁检测(POCT)血气分析仪和中心实验室血气分析仪检测结果的一致性。方法采用中心实验室血气分析仪及14台POCT血气分析仪分别检测3个浓度水平质控品,每天检测2次,连续检测4 d,共24次,根据检测结果计算pH、动脉血二氧化碳分... 目的分析14台床旁检测(POCT)血气分析仪和中心实验室血气分析仪检测结果的一致性。方法采用中心实验室血气分析仪及14台POCT血气分析仪分别检测3个浓度水平质控品,每天检测2次,连续检测4 d,共24次,根据检测结果计算pH、动脉血二氧化碳分压(PCO_(2))、动脉血氧分压(PO_(2))、K^(+)、Na^(+)、Cl^(-)、Ca^(2+)的均值、标准差和变异系数等;计算14台POCT血气分析仪检测结果与中心实验室检测结果的偏倚及偏倚率;应用ANOVA检验、Passing-Bablok回归分析对14台POCT血气分析仪与中心实验室检测结果一致性进行分析评价。结果14台POCT血气分析仪各比对项目检测结果的变异系数均小于生产商声明的性能范围。14台POCT血气分析各比对项目的检测结果与中心实验室的偏倚均小于国家卫生健康委员会临床检验中心室间质量评价标准。14台POCT台血气分析各比对项目的检测结果比较,差异均无统计学意义(P>0.05)。14台POCT血气分析仪检测结果与中心实验室pH值、PCO_(2)、PO_(2)、K^(+)、Na^(+)、Cl^(-)、Ca^(2+)检测结果模拟回归方程的截距和斜率均在95%置信区间,且P>0.05,与中心实验室检测结果具有高度的一致性。结论14台POCT血气分析仪具有良好的精密度,且14台POCT血气分析仪之间及与中心实验室间均具有较好的一致性。 展开更多
关键词 血气分析仪 床旁检测 一致性 重症监护室 急救
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2018-2023年重庆市肌钙蛋白POCT室间质量评价结果分析
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作者 朱明松 李甜 +2 位作者 万雅芳 牛长春 廖璞 《现代医药卫生》 2024年第16期2719-2722,共4页
目的分析2018-2023年重庆市肌钙蛋白即时检测(POCT)室间质量评价(EQA)结果,了解重庆市肌钙蛋白POCT检测现状,为提高重庆市肌钙蛋白POCT检测能力提供依据。方法收集2018-2023年参加重庆市临床检验中心肌钙蛋白POCT EQA实验室结果,并进行... 目的分析2018-2023年重庆市肌钙蛋白即时检测(POCT)室间质量评价(EQA)结果,了解重庆市肌钙蛋白POCT检测现状,为提高重庆市肌钙蛋白POCT检测能力提供依据。方法收集2018-2023年参加重庆市临床检验中心肌钙蛋白POCT EQA实验室结果,并进行统计分析。结果2018-2023年参加重庆市肌钙蛋白POCT EQA的实验室数从36家增加至88家,所使用的仪器品牌分组数从无增加至8个,每批次实验室合格率从最低26.32%增加至最高89.77%,但仍存在各仪器品牌分组靶值差异较大的现象,2023年各批号分组靶值的变异系数为44.72%~105.69%。结论重庆市肌钙蛋白POCT EQA参加率和检测水平尚有待提高,需持续将肌钙蛋白POCT纳入EQA计划,以定期监测全市范围内该项目的检测质量,为临床诊疗提供快速、可靠的保障。 展开更多
关键词 肌钙蛋白 即时检测 质量控制 室间质量评价 急性冠状动脉综合征
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Security Framework for Managing Data Security within Point of Care Tests
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作者 Sivanesan Tulasidas Ruth Mackay +1 位作者 Chris Hudson Wamadeva Balachandran 《Journal of Software Engineering and Applications》 2017年第2期174-193,共20页
Point of Care (PoC) devices and systems can be categorized into three broad classes (CAT 1, CAT 2, and CAT 3) based on the context of operation and usage. In this paper, the categories are defined to address certain u... Point of Care (PoC) devices and systems can be categorized into three broad classes (CAT 1, CAT 2, and CAT 3) based on the context of operation and usage. In this paper, the categories are defined to address certain usage models of the PoC device. PoC devices that are used for PoC testing and diagnostic applications are defined CAT 1 devices;PoC devices that are used for patient monitoring are defined as CAT 2 devices (PoCM);PoC devices that are used for as interfacing with other devices are defined as CAT 3 devices (PoCI). The PoCI devices provide an interface gateway for collecting and aggregating data from other medical devices. In all categories, data security is an important aspect. This paper presents a security framework concept, which is applicable for all of the classes of PoC operation. It outlines the concepts and security framework for preventing security challenges in unauthorized access to data, unintended data flow, and data tampering during communication between system entities, the user, and the PoC system. The security framework includes secure layering of basic PoC system architecture, protection of PoC devices in the context of application and network. Developing the security framework is taken into account of a thread model of the PoC system. A proposal for a low-level protocol is discussed. This protocol is independent of communications technologies, and it is elaborated in relation to providing security. An algorithm that can be used to overcome the threat challenges has been shown using the elements in the protocol. The paper further discusses the vulnerability scanning process for the PoC system interconnected network. The paper also presents a four-step process of authentication and authorization framework for providing the security for the PoC system. Finally, the paper concludes with the machine to machine (M2M) security viewpoint and discusses the key stakeholders within an actual deployment of the PoC system and its security challenges. 展开更多
关键词 point of care testing Data SECURITY SECURITY Framework THREAT Model
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两种分子POCT产品在流感病毒核酸快速诊断中的应用评价
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作者 宋晓冬 曹国君 +4 位作者 朱旻 陈瑜 陈锟 项瑾 陆美娟 《国际检验医学杂志》 CAS 2024年第2期146-149,154,共5页
目的评估两款分子即时检验(POCT)产品在临床甲型流感病毒(Flu A)、乙型流感病毒(Flu B)检测中的应用价值,并初步评估外周血感染相关指标在流感病毒感染中的诊断价值。方法选取2019年11月1日至2023年6月30日于该院就诊的、有流感样症状... 目的评估两款分子即时检验(POCT)产品在临床甲型流感病毒(Flu A)、乙型流感病毒(Flu B)检测中的应用价值,并初步评估外周血感染相关指标在流感病毒感染中的诊断价值。方法选取2019年11月1日至2023年6月30日于该院就诊的、有流感样症状的流感疑似患者491例纳入研究并收集其口咽拭子,分别用逆转录实时荧光定量聚合酶链反应(RT-qPCR)和两种分子POCT产品(Xpert TM Xpress Flu/RSV和EasyNAT Flu Assay)进行检测。以RT-qPCR结果为标准将受试者分为Flu A阳性组、Flu B阳性组和阴性组(Flu A、Flu B检测均为阴性),分析并比较两种分子POCT产品的诊断性能及受试者外周血感染相关指标,评估这些指标对Flu A、Flu B临床诊断的价值。结果491例患者标本中,Xpert TM Xpress Flu/RSV检测Flu A的灵敏度为96.88%,特异度为99.75%,检测Flu B的灵敏度为100.00%,特异度为100.00%,EasyNAT Flu Assay检测Flu A的灵敏度为94.79%,特异度为96.81%,检测Flu B的灵敏度为100.00%,特异度为100.00%,两种分子POCT检测方法的一致性较高(Kappa值为0.974)。阴性组、Flu A阳性组和Flu B阳性组外周血中的C反应蛋白和血清淀粉样蛋白A水平比较差异无统计学意义(P>0.05),但阴性组白细胞计数较Flu A阳性组和Flu B阳性组高(P<0.01)。结论该文研究了两种典型的分子POCT产品,它们的灵敏度、特异度与RT-qPCR结果具有高度一致性。分子POCT产品具有灵活、快速等优势,对于目前临床诊疗水平的提高具有重要价值。分子检测手段同时联合外周血感染相关指标,有助于流感病毒感染性疾病的早期诊断。 展开更多
关键词 流感病毒 分子即时检验 血清淀粉样蛋白A C反应蛋白 白细胞计数
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A Point-of-Care Test System for Biochemical Blood Analysis Based on ADUC824
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作者 Hui Wang Qing Tian +3 位作者 Liying Jiang Chunxiu Liu Zonghui Guo Xinxia Cai 《稀有金属材料与工程》 SCIE EI CAS CSCD 北大核心 2006年第A03期75-79,共5页
A point-of-care test system has been studied in this paper.It was used to determine substances in blood such as Hemoglobin (HB),Aspartate Aminotransferase (AST),Creatine Kinase (CK) and so on.Based on the principle ... A point-of-care test system has been studied in this paper.It was used to determine substances in blood such as Hemoglobin (HB),Aspartate Aminotransferase (AST),Creatine Kinase (CK) and so on.Based on the principle of amperometric determination,the research on detecting weak current signals was carried on.At the same time as to the weak signals (nA level),magnifying,sampling and processing the signals were also studied.Controlled by ADUC824 and assisted by other units, every substance could be determined automatically and rapidly integrated with the corresponding biosensor.In the experiment, the minimum detectable current of the instrument (YT2005-1) is 0.2 nA.With regard to the 1 nA which the experiment demanded,it could be up to the mustard.And the system can provide results in 180 s with a long term stability. 展开更多
关键词 point-of-care test ADUC824 weak signals HB AST and CK
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基于核酸适配体传感器的即时检测(POCT)技术 被引量:1
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作者 方依 朱春燕 +4 位作者 何平 朱春楠 刘晓军 郑冬云 刘超 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2023年第9期2117-2130,共14页
即时检测(point-of-care testing,POCT)是一种检测成本低、检测速度快、准确度高、能自我采样获得临床诊断结果的新型诊断技术。该技术在临床诊断、病情监控与疫情防控等领域发挥了重要作用。核酸适配体是一种能够特异性识别多种靶标的... 即时检测(point-of-care testing,POCT)是一种检测成本低、检测速度快、准确度高、能自我采样获得临床诊断结果的新型诊断技术。该技术在临床诊断、病情监控与疫情防控等领域发挥了重要作用。核酸适配体是一种能够特异性识别多种靶标的分子探针,具有易合成、批间差异小、易实现信号放大等突出优势,是生物医学传感器中重要的分子识别元件。本文概述了核酸适配体探针的现有筛选方法和进展,总结了核酸适配体POCT传感器信号放大策略,着重介绍了各类核酸适配体传感器在POCT领域的应用现状,并对核酸适配体POCT传感器的发展前景进行了展望。 展开更多
关键词 即时检测 适配体 信号放大 生物传感
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小麦中玉米赤霉烯酮高灵敏智能POCT技术研究 被引量:1
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作者 王丹 胡小风 +4 位作者 王督 唐晓倩 姜俊 李培武 张兆威 《河南工业大学学报(自然科学版)》 CAS 北大核心 2023年第3期34-41,共8页
玉米赤霉烯酮(zearalenone,ZEN)是谷物中危害大、污染重的一种真菌毒素,造成粮食大量损失。现有的检测技术存在局限性,如检测灵敏度低、智能化程度低等,难以实现对ZEN的早检测和早发现,而高灵敏智能快速检测技术是防止ZEN进入食物链的... 玉米赤霉烯酮(zearalenone,ZEN)是谷物中危害大、污染重的一种真菌毒素,造成粮食大量损失。现有的检测技术存在局限性,如检测灵敏度低、智能化程度低等,难以实现对ZEN的早检测和早发现,而高灵敏智能快速检测技术是防止ZEN进入食物链的重要技术方法。针对以上难题,在前期自主研发ZEN高亲和力抗体的基础上,制备了氧化铕乳胶微球抗体探针,研发出荧光定量高灵敏智能即时检测(Point-of-care testing,POCT)技术,实现了小麦中ZEN高灵敏快速智能检测。在优化条件下,POCT技术线性范围为0.2~2.4 ng/mL,最低检测限为0.02 ng/mL,加标回收率为104.9%~110.3%,重复性(批内)和再现性(批间)试验的回收率为95.2%~104.2%(变异系数5.5%)和92.3%~107.5%(变异系数3.4%)。本研究为真菌毒素智能POCT提供了通用型技术平台和粮食减损智慧监管技术方法。 展开更多
关键词 玉米赤霉烯酮 小麦 即时检测 智能检测
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POCT技术在军事和突发事件医学救援中的应用现状与思考
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作者 张淑艳 柯可 +2 位作者 李宁一 高蕾 刘杰 《中国急救复苏与灾害医学杂志》 2023年第3期407-410,共4页
现场快速检验技术(point of care testing,POCT)因具有快(报告结果快)、边(患者身边)、便(操作简便)和易(读取结果容易)等优势,广泛应用于军事行动及战备、事故灾难、反恐等突发事件的救援现场。主要对POCT技术在军事和突发事件医学救... 现场快速检验技术(point of care testing,POCT)因具有快(报告结果快)、边(患者身边)、便(操作简便)和易(读取结果容易)等优势,广泛应用于军事行动及战备、事故灾难、反恐等突发事件的救援现场。主要对POCT技术在军事和突发事件医学救援检验方法学、检验项目和检验模块装备等方面的应用进行阐述,并对POCT技术在应用中需改进的问题以及该技术在未来发展方向上应该侧重提高的方面进行了讨论和分析。 展开更多
关键词 现场快速检验(poct) 现场救治 检验模块 突发事件
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Assessment of platelet function: Laboratory and point-of-care methods
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作者 Rita Paniccia Raffaella Priora +2 位作者 Agatina Alessandrello Liotta Niccolò Maggini Rosanna Abbate 《World Journal of Translational Medicine》 2014年第2期69-83,共15页
In the event of blood vessel damage, human platelets are promptly recruited on the site of injury and, after their adhesion, activation and aggregation, prevent blood loss with the formation of a clot. The consequence... In the event of blood vessel damage, human platelets are promptly recruited on the site of injury and, after their adhesion, activation and aggregation, prevent blood loss with the formation of a clot. The consequence of abnormal regulation can be either hemorrhage or the development of thrombosis. Qualitative and/or quantitative defects in platelets promote bleeding, whereas the residual reactivity of platelets, despite antiplatelet therapies, play an important role in promoting arterial thrombotic complications. Platelet function is traditionally assessed to investigate the origin of a bleeding syndrome, to predict the risk of bleeding prior surgery or during pregnancy or to monitor the efficacy of antiplatelet therapy in thrombotic syndromes that, now, can be considered a new discipline. "Old" platelet function laboratory tests such as the evaluation of bleeding time and the platelet aggregation analysis inplatelet-rich plasma are traditionally utilized to aid in the diagnosis and management of patients with platelet and hemostatic disorders and used as diagnostic tools both in bleeding and thrombotic diathesis in specialized laboratories. Now, new and renewed automated systems have been introduced to provide a simple, rapid assessment of platelet function including point of care methods. These new methodologies are also suitable for being used in non-specialized laboratories and in critical area for assessing platelet function in whole blood without the requirement of sample processing. Some of these methods are also beginning to be incorporated into routine clinical use and can be utilized as not only as first panel for the diagnosis of platelet dysfunction, but also for monitoring anti-platelet therapy and to potentially assess risk of both bleeding and/or thrombosis. 展开更多
关键词 PLATELETS Method test point of care testing LABORATORY ASSESSMENT Bleeding THROMBOSIS PLATELET function
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POCT在急诊科对于高钾血症患者抢救效果的影响
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作者 耿甲芹 戴李华 +2 位作者 尹莉莉 刘芙蓉 梁立维 《外科研究与新技术》 2023年第1期74-76,共3页
目的 探析快速床旁检验(poct)在急诊科对于高钾血症患者抢救效果的影响。方法 选取2020年1月—2021年11月进行动脉血气分析检查结果为高钾血症的86例患者作为研究对象,分析这些研究对象的现场诊断与治疗效果,总结快速床旁检验(POCT),在... 目的 探析快速床旁检验(poct)在急诊科对于高钾血症患者抢救效果的影响。方法 选取2020年1月—2021年11月进行动脉血气分析检查结果为高钾血症的86例患者作为研究对象,分析这些研究对象的现场诊断与治疗效果,总结快速床旁检验(POCT),在高钾血症患者在诊断与治疗中的优势。结果 86例急诊高钾血症患者中43例进行常规血气分析送检检验科分析,43例进行床旁检验(poct)进行动脉血气分析。应用床旁检验(poct)有效的缩短了检验报告等待的时间,对于患者病情的快速诊断与治疗提供依据,提高了患者早期的确诊率,开通绿色通道,防止高钾血症并发症的发生,减少病死率,提高了患者的生存率和生活质量(P<0.05)。结论 快速床旁检验缩短了获取报告的时间,为患者诊断与治疗提供依据,及时给予治疗干预措施,使患者得到及时治疗,提高早期诊断率,提高患者满意度。 展开更多
关键词 快速床旁检验 高钾血症 抢救
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基于POCT的医院血糖信息化管理实践与效果分析
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作者 陈艳 涂文婷 +3 位作者 王红霞 魏怜恤 钱素静 吴婷婷 《医院管理论坛》 2023年第5期91-93,共3页
目的 探索基于即时检验技术的全院联动血糖信息化系统对患者血糖进行管理。方法 应用即时检验技术,实现患者床旁血糖即时检测,构建患者异常血糖管理体系,实现血糖危急值闭环管理。结果 2022年1月至10月期间测量血糖57497人,其中达标人数... 目的 探索基于即时检验技术的全院联动血糖信息化系统对患者血糖进行管理。方法 应用即时检验技术,实现患者床旁血糖即时检测,构建患者异常血糖管理体系,实现血糖危急值闭环管理。结果 2022年1月至10月期间测量血糖57497人,其中达标人数48528人,达标率84.80%。共测量1236398次,其中达标次数407517次,达标率32.96%。2022年1月至10月期间,低血糖共出现24237次,占比1.96%;异常低值共出现13333次,占比1.08%;危急低值共出现2536次,占比0.21%;异常高值共出现804644次,占比65.08%;危急高值共出现87166次,共占比7.05%。结论 基于即时检验技术的院内血糖信息化管理可简化医护人员劳动,提高工作效率,减少医疗差错,同时可对患者血糖进行全面专业管理,提高血糖危急值管理水平。 展开更多
关键词 即时检验 血糖 信息化管理
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新型检测技术在即时检测(POCT)中的应用
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作者 陈剑 《现代科学仪器》 2023年第4期5-10,共6页
即时检验(point-of-care testing,POCT),又称现场快检或床旁快检,是一种可以在现场及时完成检测并报告结果的检测方式。然而,传统POCT难以充分满足精准定量与自动化检测等需求,精准诊疗时代急切需要更准、更快、更便利、更普惠的新型POC... 即时检验(point-of-care testing,POCT),又称现场快检或床旁快检,是一种可以在现场及时完成检测并报告结果的检测方式。然而,传统POCT难以充分满足精准定量与自动化检测等需求,精准诊疗时代急切需要更准、更快、更便利、更普惠的新型POCT产品。随着生物学、化学、电子信息学、工业加工等学科的技术革新和进步,层出不穷的创新型POCT诊断技术在临床诊疗、公共卫生防控及大健康管理中展现出了极具优势的应用价值和广阔的应用前景。本综述旨在对POCT发展、新技术进行系统性概述,对传统检测技术与新型检测技术在POCT中应用进行讨论和前景展望。 展开更多
关键词 即时检验(poct) 传统检测技术 新型检测技术
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现场督查在POCT质量管理中的作用探讨
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作者 蒋玲丽 周靖 +3 位作者 杨雪 娄娇 朱俊 王青 《国际检验医学杂志》 CAS 2023年第S01期74-78,共5页
目的探讨现场督查在医疗机构即时检测(POCT)质量管理中的作用。方法对全市84家二级甲等综合及以上医院申报开展POCT项目检测的临床科室进行抽查,比较分析2019-2021年的督查结果。结果2019-2021年督查科室数分别为183、251和269个,平均... 目的探讨现场督查在医疗机构即时检测(POCT)质量管理中的作用。方法对全市84家二级甲等综合及以上医院申报开展POCT项目检测的临床科室进行抽查,比较分析2019-2021年的督查结果。结果2019-2021年督查科室数分别为183、251和269个,平均得分分别为82.66、92.64和95.81分,优秀率分别为13.11%(24/183)、54.98%(138/251)和68.03%(183/269),不合格率分别为27.32%(50/183)、3.19%(8/251)和0.00%(0/269);督查不符合分别有440、466和492项,占比前五的分别是“未参加(eEQA)”、“未开展(IQC)/开展不规范”、“无标准操作规程(SOP)/编写不规范”、“仪器未校准/校准不规范”、“POCT仪器未与常规分析仪比对/比对不规范”,合计占比79.26%(1108/1398)。结论现场督查可有效推动临床科室POCT项目检测质量的持续提高,对POCT质量管理具有很大的推动作用,值得借鉴与推广。 展开更多
关键词 即时检测 现场督查 全面质量管理 质量控制
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应用于食品检测领域的分子即时检测技术研究进展 被引量:3
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作者 王薇 付群 +4 位作者 郑艳敏 王波 刘岩 刘佳 孙万平 《食品安全质量检测学报》 CAS 2024年第1期48-56,共9页
食品安全问题关系人类民生。为有效预防和控制食品安全风险,减少食品安全经济损失,迫切需要开发出针对食源性病原体、食物掺假、转基因作物的高特异性、高敏感性、快速的核酸检测技术。即时检测(point-of-care testing,POCT)作为一种新... 食品安全问题关系人类民生。为有效预防和控制食品安全风险,减少食品安全经济损失,迫切需要开发出针对食源性病原体、食物掺假、转基因作物的高特异性、高敏感性、快速的核酸检测技术。即时检测(point-of-care testing,POCT)作为一种新兴的快速检测手段,由于其检测速度快、操作简单、现场检查等特点,在食品检测领域应用广泛。本文首先介绍了POCT技术的发展历史,而后根据食品安全事件的特点,从食源性致病菌、食物掺假、转基因作物3个方向分析了食品检测的主要对象,阐述了分子POCT技术在食品检测领域的应用现状,最后对应用于食品检测领域的分子POCT技术存在的问题和解决办法进行了分析总结,对食品检测分子POCT技术的发展方向进行了展望。本文有助于进一步了解分子POCT技术在食品检测中的应用,并为分子POCT技术在食品快速检测中的研究和应用提供参考。 展开更多
关键词 食品检测 分子即时检测 食品安全 等温扩增技术 成簇规律间隔短回文重复序列及其相关系统检测技术
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即时检测仪器与电化学发光仪检测心脏标志物的对比研究
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作者 刘文娟 郭盼 +5 位作者 杜娟 张何锐 王雅平 王海龙 徐佳 李琦 《中国医学装备》 2024年第5期16-19,25,共5页
目的:对比分析两种即时检测(POCT)仪器与Roche电化学发光仪检测心脏标志物的相关关系,为临床检验选择POCT仪器提供参考。方法:选取2020年11月在中国中医科学院西苑医院就诊的20例患者血液样本,其浓度范围覆盖检测结果可报告范围,使用两... 目的:对比分析两种即时检测(POCT)仪器与Roche电化学发光仪检测心脏标志物的相关关系,为临床检验选择POCT仪器提供参考。方法:选取2020年11月在中国中医科学院西苑医院就诊的20例患者血液样本,其浓度范围覆盖检测结果可报告范围,使用两种POCT仪器(分别命名为仪器A和仪器B)检测血浆肌红蛋白(Myo)、肌酸激酶同工酶质量(CKMB mass)、心肌钙蛋白I(cTnI)、氨基末端脑钠肽前体(NT-proBNP)/B型钠尿肽(BNP)的浓度水平,以电化学分析仪检测结果为参考,分别采用pearson相关分析和Kappa检验评价两种POCT仪器与Roche电化学发光仪检测结果的相关性和一致性。结果:仪器A和仪器B检测结果与Roche电化学发光仪检测Myo、CK-MB mass、cTnI、NT-proBNP/BNP结果均有较好的相关性(r_(仪器A)=O.994、0.989、0.917、0.996,r_(仪器B)=0.928、0.934、0.883、0.977,P<0.05)。在一致性比较中,仪器A检测Myo、CK-MB mass、cTnI、NT-proBNP与电化学分析仪的符合率分别为90%、100%、70%和100%;仪器B检测结果的符合率分别为90%、95%、70%和100%,两种POCT仪器与Roche电化学发光仪均具有较好的一致性(Kappa_(仪器A)=0.798、1.00、0.429、1.00,Kappa_(仪器B)=0.794、0.886、0.429、1.00)。两种仪器的精密度均<10%。结论:两种POCT仪器均能满足临床检测要求,在检测心脏标志物时与电化学发光仪有较好的相关性。 展开更多
关键词 即时检测(poct)仪器 心脏标志物 电化学发光 分析性能
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