丙泊酚调节MPP+诱导的SH-SY5Y细胞线粒体氧化应激和凋亡

目的探讨不同浓度的丙泊酚(propofol,PPF)对1-甲基-4-苯基吡啶离子(1-Methyl-4-phenylpyridinium,MPP+)诱导的帕金森(Parkinson’s disease,PD)模型细胞氧化应激和凋亡的作用。方法利用1 mM MPP+诱导人神经母细胞瘤细胞SH-SY5Y构建PD细胞模型。PPF处理组分别用10、20、40、80μM PPF在MPP+诱导前刺激SH-SY5Y细胞4 h。细胞计数法(cell counting kit-8,CCK-8)评估细胞增殖活力。2′,7′-二氯二氢荧光素二乙酸酯(H2DCF-DA)荧光探针用于检测细胞中活性氧(reactive oxygen species,ROS)。试剂盒分别检测丙二醛(malondialdehyde,MDA)和还原型烟酰胺腺嘌呤二核苷酸磷酸(reduced nicotinamide adenine dinucleotide phosphate oxidase,NADPH)氧化酶的水平。Western blot用于检测线粒体和细胞质中细胞色素c的蛋白表达以及细胞中Bcl-2、Bax和Cleaved caspase-3蛋白表达。流式细胞术分析细胞凋亡率。结果MPP+诱导明显抑制SH-SY5Y细胞的增殖(P<0.001),促进细胞中ROS(P<0.001)、MDA(P<0.001)、NADPH氧化酶(P<0.01)、细胞质中细胞色素c的表达(P<0.01)并诱导细胞凋亡(P<0.001)以及促凋亡蛋白Bax和Cleaved caspase-3的表达(P<0.01),减少线粒体中细胞色素c的蛋白表达(P<0.01)和抗凋亡蛋白Bcl-2的表达(P<0.01)。PPF预处理可缓解MPP+诱导引起的SH-SY5Y细胞增殖抑制以及氧化应激和凋亡的促进作用(P<0.001),且40μM和80μM对细胞的作用更为显著。结论PPF预处理可缓解MMP+诱导的SH-SY5Y细胞氧化应激,减少细胞凋亡。

基于MPP数据库的多源异构数据分布式集成平台构建

对多源异构数据进行集成,是实现数据共享、打破“信息孤岛”的关键。运用分布式并行计算技术,对基于 MPP 数据库的多源异构数据分布式集成平台的构建进行分析研究,文章分析了多源异构数据集成的发展动态,阐述了 MPP 数据库基本架构及运行机制,分四个层次设计了基于 MPP 数据库的多源异构数据分布式集成平台的框架结构,并对数据规划进行了分析。为多源异构数据分布式集成的实践应用提供了方法和思路上的借鉴。

基于轻量化PointNet网络的林果园喷雾作业靶标实时识别方法

为了进一步提高喷雾机器人靶标检测的精准性、实时性和应用部署的实用性,该研究提出一种基于轻量化PointNet网络的林果园喷雾作业靶标实时识别方法。首先通过区域提取降采样、地面分割和改进DBSCAN聚类等点云预处理方法提取原始点云中的靶标;然后通过移动最小二乘上采样将靶标点云转化为满足点云识别网络输入要求的点云数据;最终通过在PointNet网络中引入残差模块和改进循环剪枝算法轻量化PointNet网络,完成林果树靶标的实时识别。试验结果表明,在ModelNet40数据集上,轻量化PointNet网络可达89.7%的准确率;在实际苗圃环境的试验中,该研究方法对靶标的识别准确率可达92.49%,同时误识率与拒识率分别为13.4%和6.47%,相较PointNet网络识别准确率提升了4.38个百分点,误识率和拒识率分别降低了7.2和4.07个百分点;轻量化PointNet网络识别准确率仅比PointNet++网络低1.14个百分点,误识率和拒识率分别高了0.9和1.12个百分点。但是轻量化PointNet网络的模型参数量较PointNet网络和PointNet++网络的模型参数量显著减少,仅为PointNet网络的11.5%,PointNet++网络的27.02%;运算量相较PointNet网络、PointNet++网络分别减少13.3和76.79个百分点。该研究提出的轻量化PointNet网络具有较高的实时性、精确性和鲁棒性,能够满足林果园喷雾作业的靶标识别需求,可为林果园喷雾作业靶标实时识别提供参考。

基于MPPT控制的两级式直流孤岛检测方法研究

针对主动式孤岛检测方法存在扰动同步注入、影响电网供电质量等问题,提出了一种基于最大功率点跟踪(MPPT)控制的两级式直流孤岛检测方法。该方法通过检测并网变换器直流侧电流来判断疑似孤岛,然后利用疑似孤岛信号触发电压扰动的注入使得孤岛后的公共耦合点(PCC)电压出现特定频率的波动。由于扰动信号的注入受疑似孤岛信号控制,减少了正常状态下扰动的注入时长,有效降低对系统电能质量的影响。此外建立小信号模型分析了耦合点电压对扰动分量的频域特性,选取扰动信号的最优频率。最后通过仿真与实验验证了所提方法在单机与多机工况下的有效性。

基于PointNet++的邻域特征增强点云语义分割方法

随着智能驾驶、机器人导航等以点云为基础的应用蓬勃发展,点云语义分割逐渐成为研究热点。然而,现有的点云语义分割方法存在局部特征提取不充分、特征融合不完整的缺陷。针对这些不足,提出了对应的解决方案。对于局部特征提取不充分的现象,通过嵌入邻域点的坐标、方向、距离等相关信息去关联邻域点的显式特征。对于特征融合不完整的现象,提出了一种最大池化与自注意力池化相结合的混合池化方法。网络架构基于PointNet++,并结合提出的局部特征提取和融合方法,在S3DIS数据集上的实验结果表明,与基线方法PointNet++相比,各评价指标都有不同程度的提高,证实了新方法的有效性和优越性。

基于Point Transformer v2的点云枝叶分离方法研究

准确高效的点云枝叶分离对精确计算森林树木的垂直参数至关重要。然而,当前的研究方法计算成本高,且依赖先验知识导致泛化能力不足。针对以上问题,文章提出利用基于点特征的Transformer网络进行自动化的森林场景三维点云的枝叶分离研究。该方法使用Point Transformer v2网络,首先利用网格编码模块提取可学习的局部结构关系,保留点云的几何拓扑结构;其次使用分组注意力实现多通道联合学习,降低特征的冗余度,提高计算的效率;最后构建了基于点的Transformer网络实现高精度森林树木三维点云语义分割,降低了对于先验知识的需求。使用地基激光扫描仪获取的加拿大和芬兰7个不同树种样地的三维点云数据,进行枝叶分离实验和精度评价。实验结果表明,网络整体精度(OA)为94.42%,mIoU为78.89%,能够适应不同树种、不同点云密度的森林场景的枝叶分离。

基于SSA-ELM神经网络控制器的光伏MPPT方法

光伏电池板所处环境的非线性变化使得光伏电池的功率保持在最大功率点(maximum power point,MPP)非常困难。传统的最大功率点跟踪(maximum power point tracking,MPPT)方法普遍存在技术缺陷,无法满足当前需求。针对光伏发电MPPT问题,该文提出了一种基于麻雀搜索算法优化的极限学习机(sparrow search algorithm-extreme learning machine,SSA-ELM)神经网络控制器的MPPT方法。与传统技术相比,该MPPT方法在稳定性、速度、超调和MPP的振荡等方面的效果均较好。使用MATLAB/Simulink平台进行仿真实验,验证了所提控制策略及理论分析的正确性。

基于改进布谷鸟搜索算法的光伏MPPT控制

复杂阴影情况下,光伏阵列的P-V特性曲线会出现多个峰值,传统的MPPT算法因不能准确识别局部峰值和全局峰值,而无法进行复杂阴影情况下的最大功率点跟踪。针对传统布谷鸟搜索(Cuckoo Search,CS)算法因鸟窝之间缺乏交流能力导致可能陷入局部最优的问题,提出了一种多策略改进布谷鸟搜索(EGICS)算法。将传统CS算法中发现概率值的选择自适应变化,提高算法的搜索能力;将步长因子自适应化,提高算法的收敛速度;引入高斯扰动和精英反向学习策略,增加种群多样性,避免算法陷入局部最优。对EGICS算法在单峰和多峰函数中进行性能测试,并将其应用于光伏系统MPPT控制中进行仿真验证。仿真结果表明,EGICS算法在收敛速度、跟踪精度以及动态稳定三个方面有更好的效果。

基于混合算法的多峰值MPPT控制

针对光照不均匀时光伏阵列输出呈现非线性、多峰值的问题,提出一种基于自然选择粒子群(SelPSO)算法结合电导增量法(INC)的多峰值最大功率点追踪(MPPT)算法。SelPSO算法通过淘汰和替换迭代过程中适应度低的粒子,更快、更准确地完成对全局最大值点的搜索;使用INC进行局部跟踪,有效减少寻优过程中的功率振荡,达到最大功率点跟踪的目的。利用MATLAB/Simulink进行仿真试验。结果表明:与INC相比,SelPSO算法的功率振荡由12 W降至0.05 W;与PSO算法相比,跟踪时间由0.15 s缩短至0.07 s。该混合算法在复杂环境下具有较优的跟踪速度、收敛精度以及较低的功率波动。

基于改进黏菌算法的光伏多峰值MPPT控制

针对传统最大功率点跟踪技术在局部遮阴等天气条件下存在无法追踪到全局最大功率点的问题,提出一种基于改进黏菌算法的MPPT控制。首先,对太阳电池模型及多峰值特性进行分析;其次,在黏菌算法中引入领导者策略和基于最优个体的凸透镜反向学习策略,在提高算法计算精度、收敛速度的同时克服了算法易“早熟”现象;最后,根据光伏阵列最大功率输出特性分别确定算法优化模型、初始化位置及重启机制。仿真与实验结果表明:基于改进黏菌算法的MPPT控制能快速、准确地跟踪到全局最大功率点,有效规避陷入局部最优问题,提高了光伏系统的转换效率。

Two-Staged Method for Ice Channel Identification Based on Image Segmentation and Corner Point Regression

Identification of the ice channel is the basic technology for developing intelligent ships in ice-covered waters,which is important to ensure the safety and economy of navigation.In the Arctic,merchant ships with low ice class often navigate in channels opened up by icebreakers.Navigation in the ice channel often depends on good maneuverability skills and abundant experience from the captain to a large extent.The ship may get stuck if steered into ice fields off the channel.Under this circumstance,it is very important to study how to identify the boundary lines of ice channels with a reliable method.In this paper,a two-staged ice channel identification method is developed based on image segmentation and corner point regression.The first stage employs the image segmentation method to extract channel regions.In the second stage,an intelligent corner regression network is proposed to extract the channel boundary lines from the channel region.A non-intelligent angle-based filtering and clustering method is proposed and compared with corner point regression network.The training and evaluation of the segmentation method and corner regression network are carried out on the synthetic and real ice channel dataset.The evaluation results show that the accuracy of the method using the corner point regression network in the second stage is achieved as high as 73.33%on the synthetic ice channel dataset and 70.66%on the real ice channel dataset,and the processing speed can reach up to 14.58frames per second.

Material point method simulation of hydro-mechanical behaviour in twophase porous geomaterials: A state-of-the-art review

The material point method(MPM)has been gaining increasing popularity as an appropriate approach to the solution of coupled hydro-mechanical problems involving large deformation.In this paper,we survey the current state-of-the-art in the MPM simulation of hydro-mechanical behaviour in two-phase porous geomaterials.The review covers the recent advances and developments in the MPM and their extensions to capture the coupled hydro-mechanical problems involving large deformations.The focus of this review is aiming at providing a clear picture of what has or has not been developed or implemented for simulating two-phase coupled large deformation problems,which will provide some direct reference for both practitioners and researchers.

Automatic Extraction Method of 3D Feature Guidelines for Complex Cultural Relic Surfaces Based on Point Cloud

Cultural relics line graphic serves as a crucial form of traditional artifact information documentation,which is a simple and intuitive product with low cost of displaying compared with 3D models.Dimensionality reduction is undoubtedly necessary for line drawings.However,most existing methods for artifact drawing rely on the principles of orthographic projection that always cannot avoid angle occlusion and data overlapping while the surface of cultural relics is complex.Therefore,conformal mapping was introduced as a dimensionality reduction way to compensate for the limitation of orthographic projection.Based on the given criteria for assessing surface complexity,this paper proposed a three-dimensional feature guideline extraction method for complex cultural relic surfaces.A 2D and 3D combined factor that measured the importance of points on describing surface features,vertex weight,was designed.Then the selection threshold for feature guideline extraction was determined based on the differences between vertex weight and shape index distributions.The feasibility and stability were verified through experiments conducted on real cultural relic surface data.Results demonstrated the ability of the method to address the challenges associated with the automatic generation of line drawings for complex surfaces.The extraction method and the obtained results will be useful for line graphic drawing,displaying and propaganda of cultural relics.

基于改进SCSO算法的光伏MPPT研究

在解决光伏阵列在局部遮挡时发电效率降低的问题时,传统最大功率点追踪(MPPT)方法容易追踪失败。为此,提出一种改进沙猫群优化算法的最大功率点追踪方法。该算法在标准沙猫群算法的基础上,引入了精英反向学习和自适应t分布,同时优化沙猫群算法(SCSO)的局部搜索并融合Jaya算法。通过对4种典型单峰、多峰函数的测试,证明该算法具有极高的收敛速度,容易跳出局部最优值。将算法应用于MPPT控制中,仿真结果表明:在静态遮荫情况下,所提方法的搜索最大功率点的时间更少;在动态遮荫条件下,重新搜寻到最大功率点的响应时间平均为0.2 s。实验表明所提算法可以适应动态变化的天气,解决了传统算法收敛速度和防止陷入局部最优等问题。

基于改进PointNet++的输电线路关键部位点云语义分割研究

输电线路的关键部位包括塔身、导线、绝缘子、避雷线以及引流线,无人机精细化导航的首要任务是构造输电线路的点云地图并从中分割出上述部位。为解决现有算法在输电线路的绝缘子、引流线等精细结构分割时精度低的问题,通过改进PointNet++算法,提出了一种面向输电线路精细结构的点云分割方法。首先,基于无人机机载激光雷达在现场采集的点云数据,构造了输电线路点云分割数据集;其次,通过对比实验,筛选出在本输电线路场景下合理的数据增强方法,并对数据集进行了数据增强;最后,将自注意力机制以及倒置残差结构和PointNet++相结合,设计了输电线路关键部位点云语义分割算法。实验结果表明:该改进PointNet++算法在全场景输电线路现场点云数据作为输入的前提下,首次实现了对引流线、绝缘子等输电线路中精细结构和导线、杆塔塔身以及输电线路无关背景点的同时分割,平均交并比(mean intersection over union,mIoU)达80.79%,所有类别分割的平均F_(1)值(F1 score)达88.99%。

Coexistence of Dirac and Weyl points in non-centrosymmetric semimetal NbIrTe_(4)

Using angle-resolved photoemission spectroscopy and density functional theory calculations methods,we investigate the electronic structures and topological properties of ternary tellurides NbIrTe_(4),a candidate for type-II Weyl semimetal.We demonstrate the presence of several Fermi arcs connecting their corresponding Weyl points on both termination surfaces of the topological material.Our analysis reveals the existence of Dirac points,in addition to Weyl points,giving both theoretical and experimental evidences of the coexistence of Dirac and Weyl points in a single material.These findings not only confirm NbIrTe_(4) as a unique topological semimetal but also open avenues for exploring novel electronic devices based on its coexisting Dirac and Weyl fermions.

Diagnosis of indirectly driven double shell targets with point-projection hard x-ray radiography

We present an application of short-pulse laser-generated hard x rays for the diagnosis of indirectly driven double shell targets. Coneinserted double shell targets were imploded through an indirect drive approach on the upgraded SG-II laser facility. Then, based on thepoint-projection hard x-ray radiography technique, time-resolved radiography of the double shell targets, including that of their near-peakcompression, were obtained. The backlighter source was created by the interactions of a high-intensity short pulsed laser with a metalmicrowire target. Images of the target near peak compression were obtained with an Au microwire. In addition, radiation hydrodynamicsimulations were performed, and the target evolution obtained agrees well with the experimental results. Using the radiographic images, arealdensities of the targets were evaluated.

基于多策略混合改进MVO算法的光伏多峰MPPT研究

光伏阵列的电功率输出在局部遮荫工况下具有多峰特性,且随外界环境的变化而变化.为实现高效电能输出,利用多元宇宙优化(MVO)算法在解决低维度、小规模优化问题中的突出优势进行最大功率点跟踪(MPPT),并融合多种策略对其存在的缺陷进行改进.采用拉丁超立方抽样策略初始化宇宙种群,并对按照轮盘赌策略随机交换的宇宙实施柯西变异,提高宇宙种群的多样性.同时引入莱维飞行式量子粒子群优化(QPSO)算法,且对虫洞存在概率及旅行距离率进行自适应调整,以增强算法的全局勘探及局部开发能力.Matlab仿真结果表明,相比其他算法,采用该算法的MPPT时间减少了45%以上,精度亦有所提高,从而具有更优的MPPT性能,可有效提高光伏发电效率.

Exceptional points and quantum dynamics in a non-Hermitian two-qubit system

We study the exceptional-point(EP) structure and the associated quantum dynamics in a system consisting of a non-Hermitian qubit and a Hermitian qubit. We find that the system possesses two sets of EPs, which divide the systemparameter space into PT-symmetry unbroken, partially broken and fully broken regimes, each with distinct quantumdynamics characteristics. Particularly, in the partially broken regime, while the PT-symmetry is generally broken in the whole four-dimensional Hilbert space, it is preserved in a two-dimensional subspace such that the quantum dynamics in the subspace are similar to those in the PT-symmetry unbroken regime. In addition, we reveal that the competition between the inter-qubit coupling and the intra-qubit driving gives rise to a complex pattern in the EP variation with system parameters.

Prediction of collapse process and tipping points for mutualistic and competitive networks with k-core method

Ecosystems generally have the self-adapting ability to resist various external pressures or disturbances,which is always called resilience.However,once the external disturbances exceed the tipping points of the system resilience,the consequences would be catastrophic,and eventually lead the ecosystem to complete collapse.We capture the collapse process of ecosystems represented by plant-pollinator networks with the k-core nested structural method,and find that a sufficiently weak interaction strength or a sufficiently large competition weight can cause the structure of the ecosystem to collapse from its smallest k-core towards its largest k-core.Then we give the tipping points of structure and dynamic collapse of the entire system from the one-dimensional dynamic function of the ecosystem.Our work provides an intuitive and precise description of the dynamic process of ecosystem collapse under multiple interactions,and provides theoretical insights into further avoiding the occurrence of ecosystem collapse.