期刊文献+
共找到700篇文章
< 1 2 35 >
每页显示 20 50 100
Mueller matrix analysis for all optical fiber co-existence of birefringence-polarization dependent gain-mode coupling at a single wavelength
1
作者 尚超 吴重庆 +4 位作者 李政勇 杨双收 高凯强 余贶琭 冯震 《Chinese Physics B》 SCIE EI CAS CSCD 2011年第11期13-18,共6页
Birefringence (polarization-related phase-shift), polarization dependent gain (PDG) and mode coupling are three factors that may synchronously influence the transmission of single-wavelength polarized light in opt... Birefringence (polarization-related phase-shift), polarization dependent gain (PDG) and mode coupling are three factors that may synchronously influence the transmission of single-wavelength polarized light in optical fibers. This paper obtains a new Mueller matrix analysis, which can be used under conditions that all these three factors are existing and changing. According to our transmission model, the state of polarization (SOP) changes along an optical mierostructure fiber with co-existence of birefringence-PDG-mode coupling were simulated. The simulated results, which show the phenomena of SOP constringency, are in good agreement with previous theoretical analyses. 展开更多
关键词 Mueller matrix BIREFRINGENCE polarization dependent gain mode coupling
下载PDF
Polarization-dependent efficient Cherenkov radiation at visible wavelengths in hollow-core photonic crystal fiber cladding
2
作者 申向伟 苑金辉 +8 位作者 桑新柱 余重秀 饶岚 夏民 韩颖 夏长明 侯蓝田 吴中超 何晓亮 《Chinese Physics B》 SCIE EI CAS CSCD 2013年第1期222-225,共4页
Efficient Cherenkov radiation (CR) is experimentally generated by a soliton self-frequency shift (SSFS) in a knot of hollow-core photonic crystal fiber (HC-PCF). When the angle of the half-wave plate is rotated ... Efficient Cherenkov radiation (CR) is experimentally generated by a soliton self-frequency shift (SSFS) in a knot of hollow-core photonic crystal fiber (HC-PCF). When the angle of the half-wave plate is rotated from 0° to 45°, the Raman soliton shifts from 2227 to 2300 nm, the output power of the CR increases 8.15 times, and the maximum output power ratio of the CR at 556 nm to the residual pump is estimated to be 20:1. The width of the output optical spectrum at visible wavelengths broadens from 25 to 45 nm, and the conversion efficiency of the CR can be above 28%. Moreover, the influences of the pump polarization and wavelength on the CR are studied, and the corresponding nonlinear processes are discussed. 展开更多
关键词 polarization-dependent Cherenkov radiation hollow-core photonic crystal fiber (HC-PCF)
下载PDF
Wavelength dependent loss of splice of single-mode fibers 被引量:1
3
作者 YANG Bo DUAN Ji-an +1 位作者 XIE Zheng XIAO Hong-feng 《Journal of Central South University》 SCIE EI CAS 2013年第7期1832-1837,共6页
After reviewing three different definitions of mode field diameter of single-mode fibers, coupled efficiency calculation methods associated with lateral offset, longitude separation and wavelength, the effects produce... After reviewing three different definitions of mode field diameter of single-mode fibers, coupled efficiency calculation methods associated with lateral offset, longitude separation and wavelength, the effects produced by them, and the influences of splicing defects were discussed in detail. The regularities of the effects were studied according to the first order derivation of couple efficiency formula, and a simplified formula for couple efficiency calculation was presented under the circumstance of slight misalignment, with respect to wavelength, 2, and in a good agreement with the theoretical model. The simplified formula provides a new but simple approach to evaluate wavelength dependent couple efficiency of single-mode fibers. Theoretical analyses and numerical calculations show that, when those defects exist, the wavelength produces additional effects on the couple loss that growth of wavelength causes an increase on the couple efficiency for the lateral offset or longitude separation whereas lessens the couple efficiency due to angular misalignment or mode fields mismatching, and that the wavelength degrades the couple efficiency distinctly when λ≥2.5 μm whereas it distorts the couple slightly in range of λ≤2λ≤2 μm. 展开更多
关键词 wavelength dependent loss couple efficiency single-mode fiber cut-offwavelength
下载PDF
Packet-loss-dependent stabilization of NCSs with network-induced delay and packet dropout 被引量:1
4
作者 Yan Song Jingcheng Wang +1 位作者 Yuanhao Shi Chuang Li 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2012年第3期408-413,共6页
This paper is concerned with controller design of net- worked control systems (NCSs) with both network-induced delay and arbitrary packet dropout. By using a packet-loss-dependent Lyapunov function, sufficient condi... This paper is concerned with controller design of net- worked control systems (NCSs) with both network-induced delay and arbitrary packet dropout. By using a packet-loss-dependent Lyapunov function, sufficient conditions for state/output feedback stabilization and corresponding control laws are derived via a switched system approach. Different from the existing results, the proposed stabilizing controllers design is dependent on the packet loss occurring in the last two transmission intervals due to the network-induced delay. The cone complementary lineara- tion (CCL) methodology is used to solve the non-convex feasibility problem by formulating it into an optimization problem subject to linear matrix inequality (LMI) constraints. Numerical examples and simulations are worked out to demonstrate the effectiveness and validity of the proposed techniques. 展开更多
关键词 networked control systems (NCSs) network-induced delay packet dropout packet-loss-dependent cone complemen- tary linearation (CCL).
下载PDF
Polarization-Insensitive Silica on Silicon Arrayed Waveguide Grating Design 被引量:1
5
作者 安俊明 李健 +4 位作者 郜定山 夏君磊 李建光 王红杰 胡雄伟 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2004年第11期1360-1363,共4页
A new technology for fabrication of silica on silicon arrayed waveguide grating (AWG) based on deep etching and thermal oxidation is presented.Using this method,a silicon layer is remained at the side of waveguide.The... A new technology for fabrication of silica on silicon arrayed waveguide grating (AWG) based on deep etching and thermal oxidation is presented.Using this method,a silicon layer is remained at the side of waveguide.The stress distribution and effective refractive index of waveguide fabricated by this approach are calculated using finite element and finite difference beam propagation method,respectively.The results of these studies indicate that the stress of silica on silicon optical waveguide can be matched in parallel and vertical direction and AWG polarization dependent wavelength (PDλ) can be reduced effectively due to side-silicon layer. 展开更多
关键词 silica on silicon arrayed waveguide grating stress BIREFRINGENCE polarization dependent wavelength numerical analysis
下载PDF
Experimental study of polarity dependence in repetitive nanosecond-pulse breakdown 被引量:1
6
作者 邵涛 孙广生 +3 位作者 严萍 王珏 袁伟群 张适昌 《Chinese Physics B》 SCIE EI CAS CSCD 2007年第3期778-783,共6页
Pulsed breakdown of dry air at ambient pressure has been investigated in the point-plane geometry, using repetitive nanosecond pulses with 10 ns risetime, 20-30 ns duration, and up to 100 kV amplitude. A major concern... Pulsed breakdown of dry air at ambient pressure has been investigated in the point-plane geometry, using repetitive nanosecond pulses with 10 ns risetime, 20-30 ns duration, and up to 100 kV amplitude. A major concern in this paper is to study the dependence of breakdown strength on the point-electrode polarity. Applied voltage, breakdown current and repetitive stressing time are measured under the experimental conditions of some variables including pulse voltage peak, gap spacing and repetition rate. The results show that increasing the E-field strength can decrease breakdown time lag, repetitive stressing time and the number of applied pulses as expected. However, compared with the traditional polarity dependence it is weakened and not significant in the repetitive nanosecond-pulse breakdown. The ambiguous polarity dependence in the experimental study is involved with an accumulation effect of residual charges and metastable states. Moreover, it is suggested that the reactions associated with the detachment of negative ions and impact deactivation of metastable species could provide a source of primary initiating electrons for breakdown. 展开更多
关键词 gas breakdown nanosecond-pulse repetition rate point-plane geometry polarity dependence
下载PDF
Noiseless linear amplification for the single-photon entanglement of arbitrary polarization–time-bin qudit 被引量:1
7
作者 Ling-Quan Chen Yu-Bo Sheng Lan Zhou 《Chinese Physics B》 SCIE EI CAS CSCD 2019年第1期210-217,共8页
Single-photon entanglement(SPE) is an important source in quantum communication. In this paper, we put forward a single-photon-assisted noiseless linear amplification protocol to protect the SPE of an arbitrary polari... Single-photon entanglement(SPE) is an important source in quantum communication. In this paper, we put forward a single-photon-assisted noiseless linear amplification protocol to protect the SPE of an arbitrary polarization–time-bin qudit from the photon transmission loss caused by the practical channel noise. After the amplification, the fidelity of the SPE can be effectively increased. Meanwhile, the encoded polarization–time-bin features of the qudit can be well preserved. The protocol can be realized under the current experimental conditions. Moreover, the amplification protocol can be extended to resist complete photon loss and partial photon loss during the photon transmission. After the amplification, we can not only increase the fidelity of the target state, but also solve the decoherence problem simultaneously. Based on the above features, our amplification protocol may be useful in future quantum communication. 展开更多
关键词 SINGLE-PHOTON ENTANGLEMENT noiseless linear AMPLIFICATION polarization–time-bin QUDIT complete and partial photon loss
下载PDF
Ultrafine Vacancy-Rich Nb_(2)O_(5)Semiconductors Confined in Carbon Nanosheets Boost Dielectric Polarization for High-Attenuation Microwave Absorption 被引量:3
8
作者 Zhe Su Shan Yi +5 位作者 Wanyu Zhang Xiaxi Xu Yayun Zhang Shenghu Zhou Bo Niu Donghui Long 《Nano-Micro Letters》 SCIE EI CAS CSCD 2023年第10期478-493,共16页
The integration of nano-semiconductors into electromagnetic wave absorption materials is a highly desirable strategy for intensifying dielectric polarization loss;achieving high-attenuation microwave absorption and re... The integration of nano-semiconductors into electromagnetic wave absorption materials is a highly desirable strategy for intensifying dielectric polarization loss;achieving high-attenuation microwave absorption and realizing in-depth comprehension of dielectric loss mechanisms remain challenges.Herein,ultrafine oxygen vacancy-rich Nb_(2)O_(5)semiconductors are confined in carbon nanosheets(ov-Nb_(2)O_(5)/CNS)to boost dielectric polarization and achieve high attenuation.The polarization relaxation,electromagnetic response,and impedance matching of the ov-Nb_(2)O_(5)/CNS are significantly facilitated by the Nb_(2)O_(5)semiconductors with rich oxygen vacancies,which consequently realizes an extremely high attenuation performance of-80.8 dB(>99.999999%wave absorption)at 2.76 mm.As a dielectric polarization center,abundant Nb_(2)O_(5)–carbon heterointerfaces can intensify interfacial polarization loss to strengthen dielectric polarization,and the presence of oxygen vacancies endows Nb_(2)O_(5)semiconductors with abundant charge separation sites to reinforce electric dipole polarization.Moreover,the three-dimensional reconstruction of the absorber using microcomputer tomography technology provides insight into the intensification of the unique lamellar morphology regarding multiple reflection and scattering dissipation characteristics.Additionally,ov-Nb_(2)O_(5)/CNS demonstrates excellent application potential by curing into a microwave-absorbing,machinable,and heat-dissipating plate.This work provides insight into the dielectric polarization loss mechanisms of nano-semiconductor/carbon composites and inspires the design of high-performance microwave absorption materials. 展开更多
关键词 Electromagnetic wave absorption Nb_(2)O_(5)semiconductor Dielectric polarization loss Oxygen vacancy Nb_(2)O_(5)-carbon hetero-interface
下载PDF
Phase and direction dependence of photorefraction in a low-frequency strong circular-polarized plane wave
9
作者 黄永盛 王乃彦 汤秀章 《Chinese Physics B》 SCIE EI CAS CSCD 2015年第5期335-339,共5页
Contrary to the superposition principle, it is well known that photorefraction exists in the vacuum with the presence of a strong static field, a laser field, or a rotational magnetic field. Different from the classic... Contrary to the superposition principle, it is well known that photorefraction exists in the vacuum with the presence of a strong static field, a laser field, or a rotational magnetic field. Different from the classical optical crystals, the refractive index also depends on the phase of the strong electromagnetic field. We obtain the phase and direction dependence of the refractive index of a probe wave incident in the strong field of a circular-polarized plane wave by solving the Maxwell equations corrected by the effective Lagrangian. It may provide a valuable theoretical basis to calculate the polarization evolution of waves in the strong electromagnetic circumstances of pulsar or neutron stars. 展开更多
关键词 phase and direction dependence circular-polarized plane wave refractive index polarization evolution
下载PDF
Linear polarization output performance of Nd:YAG laser at 946 nm considering the energy-transfer upconversion
10
作者 冯晋霞 李渊骥 张宽收 《Chinese Physics B》 SCIE EI CAS CSCD 2018年第7期366-370,共5页
A theoretical model of quasi-three-level laser system is developed, in which both the thermally induced depolarization loss and the effect of energy-transfer upconversion are taken into account. Based on the theoretic... A theoretical model of quasi-three-level laser system is developed, in which both the thermally induced depolarization loss and the effect of energy-transfer upconversion are taken into account. Based on the theoretical investigation of the influences of output transmission and incident pump power on thermally induced depolarization loss, the output performance of 946 nm linearly polarized Nd:YAG laser is experimentally studied. By optimizing the transmission of output coupler, a 946 nm linearly polarized continuous-wave single-transverse-mode laser with an output power of 4.2 W and an optical-optical conversion efficiency of 16.8% is obtained, and the measured beam quality factors are M2 = 1.13 and My2 = 1.21. The theoretical prediction is in good agreement with the experimental result. 展开更多
关键词 946 nm laser linear polarization thermally induced depolarization losses energy-transfer upcon-version
下载PDF
Effect of the orientation of non-spherical metal nanoparticle with respect to light polarization on its transient optical response
11
作者 Asha Singh Himanshu Srivastava +1 位作者 Rama Chari J.Jayabalan 《Nanotechnology and Precision Engineering》 EI CAS CSCD 2023年第2期41-47,共7页
Nanoparticles with non-spherical shapes are now being widely used for various photonic applications.We observe experimentally that the magnitude as well as the time dependence of the transient absorption of a colloid ... Nanoparticles with non-spherical shapes are now being widely used for various photonic applications.We observe experimentally that the magnitude as well as the time dependence of the transient absorption of a colloid of silver nanoplatelets depends on the relative polarization of the pump and probe pulses.There have been a few reports about the dependence of the transient signal magnitude on polarization,but little information is available on its temporal dependence.Using a theoretical model,we show that this observed behavior arises from the fact that the energy absorption by a non-spherical nanoparticle depends on,among other factors,the nanoparticle orientation with respect to the pump and probe polarization directions.It is essential to consider this when estimating nanoparticle characteristics such as carrier thermalization time,carrier–phonon scattering time,and complex polarizability from transient absorption measurements. 展开更多
关键词 Ultrafast dynamics Metal Nanoparticles Transient Absorption polarization dependence
下载PDF
Measuring Tail Dependence for Aggregate Collateral Losses Using Bivariate Compound Shot-Noise Cox Process
12
作者 Jiwook Jang Genyuan Fu 《Applied Mathematics》 2012年第12期2191-2204,共14页
In this paper, we introduce tail dependene measures for collateral losses from catastrophic events. To calculate these measures, we use bivariate compound process where a Cox process with shot noise intensity is used ... In this paper, we introduce tail dependene measures for collateral losses from catastrophic events. To calculate these measures, we use bivariate compound process where a Cox process with shot noise intensity is used to count collateral losses. A homogeneous Poisson process is also examined as its counterpart for the case where the catastrophic loss frequency rate is deterministic. Joint Laplace transform of the distribution of the aggregate collateral losses is derived and joint Fast Fourier transform is used to obtain the joint distributions of aggregate collateral losses. For numerical illustrations, a member of Farlie-Gumbel-Morgenstern copula with exponential margins is used. The figures of the joint distributions of collateral losses, their contours and numerical calculations of risk measures are also provided. 展开更多
关键词 AGGREGATE COLLATERAL lossES BIVARIATE COMPOUND Cox PROCESS Shot Noise PROCESS Farlie-Gumbel-Morgenstern Copula Tail dependence Joint Fast Fourier Transform
下载PDF
Sensitivity of Pion versus Parton-Jet Nuclear Modification Factors to the Path-Length Dependence of Jet-Energy Loss at RHIC and LHC
13
作者 Barbara Betz Miklos Gyulassy 《Chinese Physics Letters》 SCIE CAS CSCD 2015年第12期30-34,共5页
We compare the jet-path length and beam-energy dependence of the pion nuclear modification factor and a patton-jet nuclear modification factor at RHIC and LHC, and contrast the predictions based on a linear pQCD and a... We compare the jet-path length and beam-energy dependence of the pion nuclear modification factor and a patton-jet nuclear modification factor at RHIC and LHC, and contrast the predictions based on a linear pQCD and a highly non-linear hybrid AdS holographic model of jet-energy loss. It is found that both models require a reduction of the jet-medium coupling from RHIC to LHC to account for the measured pion nuclear modification factor. In the case of the parton-jet nuclear modification factor, however, which serves as a lower bound for the LO jet nuclear modification factor of reconstructed jets, the extracted data can be characterized without a reduced jet-medium coupling at LHC energies. It is concluded that when the reconstructed jets are sensitive to both quarks and gluons and thus provide more information than the pion nuclear modification factor, their information regarding the jet-medium coupling is limited due to the superposition with NLO and medium effects. Hence, a detailed description of the underlying physics requires both the leading hadron and the reconstructed jet nuclear modification factor. Unfortunately, the results for both the pion and the parton-jet nuclear modification factor are insensitive to the jet-path dependence of the models considered. 展开更多
关键词 LHC Sensitivity of Pion versus Parton-Jet Nuclear Modification Factors to the Path-Length dependence of Jet-Energy loss at RHIC and LHC
下载PDF
Polarization Properties Study of an Apodized FBG Filter
14
作者 Moez Ferchichi Monia Najjar Houria Rezig 《通讯和计算机(中英文版)》 2012年第3期276-284,共9页
关键词 光纤光栅滤波器 偏振特性 变迹 布拉格光纤光栅 偏振相关损耗 差分群时延 耦合模理论 折射率调制
下载PDF
Infrared Fault Detection Method for Dense Electrolytic Bath Polar Plate Based on YOLOv5s
15
作者 Huiling Yu Yanqiu Hang +2 位作者 Shen Shi Kangning Wu Yizhuo Zhang 《Computers, Materials & Continua》 SCIE EI 2024年第9期4859-4874,共16页
Electrolysis tanks are used to smeltmetals based on electrochemical principles,and the short-circuiting of the pole plates in the tanks in the production process will lead to high temperatures,thus affecting normal pr... Electrolysis tanks are used to smeltmetals based on electrochemical principles,and the short-circuiting of the pole plates in the tanks in the production process will lead to high temperatures,thus affecting normal production.Aiming at the problems of time-consuming and poor accuracy of existing infrared methods for high-temperature detection of dense pole plates in electrolysis tanks,an infrared dense pole plate anomalous target detection network YOLOv5-RMF based on You Only Look Once version 5(YOLOv5)is proposed.Firstly,we modified the Real-Time Enhanced Super-Resolution Generative Adversarial Network(Real-ESRGAN)by changing the U-shaped network(U-Net)to Attention U-Net,to preprocess the images;secondly,we propose a new Focus module that introduces the Marr operator,which can provide more boundary information for the network;again,because Complete Intersection over Union(CIOU)cannot accommodate target borders that are increasing and decreasing,replace CIOU with Extended Intersection over Union(EIOU),while the loss function is changed to Focal and Efficient IOU(Focal-EIOU)due to the different difficulty of sample detection.On the homemade dataset,the precision of our method is 94%,the recall is 70.8%,and the map@.5 is 83.6%,which is an improvement of 1.3%in precision,9.7%in recall,and 7%in map@.5 over the original network.The algorithm can meet the needs of electrolysis tank pole plate abnormal temperature detection,which can lay a technical foundation for improving production efficiency and reducing production waste. 展开更多
关键词 Infrared polar plate fault detection YOLOv5 Real-ESRGAN Marr boundary detection operator Focal-EIoU loss
下载PDF
Spin-dependent transport characteristics of nanostructures based on armchair arsenene nanoribbons
16
作者 杨开巍 李明君 +3 位作者 张小姣 李新梅 高永立 龙孟秋 《Chinese Physics B》 SCIE EI CAS CSCD 2017年第9期542-548,共7页
By employing non-equilibrium Green's function combined with the spin-polarized density-functional theory, we investigate the spin-dependent electronic transport properties of armchair arsenene nanoribbons(a As NRs)... By employing non-equilibrium Green's function combined with the spin-polarized density-functional theory, we investigate the spin-dependent electronic transport properties of armchair arsenene nanoribbons(a As NRs). Our results show that the spin-metal and spin-semiconductor properties can be observed in a As NRs with different widths. We also find that there is nearly 100% bipolar spin-filtering behavior in the a As NR-based device with antiparallel spin configuration. Moreover, rectifying behavior and giant magnetoresistance are found in the device. The corresponding physical analyses have been given. 展开更多
关键词 armchair arsenene nanoribbons spin-dependent electronic transport property spin-polarized density-functional theory bipolar spin-filtering behavior
下载PDF
Integration of Electrical Properties and Polarization Loss Modulation on Atomic Fe–N‑RGO for Boosting Electromagnetic Wave Absorption
17
作者 Kaili Zhang Yuefeng Yan +4 位作者 Zhen Wang Guansheng Ma Dechang Jia Xiaoxiao Huang Yu Zhou 《Nano-Micro Letters》 SCIE EI CAS 2025年第2期517-532,共16页
Developing effective strategies to regulate graphene’s conduction loss and polarization has become a key to expanding its application in the electromagnetic wave absorption(EMWA)field.Based on the unique energy band ... Developing effective strategies to regulate graphene’s conduction loss and polarization has become a key to expanding its application in the electromagnetic wave absorption(EMWA)field.Based on the unique energy band structure of graphene,regulating its bandgap and electrical properties by introducing heteroatoms is considered a feasible solution.Herein,metal-nitrogen doping reduced graphene oxide(M–N-RGO)was prepared by embedding a series of single metal atoms M–N_(4) sites(M=Mn,Fe,Co,Ni,Cu,Zn,Nb,Cd,and Sn)in RGO using an N-coordination atom-assisted strategy.These composites had adjustable conductivity and polarization to optimize dielectric loss and impedance matching for efficient EMWA performance.The results showed that the minimum reflection loss(RL_(min))of Fe–N-RGO reaches−74.05 dB(2.0 mm)and the maximum effective absorption bandwidth(EAB_(max))is 7.05 GHz(1.89 mm)even with a low filler loading of only 1 wt%.Combined with X-ray absorption spectra(XAFS),atomic force microscopy,and density functional theory calculation analysis,the Fe–N_(4) can be used as the polarization center to increase dipole polarization,interface polarization and defect-induced polarization due to d-p orbital hybridization and structural distortion.Moreover,electron migration within the Fe further leads to conduction loss,thereby synergistically promoting energy attenuation.This study demonstrates the effectiveness of metal-nitrogen doping in regulating the graphene′s dielectric properties,which provides an important basis for further investigation of the loss mechanism. 展开更多
关键词 Electromagnetic wave absorption Fe-N-RGO Dipole polarization Conduction loss Impedance matching
下载PDF
Effect of Polarization Dependent Loss on Polarization-Multiplexed Transmission System
18
作者 H. C. Ji J. H. Lee +1 位作者 K. J. Park Y. C. Chung 《光学学报》 EI CAS CSCD 北大核心 2003年第S1期641-642,共2页
We report on the effects of the polarization-dependent loss (PDL) on the polarization-multiplexed system. The result shows that the PDL of 0.9 dB could cause 1-dB power penalty. Unlike PMD, the effect of PDL was not d... We report on the effects of the polarization-dependent loss (PDL) on the polarization-multiplexed system. The result shows that the PDL of 0.9 dB could cause 1-dB power penalty. Unlike PMD, the effect of PDL was not dependent on the transmission speed. 展开更多
关键词 PDL AS of Effect of polarization dependent loss on polarization-Multiplexed Transmission System on
原文传递
Apelin-13抑制巨噬细胞M1极化缓解全身炎症性骨丢失
19
作者 王文涛 侯振扬 +1 位作者 王熠军 徐耀增 《中国组织工程研究》 CAS 北大核心 2025年第8期1548-1555,共8页
背景:Apelin-13因具有抗炎和抗氧化等生物活性,在神经炎症、心血管损伤和肺炎等临床常见疾病中发挥着有效的治疗作用,然而对于Apelin-13在治疗炎症性骨丢失中是否同样具有良好的疗效目前尚无相关基础研究。目的:探究Apelin-13对炎症性... 背景:Apelin-13因具有抗炎和抗氧化等生物活性,在神经炎症、心血管损伤和肺炎等临床常见疾病中发挥着有效的治疗作用,然而对于Apelin-13在治疗炎症性骨丢失中是否同样具有良好的疗效目前尚无相关基础研究。目的:探究Apelin-13对炎症性骨丢失的治疗作用及其机制,以期探究治疗炎症性骨丢失的潜在药物。方法:①体外实验:将RAW264.7细胞分为3组:对照组,脂多糖组和治疗组。对照组只加入DMEM完全培养基;脂多糖组加入脂多糖(100 ng/mL)诱导炎症DMEM培养基;治疗组加入10 nmol/L Apelin-13+脂多糖诱导炎症DMEM培养基。诱导炎症24 h后,使用Western Blot检测M1型巨噬细胞的标志蛋白诱导型一氧化氮合酶和CD86的表达,并使用细胞免疫荧光染色检测诱导型一氧化氮合酶的表达。并在对照组、脂多糖组和治疗组中同时加入等量的核因子κB受体活化因子配体(50 ng/mL)诱导破骨细胞,诱导6 d后使用抗酒石酸酸性磷酸酶染色和F-actin染色评估破骨细胞诱导的结果。②体内实验:将18只C57BL/6雄性小鼠随机分为3组:假手术组、脂多糖组、治疗组。假手术组连续1周在小鼠腹腔内注射0.1 mL的PBS;脂多糖组注射0.1 mL含脂多糖(5 mg/kg)的PBS稀释液;治疗组注射0.1 mL含脂多糖(5 mg/kg)+Apelin-13(100μg/kg)的PBS稀释液。3组小鼠连续腹腔注射7 d,于第8天处死小鼠,收集每只小鼠的2个股骨,一半进行micro-CT扫描和骨参数分析,另一半进行苏木精-伊红染色。结果与结论:①体外实验:Western Blot结果显示,脂多糖组诱导型一氧化氮合酶和CD86的表达较对照组明显增多,而Apelin-13能够显著抑制脂多糖诱导的巨噬细胞M1极化,细胞免疫荧光的结果也显示治疗组诱导型一氧化氮合酶的表达较脂多糖组减少,同时抗酒石酸酸性磷酸酶染色和F-actin染色结果显示Apelin-13抑制脂多糖诱导的破骨细胞异常活化及骨吸收能力。②体内实验:micro-CT结果显示全身炎性导致股骨远端骨质出现明显丢失,而Apelin-13则能够显著抑制骨质的流失,苏木精-伊红染色结果也表明Apelin-13能够有效缓解炎症诱导的小鼠股骨远端骨质流失。③结果表明:Apelin-13能够通过抑制巨噬细胞M1极化,抑制破骨细胞的异常激活和骨吸收能力,缓解全身炎症诱导的骨丢失。 展开更多
关键词 APELIN-13 巨噬细胞极化 破骨细胞活化 全身炎症性骨丢失
下载PDF
Record Arctic Ozone Loss in Spring 2020 is Likely Caused by North Pacific Warm Sea Surface Temperature Anomalies 被引量:1
20
作者 Yan XIA Yongyun HU +2 位作者 Jiankai ZHANG Fei XIE Wenshou TIAN 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2021年第10期1723-1736,共14页
Record ozone loss was observed in the Arctic stratosphere in spring 2020.This study aims to determine what caused the extreme Arctic ozone loss.Observations and simulation results are examined in order to show that th... Record ozone loss was observed in the Arctic stratosphere in spring 2020.This study aims to determine what caused the extreme Arctic ozone loss.Observations and simulation results are examined in order to show that the extreme Arctic ozone loss was likely caused by record-high sea surface temperatures(SSTs)in the North Pacific.It is found that the record Arctic ozone loss was associated with the extremely cold and persistent stratospheric polar vortex over February-April,and the extremely cold vortex was a result of anomalously weak planetary wave activity.Further analysis reveals that the weak wave activity can be traced to anomalously warm SSTs in the North Pacific.Both observations and simulations show that warm SST anomalies in the North Pacific could have caused the weakening of wavenumber-1 wave activity,colder Arctic vortex,and lower Arctic ozone.These results suggest that for the present-day level of ozone-depleting substances,severe Arctic ozone loss could form again,as long as certain dynamic conditions are satisfied. 展开更多
关键词 Arctic ozone loss stratospheric polar vortex sea surface temperature planetary-scale wave climate change
下载PDF
上一页 1 2 35 下一页 到第
使用帮助 返回顶部