In the past two decades, extensive studies have focused on a group of so-called polarity proteins that play conserved and essential functions in establishing and maintaining cell polarity in epithelial cells. Among th...In the past two decades, extensive studies have focused on a group of so-called polarity proteins that play conserved and essential functions in establishing and maintaining cell polarity in epithelial cells. Among them, Crumbs （Crb） is the only trans- membrane polarity protein characterized to date （Tepass et al.,展开更多
Protein arginine methyltransferase 7(PRMT7)is closely related to the formation of lung cancer,breast cancer and other malignant tumors,and it may be a potential target gene for malignant tumor therapy.Dishevelleds(DVL...Protein arginine methyltransferase 7(PRMT7)is closely related to the formation of lung cancer,breast cancer and other malignant tumors,and it may be a potential target gene for malignant tumor therapy.Dishevelleds(DVLs)are key factors involved in cell proliferation,invasion and metastasis.Among the dishevelleds,the dishevelled segment polarity protein 3(DVL3)is a key protein in the Wnt signaling pathway,and its abnormal expression plays an important role in the occurrence and development of malignant tumors.This paper reviewed the advances in research of PRMT7 and DVL3 in gastric cancer.展开更多
Asymmetric cell division(ACD) is a fundamental process that generates new cell types during development in eukaryotic species.In plant development,post-embryonic organogenesis driven by ACD is universal and more impor...Asymmetric cell division(ACD) is a fundamental process that generates new cell types during development in eukaryotic species.In plant development,post-embryonic organogenesis driven by ACD is universal and more important than in animals,in which organ pattern is preset during embryogenesis.Thus,plant development provides a powerful system to study molecular mechanisms underlying ACD.During the past decade,tremendous progress has been made in our understanding of the key components and mechanisms involved in this important process in plants.Here,we present an overview of how ACD is determined and regulated in multiple biological processes in plant development and compare their conservation and specificity among different model cell systems.We also summarize the molecular roles and mechanisms of the phytohormones in the regulation of plant ACD.Finally,we conclude with the overarching paradigms and principles that govern plant ACD and consider how new technologies can be exploited to fill the knowledge gaps and make new advances in the field.展开更多
基金supported by the grants from the National Institutes of Health of USA(NCRR R21RR024869, NIGMS RO1GM086423 and RO1GM121534 to Y.H.)the Start-up Foundation from Nanjing Medical University (2012RC04 to J.H.)University of Pittsburgh Medical School Center for Biologic Imaging was supported by the grant 1S100D019973-01 from NIH, USA
文摘In the past two decades, extensive studies have focused on a group of so-called polarity proteins that play conserved and essential functions in establishing and maintaining cell polarity in epithelial cells. Among them, Crumbs （Crb） is the only trans- membrane polarity protein characterized to date （Tepass et al.,
基金Supported by Chengde Medical University-National Natural Science Foundation of China Project Cultivation Fund (202114)Chengde Medical UniversitySchool-level Key Project Fund (201711)+1 种基金Key Discipline Construction Project of Hebei Province [Ji Jiao Gao (2013) No. 4:Pathology and Pathophysiology]Master Candidate Innovation Ability Training Funding Project of Hebei Province (CXZZSS2022141)
文摘Protein arginine methyltransferase 7(PRMT7)is closely related to the formation of lung cancer,breast cancer and other malignant tumors,and it may be a potential target gene for malignant tumor therapy.Dishevelleds(DVLs)are key factors involved in cell proliferation,invasion and metastasis.Among the dishevelleds,the dishevelled segment polarity protein 3(DVL3)is a key protein in the Wnt signaling pathway,and its abnormal expression plays an important role in the occurrence and development of malignant tumors.This paper reviewed the advances in research of PRMT7 and DVL3 in gastric cancer.
基金supported by grants from the National Natural Science Foundation of China (grant nos.32130010,31422008) to T.X.the National Institute of Health (grant no.GM131827)the National Science Foundation (grant nos.1851907,1952823,and 2049642) to J.D。
文摘Asymmetric cell division(ACD) is a fundamental process that generates new cell types during development in eukaryotic species.In plant development,post-embryonic organogenesis driven by ACD is universal and more important than in animals,in which organ pattern is preset during embryogenesis.Thus,plant development provides a powerful system to study molecular mechanisms underlying ACD.During the past decade,tremendous progress has been made in our understanding of the key components and mechanisms involved in this important process in plants.Here,we present an overview of how ACD is determined and regulated in multiple biological processes in plant development and compare their conservation and specificity among different model cell systems.We also summarize the molecular roles and mechanisms of the phytohormones in the regulation of plant ACD.Finally,we conclude with the overarching paradigms and principles that govern plant ACD and consider how new technologies can be exploited to fill the knowledge gaps and make new advances in the field.
